-
1
-
-
0025647249
-
Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6
-
Kimura H., Ishibashi T., Shikama Y., et al. Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. Blood 1990, 76(12):2493-2500.
-
(1990)
Blood
, vol.76
, Issue.12
, pp. 2493-2500
-
-
Kimura, H.1
Ishibashi, T.2
Shikama, Y.3
-
2
-
-
0028343099
-
Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
-
Bartley T.D., Bogenberger J., Hunt P., et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994, 77(7):1117-1124.
-
(1994)
Cell
, vol.77
, Issue.7
, pp. 1117-1124
-
-
Bartley, T.D.1
Bogenberger, J.2
Hunt, P.3
-
3
-
-
0028199208
-
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
-
Lok S., Kaushansky K., Holly R.D., et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994, 369(6481):565-568.
-
(1994)
Nature
, vol.369
, Issue.6481
, pp. 565-568
-
-
Lok, S.1
Kaushansky, K.2
Holly, R.D.3
-
4
-
-
0028302409
-
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
-
de Sauvage F.J., Hass P.E., Spencer S.D., et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994, 369(6481):533-538.
-
(1994)
Nature
, vol.369
, Issue.6481
, pp. 533-538
-
-
de Sauvage, F.J.1
Hass, P.E.2
Spencer, S.D.3
-
5
-
-
0028117771
-
The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production
-
Kuter D.J., Beeler D.L., Rosenberg R.D. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci U S A 1994, 91(23):11104-11108.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.23
, pp. 11104-11108
-
-
Kuter, D.J.1
Beeler, D.L.2
Rosenberg, R.D.3
-
6
-
-
0029148579
-
Purification and characterization of thrombopoietin
-
Kato T., Ogami K., Shimada Y., et al. Purification and characterization of thrombopoietin. J Biochem 1995, 118(1):229-236.
-
(1995)
J Biochem
, vol.118
, Issue.1
, pp. 229-236
-
-
Kato, T.1
Ogami, K.2
Shimada, Y.3
-
7
-
-
0022539087
-
In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF
-
Metcalf D., Burgess A.W., Johnson G.R., et al. In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF. J Cell Physiol 1986, 128(3):421-431.
-
(1986)
J Cell Physiol
, vol.128
, Issue.3
, pp. 421-431
-
-
Metcalf, D.1
Burgess, A.W.2
Johnson, G.R.3
-
8
-
-
0027241138
-
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells
-
Debili N., Masse J.M., Katz A., Guichard J., Breton-Gorius J., Vainchenker W. Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells. Blood 1993, 82(1):84-95.
-
(1993)
Blood
, vol.82
, Issue.1
, pp. 84-95
-
-
Debili, N.1
Masse, J.M.2
Katz, A.3
Guichard, J.4
Breton-Gorius, J.5
Vainchenker, W.6
-
9
-
-
0028273187
-
Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin
-
Leonard J.P., Quinto C.M., Kozitza M.K., Neben T.Y., Goldman S.J. Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood 1994, 83(6):1499-1506.
-
(1994)
Blood
, vol.83
, Issue.6
, pp. 1499-1506
-
-
Leonard, J.P.1
Quinto, C.M.2
Kozitza, M.K.3
Neben, T.Y.4
Goldman, S.J.5
-
10
-
-
0023110326
-
Hemopoietic responses in mice injected with purified recombinant murine GM-CSF
-
Metcalf D., Begley C.G., Williamson D.J., et al. Hemopoietic responses in mice injected with purified recombinant murine GM-CSF. Exp Hematol 1987, 15(1):1-9.
-
(1987)
Exp Hematol
, vol.15
, Issue.1
, pp. 1-9
-
-
Metcalf, D.1
Begley, C.G.2
Williamson, D.J.3
-
11
-
-
0022468416
-
Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice
-
Metcalf D., Begley C.G., Johnson G.R., Nicola N.A., Lopez A.F., Williamson D.J. Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood 1986, 68(1):46-57.
-
(1986)
Blood
, vol.68
, Issue.1
, pp. 46-57
-
-
Metcalf, D.1
Begley, C.G.2
Johnson, G.R.3
Nicola, N.A.4
Lopez, A.F.5
Williamson, D.J.6
-
12
-
-
9244234420
-
A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
-
Tepler I., Elias L., Smith J.W., et al. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 1996, 87(9):3607-3614.
-
(1996)
Blood
, vol.87
, Issue.9
, pp. 3607-3614
-
-
Tepler, I.1
Elias, L.2
Smith, J.W.3
-
13
-
-
0032246170
-
A randomized trial of recombinant human interleukin-11 following autologous bone marrow transplantation with peripheral blood progenitor cell support in patients with breast cancer
-
Vredenburgh J.J., Hussein A., Fisher D., et al. A randomized trial of recombinant human interleukin-11 following autologous bone marrow transplantation with peripheral blood progenitor cell support in patients with breast cancer. Biol Blood Marrow Transplant 1998, 4(3):134-141.
-
(1998)
Biol Blood Marrow Transplant
, vol.4
, Issue.3
, pp. 134-141
-
-
Vredenburgh, J.J.1
Hussein, A.2
Fisher, D.3
-
14
-
-
0000009286
-
Demonstration and some properties of human thrombopoietin in thrombocythaemic sera
-
Kelemen E., Cserhati I., Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta Haematol 1958, 20:350-355.
-
(1958)
Acta Haematol
, vol.20
, pp. 350-355
-
-
Kelemen, E.1
Cserhati, I.2
Tanos, B.3
-
15
-
-
84973584812
-
Thrombopoietin
-
Kelemen E. Thrombopoietin. BMJ 1970, 2(711):733-734.
-
(1970)
BMJ
, vol.2
, Issue.711
, pp. 733-734
-
-
Kelemen, E.1
-
16
-
-
0028961798
-
Specific thrombopoietin cloned and sequenced-with personal retrospect and clinical prospects [editorial]
-
Kelemen E. Specific thrombopoietin cloned and sequenced-with personal retrospect and clinical prospects [editorial]. Leukemia 1995, 9(1):1-2.
-
(1995)
Leukemia
, vol.9
, Issue.1
, pp. 1-2
-
-
Kelemen, E.1
-
17
-
-
0029035989
-
Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor
-
Hunt P., Li Y.S., Nichol J.L., et al. Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 1995, 86(2):540-547.
-
(1995)
Blood
, vol.86
, Issue.2
, pp. 540-547
-
-
Hunt, P.1
Li, Y.S.2
Nichol, J.L.3
-
18
-
-
0028022980
-
Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit
-
Kuter D.J., Rosenberg R.D. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994, 84(5):1464-1472.
-
(1994)
Blood
, vol.84
, Issue.5
, pp. 1464-1472
-
-
Kuter, D.J.1
Rosenberg, R.D.2
-
19
-
-
0025674093
-
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
-
Souyri M., Vigon I., Penciolelli J.F., Heard J.M., Tambourin P., Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990, 63(6):1137-1147.
-
(1990)
Cell
, vol.63
, Issue.6
, pp. 1137-1147
-
-
Souyri, M.1
Vigon, I.2
Penciolelli, J.F.3
Heard, J.M.4
Tambourin, P.5
Wendling, F.6
-
20
-
-
0026684707
-
Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily
-
Vigon I., Mornon J.P., Cocault L., et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992, 89(12):5640-5644.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.12
, pp. 5640-5644
-
-
Vigon, I.1
Mornon, J.P.2
Cocault, L.3
-
21
-
-
0028557354
-
Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization
-
Foster D.C., Sprecher C.A., Grant F.J., et al. Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci U S A 1994, 91(26):13023-13027.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.26
, pp. 13023-13027
-
-
Foster, D.C.1
Sprecher, C.A.2
Grant, F.J.3
-
22
-
-
0035760892
-
Thrombocytopenia caused by the development of antibodies to thrombopoietin
-
Li J., Yang C., Xia Y., et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001, 98(12):3241-3248.
-
(2001)
Blood
, vol.98
, Issue.12
, pp. 3241-3248
-
-
Li, J.1
Yang, C.2
Xia, Y.3
-
23
-
-
0030461838
-
Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246
-
Hoffman R.C., Andersen H., Walker K., et al. Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246. Biochemistry 1996, 35(47):14849-14861.
-
(1996)
Biochemistry
, vol.35
, Issue.47
, pp. 14849-14861
-
-
Hoffman, R.C.1
Andersen, H.2
Walker, K.3
-
24
-
-
12644303248
-
Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin
-
Kato T., Oda A., Inagaki Y., et al. Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin. Proc Natl Acad Sci USA 1997, 94(9):4669-4674.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.9
, pp. 4669-4674
-
-
Kato, T.1
Oda, A.2
Inagaki, Y.3
-
25
-
-
0028899548
-
Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
-
Gurney A.L., Kuang W.J., Xie M.H., Malloy B.E., Eaton D.L., de Sauvage F.J. Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 1995, 85(4):981-988.
-
(1995)
Blood
, vol.85
, Issue.4
, pp. 981-988
-
-
Gurney, A.L.1
Kuang, W.J.2
Xie, M.H.3
Malloy, B.E.4
Eaton, D.L.5
de Sauvage, F.J.6
-
26
-
-
0029089989
-
Thrombopoietin and neurotrophins share a common domain
-
Li B., Dai W. Thrombopoietin and neurotrophins share a common domain. Blood 1995, 86(4):1643-1644.
-
(1995)
Blood
, vol.86
, Issue.4
, pp. 1643-1644
-
-
Li, B.1
Dai, W.2
-
27
-
-
0031458673
-
A structural model of the human thrombopoietin receptor complex
-
185-8
-
Deane C.M., Kroemer R.T., Richards W.G. A structural model of the human thrombopoietin receptor complex. J Mol Graph Model 1997, 15(3):170-178. 185-8.
-
(1997)
J Mol Graph Model
, vol.15
, Issue.3
, pp. 170-178
-
-
Deane, C.M.1
Kroemer, R.T.2
Richards, W.G.3
-
28
-
-
0029086661
-
Characterization of the truncated thrombopoietin variants
-
Wada T., Nagata Y., Nagahisa H., et al. Characterization of the truncated thrombopoietin variants. Biochem Biophys Res Comm 1995, 213(3):1091-1098.
-
(1995)
Biochem Biophys Res Comm
, vol.213
, Issue.3
, pp. 1091-1098
-
-
Wada, T.1
Nagata, Y.2
Nagahisa, H.3
-
29
-
-
0032142794
-
Human thrombopoietin structure-function relationships: identification of functionally important residues
-
Jagerschmidt A., Fleury V., Anger-Leroy M., Thomas C., Agnel M., O'Brien D.P. Human thrombopoietin structure-function relationships: identification of functionally important residues. Biochem J 1998, 333(Pt 3):729-734.
