Thrombopoietin production is inhibited by a translational mechanism

Blood

Volumn 92, Issue 11, 1998, Pages 4023-4030

  Ghilardi, Nico ^a   Wiestner, Adrian ^a   Skoda, Radek C ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CODON; CONTROLLED STUDY; EXON; HUMAN; HUMAN TISSUE; LIVER; MEGAKARYOPOIESIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; RNA SPLICING; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS;

EID: 0032400867     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.11.4023.423k54_4023_4030     Document Type: Article

References (48)

1. Kaushansky K: Thrombopoietin: Understanding and manipulating platelet production. Annu Rev Med 48:1, 1997
2. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LA, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-mpl ligand. Nature 369:533, 1994
3. Foster DC, Sprecher CA, Grant FJ, Kramer JM, Kuijper JL, Holly RD, Whitmore TE, Heipel MD, Bell LA, Ching A, Mcgrane V, Hart C, Ohara PJ, Lok S: Human thrombopoietin: Gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci USA 91:13023, 1994
4. Sungaran R, Markovic B, Chong BH: Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 89:101, 1997
5. Guerriero A, Worford L, Holland HK, Guo GR, Sheehan K, Waller EK: Thrombopoietin is synthesized by bone marrow stromal cells. Blood 90:3444, 1997
6. Kosugi S, Kurata Y, Tomiyama Y, Tahara T, Kato T, Tadokoro S, Shiraga M, Honda S, Kanakura Y, Matsuzawa Y: Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br J Haematol 93:704, 1996
7. Tahara T, Usuki K, Sato H, Ohashi H, Morita H, Tsumura H, Matsumoto A, Miyazaki H, Urabe A, Kato T: A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. Br J Haematol 93:783, 1996
8. Emmons RVB, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR: Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068, 1996
9. Kelemen E: Specific thrombopoietin cloned and sequenced - With personal retrospect and clinical prospects. Leukemia 9:1, 1995
10. Kuter DJ, Rosenberg RD: Regulation of megakaryocyte ploidy in vivo in the rat. Blood 75:74, 1990
11. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Bretongorius J, Cosman D, Vainchenker W: C-mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
12. Stoffel R, Wiestner A, Skoda RC: Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 87:567, 1996
13. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
14. Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendling F: Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood 88:2578, 1996
15. McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K: Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 86:3668, 1995
16. De Gabriele G, Penington DG: Regulation of platelet production: "Hypersplenism" in the experimental animal. Br J Haematol 13:384, 1967
17. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
18. Eaton DL, de Sauvage FJ: Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 25:1, 1997
19. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
20. de Sauvage FJ, Carver-Moore K, Luoh SM, Ryan A, Dowd M, Eaton DL, Moore MW: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183:651, 1996
21. Bunn H, Gu J, Huang L, Park JW: Erythropoietin: A model system for studying oxygen-dependent gene regulation. J Exp Biol 201:1197, 1998
22. Pitcher L, Taylor K, Nichol J, Selsi D, Rodwell R, Marty J, Taylor D, Wright S, Moore D, Kelly C, Rentoul A: Thrombopoietin measurement in thrombocytosis: Dysregulation and lack of feedback inhibition in essential thrombocythaemia. Br J Haematol 99:929, 1997
23. Cerutti A, Custodi P, Duranti M, Noris P, Balduini CL: Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br J Haematol 99:281, 1997
24. Wiestner A, Schlemper RJ, van der Maas AP, Skoda RC: An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nat Genet 18:49, 1998
25. Kozak M: Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Biol Chem 266:19867, 1991
26. Kozak M: Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol Cell Biol 9:5134, 1989
27. Kozak M: Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc Natl Acad Sci USA 83:2850, 1986
28. Kozak M: The scanning model for translation: An update. J Cell Biol 108:229, 1989
29. Kozak M: An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125, 1987
30. Luukkonen BG, Tan W, Schwartz S: Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance. J Virol 69:4086, 1995
31. Kozak M: An analysis of vertebrate mRNA sequences: Intimations of translational control. J Cell Biol 115:887, 1991
32. Chang MS, McNinch J, Basu R, Shutter J, Hsu RY, Perkins C, Mar V, Suggs S, Welcher A, Li L, Lu H, Bartley T, Hunt P, Martin F, Samal B, Bogenberger J: Cloning and characterization of the human megakaryocyte growth and development factor (mgdf) gene. J Biol Chem 270:511, 1995
33. Krieg PA, Melton DA: In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol 155:397, 1987
34. Chomczynski P, Sachhi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
35. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR: Site directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51, 1989
36. Seed B, Aruffo A: Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc Natl Acad Sci USA 84:3365, 1987
37. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H: Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353:57, 1994
38. Kamura T, Handa H, Hamasaki N, Kitajima S: Characterization of the human thrombopoietin gene promoter - A possible role of an Ets transcription factor, E4TF1/GABP. J Biol Chem 272:11361, 1997
39. Gurney AL, Kuang WJ, Xie MH, Malloy BE, Eaton DL, de Sauvage FJ: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 85:981, 1995
40. Jaeger JA, Turner DH, Zuker M: Improved predictions of secondary structures for RNA. Proc Natl Acad Sci USA 86:7706, 1989
41. Nielsen H, Engelbrecht E, Brunak S, von Heijne G: Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng 10:1, 1997
42. Peabody DS: Translation initiation at non-AUG triplets in mammalian cells. J Biol Chem 264:5031, 1989
43. Lok S, Kaushansky K, Holly RD, Kuijper JL, Loftonday CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching A, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, Ohara PJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
44. Ogami K, Shimada Y, Sohma Y, Akahori H, Kato T, Kawamura K, Miyazaki H: The sequence of a rat cDNA encoding thrombopoietin. Gene 158:309, 1995
45. Bamford RN, Battiata AP, Burton JD, Sharma H, Waldmann TA: Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc Natl Acad Sci USA 93:2897, 1996
46. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S: Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571, 1988
47. Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y: Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol 160:936, 1998
48. Konig H, Ponta H, Herrlich P: Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator. EMBO J 17:2904, 1998