Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates

Blood

Volumn 87, Issue 5, 1996, Pages 1833-1844

  Harker, Laurence A ^a   Hunt, Pamela ^b   Marzec, Ulla M ^b   Kelly, Andrew B ^b   Tomer, Aaron ^b   Hanson, Stephen R ^b   Stead, Richard B ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR;

ANIMAL CELL; ARTICLE; BABOON; FLOW CYTOMETRY; MALE; MEGAKARYOCYTE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS;

EID: 0030068687     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.5.1833.bloodjournal8751833     Document Type: Article

References (67)

1. Odell TT, McDonald TP, Detwiler TC: Stimulation of platelet production by serum of platelet-depleted rats. Proc Soc Exp Biol Med 108:428, 1961
2. Harker LA: Kinetics of thrombopoiesis. J Clin Invest 47:458, 1968
3. Paulus JM: Platelet Kinetics: Radioisotopic, Cytological, Mathematical and Clinical Aspects. Amsterdam, The Netherlands, North-Holland, 1971
4. Evatt BL, Shreiner DP, Levin J: Thrombopoietic activity of fractions of rabbit plasma: Studies in rabbits and mice. J Lab Clin Med 83:364, 1974
5. Mazur E, South K: Human megakaryocyte colony-stimulating factor in serafrom apiastic anemia dogs: Partial purification, characterization and determination of hematopoietic cell lineage specificity. Exp Hematol 13:1164, 1985
6. Tayrien G, Rosenberg RD: Purification and properties of a megakaryocyte stimulatory factor present both in ihe serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma. J Biol Chem 262:3262, 1987
7. Gewirtz AM: Human megakaryocytopoiesis. Semin Hematol 23:27, 1986
8. Greenberg SM, Kuter DJ, Rosenberg RD: In vitro stimulation of megakaryocyte maturation by megakaryocyte stimulatory factor J Biol Chem 262:3269, 1987
9. Vainchenker W, Kieffer N: Human megakaryocytopoiesis: In vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers. Blood Rev 2:102, 1988
10. Tomer A, Harker LA, Burstein SA: Flow cytometric analysis of normal human megakaryocytes. Blood 71:1244, 1988
11. Harker LA: Regulation of thrombopoiesis. Am J Physiol 218:1376, 1970
12. Breton-Gorius J, Vainchenker W: Expression of platelet proteins during the in vitro and in vivo differentiation of megakaryocytes and morphological aspects of their maturation. Semin Hematol 23:43, 1986
13. Choi ES, Hokom M, Bartley T, Li Y-S, Ohashi H, Kato T, Nichol JL, Skrine J, Knudten A, Chen J, Hornkohl A, Grampp G, Sleeman L, Cole S, Trail G, Hunt P: Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro. Stem Cells 13:317, 1995
14. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Grouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
15. Chang MS, McNinch J, Basu R, Shutter J, Hsu RY, Perkins C, Mar V, Suggs S, Welcher A, Li L, Lu L, Bartley T, Hunt P, Martin F, Samal B, Bogenherger J: Cloning and characterization of the human megakaryocyte growth and development factor (MGDH) gene. J Biol Chem 270:511, 1995
16. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
17. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature 369:568, 1994
18. deSauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand Nature 369:533, 1994
19. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
20. Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
21. Methia N, Louache F, Vainchenker W, Wendling F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
22. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
23. Nichol JL, Hornkohl ES, Choi ES, et al: Enrichment and characterization of peripheral blood-derived megakaryocyte progenitors that mature in short-term liquid culture. Stem Cells 12:494, 1994
24. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P: Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95-2973, 1995
25. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
26. Harker LA, Kelly AB, Hanson SR. Experimental arterial thrombosis in non-human primates Circulation 83:IV-41, 1991 (suppl IV)
27. Hanson SR, Pareti FI, Ruggeri ZM, Kunicki TJ, Montgomery RR, Zimmerman TS, Harker LA: Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon. J Clin Invest 81:149, 1988
28. Kelly AB, Marzec UM, Krupski W, Bass A, Cadroy Y, Hanson SR, Harker LA: Hirudin interruption of heparin-resistant arterial thrombus formation in baboons. Blood 77:1006, 1991
29. Cadroy Y, Hanson SR, Kelly AB, Marzec UM, Evatt BL, Kunicki TJ, Montgomery RR, Harker LA: Relative antithrombotic effects of monoclonal antibodies targeting different platelet glycoprotein-adhesive molecule interactions in non-human primates. Blood 83:3218, 1994
30. Frelinger AL III, Cohen I, Plow EF, Smith MA, Roberts J, Lam SC, Ginsberg MH: Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem 265:6346, 1990
31. Scharf RE, Tomer A, Marzec UM, Teirstein PS, Ruggeri ZM, Harker LA: Activation of platelets in blood perfusing angioplasty-damaged coronary arteries. Flow cytometric detection. Arterioscler Thromb 12:1475, 1992
32. Stenberg PE, McEver RP, Shuman MA: A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 101:880, 1985
33. Thiagaraian P, Tait JF: Binding of annexin V/placental anticoagulant protein I to platelets. J Biol Chem 265:17420, 1990
