Thrombopoietin: Biology, clinical applications, role in the donor setting

Journal of Clinical Apheresis

Volumn 11, Issue 3, 1996, Pages 149-159

  Kuter, David J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

cytokines; growth factors; hematopoiesis; megakaryocytes; platelets; transfusion medicine

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CYTOKINE; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; MESNA; MYELOPOIETIN; PROMEGAPOIETIN; RECOMBINANT THROMBOPOIETIN; SYNTHOKINE; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER PATIENT; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; MEGAKARYOCYTE; MYELOFIBROSIS; NONHUMAN; SURGICAL PATIENT; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOCYTOSIS; THROMBOSIS; TREATMENT OUTCOME;

ANIMALS; BLOOD DONORS; BLOOD TRANSFUSION; HUMANS; THROMBOPOIETIN;

EID: 0029805293     PISSN: 07332459     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1101(1996)11:3<149::AID-JCA6>3.0.CO;2-B     Document Type: Conference Paper

References (69)

1. Wright JH: Differential staining of blood films and malarial parasites. J Medical Res 7:138-144, 1902.
2. Wright JH: The histogenesis of the blood platelets. J Morph 21: 263-278, 1910.
3. Wright JH: The origin and nature of blood plates. Boston Medical and Surgical Journal 154:643-645, 1906.
4. Harker LA: Kinetics of thrombopoiesis. J Clin Invest 47:458-465, 1968.
5. Kelemen E, Cserhati I, Tanos B: Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta Haematol 20:350-355, 1958.
6. de Sauvage FJ, Hass PE, Spencer SD Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W, Oles KJ, Hultgren B, Solberg LA, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533-538, 1994.
7. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samai B, Nichol JL, Swift S, Johnson MJ, Hsu RY, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castiilo J, Biron J, Cole S, Hu MCT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117-1124, 1994.
8. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Hone K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H: Purification and characterization of thrombopoietin. J Biochem 119:229-236, 1995.
9. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565-568, 1994.
10. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104-11108, 1994.
11. Souryi M, Vignon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendung F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137-1147, 1990.
12. Vignon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640-5644, 1992.
13. Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W: The MpI receptor is expressed in the megakaryocyte lineage from later progenitors to platelets. Blood 85:391-401, 1995.
14. Methia N, Louache F, Vainchenker W, Wendung F: Oligodeoxy-nucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395-1401, 1993.
15. Wendling F, Maraskovsky E, Debill N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571-574, 1994.
16. Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenta associated with carboplatin and irradiation in mice. Blood 86:4486-4492, 1995.
17. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FS: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154-2161, 1996.
18. Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P: Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85:40213, 1995.
19. Choi ES, Hokom MM, Chen J-L, Dwyer E, Skrine J, Rowan C, Hunt P: The role of megakaryocyte growth and development factor (MGDF) in terminal stages of thrombopoiesis. Blood 86:285a, 1995.
20. Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719-1726, 1995.
21. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (Mpl-ligand) enhances proliferation of erythroid progenitors. Blood 86:2494-2499, 1995
22. Basser R, Clarke K, Fox R, Green M, Cebon J, Many J, Menchaca D, Tomita D: Randomized, double-blinded, placebo-controlled phase 1 trial of pegylated megakaryocyte growth and development factor (PEG-rHuMGDF) administered to patients with advanced cancer before and after chemotherapy - early results. Blood 86: 257a, 1995.