-
(1998)
Biochem J
, vol.333
, Issue.PT 3
, pp. 729-734
-
-
Jagerschmidt, A.1
Fleury, V.2
Anger-Leroy, M.3
Thomas, C.4
Agnel, M.5
O'Brien, D.P.6
-
30
-
-
2642679282
-
Identification of functionally important residues of human thrombopoietin
-
Park H., Park S.S., Jin E.H., et al. Identification of functionally important residues of human thrombopoietin. J Biol Chem 1998, 273(1):256-261.
-
(1998)
J Biol Chem
, vol.273
, Issue.1
, pp. 256-261
-
-
Park, H.1
Park, S.S.2
Jin, E.H.3
-
31
-
-
1842292815
-
Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites
-
Pearce K.H., Potts B.J., Presta L.G., Bald L.N., Fendly B.M., Wells J.A. Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites. J Biol Chem 1997, 272(33):20595-20602.
-
(1997)
J Biol Chem
, vol.272
, Issue.33
, pp. 20595-20602
-
-
Pearce, K.H.1
Potts, B.J.2
Presta, L.G.3
Bald, L.N.4
Fendly, B.M.5
Wells, J.A.6
-
32
-
-
10744223059
-
Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
-
Feese M.D., Tamada T., Kato Y., et al. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci U S A 2004, 101(7):1816-1821.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.7
, pp. 1816-1821
-
-
Feese, M.D.1
Tamada, T.2
Kato, Y.3
-
33
-
-
0028803099
-
Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
-
Hokom M.M., Lacey D., Kinstler O.B., et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 1995, 86(12):4486-4492.
-
(1995)
Blood
, vol.86
, Issue.12
, pp. 4486-4492
-
-
Hokom, M.M.1
Lacey, D.2
Kinstler, O.B.3
-
34
-
-
0001694426
-
The biological significance of truncated and full-length forms of Mpl ligand
-
Humana Press, Totowa, D.J. Kuter, P. Hunt, W. Sheridan, D. Zucker-Franklin (Eds.)
-
Foster D., Hunt P. The biological significance of truncated and full-length forms of Mpl ligand. Thrombopoiesis and thrombopoietins: molecular, cellular, preclinical, and clinical biology 1997, 203-214. Humana Press, Totowa. D.J. Kuter, P. Hunt, W. Sheridan, D. Zucker-Franklin (Eds.).
-
(1997)
Thrombopoiesis and thrombopoietins: molecular, cellular, preclinical, and clinical biology
, pp. 203-214
-
-
Foster, D.1
Hunt, P.2
-
35
-
-
0024562079
-
The in vivo metabolism of recombinant human erythropoietin in the rat
-
Spivack J.L., Hogans B.B. The in vivo metabolism of recombinant human erythropoietin in the rat. Blood 1989, 73:90-99.
-
(1989)
Blood
, vol.73
, pp. 90-99
-
-
Spivack, J.L.1
Hogans, B.B.2
-
36
-
-
0030307588
-
Biological roles for the second domain of thrombopoietin
-
Foster D., Lok S. Biological roles for the second domain of thrombopoietin. Stem Cells 1996, 14(Suppl. 1):102-107.
-
(1996)
Stem Cells
, vol.14
, Issue.SUPPL. 1
, pp. 102-107
-
-
Foster, D.1
Lok, S.2
-
37
-
-
0030465354
-
Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26
-
Schnittger S., de Sauvage F.J., Le Paslier D., Fonatsch C. Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26. Leukemia 1996, 10(12):1891-1896.
-
(1996)
Leukemia
, vol.10
, Issue.12
, pp. 1891-1896
-
-
Schnittger, S.1
de Sauvage, F.J.2
Le Paslier, D.3
Fonatsch, C.4
-
38
-
-
0031317721
-
Cloning and sequencing of human thrombopoietin cDNA
-
Fan Y., Gao T., Ye Y., Tien B. Cloning and sequencing of human thrombopoietin cDNA. Chin J Biotechnol 1997, 13(4):219-223.
-
(1997)
Chin J Biotechnol
, vol.13
, Issue.4
, pp. 219-223
-
-
Fan, Y.1
Gao, T.2
Ye, Y.3
Tien, B.4
-
39
-
-
0034490533
-
The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia
-
Li J., Xia Y., Kuter D.J. The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia. Br J Haematol 2000, 111(3):943-953.
-
(2000)
Br J Haematol
, vol.111
, Issue.3
, pp. 943-953
-
-
Li, J.1
Xia, Y.2
Kuter, D.J.3
-
40
-
-
0028898571
-
Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene
-
Chang M.S., McNinch J., Basu R., et al. Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene. J Biol Chem 1995, 270(2):511-514.
-
(1995)
J Biol Chem
, vol.270
, Issue.2
, pp. 511-514
-
-
Chang, M.S.1
McNinch, J.2
Basu, R.3
-
41
-
-
0033568423
-
Production of thrombopoietin by human carcinomas and its novel isoforms
-
Sasaki Y., Takahashi T., Miyazaki H., et al. Production of thrombopoietin by human carcinomas and its novel isoforms. Blood 1999, 94(6):1952-1960.
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1952-1960
-
-
Sasaki, Y.1
Takahashi, T.2
Miyazaki, H.3
-
42
-
-
0032400867
-
Thrombopoietin production is inhibited by a translational mechanism
-
Ghilardi N., Wiestner A., Skoda R.C. Thrombopoietin production is inhibited by a translational mechanism. Blood 1998, 92:4023-4030.
-
(1998)
Blood
, vol.92
, pp. 4023-4030
-
-
Ghilardi, N.1
Wiestner, A.2
Skoda, R.C.3
-
43
-
-
0030801895
-
In vitro senescence and apoptotic cell death of human megakaryocytes
-
Zauli G., Vitale M., Falcieri E., et al. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 1997, 90(6):2234-2243.
-
(1997)
Blood
, vol.90
, Issue.6
, pp. 2234-2243
-
-
Zauli, G.1
Vitale, M.2
Falcieri, E.3
-
44
-
-
0032842829
-
Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics
-
Li J., Xia Y., Kuter D.J. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics. Br J Haematol 1999, 106(2):345-356.
-
(1999)
Br J Haematol
, vol.106
, Issue.2
, pp. 345-356
-
-
Li, J.1
Xia, Y.2
Kuter, D.J.3
-
45
-
-
0028928884
-
Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional
-
Choi E.S., Nichol J.L., Hokom M.M., Hornkohl A.C., Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995, 85:402-413.
-
(1995)
Blood
, vol.85
, pp. 402-413
-
-
Choi, E.S.1
Nichol, J.L.2
Hokom, M.M.3
Hornkohl, A.C.4
Hunt, P.5
-
46
-
-
0029804163
-
The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis
-
Choi E.S., Hokom M.M., Chen J.L., et al. The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis. Br J Haematol 1996, 95(2):227-233.
-
(1996)
Br J Haematol
, vol.95
, Issue.2
, pp. 227-233
-
-
Choi, E.S.1
Hokom, M.M.2
Chen, J.L.3
-
47
-
-
0029819554
-
A sequential dimerization mechanism for erythropoietin receptor activation
-
Matthews D.J., Topping R.S., Cass R.T., Giebel L.B. A sequential dimerization mechanism for erythropoietin receptor activation. Proc Natl Acad Sci U S A 1996, 93(18):9471-9476.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.18
, pp. 9471-9476
-
-
Matthews, D.J.1
Topping, R.S.2
Cass, R.T.3
Giebel, L.B.4
-
48
-
-
0033548048
-
Erythropoietin receptor activation by a ligand-induced conformation change
-
Remy I., Wilson I.A., Michnick S.W. Erythropoietin receptor activation by a ligand-induced conformation change. Science 1999, 283(5404):990-993.
-
(1999)
Science
, vol.283
, Issue.5404
, pp. 990-993
-
-
Remy, I.1
Wilson, I.A.2
Michnick, S.W.3
-
49
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah O., Stura E.A., Middleton S.A., Johnson D.L., Jolliffe L.K., Wilson I.A. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 1999, 283(5404):987-990.
-
(1999)
Science
, vol.283
, Issue.5404
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
50
-
-
0030968519
-
Human platelets display high-affinity receptors for thrombopoietin
-
Broudy V.C., Lin N.L., Sabath D.F., Papayannopoulou T., Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin. Blood 1997, 89(6):1896-1904.
-
(1997)
Blood
, vol.89
, Issue.6
, pp. 1896-1904
-
-
Broudy, V.C.1
Lin, N.L.2
Sabath, D.F.3
Papayannopoulou, T.4
Kaushansky, K.5
-
51
-
-
0029865443
-
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
-
Fielder P.J., Gurney A.L., Stefanich E., et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996, 87(6):2154-2161.
-
(1996)
Blood
, vol.87
, Issue.6
, pp. 2154-2161
-
-
Fielder, P.J.1
Gurney, A.L.2
Stefanich, E.3
-
52
-
-
0037630266
-
Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs
-
Dahlen D.D., Broudy V.C., Drachman J.G. Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs. Blood 2003, 102(1):102-108.
-
(2003)
Blood
, vol.102
, Issue.1
, pp. 102-108
-
-
Dahlen, D.D.1
Broudy, V.C.2
Drachman, J.G.3
-
53
-
-
0029864161
-
Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice
-
Kaushansky K., Lin N., Grossmann A., Humes J., Sprugel K.H., Broudy V.C. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 1996, 24(2):265-269.
-
(1996)
Exp Hematol
, vol.24
, Issue.2
, pp. 265-269
-
-
Kaushansky, K.1
Lin, N.2
Grossmann, A.3
Humes, J.4
Sprugel, K.H.5
Broudy, V.C.6
-
54
-
-
0032126638
-
Role of c-mpl in early hematopoiesis
-
Solar G.P., Kerr W.G., Zeigler F.C., et al. Role of c-mpl in early hematopoiesis. Blood 1998, 92(1):4-10.
