H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 1, 2007, Pages

  Erdei, Nóra ^b   Bagi, Zsolt ^b   Édes, István ^b   Kaley, Gabor ^a   Koller, Akos ^a,c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

3 nitrotyrosine; Arteriolar tone; Cyclooxygenase 2; db db; Thromboxane A2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 NITROTYROSINE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; CATALASE; DICHLOROFLUORESCEIN; HYDROGEN PEROXIDE; PROSTAGLANDIN H2; PROSTAGLANDIN RECEPTOR; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CAROTID ARTERY; CONTROLLED STUDY; GRACILIS MUSCLE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MUSCLE BLOOD FLOW; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; ANIMAL; ARTERIOLE; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

ANIMALS; ARTERIOLES; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; PROSTAGLANDINS; VASOCONSTRICTION;

EID: 33846204372     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00596.2006     Document Type: Article

References (46)

1. Baber SR, Champion HC, Bivalacqua TJ, Hyman AL, Kadowitz PJ. Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds. Circulation 108: 896-901, 2003.
2. Bagi Z, Erdei N, Toth A, Li W, Hintze TH, Koller A, Kaley G. Type 2 diabetic mice have increased arteriolar tone and blood pressure. Enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25: 1610-1616, 2005.
3. Bagi Z, Toth E, Koller A, Kaley G. Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH4. Am J Physiol Heart Circ Physiol 287: H626-H633, 2004.
4. Bagi Z, Koller A, Kaley G. Superoxide-NO interaction decreases flowand agonist-induced dilation of coronary arterioles in Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 285: H1404-H1410, 2003.
5. Bagi Z, Koller A, Kaley G. PPARγ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. Am J Physiol Heart Circ Physiol 286: H742-H748, 2004.
6. Belton OA, Duffy A, Toomey S, Fitzgerald DJ. Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis. Circulation 108: 3017-3023, 2003.
7. Bogatcheva NV, Sergeeva MG, Dudek SM, Verin AD. Arachidonic acid cascade in endothelial pathobiology. Microvasc Res 69: 107-127, 2005.
8. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
9. Cseko C, Bagi Z, Koller A. Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways. J Appl Physiol 97: 1130-1137, 2004.
10. De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol 130: 963-974, 2000.
11. Erdos B, Simandle SA, Snipes JA, Miller AW, Busija DW. Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species. Stroke 35: 964-969, 2004.
12. Frisbee JC, Maier KG, Stepp DW. Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats. Am J Physiol Heart Circ Physiol 283: H2160-H2168, 2002.
13. 2 production. Br J Pharmacol 134: 1639-1646, 2001.
14. Garcia-Cohen EC, Marin J, Diez-Picazo LD, Baena AB, Salaices M, and Rodriguez-Martinez MA. Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J Pharmacol Exp Ther 293: 75-81, 2000.
15. Guo Z, Su W, Allen S, Pang H, Daugherty A, Smart E, Gong MC. COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res 67: 723-735, 2005.
16. Helmersson J, Vessby B, Larsson A, Basu S. Association of Type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. Circulation 109: 1729-1734, 2004.
17. 2 in aorta of the spontaneously hypertensive rat. J Cardiovasc Pharmacol 33: 605-610, 1999.
18. Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 153: 1127-1128, 1966.
19. Jaap AJ, Shore AC, Tooke JE. The influence of hypertension on microvascular blood flow and resistance to flow in the skin of patients with Type 2 (non-insulin-dependent) diabetes. Diabet Med 11: 883-887, 1994.
20. Kobayashi T, Kamata K. Modulation by hydrogen peroxide of noradrenaline-induced contraction in aorta from streptozotocin-induced diabetic rat. Eur J Pharmacol 441: 83-89, 2002.
21. Koller A. Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation 9: 277-294, 2002.
22. Koller A, Sun D, Huang A, Kaley G. Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles. Am J Physiol Heart Circ Physiol 267: H326-H332, 1994.
23. Kromer BM, Tippins JR. Coronary artery constriction by the isoprostane 8-epi prostaglandin F2 alpha. Br J Pharmacol 119: 1276-1280, 1996.
24. Kulmacz RJ, Wang LH. Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2. J Biol Chem 270: 24019-24023, 1995.
25. Kunsch C, Medford RM. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 85: 753-766, 1999.
26. Lacy F, Kailasam MT, O'Connor DT, Schmid-Schonbein GW, Parmer RJ. Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 36: 878-84, 2000.
27. 2 effects on cerebral prostanoids and pial arteriolar diameter in piglets. Am J Physiol Heart Circ Physiol 258: H1382-H1387, 1990.
28. Marshall HE, Merchant K, Stamler JS. Nitrosation and oxidation in the regulation of gene expression. FASEB J 14: 1889-1900, 2000.
29. Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD. Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res 92: 31- 40, 2003.
30. 2/ prostaglandin endoperoxide receptors in porcine carotid arteries. Biochem Biophys Res Commun 225: 915-923, 1996.
31. Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 44: 2293-2300, 2004.
32. Nowicki PT, Flavahan S, Hassanain H, Mitra S, Holland S, Goldschmidt-Clermont PJ, Flavahan NA. Redox signaling of the arteriolar myogenic response. Circ Res 89: 114-6, 2001.
33. Quilley J, Chen YJ. Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney. Hypertension 42: 837-843, 2003.
34. Roberts LJ, Morrow JD. Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. Ann NY Acad Sci 744: 237-242, 1994.
35. Rodriguez-Martinez MA, Garcia-Cohen EC, Baena AB, Gonzalez R, Salaices M, Marin J. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved. Br J Pharmacol 125: 1329-1335, 1998.
36. Stehouwer CD, Lambert J, Donker AJ, van Hinsbergh VW. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 34: 55-68, 1997.
37. Swei A, Lacy F, DeLano FA, and Schmid-Schonbein GW. Oxidative stress in the Dahl hypertensive rat. Hypertension 30: 1628-1633, 1997.
38. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol Heart Circ Physiol 263: H321-H326, 1992.
39. Thengchaisri N, Kuo L. Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels. Am J Physiol Heart Circ Physiol 285: H2255-H2263, 2003.
40. Turner RC, Millns H, Neil HA, Stratton IM, Manley SE, Matthews DR, Holman RR. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 316: 823-828, 1998.
41. 2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine. Hypertension 16: 162-169, 1990.
42. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119, 2005.
43. Wolin MS. Activated oxygen metabolites as regulators of vascular tone. Klin Wochenschr 69: 1046-1049, 1991.
44. Zou M, Jendral M, Ullrich V. Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol 126: 1283-1292, 1999.
45. Zou M, Yesilkaya A, Ullrich V. Peroxynitrite inactivates prostacyclin synthase by heme-thiolate-catalyzed tyrosine nitration. Drug Metab Rev 31: 343-349, 1999.
46. Zou MH, Cohen R, Ullrich V. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium 11: 89-97, 2004.