Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise

Hypertension

Volumn 50, Issue 2, 2007, Pages 403-409

  Van Guilder, Gary P ^a   Westby, Christian M ^a   Greiner, Jared J ^a   Stauffer, Brian L ^a,b,c   DeSouza, Christopher A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c DENVER HEALTH MEDICAL CENTER   (United States)

Author keywords

Blood flow regulation; Elderly; Endothelin; Exercise

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; VASOCONSTRICTOR AGENT;

ADULT; AEROBIC EXERCISE; AGE DISTRIBUTION; AGED; AGING; ARTICLE; BLOOD VESSEL TONE; COMPARATIVE STUDY; CONTROLLED STUDY; FOREARM BLOOD FLOW; HUMAN; MALE; NORMAL HUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; SITTING;

ADULT; AGE FACTORS; AGED; AGING; ANALYSIS OF VARIANCE; BODY COMPOSITION; COHORT STUDIES; CORONARY CIRCULATION; CORONARY DISEASE; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; EXERCISE; HUMANS; INTERVENTION STUDIES; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PROBABILITY; PROGNOSIS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; VASOCONSTRICTION;

EID: 34547647233     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.088294     Document Type: Article

References (48)

1. Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I, Salvetti A. Hypertension causes premature aging of endothelial function in humans. Hypertension. 1997;29:736-743.
2. Shimokawa H. Primary endothelial dysfunction: atherosclerosis. J Mol Cell Cardiol. 1999;31:23-37.
3. Cernak P, Stewart DJ, Monge J-C, Rouleau J-C. The endothelin system and its role in acute myocardial infarction. Can J Physiol Pharmacol. 2003;81:598-606.
4. Mano T, Masuyama T, Yamamoto K, Naito J, Kondo H, Nagano R, Tanouchi J, Hori M, Inoue M, Kamada T. Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound. Am Heart J. 1996;131:231-238.
5. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekshtein VI, Selwyn AP, Ganz P. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990;81:491-497.
6. Yasue H, Matsuyama K, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis. Circulation. 1990;81:482-490.
7. Luscher TF, Barton M. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation. 2000;102:2434-2440.
8. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999;61:391-415.
9. Kelly JJ, Whitworth JA. Endothelin-1 as a mediator in cardiovascular disease. Clin Exp Pharmacol Physiol. 1999;26:158-161.
10. Touyz RM, Schiffrin EL. Role of endothelin in human hypertension. Can J Physiol Pharmacol. 2003;81:533-541.
11. Ishihata A, Katano Y, Morinobu S, Endoh M. Influence of aging on the contractile response to endothelin of rat thoracic aorta. Eur J Pharmacol. 1991;200:199-201.
12. Goettsch W, Lattmann T, Amann K, Szibor M, Morawietz H, Munter K, Muller SP, Shaw S, Barton M. Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis. Biochem Biophys Res Comm. 2001;280:908-913.
13. Kumazaki T, Fujii T, Kobayashi M, Mitsui Y. Aging-and growth-dependent modulation of endothelin-1 gene expression in human vascular endothelial cells. Exp Cell Res. 1994;211:6-11.
14. White M, Courtemanche M, Stewart DJ, Talajic M, Mikes E, Cernacek P, Vantrimpont P, Leclerc D, Bussieres L, Rouleau JL. Age-and gender-related changes in endothelin and catecholamine release, and in autonomicbalance in response to head-up tilt. Clin Sci (Lond). 1997;93:309-316.
15. Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, Ajisaka R, Yamaguchi I, Matsuda M. Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J Appl Physiol. 2003;95:336-341.
16. Sayama H, Nakamura N, Saito N, Konoshita M. Does the plasma endothelin-1 concentration reflect atherosclerosis in the elderly? Gerontology. 1999;45:312-316.
17. Cardillo C, Kilcoyne CM, Cannon RO, Panza JA. Interactions between nitric oxide and endothelin in the regulation of vascular tone in human resistance vessels in vivo. Hypertension. 2000;35:1237-1241.
18. Cardillo C, Kilcoyne CM, Waclawiw M, Cannon RO, Panza JA. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension. 1999;33:753-758.
19. Taddei S, Virdis A, Ghiadoni L, Sudano I, Notari M, Salvetti A. Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension. Circulation. 1999;100:1680-1683.
20. Mather KJ, Mirzamohammadi B, Lteif A, Steinberg HO, Baron AD. Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes. Diabetes. 2002;51:3517-3523.
21. Lohman TG, Roche AF, Mortorell R. Athropometric Standardization Reference Manual. Champaign, IL: Human Kinetics; 1988.