-
(1998)
Blood
, vol.92
, Issue.1
, pp. 4-10
-
-
Solar, G.P.1
Kerr, W.G.2
Zeigler, F.C.3
-
55
-
-
20044380142
-
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
-
Ehrenreich H., Hasselblatt M., Knerlich F., et al. A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A 2005, 102(3):862-867.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.3
, pp. 862-867
-
-
Ehrenreich, H.1
Hasselblatt, M.2
Knerlich, F.3
-
56
-
-
77954932441
-
Inflammation stimulates thrombopoietin (TPO) expression in rat brain-derived microvascular endothelial cells, but suppresses TPO in astrocytes and microglia
-
Zhang J., Freyer D., Rung O., Im A.R., Hoffmann O., Dame C. Inflammation stimulates thrombopoietin (TPO) expression in rat brain-derived microvascular endothelial cells, but suppresses TPO in astrocytes and microglia. J Interferon Cytokine Res 2010, 30(7):465-469.
-
(2010)
J Interferon Cytokine Res
, vol.30
, Issue.7
, pp. 465-469
-
-
Zhang, J.1
Freyer, D.2
Rung, O.3
Im, A.R.4
Hoffmann, O.5
Dame, C.6
-
57
-
-
0030068687
-
Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates
-
Harker L.A., Hunt P., Marzec U.M., et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996, 87:1833-1844.
-
(1996)
Blood
, vol.87
, pp. 1833-1844
-
-
Harker, L.A.1
Hunt, P.2
Marzec, U.M.3
-
58
-
-
0029943307
-
Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
-
Harker L.A., Marzec U.M., Hunt P., et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996, 88(2):511-521.
-
(1996)
Blood
, vol.88
, Issue.2
, pp. 511-521
-
-
Harker, L.A.1
Marzec, U.M.2
Hunt, P.3
-
59
-
-
0035469813
-
Thrombopoietin therapy increases platelet yields in healthy platelet donors
-
Kuter D.J., Goodnough L.T., Romo J., et al. Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 2001, 98(5):1339-1345.
-
(2001)
Blood
, vol.98
, Issue.5
, pp. 1339-1345
-
-
Kuter, D.J.1
Goodnough, L.T.2
Romo, J.3
-
60
-
-
10344235968
-
Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
-
Basser R.L., Rasko J.E., Clarke K., et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 1996, 348(9037):1279-1281.
-
(1996)
Lancet
, vol.348
, Issue.9037
, pp. 1279-1281
-
-
Basser, R.L.1
Rasko, J.E.2
Clarke, K.3
-
61
-
-
0002357056
-
Effect of a single dose of pegylated human recombinant megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet counts: implications for platelet apheresis
-
Tomita D., Petrarca M., Paine T., Olson K., Roskos L., Cheung E. Effect of a single dose of pegylated human recombinant megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet counts: implications for platelet apheresis. Transfusion 1997, 37:2S.
-
(1997)
Transfusion
, vol.37
-
-
Tomita, D.1
Petrarca, M.2
Paine, T.3
Olson, K.4
Roskos, L.5
Cheung, E.6
-
62
-
-
0028820319
-
Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin
-
Chen J., Herceg-Harjacek L., Groopman J.E., Grabarek J. Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995, 86(11):4054-4062.
-
(1995)
Blood
, vol.86
, Issue.11
, pp. 4054-4062
-
-
Chen, J.1
Herceg-Harjacek, L.2
Groopman, J.E.3
Grabarek, J.4
-
63
-
-
9444287622
-
Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation
-
Kubota Y., Arai T., Tanaka T., et al. Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation. Stem Cells 1996, 14(4):439-444.
-
(1996)
Stem Cells
, vol.14
, Issue.4
, pp. 439-444
-
-
Kubota, Y.1
Arai, T.2
Tanaka, T.3
-
64
-
-
0029912139
-
Effects of recombinant human megakaryocyte growth and development factor on platelet activation
-
Montrucchio G., Brizzi M.F., Calosso G., Marengo S., Pegoraro L., Camussi G. Effects of recombinant human megakaryocyte growth and development factor on platelet activation. Blood 1996, 87(7):2762-2768.
-
(1996)
Blood
, vol.87
, Issue.7
, pp. 2762-2768
-
-
Montrucchio, G.1
Brizzi, M.F.2
Calosso, G.3
Marengo, S.4
Pegoraro, L.5
Camussi, G.6
-
65
-
-
0034623228
-
Dual regulation of platelet protein kinase B
-
Kroner C., Eybrechts K., Akkerman J.W. Dual regulation of platelet protein kinase B. J Biol Chem 2000, 275(36):27790-27798.
-
(2000)
J Biol Chem
, vol.275
, Issue.36
, pp. 27790-27798
-
-
Kroner, C.1
Eybrechts, K.2
Akkerman, J.W.3
-
66
-
-
0033044292
-
Effect of recombinant human megakaryocyte growth and development factor coupled with polyethylene glycol on the platelet storage lesion
-
Snyder E., Perrotta P., Rinder H., Baril L., Nichol J., Gilligan D. Effect of recombinant human megakaryocyte growth and development factor coupled with polyethylene glycol on the platelet storage lesion. Transfusion 1999, 39(3):258-264.
-
(1999)
Transfusion
, vol.39
, Issue.3
, pp. 258-264
-
-
Snyder, E.1
Perrotta, P.2
Rinder, H.3
Baril, L.4
Nichol, J.5
Gilligan, D.6
-
67
-
-
0033624557
-
Thrombopoietin and the TPO receptor during platelet storage
-
Xia Y., Li J., Bertino A., Kuter D.J. Thrombopoietin and the TPO receptor during platelet storage. Transfusion 2000, 40(8):976-987.
-
(2000)
Transfusion
, vol.40
, Issue.8
, pp. 976-987
-
-
Xia, Y.1
Li, J.2
Bertino, A.3
Kuter, D.J.4
-
68
-
-
0038646211
-
Apoptotic markers are increased in platelets stored at 37 degrees C
-
Bertino A.M., Qi X.Q., Li J., Xia Y., Kuter D.J. Apoptotic markers are increased in platelets stored at 37 degrees C. Transfusion 2003, 43(7):857-866.
-
(2003)
Transfusion
, vol.43
, Issue.7
, pp. 857-866
-
-
Bertino, A.M.1
Qi, X.Q.2
Li, J.3
Xia, Y.4
Kuter, D.J.5
-
69
-
-
0030753987
-
Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization
-
Nomura S., Ogami K., Kawamura K., et al. Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization. Exp Hematol 1997, 25(7):565-572.
-
(1997)
Exp Hematol
, vol.25
, Issue.7
, pp. 565-572
-
-
Nomura, S.1
Ogami, K.2
Kawamura, K.3
-
70
-
-
0028109434
-
The structure, biology and potential therapeutic applications of recombinant thrombopoietin
-
Lok S., Foster D.C. The structure, biology and potential therapeutic applications of recombinant thrombopoietin. Stem Cells 1994, 12(6):586-598.
-
(1994)
Stem Cells
, vol.12
, Issue.6
, pp. 586-598
-
-
Lok, S.1
Foster, D.C.2
-
71
-
-
0028892286
-
Murine thrombopoietin mRNA levels are modulated by platelet count
-
McCarty J.M., Sprugel K.H., Fox N.E., Sabath D.E., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995, 86(10):3668-3675.
-
(1995)
Blood
, vol.86
, Issue.10
, pp. 3668-3675
-
-
McCarty, J.M.1
Sprugel, K.H.2
Fox, N.E.3
Sabath, D.E.4
Kaushansky, K.5
-
72
-
-
0030780645
-
Thrombopoietin is synthesized by bone marrow stromal cells
-
Guerriero A., Worford L., Holland H.K., Guo G.R., Sheehan K., Waller E.K. Thrombopoietin is synthesized by bone marrow stromal cells. Blood 1997, 90(9):3444-3455.
-
(1997)
Blood
, vol.90
, Issue.9
, pp. 3444-3455
-
-
Guerriero, A.1
Worford, L.2
Holland, H.K.3
Guo, G.R.4
Sheehan, K.5
Waller, E.K.6
-
73
-
-
79955953727
-
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
-
Kohler A., De Filippo K., Hasenberg M., et al. G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood 2011, 117(16):4349-4357.
-
(2011)
Blood
, vol.117
, Issue.16
, pp. 4349-4357
-
-
Kohler, A.1
De Filippo, K.2
Hasenberg, M.3
-
74
-
-
0031035555
-
Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization
-
Sungaran R., Markovic B., Chong B.H. Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 1997, 89(1):101-107.
-
(1997)
Blood
, vol.89
, Issue.1
, pp. 101-107
-
-
Sungaran, R.1
Markovic, B.2
Chong, B.H.3
-
75
-
-
0032530534
-
Primary role of the liver in thrombopoietin production shown by tissue-specific knockout
-
Quin S., Fu F., Li W., Chen Q., de Sauvage F.J. Primary role of the liver in thrombopoietin production shown by tissue-specific knockout. Blood 1998, 92:2189-2191.
-
(1998)
Blood
, vol.92
, pp. 2189-2191
-
-
Quin, S.1
Fu, F.2
Li, W.3
Chen, Q.4
de Sauvage, F.J.5
-
76
-
-
12944249537
-
Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production
-
Peck-Radosavljevic M., Wichlas M., Zacherl J., et al. Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production. Blood 2000, 95(3):795-801.
-
(2000)
Blood
, vol.95
, Issue.3
, pp. 795-801
-
-
Peck-Radosavljevic, M.1
Wichlas, M.2
Zacherl, J.3
-
77
-
-
0030737715
-
Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?
-
Peck-Radosavljevic M., Zacherl J., Meng Y.G., et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?. J Hepatol 1997, 27(1):127-131.
-
(1997)
J Hepatol
, vol.27
, Issue.1
, pp. 127-131
-
-
Peck-Radosavljevic, M.1
Zacherl, J.2
Meng, Y.G.3
-
78
-
-
0032899072
-
The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat
-
Yang C., Li J., Kuter D.J. The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Br J Haematol 1999, 105(2):478-485.
-
(1999)
Br J Haematol
, vol.105
, Issue.2
, pp. 478-485
-
-
Yang, C.1
Li, J.2
Kuter, D.J.3
-
79
-
-
0030048887
-
Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets
-
Stoffel R., Wiestner A., Skoda R.C. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996, 87(2):567-573.
-
(1996)
Blood
, vol.87
, Issue.2
, pp. 567-573
-
-
Stoffel, R.1
Wiestner, A.2
Skoda, R.C.3
-
80
-
-
0034657832
-
The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells
-
Sungaran R., Chisholm O.T., Markovic B., Khachigian L.M., Tanaka Y., Chong B.H. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood 2000, 95(10):3094-3101.