23. Cebon J, Basser R, Clarke K, Fox R, Green M, Chipman M, Zalcberg J, Marty J, Mechaca D, Sheridan W, Begley O: Effects of the in vivo administration of pegylated recombinant human megakaryocyte growth and development factor (MGDF) in patients with advanced cancer. Annals of Oncology (Suppl 1) 7:60, 1996.
24. Farese AM, Hunt P, Boone TC, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal primates. Blood 86:54-59, 1995.
25. Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87:1833-1844, 1996.
26. Erslev AJ. Erythropoietin titers in health and disease. Semin Hematol 28:2-8, 1991.
27. Haas R, Geriete G, Wirt B, Cayeux S, Hunstein W: Increased serum levels of granulocyte colony-stimulating factor after autologous bone marrow or blood stem cell transplantation. Exp Hematol 21:109-113, 1993.
28. Gurney AL, Caver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-Mpl-deficient mice. Science 265:1445-1447, 1994.
29. de Sauvage FS, Carver-Moore K, Luoh S-M, Ryan A, Dowd M, Eaton DL, Moore MW: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183:651-656, 1996.
30. Nichol J, Homkohl A, Selesi D, Wyres M, Hunt P: TPO levels in plasma of patients with thrombocytopenia or thrombocytosis. Blood 86:371a, 1995.
31. Stoffel R, Wiestner A, Skoda RC: Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 87:567-573, 1996.
32. Goldberg MA, Imagawa S, Strair RK, Bunn HF: Regulation of the erythropoietin gene in Hep 3B cells. Semin Hematol 28:35-39, 1991.
33. Bartocci A, Mastrogiannis DS, Migliorati G, Stocken RJ, Wolkoff AW, Stanley ER: Macrophages specifically regulate the concentration of their own growth factor in the circulation. Proc Natl Acad Sci USA 84:6179-6183, 1987.
34. Schiffer CA: Potential clinical applications of thrombopoietic growth factors. In Kuter DJ, Hunt P, Sheridan WP, Zucker-Franklin D (eds): "Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology." New York: Humana Press, 1996. In press.
35. Demetri GD, Berry D, Younger J, Roben NJ, Duggan D, Stoner P, Henderson IC: Dose-intensified cyclophosphamide/doxorubicin (CD) followed by taxol (T) as adjuvant systemic chemotherapy for node-positive breast cancer (CALGB 9141): Randomized comparison of two dose levels of G-CSF. Proceedings ASCO 13:65, 1994.
36. Fibbe WE, Heemskerk DPM, Laterveer L, Pruijt JFM, Foster D, Kaushansky K, Willemze R: Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 86:3308-3313, 1995.
37. Neelis KJ, Wognum AW, Eaton D, Thomas R, Wagemaker G: Preclinical evaluation of thrombopoietin in rhesus monkeys. Blood 86:256a, 1995.
38. Ishibashi T, Shikama Y, Kimura H, Foster DC, Maruyama Y: In vitro effect of human c-Mpl-ligand on megakaryocytopoiesis in normal individuals and patients with aptastic anemia and myelodysplastic syndromes. Stem Cells, in press.
39. Harker LA, Finch CA: Thrombokinetics in man. J Clin Invest 48:963-974, 1969.
40. Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter SJ: Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. J Clin Invest 80:33-40, 1987.
41. Kuter DJ, Ellman L, McCluskey RT: CPC - An 85-year-old woman with renal failure, neurologic deterioration, and seizures. New Engl J Med 325:265-273, 1991.
42. Nyilas E, Leinbach RC, Caulfied JB, Buckley MJ, Austen WG: Development of blood-compatible elastomers. III. Hematologic effects of avcothane intra-aortic balloon pumps in cardiac patients. J. Biomed Mater Res Symp 3:129-154, 1972.
43. Dupuis MP, England K, Blair AJ, Kim J, Theisen L: Preoperative autologous platelet harvesting may maximally benefit certain sub-populations of patients undergoing open heart surgery. J Clinical Apheresis (Suppl) 11: In press.
44. Alvarez JM, Gates R, Brady PW: Complications from intra-aortic balloon counterpulsation: a review of 303 cardiac surgical patients. Eur J Cardio-thorac Surg 6:530-535, 1992.
45. Dorman BH, Spinale FG, Bailey MK, Kratz JM, Roy RC: Identification of patients at risk for excessive blood loss during coronary artery bypass surgery: Thromboelastograph versus coagulation screen. Cardiovasc Anes 76:694-700, 1993.
46. Aster RH: Pooling of platelets in the spleen: Role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest 45:645-657, 1966.