22. DeSouza CA, Jones PP, Seals DR. Physical activity status and age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998;18:362-368.
23. Van Guilder GP, Hoetzer GL, Smith DT, Irmiger HM, Greiner JJ, Stauffer BL, DeSouza CA. Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obes Res. 2006;12:2127-2131.
24. DeSouza CA, Clevenger CM, Greiner JJ, Smith DT, Hoetzer GL, Shapiro LF, Stauffer BL. Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans. J Physiol (Lond). 2002;542:255-262.
25. Cardillo C, Campia U, Bryant MB, Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation. 2002;106:1783-1787.
26. Cardillo C, Campia U, Kilcoyne CM, Bryant MB, Panza JA. Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation. 2002;105:452-456.
27. Van Guilder GP, Hoetzer GL, Smith DT, Irmiger HM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. Am J Physiol. 2005;289:E807-E813.
28. Ferro CJ, Haynes WG, Hand MF, Webb DJ. Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension. Clin Sci (Lond). 2002;103(suppl 48):53S-58S.
29. Ferro CJ, Webb DJ. Endothelial dysfunction and hypertension. Drugs. 1997;53(suppl 1):30-41.
30. Kuc RE, Davenport AP. Endothelin-A-receptors in human aorta and pulmonary arteries are downregulated in patients with cardiovascular disease: an adaptive response to increased levels of endothelin-1? J Cardiovasc Pharmacol. 2000;36(5 suppl 1):S377-S379.
31. Nohria A, Garrett L, Johnson W, Kinlay S, Ganz P, Creager MA. Endothelin-1 and vascular tone in subjects with atherogenic risk factors. Hypertension. 2003;42:43-48.
32. Cardillo C, Kilcoyne CM, Cannon RO, Panza JA. Increased activity of endougenous endothelin in patients with hypercholesterolemia. J Am Coll Cardiol. 2000;36:1483-1488.
33. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38:274-279.
34. Pollock DM, Pollock JS. Endothelin and oxidative stress in the vascular system. Curr Vasc Pharmacol. 2005;3:365-367.
35. Haug C, Schmid-Kotsas A, Zorn U, Schuett S, Gross HJ, Gruenert A, Bachem MG. Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins. J Mol Cell Cardiol. 2001;33:1701-1712.
36. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, Guralnik JM, Longo DL. The origins of age-related proinflammatory state. Blood. 2005;105:2294-2299.
37. Bruunsgaard H, Skinhoj P, Pedersen AN, Schroll M, Pedersen BK. Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis. Clin Exp Immunol. 2000;121:255-260.
38. Verma S, Li SH, Badiwala MV, Weisel RD, Fedak PW, Li RK, Dhillon B, Mickle DA. Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation. 2002;105:1890-1896.
39. Patel JN, Jager A, Schalkwijk C, Corder R, Douthwaite JA, Yudkin JS, Coppack SW, Stehouwer CD. Effects of tumor necrosis factor-alpha in the human forearm: blood flow and endothelin-1 release. Clin Sci (Lond). 2002;103:409-415.
40. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores the age-related decline in endothelium-dependent vasodilation in healthy men. Circulation. 2000;102:1351-1357.
41. Hoetzer GL, Van Guilder GP, Irmiger H, Keith RS, Stauffer BL, DeSouza CA. Aging, exercise and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol. 2007;102:847-852.
42. Smith DT, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. J Physiol (Lond). 2003;546:289-298.
43. Bauman AE. Updating the evidence that physical activity is good for health: an epidemiological review 2000-2003. J Sci Med Sport. 2004;7(1 suppl):6-19.
44. Blair SN, Kohl HW, Paffenbarger RS, Clark DG, Cooper KH. Physical fitness and all-cause mortality. A perspective study of healthy men and women. JAMA. 1989;262:2395-2401.
45. Hoetzer GL, Maceneaney OJ, Irmiger HM, Keith R, Van Guilder GP, Stauffer BL, Desouza CA. Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults. Am J Cardiol. 2007;99:46-48.
46. Stauffer BL, Hoetzer GL, Van Guilder GP, Smith DT, Desouza CA. Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults. J Am Coll Cardiol. 2005;45:1547-1549.
47. McAuley DF, Nugent AG, Mcgurk C, Maguire S, Hayes JR, Johnston GD. Vasoconstriction to endogenous endothelin-1 is impaired in patients with type II diabetes mellitus. Clin Sci (Lond). 2000;99:175-179.
48. Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ. Endothelin-a receptor antagonist-mediated vasodilation is attenuated by inhibition of nitric oxide synthesis and by endothelin-b receptor blockade. Circulation. 1998;97:752-756.