-
(2000)
Blood
, vol.95
, Issue.10
, pp. 3094-3101
-
-
Sungaran, R.1
Chisholm, O.T.2
Markovic, B.3
Khachigian, L.M.4
Tanaka, Y.5
Chong, B.H.6
-
81
-
-
18844466475
-
CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells
-
Solanilla A., Dechanet J., El Andaloussi A., et al. CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells. Blood 2000, 95(12):3758-3764.
-
(2000)
Blood
, vol.95
, Issue.12
, pp. 3758-3764
-
-
Solanilla, A.1
Dechanet, J.2
El Andaloussi, A.3
-
82
-
-
0033568229
-
Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity
-
Sakamaki S., Hirayama Y., Matsunaga T., et al. Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity. Blood 1999, 94(6):1961-1970.
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1961-1970
-
-
Sakamaki, S.1
Hirayama, Y.2
Matsunaga, T.3
-
83
-
-
0029960265
-
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
-
Alexander W.S., Roberts A.W., Nicola N.A., Li R., Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 1996, 87(6):2162-2170.
-
(1996)
Blood
, vol.87
, Issue.6
, pp. 2162-2170
-
-
Alexander, W.S.1
Roberts, A.W.2
Nicola, N.A.3
Li, R.4
Metcalf, D.5
-
84
-
-
0028086542
-
Thrombocytopenia in c-mpl-deficient mice
-
Gurney A.L., Carver-Moore K., de Sauvage F.J., Moore M.W. Thrombocytopenia in c-mpl-deficient mice. Science 1994, 265(5177):1445-1447.
-
(1994)
Science
, vol.265
, Issue.5177
, pp. 1445-1447
-
-
Gurney, A.L.1
Carver-Moore, K.2
de Sauvage, F.J.3
Moore, M.W.4
-
85
-
-
0030024685
-
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
-
de Sauvage F.J., Carver-Moore K., Luoh S.M., et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996, 183(2):651-656.
-
(1996)
J Exp Med
, vol.183
, Issue.2
, pp. 651-656
-
-
de Sauvage, F.J.1
Carver-Moore, K.2
Luoh, S.M.3
-
86
-
-
0029684417
-
Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice
-
Carver-Moore K., Broxmeyer H.E., Luoh S.M., et al. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood 1996, 88(3):803-808.
-
(1996)
Blood
, vol.88
, Issue.3
, pp. 803-808
-
-
Carver-Moore, K.1
Broxmeyer, H.E.2
Luoh, S.M.3
-
87
-
-
0032522963
-
Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production
-
Gainsford T., Roberts A.W., Kimura S., et al. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Blood 1998, 91(8):2745-2752.
-
(1998)
Blood
, vol.91
, Issue.8
, pp. 2745-2752
-
-
Gainsford, T.1
Roberts, A.W.2
Kimura, S.3
-
88
-
-
0034650935
-
The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor
-
Gainsford T., Nandurkar H., Metcalf D., Robb L., Begley C.G., Alexander W.S. The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor. Blood 2000, 95(2):528-534.
-
(2000)
Blood
, vol.95
, Issue.2
, pp. 528-534
-
-
Gainsford, T.1
Nandurkar, H.2
Metcalf, D.3
Robb, L.4
Begley, C.G.5
Alexander, W.S.6
-
89
-
-
11144356721
-
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
-
Avecilla S.T., Hattori K., Heissig B., et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004, 10(1):64-71.
-
(2004)
Nat Med
, vol.10
, Issue.1
, pp. 64-71
-
-
Avecilla, S.T.1
Hattori, K.2
Heissig, B.3
-
90
-
-
0029030356
-
The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
-
Kuter D.J., Rosenberg R.D. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995, 85(10):2720-2730.
-
(1995)
Blood
, vol.85
, Issue.10
, pp. 2720-2730
-
-
Kuter, D.J.1
Rosenberg, R.D.2
-
91
-
-
0029805293
-
Thrombopoietin: biology, clinical applications, role in the donor setting
-
Kuter D.J. Thrombopoietin: biology, clinical applications, role in the donor setting. J Clin Apheresis 1996, 11(3):149-159.
-
(1996)
J Clin Apheresis
, vol.11
, Issue.3
, pp. 149-159
-
-
Kuter, D.J.1
-
92
-
-
0030307622
-
The physiology of platelet production
-
Kuter D.J. The physiology of platelet production. Stem Cells 1996, 14(Suppl. 1):88-101.
-
(1996)
Stem Cells
, vol.14
, Issue.SUPPL. 1
, pp. 88-101
-
-
Kuter, D.J.1
-
93
-
-
0002184519
-
Thrombopoietin: biology and clinical applications
-
Kuter D.J. Thrombopoietin: biology and clinical applications. Oncologist 1996, 1:98-106.
-
(1996)
Oncologist
, vol.1
, pp. 98-106
-
-
Kuter, D.J.1
-
94
-
-
0037111558
-
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
-
Kuter D.J., Begley C.G. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002, 100(10):3457-3469.
-
(2002)
Blood
, vol.100
, Issue.10
, pp. 3457-3469
-
-
Kuter, D.J.1
Begley, C.G.2
-
95
-
-
0036516690
-
Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo
-
Scheding S., Bergmann M., Shimosaka A., et al. Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo. Transfusion 2002, 42(3):321-327.
-
(2002)
Transfusion
, vol.42
, Issue.3
, pp. 321-327
-
-
Scheding, S.1
Bergmann, M.2
Shimosaka, A.3
-
96
-
-
0032842829
-
Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacodynamics
-
Li J., Xia Y., Kuter D. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacodynamics. Br J Haematol 1999, 106:345-356.
-
(1999)
Br J Haematol
, vol.106
, pp. 345-356
-
-
Li, J.1
Xia, Y.2
Kuter, D.3
-
97
-
-
0030901558
-
Human platelets as a model for the binding and degradation of thrombopoietin
-
Fielder P.J., Hass P., Nagel M., et al. Human platelets as a model for the binding and degradation of thrombopoietin. Blood 1997, 89(8):2782-2788.
-
(1997)
Blood
, vol.89
, Issue.8
, pp. 2782-2788
-
-
Fielder, P.J.1
Hass, P.2
Nagel, M.3
-
98
-
-
0028843848
-
Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice
-
Yan X.Q., Lacey D., Fletcher F., et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 1995, 86(11):4025-4033.
-
(1995)
Blood
, vol.86
, Issue.11
, pp. 4025-4033
-
-
Yan, X.Q.1
Lacey, D.2
Fletcher, F.3
-
99
-
-
0030718597
-
High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
-
Villeval J.L., Cohen-Solal K., Tulliez M., et al. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 1997, 90(11):4369-4383.
-
(1997)
Blood
, vol.90
, Issue.11
, pp. 4369-4383
-
-
Villeval, J.L.1
Cohen-Solal, K.2
Tulliez, M.3
-
100
-
-
0031963996
-
Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis
-
Frey BMq Rafii S, Teterson M., Eaton D., Crystal R.G., Moore M.A. Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis. J Immunol 1998, 160(2):691-699.
-
(1998)
J Immunol
, vol.160
, Issue.2
, pp. 691-699
-
-
Frey, R.S.1
Teterson, M.2
Eaton, D.3
Crystal, R.G.4
Moore, M.A.5
-
101
-
-
0031975482
-
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia
-
Wiestner A., Schlemper R.J., van der Maas A.P., Skoda R.C. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nature Genetics 1998, 18(1):49-52.
-
(1998)
Nature Genetics
, vol.18
, Issue.1
, pp. 49-52
-
-
Wiestner, A.1
Schlemper, R.J.2
van der Maas, A.P.3
Skoda, R.C.4
-
102
-
-
0032529663
-
Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene
-
Kondo T., Okabe M., Sanada M., et al. Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene. Blood 1998, 92(4):1091-1096.
-
(1998)
Blood
, vol.92
, Issue.4
, pp. 1091-1096
-
-
Kondo, T.1
Okabe, M.2
Sanada, M.3
-
103
-
-
0032757997
-
Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene
-
Ghilardi N., Wiestner A., Kikuchi M., Ohsaka A., Skoda R.C. Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene. Br J Haematol 1999, 107(2):310-316.
-
(1999)
Br J Haematol
, vol.107
, Issue.2
, pp. 310-316
-
-
Ghilardi, N.1
Wiestner, A.2
Kikuchi, M.3
Ohsaka, A.4
Skoda, R.C.5
-
104
-
-
0035704766
-
Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia
-
Allen A.J., Gale R.E., Harrison C.N., Machin S.J., Linch D.C. Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia. Eur J Haematol 2001, 67(4):232-237.
-
(2001)
Eur J Haematol
, vol.67
, Issue.4
, pp. 232-237
-
-
Allen, A.J.1
Gale, R.E.2
Harrison, C.N.3
Machin, S.J.4
Linch, D.C.5
-
105
-
-
0022585336
-
Familial essential thrombocythemia
-
Eyster M.E., Saletan S.L., Rabellino E.M., et al. Familial essential thrombocythemia. Am J Med 1986, 80(3):497-502.
-
(1986)
Am J Med
, vol.80
, Issue.3
, pp. 497-502
-
-
Eyster, M.E.1
Saletan, S.L.2
Rabellino, E.M.3
-
106
-
-
0022342923
-
Acute megakaryoblastic leukaemia with 3q inversion and elevated thrombopoietin (TSF): an autocrine role for TSF?
-
Pinto M.R., King M.A., Goss G.D., et al. Acute megakaryoblastic leukaemia with 3q inversion and elevated thrombopoietin (TSF): an autocrine role for TSF?. Brit J Haematol 1985, 61(4):687-694.
-
(1985)
Brit J Haematol
, vol.61
, Issue.4
, pp. 687-694
-
-
Pinto, M.R.1
King, M.A.2
Goss, G.D.3
-
107
-
-
0028879896
-
Thrombopoietin is not responsible for the thrombocytosis observed in patients with acute myeloid leukemias and the 3q21q26 syndrome
-
Bouscary D., Fontenay-Roupie M., Chretien S., et al. Thrombopoietin is not responsible for the thrombocytosis observed in patients with acute myeloid leukemias and the 3q21q26 syndrome. Brit J Haematol 1995, 91(2):425-427.
-
(1995)
Brit J Haematol
, vol.91
, Issue.2
, pp. 425-427
-
-
Bouscary, D.1
Fontenay-Roupie, M.2
Chretien, S.3
-
108
-
-
0035174334
-
C-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
-
Ballmaier M., Germeshausen M., Schulze H., et al. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood 2001, 97(1):139-146.