47. Arnold J, Daw NC, Stenberg PE, Jackson CW: Increased platelet production in response to pegylated murine megakaryocyte growth and development factor (MGDF) results from in vivo stimulation of megakaryocyte proliferation and maturation. Proceedings of Keystone Symposium of Platelet Regulation. Taos, NM, February 16-22, 1996, p 14.
48. Rao GHR. Escolar G, White JG: Biochemistry, physiology, and function of platelets stored as concentrates. Transfusion 33:766-778, 1993.
49. Farrugia A: Platelet concentrates for transfusion - metabolic and storage aspects. Platelets 5:177-185, 1994.
50. Holme S: Platelet storage in a liquid environment. Transfus Sci 15:117-130, 1994.
51. George JN: Changes in platelet membrane glycoproteins during blood bank storage. Blood Cells 18:501-511, 1992.
52. Owens M, Werner E, Holme S, Afflerbach C: Membrane glycoproteins in cryopreserved platelets. Vox Sang 67:28-31, 1994.
53. Koerner TAW, Cunningham MT, Zhang D: The role of membrane lipid in the platelet storage lesion. Blood Cells 18:481-497, 1992.
54. Escolar G, Mazzara R, White JG, Castillo R, Ordinas A: Contribution of perfusion techniques to the evaluation of the hemostatic effectiveness of platelet concentrates. Blood Cells 18:403-415, 1992.
55. Rinder HM, Synder EL: Activation of platelet concentrate during preparation and storage. Blood Cells 18:445-156. 1992.
56. Bode AP, Holme S, Heaton WA, Swanson MS: Sustained elevation of intracellular cyclic 3′-5′ adenosine monophosphate is necessary for preservation of platelet integrity during long-term storage at 22°C. Blood 83:1235-1243. 1994.
57. Qian KC, Zhang QH, Bai NQ, Xu C, Yu Y, Cao F, Lee A, Lee TD: The effect of acidified glucose nutrient solution on preservation of platelet concentrate. Clin Lab Haemat 15:45-53, 1993.
58. Fratantoni, JC: Review: the platelet storage lesion: Possible role of plasticizers? Blood Cells 18:435-440, 1992.
59. Mitchell SG, Hawker RJ, Turner VS, Hesslewood SR, Handing LK: Effect of agitation on the quality of platelet concentrates. Vox Sang 67:160-165, 1994.
60. Rácz Z, Baróti C, Hasitz M. Increased in vitro aggregation of stored platelets at room temperature in contrast to 37°C. Platelets 5:40-44, 1994.
61. Koerner K, Sahlmen P, Zimmermann B, Cardoso M, Kubanek B: In vitro platelet function during storage in three different additive solutions. Vox Sang 67:154-159, 1994.
62. Holme S, Heaton WA, Smith KT, Buchholz DH: Evaluation of apheresis platelet concentrates collected with a reduced (30-ml) collection chamber with resuspension and storage in a synthetic medium. Vox Sang 67:149-153, 1994.
63. Yan X-Q, Lacey D, Fletcher F, Hartley C, McElroy T, Sun Y, Xia M, Mu S, Saris C, Hill D, Hawley RG, McNiece I: Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 86:4025-4033, 1995.
64. Kuter DJ. Hemorrhagic disorders II - The platelet In Beck WS (ed): "Hematology, 5th Ed." Cambridge, MA: MIT Press, 1991, pp 543-575.
65. Vigon I, Dreyfus F, Melle J, Viguie F, Ribrag V, Cocault L, Souryi M, Gisselbrecht S: Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 82:877-883, 1993.
66. Columbyova L, Loda M, Scadden DT: Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res 55:3509-3512, 1995.
67. D'Hondt V, Weynants P, Humblet Y, Guillaume T, Canon JL, Beauduin M, Duprez P, Longueville J, Mull R, Chatelain C, Symann M. Dose-dependent IL-3 stimulation of thrombopoiesis and neutropoiesis in patients with small cell lung carcinoma before and following chemotherapy: a placebo controlled randomized phase Ib study. J Clin Oncol 11:2063-2071, 1993.
68. D'Hondt V, Humblet Y, Guillaume T, Baatout S, Chatelain C, Berliere M, Longueville J, Feyens AM, De Greve J, Van Oosterom A, Von Graffenreid B, Donnez J, Symann M. Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: A multicentric placebo-controlled, randomized phase Ib study. Blood 85:2347-2353, 1995.
69. Elias L, Tepler I, Smith JW, Hussein MA, Kuca B, Beach K, Loewy J, Kaye JA: Randomized trial of recombinant human interleukin eleven (Neumega rhII-11 growth factor) in patients with severe chemotherapy-induced thrombocytopenia. Blood 86: 498a, 1995.