34. Dachary-Prigent J, Freyssinet J-M, Pasquel J-M, Carron J-C, Nurden AT: Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups. Blood 81:2554, 1993
35. Harker LA, Hanson SR: Platelet factors predisposing to arterial thrombosis, in Meade TW (ed): Bailliere's Clinical Haematology London, UK. Bailliere Tindall, 1994, p 499
36. Funakoshi T, Heimark R, Hendrickson L, McMullen B, Fujikawa K: Human placental anticoagulant protein: Isolation and characterization. Biochemistry 26:5572, 1987
37. Iwasaki A, Suda M, Nakao H, Nagoya T, Saino Y, Arai K, Mizoguchi T, Sato F, Yoshizaki H, Hirata M, Miyata T, Shidara Y, Murata M, Maki M: Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: A new lipocortin-like protein. J Biochem 102:1261, 1987
38. Creutz C: The annexins and exocytosis. Science 258:924, 1992
39. Zwaal RFA, Comfurius P, Bevers EM: Platelet procoagulant activity and microvesicle formation Its putative role in hemostasis and thrombosis Biochim Biophys Acta Mol Basis Dis 1180:1, 1992
40. Shapiro HM: Practical Flow Cytometry. New York, NY, Wiley-Liss, 1995
41. Tomer A, Friese P, Conklin R, Bales W, Archer L, Harker LA, Burstein SA: Flow cytometric analysis of megakaryocytes from patients with abnormal platelet counts. Blood 74:594, 1989
42. Tomer A, Harker LA: Thrombocytopoiesis, in Anderson KC, Ness PM (eds): Scientific Basis of Transfusion Medicine. Philadelphia, PA, Saunders, 1994, p 40
43. Tomer A, Harker LA: Effects of anagrelide on human megakaryocytopoiesis. Clin Res 39:40a, 1991 (abstr)
44. Tomer A, Scharf RE, McMillan R, Ruggeri ZM, Harker LA: Bernard-Soulier syndrome: Quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. Eur J Haematol 52:193, 1994
45. Finch CA, Harker LA, Cook JD: Kinetics of the formed elements of human blood. Blood 50'699, 1977
46. Harker LA, Finch CA: Thrombokinetics in man. J Clin Invest 48:963, 1969
47. Slichter SJ, Harker LA: Thrombocytopenia mechanisms and management of defects in platelet production. Clin Haematol 7:523, 1978
48. Tomer A, Hanson SR, Harker LA: Autologous platelet kinetics in patients with severe thrombocytopema: Discrimination between disorders of production and destruction. J Lab Clin Med 118:546, 1991
49. 111Indium-labeled platelets in baboons. Blood 68:386, 1986
50. Harker LA, Hanson SR, Kirkman TR: Experimental arterial thromboembolism in baboons. Mechanism, quantitation, and pharmacologic prevention. J Clin Invest 64:559, 1979
51. Hanson SR, Harker LA: Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethylketone. Proc Natl Acad Sci USA 85:3184, 1988
52. Kelly AB, Maraganore JM, Bourdon P, Hanson SR, Harker LA: Antithrombotic effects of synthetic peptides targeting different functional domains of thrombin. Proc Natl Acad Sci USA 89:6040, 1992
53. Lumsden AB, Kelly AB, Schneider PA, Krupski WC, Dodson T, Hanson SR, Harker LA: Lasting safe interruption of endarterectomy thrombosis by transiently infused antithrombin peptide D-Phe-Pro-ArgCH2Cl in baboons. Blood 81:1762, 1993
54. Hanson SR, Kotze HF, Savage B, Harker LA: Platelet interactions with Dacron vascular grafts: A model of acute thrombosis in baboons. Arteriosclerosis 5:595, 1985
55. Jacobsson KI: Studies on the determination of fibrinogen in human blood plasma. II. Studies on the trypsin and plasmin inhibitors in human blood serum. Scand J Clin Lab Invest 7:7, 1955 (suppl 14)
56. Hanson SR, Reidy MA, Hattori A, Harker LA: Pharmacologic modification of acute vascular graft thrombosis. Scanning Electron Microsc 2.773, 1982
57. Bailar JC, Mosteller F: Guidelines for statistical reporting in articles for medical journals. Ann Intern Med 108:266, 1988
58. Jackson CW, Steward SA, Brown LK, Look AT: Inverse relationship between megakaryocyte buoyant density and maturity. Br J Haematol 64:33, 1986
59. O'Brien JR, Jamieson S: A relationship between platelet volume and platelet number. Thromb Diath Hemorrh 31:363, 1974
60. Bessman JD, Williams LJ, Gilmer PR Jr: Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 76:289, 1981
61. Savage B, Hunter CS, Harker LA, Hanson SR: Origins and significance of platelet heterogeneity in a non-human primate model, in Martin JF (ed): Platelet Heterogeneity: Biology and Pathology. London, UK, Springer-Verlag, 1990, p 77
62. Savage B, Hanson SR, Harker LA: Selective decrease in platelet dense granule adenine nucleotides during recovery from acute experimental thrombocytopenia and ensuing thrombocytosis in baboons. Br J Haematol 68:75, 1988
63. Martin JF, Trowbridge EA, Salmon GL, Slater DN: The relationship between platelet and megakaryocyte volumes. Thromb Res 28:477, 1982
64. Corash L, Chen HY, Levin J, Baker G, Lu H, Mok Y: Regulation of thrombopoiesis: Effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood 70:177, 1987
65. Harker LA, Slichter SJ: The bleeding time as a screening test for evaluation of platelet function. N Engl J Med 287:155, 1972
66. Shulman NR, Watkins SP Jr, Itscoitz SB, Students AB: Evidence that the spleen retains the youngest and hemostatically most effective platelets. Trans Assoc Am Physician 81:302, 1968
67. Blajchman MA, Senyi AF, Hirsh J, Genton E, George JN: Hemostatic function, survival, and membrane glycoprotein changes in young versus old rabbit platelets. J Clin Invest 68:1289, 1981