-
(2001)
Blood
, vol.97
, Issue.1
, pp. 139-146
-
-
Ballmaier, M.1
Germeshausen, M.2
Schulze, H.3
-
109
-
-
0033845012
-
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia
-
van den Oudenrijn S., Bruin M., Folman C.C., et al. Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. Br J Haematol 2000, 110(2):441-448.
-
(2000)
Br J Haematol
, vol.110
, Issue.2
, pp. 441-448
-
-
van den Oudenrijn, S.1
Bruin, M.2
Folman, C.C.3
-
110
-
-
0033897370
-
Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia
-
Wiestner A., Padosch S.A., Ghilardi N., et al. Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia. Br J Haematol 2000, 110(1):104-109.
-
(2000)
Br J Haematol
, vol.110
, Issue.1
, pp. 104-109
-
-
Wiestner, A.1
Padosch, S.A.2
Ghilardi, N.3
-
111
-
-
0033019932
-
Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia
-
Ihara K., Ishii E., Eguchi M., et al. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Proc Natl Acad Sci U S A 1999, 96(6):3132-3136.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.6
, pp. 3132-3136
-
-
Ihara, K.1
Ishii, E.2
Eguchi, M.3
-
112
-
-
20444399868
-
Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation
-
Heller P.G., Glembotsky A.C., Gandhi M.J., et al. Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation. Blood 2005, 105(12):4664-4670.
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4664-4670
-
-
Heller, P.G.1
Glembotsky, A.C.2
Gandhi, M.J.3
-
113
-
-
0036050145
-
A novel MPL point mutation resulting in thrombopoietin-independent activation
-
Abe M., Suzuki K., Inagaki O., Sassa S., Shikama H. A novel MPL point mutation resulting in thrombopoietin-independent activation. Leukemia 2002, 16(8):1500-1506.
-
(2002)
Leukemia
, vol.16
, Issue.8
, pp. 1500-1506
-
-
Abe, M.1
Suzuki, K.2
Inagaki, O.3
Sassa, S.4
Shikama, H.5
-
114
-
-
2542502506
-
Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
-
Ding J., Komatsu H., Wakita A., et al. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 2004, 103(11):4198-4200.
-
(2004)
Blood
, vol.103
, Issue.11
, pp. 4198-4200
-
-
Ding, J.1
Komatsu, H.2
Wakita, A.3
-
115
-
-
3843052277
-
Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis
-
Moliterno A.R., Williams D.M., Gutierrez-Alamillo L.I., Salvatori R., Ingersoll R.G., Spivak J.L. Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis. Proc Natl Acad Sci U S A 2004, 101(31):11444-11447.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.31
, pp. 11444-11447
-
-
Moliterno, A.R.1
Williams, D.M.2
Gutierrez-Alamillo, L.I.3
Salvatori, R.4
Ingersoll, R.G.5
Spivak, J.L.6
-
116
-
-
0034125214
-
Hereditary thrombocytopenia due to reduced platelet production-report on two families and mutational screening of the thrombopoietin receptor gene (c-mpl)
-
Tonelli R., Strippoli P., Grossi A., et al. Hereditary thrombocytopenia due to reduced platelet production-report on two families and mutational screening of the thrombopoietin receptor gene (c-mpl). Thromb Haemost 2000, 83(6):931-936.
-
(2000)
Thromb Haemost
, vol.83
, Issue.6
, pp. 931-936
-
-
Tonelli, R.1
Strippoli, P.2
Grossi, A.3
-
117
-
-
0032126712
-
Association of thrombocytopenia with the use of intra-aortic balloon pumps
-
Vonderheide R.H., Thadhani R., Kuter D.J. Association of thrombocytopenia with the use of intra-aortic balloon pumps. Am J Med 1998, 105(1):27-32.
-
(1998)
Am J Med
, vol.105
, Issue.1
, pp. 27-32
-
-
Vonderheide, R.H.1
Thadhani, R.2
Kuter, D.J.3
-
118
-
-
84882646378
-
Thrombopoietin (TPO) levels may predict responsiveness to therapy with TPO agonists in patients with immune thrombocytopenia
-
Makar R., Shukov O., Sahud M., Kuter D. Thrombopoietin (TPO) levels may predict responsiveness to therapy with TPO agonists in patients with immune thrombocytopenia. Blood 2011, 118:3288a.
-
(2011)
Blood
, vol.118
-
-
Makar, R.1
Shukov, O.2
Sahud, M.3
Kuter, D.4
-
119
-
-
0029881744
-
Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
-
Emmons R.V., Reid D.M., Cohen R.L., et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996, 87(10):4068-4071.
-
(1996)
Blood
, vol.87
, Issue.10
, pp. 4068-4071
-
-
Emmons, R.V.1
Reid, D.M.2
Cohen, R.L.3
-
120
-
-
0031877979
-
Thrombopoietin levels after chemotherapy and in naturally occurring human diseases
-
Nichol J.L. Thrombopoietin levels after chemotherapy and in naturally occurring human diseases. Curr Opin Hematol 1998, 5(3):203-208.
-
(1998)
Curr Opin Hematol
, vol.5
, Issue.3
, pp. 203-208
-
-
Nichol, J.L.1
-
121
-
-
0030732423
-
Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia
-
Horikawa Y., Matsumura I., Hashimoto K., et al. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood 1997, 90(10):4031-4038.
-
(1997)
Blood
, vol.90
, Issue.10
, pp. 4031-4038
-
-
Horikawa, Y.1
Matsumura, I.2
Hashimoto, K.3
-
122
-
-
74049127615
-
New thrombopoietic growth factors
-
Kuter D.J. New thrombopoietic growth factors. Clin Lymphoma Myeloma 2009, 9(Suppl. 3):S347-S356.
-
(2009)
Clin Lymphoma Myeloma
, vol.9
, Issue.SUPPL. 3
-
-
Kuter, D.J.1
-
123
-
-
77953896640
-
Biology and chemistry of thrombopoietic agents
-
Kuter D.J. Biology and chemistry of thrombopoietic agents. Semin Hematol 2010, 47(3):243-248.
-
(2010)
Semin Hematol
, vol.47
, Issue.3
, pp. 243-248
-
-
Kuter, D.J.1
-
124
-
-
66749122752
-
Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia
-
Kuter D.J. Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med 2009, 60:193-206.
-
(2009)
Annu Rev Med
, vol.60
, pp. 193-206
-
-
Kuter, D.J.1
-
125
-
-
0030773876
-
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
-
Cwirla S.E., Balasubramanian P., Duffin D.J., et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 1997, 276(5319):1696-1699.
-
(1997)
Science
, vol.276
, Issue.5319
, pp. 1696-1699
-
-
Cwirla, S.E.1
Balasubramanian, P.2
Duffin, D.J.3
-
126
-
-
0032797771
-
Immunogenicity of thrombopoietin mimetic peptide GW395058 in BALB/c mice and New Zealand white rabbits: evaluation of the potential for thrombopoietin neutralizing antibody production in man
-
de Serres M., Ellis B., Dillberger J.E., et al. Immunogenicity of thrombopoietin mimetic peptide GW395058 in BALB/c mice and New Zealand white rabbits: evaluation of the potential for thrombopoietin neutralizing antibody production in man. Stem Cells 1999, 17(4):203-209.
-
(1999)
Stem Cells
, vol.17
, Issue.4
, pp. 203-209
-
-
de Serres, M.1
Ellis, B.2
Dillberger, J.E.3
-
127
-
-
79952822776
-
The development of romiplostim for patients with immune thrombocytopenia
-
Molineux G. The development of romiplostim for patients with immune thrombocytopenia. Ann N Y Acad Sci 2011, 1222:55-63.
-
(2011)
Ann N Y Acad Sci
, vol.1222
, pp. 55-63
-
-
Molineux, G.1
-
128
-
-
10044296968
-
Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
-
Wang B., Nichol J.L., Sullivan J.T. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004, 76(6):628-638.
-
(2004)
Clin Pharmacol Ther
, vol.76
, Issue.6
, pp. 628-638
-
-
Wang, B.1
Nichol, J.L.2
Sullivan, J.T.3
-
129
-
-
0346881171
-
AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
-
Broudy V.C., Lin N.L. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 2004, 25(2):52-60.
-
(2004)
Cytokine
, vol.25
, Issue.2
, pp. 52-60
-
-
Broudy, V.C.1
Lin, N.L.2
-
130
-
-
78149479585
-
Romiplostim or standard of care in patients with immune thrombocytopenia
-
Kuter D.J., Rummel M., Boccia R., et al. Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 2010, 363(20):1889-1899.
-
(2010)
N Engl J Med
, vol.363
, Issue.20
, pp. 1889-1899
-
-
Kuter, D.J.1
Rummel, M.2
Boccia, R.3
-
131
-
-
33750035507
-
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
-
Bussel J.B., Kuter D.J., George J.N., et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. New Engl J Med 2006, 355(16):1672-1681.
-
(2006)
New Engl J Med
, vol.355
, Issue.16
, pp. 1672-1681
-
-
Bussel, J.B.1
Kuter, D.J.2
George, J.N.3
-
132
-
-
63849111465
-
Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
-
Bussel J.B., Kuter D.J., Pullarkat V., Lyons R.M., Guo M., Nichol J.L. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood 2009, 113(10):2161-2171.
-
(2009)
Blood
, vol.113
, Issue.10
, pp. 2161-2171
-
-
Bussel, J.B.1
Kuter, D.J.2
Pullarkat, V.3
Lyons, R.M.4
Guo, M.5
Nichol, J.L.6
-
133
-
-
0035950101
-
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
-
Duffy K.J., Darcy M.G., Delorme E., et al. Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem 2001, 44(22):3730-3745.
-
(2001)
J Med Chem
, vol.44
, Issue.22
, pp. 3730-3745
-
-
Duffy, K.J.1
Darcy, M.G.2
Delorme, E.3
-
134
-
-
0037103339
-
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics
-
Duffy K.J., Shaw A.N., Delorme E., et al. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics. J Med Chem 2002, 45(17):3573-3575.
-
(2002)
J Med Chem
, vol.45
, Issue.17
, pp. 3573-3575
-
-
Duffy, K.J.1
Shaw, A.N.2
Delorme, E.3
-
135
-
-
0037103160
-
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics
-
Duffy K.J., Price A.T., Delorme E., et al. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics. J Med Chem 2002, 45(17):3576-3578.
-
(2002)
J Med Chem
, vol.45
, Issue.17
, pp. 3576-3578
-
-
Duffy, K.J.1
Price, A.T.2
Delorme, E.3
-
136
-
-
19944432021
-
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
-
Erickson-Miller C.L., DeLorme E., Tian S.S., et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005, 33(1):85-93.
