A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

Blood

Volumn 87, Issue 9, 1996, Pages 3615-3624

  Gordon, Michael S ^a   McCaskill Stevens, Worta J ^a   Battiato, Linda A ^a   Loewy, John ^a   Loesch, David ^a   Breeden, Elyse ^a   Hoffman, Ron ^a   Beach, Kathleen J ^a   Kuca, Bernice ^a   Kaye, James ^a   Sledge Jr , George W ^a  

^a UH 1730 ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 11;

ADULT; AGED; ARTHRALGIA; ARTICLE; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFICACY; EDEMA; FATIGUE; FEMALE; FEVER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MYALGIA; NEUROTOXICITY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; WEIGHT GAIN;

EID: 15844395460     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.9.3615.bloodjournal8793615     Document Type: Article

References (20)

1. Demetri G, Younger J, Shapiro C, Douville L, Colecchi C, Armstrong S, McGuire B, Henderson I: A Phase I study of dose-intensified CAF chemotherapy with adjunctive G-CSF in patients with advanced breast cancer. Proc ASCO 11:255a, 1992 (abstr)
2. Paul S, Bennett F, Calvetti J, Kelleher K, Wood C, O'Hara R Jr., Leary A, Sibley B, Clark S, Williams D, Yang Y-C: Molecular cloning of a cDNA encoding interteukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA 87:7512, 1990
3. Neben S, Donaldson D, Sieff C, Mauch P, Bodine D, Ferrara J, Yetz-Aldape J, Turner K: Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture. Exp Hematol 22:353, 1994
4. Bruno E. Briddell R, Cooper R, Hoffman R: Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells. Exp Hematol 19:378, 1991
5. Musashi M, Yang Y-C, Paul S, Clark S, Sudo T: Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture. Proc Natl Acad Sci USA 88:765, 1991
6. Teramura M, Kobayashi S, Hoshino S, Oshimi K, Mizoguchi H: Interleukin 11 enhances human megakaryocytopoiesis in vitro. Blood 79:327, 1992
7. Goldman S, Loebelanz J, McCarthy K, Hayes L, Neben T, Stoudemire J, Schaub R: Recombinant human interleukin-11 (rhIL-11) stimulates megakaryocyte maturation and increase in peripheral platelet number in vivo. Blood 78:518a, 1991 (abstr, suppl 1)
8. Goldman S, Neben T, Quinto C, Leonard J, Lamont C, Mauch P: Constant subcutaneous infusion of recombinant human interleukin-11 induces stem cell mobilization and causes prolonged elevation of peripheral platelets. Blood 80:354a, 1992 (abstr, suppl 1)
9. Hangoc G, Yin T, Cooper S, Schendel P, Yang Y-C, Broxmeyer HE: In vivo effects of recombinant interleukin-11 on myelopoiesis in mice. Blood 81:965, 1992
10. Du X, Neben T, Goldman S, Williams D: Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: Acceleration of recovery of peripheral blood neutrophils and platelets. Blood 81:27, 1993
11. World Health Organization Handbook for Reporting Results of Cancer Treatment, in: WHO Offset Publication No. 48 (vol 2). Geneva, Switzerland, World Health Organization, 1979, p 16
12. Neidhart J, Managalik A, Stidley C, Tebich S, Sarmiento L, Pfile J, Oette D, Oldham F: Dosing regimen of granulocyte-macrophage colony-stimulating factor to support dose-intense chemotherapy. J Clin Oncol 10:1460, 1992
13. Neidhart J, Mangalik A, Kohler W, Stidley C, Saiki J, Duncan P, Souza L, Downing M: Granulocyte colony-stimulating factor stimulates recovery of granulocytes in patients receiving dose-intensive chemotherapy without bone marrow transplantation. J Clin Oncol 7:1685, 1989
14. Abels R, Larholt K, Krantz K, Bryant E: Recombinant human erythrooietin (r-HuEPO) for the treatment of the anemia of cancer, in Murphy M Jr (ed): Blood Cell Growth Factors: Their Present and Future Use in Hematology and Oncology. Proceedings of the Beijing Symposium. Dayton, OH, AlphaMed, 1991, p 121
15. Dutcher J, Schiffer C, Aisner J, Wiernik P: Alloimmunization following platelet transfusion: The absence of a dose-response relationship. Blood 57:395, 1981
16. Kaye J, Loewy J, Blume J, Clendaniel A, Egan A, Garnick M, Milchell J, Knowles C, Ault K: Recombinant human interleukin eleven (Neumega™ rhIL-11 growth factor) increases plasma von Willebrand factor and fibrinogen concentrations in normal human subjects. Blood 84:1088a, 1994 (abstr, suppl 1)
17. Ault K, Mitchell J, Knowles C, Clendaniel A, Egan A, Loewy J, Garnick M, Kaye J: Recombinant human interleukin eleven (Neumega™ rhIL-11 growth factor) increases plasma volume and decreases urine sodium excretion in normal human subjects. Blood 84:1089a, 1994 (abstr, suppl 1)
18. Atkins M, Kappler K, Mier J, Isaacs R, Berkman E: Interleukin-6-associated anemia: Determination of the underlying mechanism. Blood 86:1288, 1995
19. Nieken J, Mulder N, Buter J, Vellenga E, Limburg P, Piers D, de Vries E: Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients. Blood 86:900, 1995
20. Orazi A, Cooper R, Tong J, Gordon MS, Battiato L, Sledge GW Jr, Kaye JA, Hoffman R: Effects of recombinant human interleukin eleven (NEUMEGA™ rhIL-11 growth factor) on megakaryocytopoiesis in human bone marrow. Exp Hematol (in press)