Human platelets display high-affinity receptors for thrombopoietin

Blood

Volumn 89, Issue 6, 1997, Pages 1896-1904

  Broudy, Virginia C ^a   Lin, Nancy L ^a   Sabath, Diana F ^a   Papayannopoulou, Thalia ^a   Kaushansky, Kenneth ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN RECEPTOR; THROMBOCYTE RECEPTOR; THROMBOPOIETIN;

ADULT; ARTICLE; AUTORADIOGRAPHY; BONE MARROW CELL; BURST FORMING UNIT E; CONTROLLED STUDY; ERYTHROID PRECURSOR CELL; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; THROMBOCYTE;

EID: 0030968519     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.6.1896     Document Type: Article

References (60)

1. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
2. Broudy VC, Lin N, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
3. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
4. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp, Hunt P: Megakaryocyte growth and development factor. Analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95:2973, 1995
5. Debili N, Wendung F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
6. Banu N, Wang JF, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 86:1331, 1995
7. Chen J, Herceg-Harjacek L, Groopman JE, Grabarek J: Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 86:4054, 1995
8. Harker LA, Hunt P, Marzek UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87:1833, 1996
9. Ku H, Kaushansky K, Ogawa A: Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544, 1996
10. Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K: The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998, 1996
11. Gurney AL, Carver-Moore, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
12. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162, 1996
13. de Sauvage EJ, Carver-Moore K, Luoh S-M, Ryan A, Dowd M, Eaton DL, Moore MW: Physiologic regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183:651, 1996
14. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher A, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
15. Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 86:54, 1995
16. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86:971, 1995
17. Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
18. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
19. Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin, P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
20. Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
21. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494, 1995
22. Papayannopoulou T, Brice M, Farrer D, Kaushansky K: Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. Exp Hematol 24:660, 1996
23. -) human hematopoietic cells: Novel responses to Flt3-ligand and thrombopoietin. J Exp Med 183:2551, 1996
24. Kieran MW, Perkins AC, Orkin SH, Zon LI: Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci USA 93:9126, 1996
25. Drachman JG, Griffin JD, Kaushansky K: The c-mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, shc, and c-Mpl. J Biol Chem 270:4979, 1995
26. Tortolani PJ, Johnston JA, Bacon CM, McVicar DW, Shimosaka A, Linnekin D, Longo DL, O'Shea JJ: Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2. Blood 85:3444, 1995
27. Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ: Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci USA 92:5292, 1995
28. Miyakawa Y, Oda A, Druker BJ, Kato T, Miyazaki H, Handa M, Ikeda Y: Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. Blood 86:23, 1995
29. Sattler M, Durstin MA, Frank DA, Okua K, Kaushansky K, Salgia R, Griffin JD: The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp Hematol 23:1040, 1995
30. Morella KK, Bruno E, Kumaki S, Lai C-F, Fu J, Wang H-M, Murray L, Hoffman R, Timour M, Bénit L, Gisselbrecht S, Zhuang H, Wojchowski DM, Baumann H, Gearing DP: Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells. Blood 86:557, 1995
31. Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y: Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 87:439, 1996
32. Methia N, Louache F, Vainchenker W, Wendling F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
33. Vigon I, Dreyfus F, Melle J, Viguié F, Ribrag V, Cocault L, Souyri M, Gisselbrecht S: Expression of the c-mpl proto-oncogene in human-hematologic malignancies. Blood 82:877, 1993
34. Matsumura I, Kanakura Y, Kato T, Ikeda H, Ishikawa J, Horikawa Y, Hashimoto K, Moriyama Y, Tsujimura T, Nishiura T, Miyazaki H, Matsuzawa Y: Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood 86:703, 1995
35. Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W: The Mpl receptor is expressed in the megakaryoeytic lineage from late progenitors to platelets. Blood 85:391, 1995
36. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
37. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
38. Broudy VC, Tait JF, Powell JS: Recombinant human erythropoietin: Purification and analysis of carbohydrate linkage. Arch Biochem Biophys 265:329, 1988
39. Broudy VC, Lin N, Brice M, Nakamoto B, Papayannopoulou T: Erythropoietin receptor characteristics on primary human erythroid cells. Blood 77:2583, 1991
40. Michelson AD: Flow cytometry: A clinical test of platelet function. Blood 87:4925, 1996
41. Wun T, Paglieroni TG, Lachant NA: Desmopressin stimulates the expression of P-selectin on human platelets in vitro. J Lab Clin Med 125:401, 1995
42. Calvo JC, Radicella JP, Charreau EH: Measurement of specific radioactivities in labeled hormones by self-displacement analysis. Biochem J 212:259, 1983
43. Broudy VC, Lin N, Zsebo KM, Birkett NC, Smith KA, Bernstein ID, Papayannopoulou T: Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor. Blood 79:338, 1992
44. Broudy VC, Morgan DA, Lin N, Zsebo K, Jacobsen FW, Papayannopoulou T: Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor. Blood 82:436, 1993
45. Munson PJ, Rodbard D: LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220, 1980
46. Foster DC, Sprecher CA, Grant FJ, Kramer JM, Kuijper JL, Holly RD, Whitmore TE, Heipel MD, Bell LA, Ching AFT, McGrane V, Hart C, O'Hara PJ, Lok S: Human thrombopoietin: Gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci USA 91:13023, 1994
47. McEver RP, Baenziger NL, Majerus PW: Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest 66:1311, 1980
48. Fraser JK, Lin F-K, Berridge MV: Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL. Exp Hematol 16:836, 1988
49. Broudy VC, Smith FO, Lin N, Zsebo KM, Egrie J, Bernstein ID: Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor. Blood 80:60, 1992
50. Nichol J, Hornkohl A, Selesi D, Wyres M, Hunt P: TPO levels in plasma of patients with thrombocytopenia or thrombocytosis. Blood 86:371a, 1995 (abstr, suppl 1)
51. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695, 1995
52. Emmons RVB, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR: Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068, 1996
53. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 24:265, 1996
54. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3. Blood 88:429, 1996
55. Carver-Moore K, Broxmeyer HE, Luoh S-M, Cooper S, Peng J, Burstein SA, Moore MW, de Sauvage FJ: Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 88:803, 1996
56. Vigon I, Florindo C, Fichelson S, Guenet J-L, Mattel M-G, Souyri M, Cosman D, Gisselbrecht S: Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: Molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8:2607, 1993
57. Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P: Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 12:2645, 1993
58. Lofton-Day C, Buddle M, Berry J, Lok S: Differential binding of murine thrombopoietin to two isoforms of murine C-MPL. Blood 86:594a, 1995 (abstr, suppl 1)
59. Miyajima A, Mui AL-F, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960, 1993
60. Wu H, Klingmüller, Besmer P, Lodish HF: Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377:242, 1995