-
(2005)
Exp Hematol
, vol.33
, Issue.1
, pp. 85-93
-
-
Erickson-Miller, C.L.1
DeLorme, E.2
Tian, S.S.3
-
137
-
-
62549153611
-
Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
-
Erickson-Miller C.L., Delorme E., Tian S.S., et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells 2009, 27(2):424-430.
-
(2009)
Stem Cells
, vol.27
, Issue.2
, pp. 424-430
-
-
Erickson-Miller, C.L.1
Delorme, E.2
Tian, S.S.3
-
138
-
-
60249099882
-
Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial
-
Bussel J.B., Provan D., Shamsi T., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 2009, 373(9664):641-648.
-
(2009)
Lancet
, vol.373
, Issue.9664
, pp. 641-648
-
-
Bussel, J.B.1
Provan, D.2
Shamsi, T.3
-
139
-
-
79251583872
-
Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study
-
Cheng G., Saleh M.N., Marcher C., et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet 2011, 377(9763):393-402.
-
(2011)
Lancet
, vol.377
, Issue.9763
, pp. 393-402
-
-
Cheng, G.1
Saleh, M.N.2
Marcher, C.3
-
140
-
-
36549047972
-
Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
-
McHutchison J.G., Dusheiko G., Shiffman M.L., et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007, 357(22):2227-2236.
-
(2007)
N Engl J Med
, vol.357
, Issue.22
, pp. 2227-2236
-
-
McHutchison, J.G.1
Dusheiko, G.2
Shiffman, M.L.3
-
141
-
-
34249719511
-
Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
-
Jenkins J.M., Williams D., Deng Y., et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007, 109(11):4739-4741.
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4739-4741
-
-
Jenkins, J.M.1
Williams, D.2
Deng, Y.3
-
142
-
-
33744497342
-
Species specificity and receptor domain interaction of a small molecule TPO receptor agonist
-
Erickson-Miller C., Delorme E., Iskander M., et al. Species specificity and receptor domain interaction of a small molecule TPO receptor agonist. Blood 2004, 104:795a.
-
(2004)
Blood
, vol.104
-
-
Erickson-Miller, C.1
Delorme, E.2
Iskander, M.3
-
143
-
-
82355194935
-
What is the potential for thrombopoietic agents in acute leukemia
-
Kuter D. What is the potential for thrombopoietic agents in acute leukemia. Best Pract Res Clin Obstet Haematol 2011, 24:553-558.
-
(2011)
Best Pract Res Clin Obstet Haematol
, vol.24
, pp. 553-558
-
-
Kuter, D.1
-
144
-
-
68549092703
-
Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function
-
Erhardt J.A., Erickson-Miller C.L., Aivado M., Abboud M., Pillarisetti K., Toomey J.R. Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function. Exp Hematol 2009, 37(9):1030-1037.
-
(2009)
Exp Hematol
, vol.37
, Issue.9
, pp. 1030-1037
-
-
Erhardt, J.A.1
Erickson-Miller, C.L.2
Aivado, M.3
Abboud, M.4
Pillarisetti, K.5
Toomey, J.R.6
-
145
-
-
3543123430
-
An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis
-
Deng B., Banu N., Malloy B., et al. An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis. Blood 1998, 92(6):1981-1988.
-
(1998)
Blood
, vol.92
, Issue.6
, pp. 1981-1988
-
-
Deng, B.1
Banu, N.2
Malloy, B.3
-
146
-
-
19944429567
-
A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
-
Orita T., Tsunoda H., Yabuta N., et al. A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor. Blood 2005, 105(2):562-566.
-
(2005)
Blood
, vol.105
, Issue.2
, pp. 562-566
-
-
Orita, T.1
Tsunoda, H.2
Yabuta, N.3
-
147
-
-
0029051730
-
Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice
-
Ulich T.R., del Castillo J., Yin S., et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995, 86(3):971-976.
-
(1995)
Blood
, vol.86
, Issue.3
, pp. 971-976
-
-
Ulich, T.R.1
del Castillo, J.2
Yin, S.3
-
148
-
-
0029963122
-
Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia
-
Farese A.M., Hunt P., Grab L.B., MacVittie T.J. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J Clin Invest 1996, 97(9):2145-2151.
-
(1996)
J Clin Invest
, vol.97
, Issue.9
, pp. 2145-2151
-
-
Farese, A.M.1
Hunt, P.2
Grab, L.B.3
MacVittie, T.J.4
-
149
-
-
0034924597
-
Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice
-
Stefanich E.G., Carlson-Zermeno C.C., McEvoy K., Reich M., Fielder P.J. Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice. Cancer Chemother Pharmacol 2001, 47(1):70-77.
-
(2001)
Cancer Chemother Pharmacol
, vol.47
, Issue.1
, pp. 70-77
-
-
Stefanich, E.G.1
Carlson-Zermeno, C.C.2
McEvoy, K.3
Reich, M.4
Fielder, P.J.5
-
150
-
-
0032170081
-
A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells
-
Neelis K.J., Visser T.P., Dimjati W., et al. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells. Blood 1998, 92(5):1586-1597.
-
(1998)
Blood
, vol.92
, Issue.5
, pp. 1586-1597
-
-
Neelis, K.J.1
Visser, T.P.2
Dimjati, W.3
-
151
-
-
0033065969
-
Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation
-
Mouthon M.A., Van der Meeren A., Gaugler M.H., et al. Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. Int J Radiat Oncol Biol Phys 1999, 43(4):867-875.
-
(1999)
Int J Radiat Oncol Biol Phys
, vol.43
, Issue.4
, pp. 867-875
-
-
Mouthon, M.A.1
Van der Meeren, A.2
Gaugler, M.H.3
-
152
-
-
0030711568
-
Thrombopoietin: more than a lineage-specific megakaryocyte growth factor
-
Kaushansky K. Thrombopoietin: more than a lineage-specific megakaryocyte growth factor. Stem Cells 1997, 15:97-103.
-
(1997)
Stem Cells
, vol.15
, pp. 97-103
-
-
Kaushansky, K.1
-
153
-
-
0028787175
-
Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice
-
Fibbe W.E., Heemskerk D.P., Laterveer L., et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995, 86(9):3308-3313.
-
(1995)
Blood
, vol.86
, Issue.9
, pp. 3308-3313
-
-
Fibbe, W.E.1
Heemskerk, D.P.2
Laterveer, L.3
-
154
-
-
0033529218
-
Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin
-
Yagi M., Ritchie K.A., Sitnicka E., Storey C., Roth G.J., Bartelmez S. Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proc Natl Acad Sci USA 1999, 96(14):8126-8131.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.14
, pp. 8126-8131
-
-
Yagi, M.1
Ritchie, K.A.2
Sitnicka, E.3
Storey, C.4
Roth, G.J.5
Bartelmez, S.6
-
155
-
-
0031810565
-
Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor
-
Harker L.A., Marzec U.M., Novembre F., et al. Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor. Blood 1998, 91(12):4427-4433.
-
(1998)
Blood
, vol.91
, Issue.12
, pp. 4427-4433
-
-
Harker, L.A.1
Marzec, U.M.2
Novembre, F.3
-
156
-
-
0032228027
-
The use of PEG-rhuMGDF in platelet apheresis
-
Kuter D.J. The use of PEG-rhuMGDF in platelet apheresis. Stem Cells 1998, 16(Suppl. 2):231-242.
-
(1998)
Stem Cells
, vol.16
, Issue.SUPPL. 2
, pp. 231-242
-
-
Kuter, D.J.1
-
157
-
-
0031049879
-
Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
-
Fanucchi M., Glaspy J., Crawford J., et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. New Engl J Med 1997, 336(6):404-409.
-
(1997)
New Engl J Med
, vol.336
, Issue.6
, pp. 404-409
-
-
Fanucchi, M.1
Glaspy, J.2
Crawford, J.3
-
158
-
-
17944389931
-
Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
-
Basser R.L., Rasko J.E., Clarke K., et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997, 89(9):3118-3128.
-
(1997)
Blood
, vol.89
, Issue.9
, pp. 3118-3128
-
-
Basser, R.L.1
Rasko, J.E.2
Clarke, K.3
-
159
-
-
0034050651
-
Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
-
Vadhan-Raj S., Verschraegen C.F., Bueso-Ramos C., et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med 2000, 132(5):364-368.
-
(2000)
Ann Intern Med
, vol.132
, Issue.5
, pp. 364-368
-
-
Vadhan-Raj, S.1
Verschraegen, C.F.2
Bueso-Ramos, C.3
-
160
-
-
0031843498
-
Recombinant human thrombopoietin: clinical experience and in vivo biology
-
Vadhan-Raj S. Recombinant human thrombopoietin: clinical experience and in vivo biology. Semin Hematol 1998, 35(3):261-268.
-
(1998)
Semin Hematol
, vol.35
, Issue.3
, pp. 261-268
-
-
Vadhan-Raj, S.1
-
161
-
-
0030966361
-
Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
-
Vadhan-Raj S., Murray L.J., Bueso-Ramos C., et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Int Med 1997, 126(9):673-681.
-
(1997)
Ann Int Med
, vol.126
, Issue.9
, pp. 673-681
-
-
Vadhan-Raj, S.1
Murray, L.J.2
Bueso-Ramos, C.3
-
162
-
-
0034655649
-
A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
-
Schiffer C.A., Miller K., Larson R.A., et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000, 95(8):2530-2535.
-
(2000)
Blood
, vol.95
, Issue.8
, pp. 2530-2535
-
-
Schiffer, C.A.1
Miller, K.2
Larson, R.A.3
-
163
-
-
0033485568
-
A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
-
Archimbaud E., Ottmann O.G., Yin J.A., et al. A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 1999, 94(11):3694-3701.
-
(1999)
Blood
, vol.94
, Issue.11
, pp. 3694-3701
-
-
Archimbaud, E.1
Ottmann, O.G.2
Yin, J.A.3
-
164
-
-
0036753566
-
The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation
-
Schuster M.W., Beveridge R., Frei-Lahr D., et al. The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. Exp Hematol 2002, 30(9):1044-1050.
-
(2002)
Exp Hematol
, vol.30
, Issue.9
, pp. 1044-1050
-
-
Schuster, M.W.1
Beveridge, R.2
Frei-Lahr, D.3
-
165
-
-
0001690215
-
Effects of PEGylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) before high dose chemotherapy (HDC) with peripheral blood progenitor cell (PBPC) support
-
Glaspy J., Vredenburgh J., Demetri G.D., et al. Effects of PEGylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) before high dose chemotherapy (HDC) with peripheral blood progenitor cell (PBPC) support. Blood 1997, 90:580a.
-
(1997)
Blood
, vol.90
-
-
Glaspy, J.1
Vredenburgh, J.2
Demetri, G.D.3
-
166
-
-
0033930709
-
Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation
-
Bolwell B., Vredenburgh J., Overmoyer B., et al. Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation. Bone Marrow Transplant 2000, 26(2):141-145.
-
(2000)
Bone Marrow Transplant
, vol.26
, Issue.2
, pp. 141-145
-
-
Bolwell, B.1
Vredenburgh, J.2
Overmoyer, B.3
-
167
-
-
0033631018
-
A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation
-
Nash R.A., Kurzrock R., DiPersio J., et al. A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2000, 6(1):25-34.
-
(2000)
Biol Blood Marrow Transplant
, vol.6
, Issue.1
, pp. 25-34
-
-
Nash, R.A.1
Kurzrock, R.2
DiPersio, J.3
-
168
-
-
0033135719
-
Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy
-
Somlo G., Sniecinski I., ter Veer A., et al. Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy. Blood 1999, 93(9):2798-2806.
-
(1999)
Blood
, vol.93
, Issue.9
, pp. 2798-2806
-
-
Somlo, G.1
Sniecinski, I.2
ter Veer, A.3
-
169
-
-
4243219531
-
Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy
-
Harker L.A., Carter R.A., Marzec U.M., et al. Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy. Blood 1998, 92:707a.
-
(1998)
Blood
, vol.92
-
-
Harker, L.A.1
Carter, R.A.2
Marzec, U.M.3
-
170
-
-
0029744304
-
Serum thrombopoietin level in various hematological diseases
-
Usuki K., Tahara T., Iki S., et al. Serum thrombopoietin level in various hematological diseases. Stem Cells 1996, 14(5):558-565.
-
(1996)
Stem Cells
, vol.14
, Issue.5
, pp. 558-565
-
-
Usuki, K.1
Tahara, T.2
Iki, S.3
-
171
-
-
9344231924
-
Circulating thrombopoietin level in chronic immune thrombocytopenic purpura
-
Kosugi S., Kurata Y., Tomiyama Y., et al. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br J Haematol 1996, 93(3):704-706.
-
(1996)
Br J Haematol
, vol.93
, Issue.3
, pp. 704-706
-
-
Kosugi, S.1
Kurata, Y.2
Tomiyama, Y.3
-
172
-
-
0029858508
-
Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production
-
Chang M., Suen Y., Meng G., et al. Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood 1996, 88(9):3354-3362.
-
(1996)
Blood
, vol.88
, Issue.9
, pp. 3354-3362
-
-
Chang, M.1
Suen, Y.2
Meng, G.3
-
173
-
-
0030472273
-
Serum thrombopoietin levels in patients with aplastic anaemia
-
Marsh J.C., Gibson F.M., Prue R.L., et al. Serum thrombopoietin levels in patients with aplastic anaemia. Br J Haematol 1996, 95(4):605-610.
-
(1996)
Br J Haematol
, vol.95
, Issue.4
, pp. 605-610
-
-
Marsh, J.C.1
Gibson, F.M.2
Prue, R.L.3
-
174
-
-
0026448738
-
Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection
-
Ballem P.J., Belzberg A., Devine D.V., et al. Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection. N Engl J Med 1992, 327(25):1779-1784.
-
(1992)
N Engl J Med
, vol.327
, Issue.25
, pp. 1779-1784
-
-
Ballem, P.J.1
Belzberg, A.2
Devine, D.V.3
-
175
-
-
0023218341
-
Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
-
Ballem P.J., Segal G.M., Stratton J.R., Gernsheimer T., Adamson J.W., Slichter S.J. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987, 80(1):33-40.
-
(1987)
J Clin Invest
, vol.80
, Issue.1
, pp. 33-40
-
-
Ballem, P.J.1
Segal, G.M.2
Stratton, J.R.3
Gernsheimer, T.4
Adamson, J.W.5
Slichter, S.J.6
-
176
-
-
0020031045
-
Kinetics and sites of destruction of 111Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study
-
Heyns A.D., Lotter M.G., Badenhorst P.N., et al. Kinetics and sites of destruction of 111Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol 1982, 12(2):167-177.
-
(1982)
Am J Hematol
, vol.12
, Issue.2
, pp. 167-177
-
-
Heyns, A.D.1
Lotter, M.G.2
Badenhorst, P.N.3
-
177
-
-
0022623857
-
Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ
-
Heyns Adu P., Badenhorst P.N., Lotter M.G., Pieters H., Wessels P., Kotze H.F. Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ. Blood 1986, 67(1):86-92.
-
(1986)
Blood
, vol.67
, Issue.1
, pp. 86-92
-
-
Heyns Adu, P.1
Badenhorst, P.N.2
Lotter, M.G.3
Pieters, H.4
Wessels, P.5
Kotze, H.F.6
-
178
-
-
0043245959
-
Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
-
Chang M., Nakagawa P.A., Williams S.A., et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003, 102(3):887-895.
-
(2003)
Blood
, vol.102
, Issue.3
, pp. 887-895
-
-
Chang, M.1
Nakagawa, P.A.2
Williams, S.A.3
-
179
-
-
0942287736
-
Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
-
Houwerzijl E.J., Blom N.R., van der Want J.J., et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 2004, 103(2):500-506.
-
(2004)
Blood
, vol.103
, Issue.2
, pp. 500-506
-
-
Houwerzijl, E.J.1
Blom, N.R.2
van der Want, J.J.3
-
180
-
-
0842328846
-
Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
-
McMillan R., Wang L., Tomer A., Nichol J., Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004, 103(4):1364-1369.
-
(2004)
Blood
, vol.103
, Issue.4
, pp. 1364-1369
-
-
McMillan, R.1
Wang, L.2
Tomer, A.3
Nichol, J.4
Pistillo, J.5
-
181
-
-
0034781155
-
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
-
Rice L., Nichol J.L., McMillan R., Roskos L.K., Bacile M. Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am J Hematol 2001, 68(3):210-214.
-
(2001)
Am J Hematol
, vol.68
, Issue.3
, pp. 210-214
-
-
Rice, L.1
Nichol, J.L.2
McMillan, R.3
Roskos, L.K.4
Bacile, M.5
-
182
-
-
0037100423
-
Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
-
Nomura S., Dan K., Hotta T., Fujimura K., Ikeda Y. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002, 100(2):728-730.
-
(2002)
Blood
, vol.100
, Issue.2
, pp. 728-730
-
-
Nomura, S.1
Dan, K.2
Hotta, T.3
Fujimura, K.4
Ikeda, Y.5
-
183
-
-
38649120593
-
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
-
Kuter D.J., Bussel J.B., Lyons R.M., et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 2008, 371(9610):395-403.
-
(2008)
Lancet
, vol.371
, Issue.9610
, pp. 395-403
-
-
Kuter, D.J.1
Bussel, J.B.2
Lyons, R.M.3
-
184
-
-
0013912854
-
Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia
-
Aster R.H. Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest 1966, 45:645-657.
-
(1966)
J Clin Invest
, vol.45
, pp. 645-657
-
-
Aster, R.H.1
-
185
-
-
9844268495
-
The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia
-
Adams J.A., Liu Yin J.A., Brereton M.L., Briggs M., Burgess R., Hyde K. The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia. Br J Haematol 1997, 99(1):139-146.
-
(1997)
Br J Haematol
, vol.99
, Issue.1
, pp. 139-146
-
-
Adams, J.A.1
Liu Yin, J.A.2
Brereton, M.L.3
Briggs, M.4
Burgess, R.5
Hyde, K.6
-
186
-
-
19244377909
-
Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia
-
Fontenay-Roupie M., Dupont J.M., Picard F., et al. Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia. Leuk Res 1998, 22(6):527-535.
-
(1998)
Leuk Res
, vol.22
, Issue.6
, pp. 527-535
-
-
Fontenay-Roupie, M.1
Dupont, J.M.2
Picard, F.3
-
187
-
-
4243689989
-
Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts (plt) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS)
-
Komatsu N., Okamoto T., Yoshida T., et al. Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts (plt) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS). Blood 2000, 96:296a.
-
(2000)
Blood
, vol.96
-
-
Komatsu, N.1
Okamoto, T.2
Yoshida, T.3
-
188
-
-
75749124291
-
Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia
-
Kantarjian H., Fenaux P., Sekeres M.A., et al. Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia. J Clin Oncol 2010, 28(3):437-444.
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 437-444
-
-
Kantarjian, H.1
Fenaux, P.2
Sekeres, M.A.3
-
189
-
-
78049378253
-
Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy
-
Kantarjian H.M., Giles F.J., Greenberg P.L., et al. Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy. Blood 2010, 116(17):3163-3170.
-
(2010)
Blood
, vol.116
, Issue.17
, pp. 3163-3170
-
-
Kantarjian, H.M.1
Giles, F.J.2
Greenberg, P.L.3
-
190
-
-
84882707749
-
-
Amgen. Letter to physicians-romiplostim in MDS (July 21)
-
Amgen. Letter to physicians-romiplostim in MDS (July 21), 2011.
-
(2011)
-
-
-
191
-
-
0030789326
-
Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin
-
Ballmaier M., Schulze H., Strauss G., et al. Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin. Blood 1997, 90(2):612-619.
-
(1997)
Blood
, vol.90
, Issue.2
, pp. 612-619
-
-
Ballmaier, M.1
Schulze, H.2
Strauss, G.3
-
192
-
-
0036229482
-
Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders
-
Pecci A., Noris P., Invernizzi R., et al. Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders. Br J Haematol 2002, 117(1):164-167.
-
(2002)
Br J Haematol
, vol.117
, Issue.1
, pp. 164-167
-
-
Pecci, A.1
Noris, P.2
Invernizzi, R.3
-
193
-
-
80053205810
-
Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells
-
Pecci A., Bozzi V., Panza E., et al. Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells. Thromb Haemost 2011, 106(4):693-704.
-
(2011)
Thromb Haemost
, vol.106
, Issue.4
, pp. 693-704
-
-
Pecci, A.1
Bozzi, V.2
Panza, E.3
-
194
-
-
78650669297
-
Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations
-
Pecci A., Gresele P., Klersy C., et al. Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations. Blood 2010, 116(26):5832-5837.
-
(2010)
Blood
, vol.116
, Issue.26
, pp. 5832-5837
-
-
Pecci, A.1
Gresele, P.2
Klersy, C.3
-
195
-
-
0032192491
-
Recombinant human megakaryocyte growth and development factor attenuates postbypass thrombocytopenia
-
Nakamura M., Toombs C.F., Duarte I.G., et al. Recombinant human megakaryocyte growth and development factor attenuates postbypass thrombocytopenia. Ann Thorac Surg 1998, 66(4):1216-1223.
-
(1998)
Ann Thorac Surg
, vol.66
, Issue.4
, pp. 1216-1223
-
-
Nakamura, M.1
Toombs, C.F.2
Duarte, I.G.3
-
196
-
-
0031000903
-
Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
-
Piacibello W., Sanavio F., Garetto L., et al. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood 1997, 89:2644-2653.
-
(1997)
Blood
, vol.89
, pp. 2644-2653
-
-
Piacibello, W.1
Sanavio, F.2
Garetto, L.3
-
197
-
-
0035469854
-
Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin
-
Goodnough L.T., Kuter D.J., McCullough J., et al. Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin. Blood 2001, 98(5):1346-1351.
-
(2001)
Blood
, vol.98
, Issue.5
, pp. 1346-1351
-
-
Goodnough, L.T.1
Kuter, D.J.2
McCullough, J.3
-
198
-
-
0037157612
-
Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study
-
Vadhan-Raj S., Kavanagh J.J., Freedman R.S., et al. Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study. Lancet 2002, 359(9324):2145-2152.
-
(2002)
Lancet
, vol.359
, Issue.9324
, pp. 2145-2152
-
-
Vadhan-Raj, S.1
Kavanagh, J.J.2
Freedman, R.S.3
-
199
-
-
0036530040
-
Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
-
Basser R.L., O'Flaherty E., Green M., et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002, 99(7):2599-2602.
-
(2002)
Blood
, vol.99
, Issue.7
, pp. 2599-2602
-
-
Basser, R.L.1
O'Flaherty, E.2
Green, M.3
-
200
-
-
84882654301
-
In Brief: amgen Megagen
-
F-D-C- Reports
-
F-D-C- Reports In Brief: amgen Megagen. The Pink Sheet 1998, 60:27.
-
(1998)
The Pink Sheet
, vol.60
, pp. 27
-
-
-
201
-
-
49549088612
-
Increased procoagulant cell-derived microparticles (C-MP) in splenectomized patients with ITP
-
Fontana V., Jy W., Ahn E.R., et al. Increased procoagulant cell-derived microparticles (C-MP) in splenectomized patients with ITP. Thromb Res 2008, 122(5):599-603.
-
(2008)
Thromb Res
, vol.122
, Issue.5
, pp. 599-603
-
-
Fontana, V.1
Jy, W.2
Ahn, E.R.3
-
202
-
-
3042637761
-
Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies
-
Aledort L.M., Hayward C.P., Chen M.G., Nichol J.L., Bussel J. Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies. Am J Hematol 2004, 76(3):205-213.
-
(2004)
Am J Hematol
, vol.76
, Issue.3
, pp. 205-213
-
-
Aledort, L.M.1
Hayward, C.P.2
Chen, M.G.3
Nichol, J.L.4
Bussel, J.5
-
203
-
-
78651277473
-
Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study
-
Severinsen M.T., Engebjerg M.C., Farkas D.K., et al. Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. Br J Haematol 2011, 152(3):360-362.
-
(2011)
Br J Haematol
, vol.152
, Issue.3
, pp. 360-362
-
-
Severinsen, M.T.1
Engebjerg, M.C.2
Farkas, D.K.3
-
204
-
-
0029897491
-
Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice
-
Ulich T.R., del Castillo J., Senaldi G., et al. Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood 1996, 87(12):5006-5015.
-
(1996)
Blood
, vol.87
, Issue.12
, pp. 5006-5015
-
-
Ulich, T.R.1
del Castillo, J.2
Senaldi, G.3
-
205
-
-
0031916263
-
Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression
-
Abina M.A., Tulliez M., Lacout C., et al. Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression. Gene Therapy 1998, 5(4):497-506.
-
(1998)
Gene Therapy
, vol.5
, Issue.4
, pp. 497-506
-
-
Abina, M.A.1
Tulliez, M.2
Lacout, C.3
-
206
-
-
0029956149
-
A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation
-
Yan X.Q., Lacey D., Hill D., et al. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 1996, 88(2):402-409.
-
(1996)
Blood
, vol.88
, Issue.2
, pp. 402-409
-
-
Yan, X.Q.1
Lacey, D.2
Hill, D.3
-
207
-
-
0036263664
-
Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders
-
Douglas V.K., Tallman M.S., Cripe L.D., Peterson L.C. Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Pathol 2002, 117(6):844-850.
-
(2002)
Am J Clin Pathol
, vol.117
, Issue.6
, pp. 844-850
-
-
Douglas, V.K.1
Tallman, M.S.2
Cripe, L.D.3
Peterson, L.C.4
-
208
-
-
70449704426
-
Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
-
Kuter D.J., Mufti G.J., Bain B.J., Hasserjian R.P., Davis W., Rutstein M. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Blood 2009, 114(18):3748-3756.
-
(2009)
Blood
, vol.114
, Issue.18
, pp. 3748-3756
-
-
Kuter, D.J.1
Mufti, G.J.2
Bain, B.J.3
Hasserjian, R.P.4
Davis, W.5
Rutstein, M.6
-
209
-
-
84855345560
-
Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities
-
Boiocchi L., Orazi A., Ghanima W., Arabadjief M., Bussel J.B., Geyer J.T. Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities. Mod Pathol 2012, 25(1):65-74.
-
(2012)
Mod Pathol
, vol.25
, Issue.1
, pp. 65-74
-
-
Boiocchi, L.1
Orazi, A.2
Ghanima, W.3
Arabadjief, M.4
Bussel, J.B.5
Geyer, J.T.6
-
210
-
-
34848876335
-
Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres
-
Kuter D.J., Bain B., Mufti G., Bagg A., Hasserjian R.P. Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres. Br J Haematol 2007, 139(3):351-362.
-
(2007)
Br J Haematol
, vol.139
, Issue.3
, pp. 351-362
-
-
Kuter, D.J.1
Bain, B.2
Mufti, G.3
Bagg, A.4
Hasserjian, R.P.5
-
211
-
-
0027257805
-
Expression of the c-mpl proto-oncogene in human hematologic malignancies
-
Vigon I., Dreyfus F., Melle J., et al. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 1993, 82(3):877-883.
-
(1993)
Blood
, vol.82
, Issue.3
, pp. 877-883
-
-
Vigon, I.1
Dreyfus, F.2
Melle, J.3
-
212
-
-
0029129618
-
Thrombopoietin receptor expression in human cancer cell lines and primary tissues
-
Columbyova L., Loda M., Scadden D.T. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Research 1995, 55:3509-3512.
-
(1995)
Cancer Research
, vol.55
, pp. 3509-3512
-
-
Columbyova, L.1
Loda, M.2
Scadden, D.T.3
-
213
-
-
0030847329
-
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis
-
Nandurkar H.H., Robb L., Tarlinton D., Barnett L., Kontgen F., Begley G.C. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood 1997, 90:2148-2159.
-
(1997)
Blood
, vol.90
, pp. 2148-2159
-
-
Nandurkar, H.H.1
Robb, L.2
Tarlinton, D.3
Barnett, L.4
Kontgen, F.5
Begley, G.C.6
-
214
-
-
0031916723
-
Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
-
Robb L., Li R., Hartley L., Nandurkar H.H., Koentgen F., Begley C.G. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nature Medicine 1998, 4:303-308.
-
(1998)
Nature Medicine
, vol.4
, pp. 303-308
-
-
Robb, L.1
Li, R.2
Hartley, L.3
Nandurkar, H.H.4
Koentgen, F.5
Begley, C.G.6
-
215
-
-
0027469684
-
The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin
-
Smith JWd Longo DL, Alvord W.G., et al. The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin. New Engl J Med 1993, 328(11):756-761.
-
(1993)
New Engl J Med
, vol.328
, Issue.11
, pp. 756-761
-
-
Smith JWd, L.D.L.1
Alvord, W.G.2
-
216
-
-
0028174971
-
Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer
-
Vadhan-Raj S., Kudelka A.P., Garrison L., et al. Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer. J Clin Oncol 1994, 12(4):707-714.
-
(1994)
J Clin Oncol
, vol.12
, Issue.4
, pp. 707-714
-
-
Vadhan-Raj, S.1
Kudelka, A.P.2
Garrison, L.3
-
217
-
-
0029075385
-
A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia
-
Gordon M.S., Nemunaitis J., Hoffman R., et al. A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia. Blood 1995, 85(11):3066-3076.
-
(1995)
Blood
, vol.85
, Issue.11
, pp. 3066-3076
-
-
Gordon, M.S.1
Nemunaitis, J.2
Hoffman, R.3
-
218
-
-
0029003110
-
Phase I multicenter trial of interleukin 6 therapy after autologous bone marrow transplantation in advanced breast cancer
-
Lazarus H.M., Winton E.F., Williams S.F., et al. Phase I multicenter trial of interleukin 6 therapy after autologous bone marrow transplantation in advanced breast cancer. Bone Marrow Transplant 1995, 15(6):935-942.
-
(1995)
Bone Marrow Transplant
, vol.15
, Issue.6
, pp. 935-942
-
-
Lazarus, H.M.1
Winton, E.F.2
Williams, S.F.3
-
219
-
-
0029096426
-
Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients
-
Nieken J., Mulder N.H., Buter J., et al. Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients. Blood 1995, 86(3):900-905.
-
(1995)
Blood
, vol.86
, Issue.3
, pp. 900-905
-
-
Nieken, J.1
Mulder, N.H.2
Buter, J.3
-
220
-
-
15844395460
-
A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy
-
Gordon M.S., McCaskill-Stevens W.J., Battiato L.A., et al. A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. Blood 1996, 87(9):3615-3624.
-
(1996)
Blood
, vol.87
, Issue.9
, pp. 3615-3624
-
-
Gordon, M.S.1
McCaskill-Stevens, W.J.2
Battiato, L.A.3
-
221
-
-
22244475160
-
An oral, non-peptide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects
-
Jenkins J., Nicholl R., Williams D., et al. An oral, non-peptide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects. Blood 2004, 104:797a.
-
(2004)
Blood
, vol.104
-
-
Jenkins, J.1
Nicholl, R.2
Williams, D.3
|