-
1
-
-
0028302409
-
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
-
de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LAJ, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
-
(1994)
Nature
, vol.369
, pp. 533
-
-
De Sauvage, F.J.1
Hass, P.E.2
Spencer, S.D.3
Malloy, B.E.4
Gurney, A.L.5
Spencer, S.A.6
Darbonne, W.C.7
Henzel, W.J.8
Wong, S.C.9
Kuang, W.J.10
Oles, K.J.11
Hultgren, B.12
Solberg, L.A.J.13
Goeddel, D.V.14
Eaton, D.L.15
-
2
-
-
0028199208
-
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
-
Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presneli SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
-
(1994)
Nature
, vol.369
, pp. 565
-
-
Lok, S.1
Kaushansky, K.2
Holly, R.D.3
Kuijper, J.L.4
Lofton-Day, C.E.5
Oort, P.J.6
Grant, F.J.7
Heipel, M.D.8
Burkhead, S.K.9
Kramer, J.M.10
Bell, L.A.11
Sprecher, C.A.12
Blumberg, H.13
Johnson, R.14
Prunkard, D.15
Ching, A.F.T.16
Mathewes, S.L.17
Bailey, M.C.18
Forstrom, J.W.19
Buddle, M.M.20
Osborn, S.G.21
Evans, S.J.22
Sheppard, P.O.23
Presneli, S.R.24
O'Hara, P.J.25
Hagen, F.S.26
Roth, G.J.27
Foster, D.C.28
more..
-
3
-
-
0028176283
-
CMpl ligand is a humoral regulator of megakaryocytopoiesis
-
Wendung F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
-
(1994)
Nature
, vol.369
, pp. 571
-
-
Wendung, F.1
Maraskovsky, E.2
Debili, N.3
Florindo, C.4
Teepe, M.5
Titeux, M.6
Methia, N.7
Breton-Gorius, J.8
Cosman, D.9
Vainchenker, W.10
-
4
-
-
0028086542
-
Thrombocytopenia in c-mpl-deficient mice
-
Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
-
(1994)
Science
, vol.265
, pp. 1445
-
-
Gurney, A.L.1
Carver-Moore, K.2
De Sauvage, F.J.3
Moore, M.W.4
-
5
-
-
0030024685
-
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
-
de Sauvage FJ, Carver-Moore K, Luoh SM, Ryan A, Dowd M, Eaton DL, Moore MW: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin, J Exp Med 183:651, 1996
-
(1996)
J Exp Med
, vol.183
, pp. 651
-
-
Sauvage, F.J.1
Carver-Moore, K.2
Luoh, S.M.3
Ryan, A.4
Dowd, M.5
Eaton, D.L.6
Moore, M.W.7
-
6
-
-
0029051730
-
Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice
-
Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86:971, 1995
-
(1995)
Blood
, vol.86
, pp. 971
-
-
Ulich, T.R.1
Del Castillo, J.2
Yin, S.3
Swift, S.4
Padilla, D.5
Senaldi, G.6
Bennett, L.7
Shutter, J.8
Bogenberger, J.9
Sun, D.10
Samal, B.11
Shimamoto, G.12
Lee, R.13
Steinbrink, R.14
Boone, T.15
Sheridan, W.T.16
Hunt, P.17
-
7
-
-
0029062371
-
Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates
-
Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 86:54, 1995
-
(1995)
Blood
, vol.86
, pp. 54
-
-
Farese, A.M.1
Hunt, P.2
Boone, T.3
MacVittie, T.J.4
-
8
-
-
0030882894
-
Simultaneous administration of Tt>O and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia and promotes the recovery of immature bone marrow cells
-
Neelis KJ, Dubbelman YD, Luo Q, Thomas GR, Eaton DL, Wagemaker G: Simultaneous administration of Tt>O and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia and promotes the recovery of immature bone marrow cells. Exp Hematol 25;1084, 1997
-
(1997)
Exp Hematol
, vol.25
, pp. 1084
-
-
Neelis, K.J.1
Dubbelman, Y.D.2
Luo, Q.3
Thomas, G.R.4
Eaton, D.L.5
Wagemaker, G.6
-
9
-
-
0029963122
-
Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimuteting factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiationinduced marrow aplasia
-
Farese AM, Hunt P, Grab LB, MacVittie TJ: Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimuteting factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiationinduced marrow aplasia. J Clin Invest 97:2145, 1996
-
(1996)
J Clin Invest
, vol.97
, pp. 2145
-
-
Farese, A.M.1
Hunt, P.2
Grab, L.B.3
MacVittie, T.J.4
-
10
-
-
0029839244
-
Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation
-
Molineux G, Hartley CA, McEIroy P, McCrea C, McNiece IK: Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation. Blood 88:1509, 1996
-
(1996)
Blood
, vol.88
, pp. 1509
-
-
Molineux, G.1
Hartley, C.A.2
McEiroy, P.3
McCrea, C.4
McNiece, I.K.5
-
11
-
-
0029796257
-
Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice
-
Grossmann A, Lenox J, Ren HP, Humes JM, Forstrom JW, Kaushmisky K, Sprugel KH: Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. Exp Hematol 24:1238, 1996
-
(1996)
Exp Hematol
, vol.24
, pp. 1238
-
-
Grossmann, A.1
Lenox, J.2
Ren, H.P.3
Humes, J.M.4
Forstrom, J.W.5
Kaushmisky, K.6
Sprugel, K.H.7
-
12
-
-
0030921072
-
Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion
-
Neelis KJ, Luo Q, Thomas GR, Cohen BL, Eaton DL, Wagemaker G: Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion. Blood 90;58, 1997
-
(1997)
Blood
, vol.90
, pp. 58
-
-
Neelis, K.J.1
Luo, Q.2
Thomas, G.R.3
Cohen, B.L.4
Eaton, D.L.5
Wagemaker, G.6
-
13
-
-
0030307632
-
In vivo biological effects of various forms of thrombopoietin in a marine model of transient pancytopenia
-
suppl 1
-
Thomas GR, Thibodeaux H, Erret CJ, Mathias J, Marian M, Meng G, Vandlen RL, Eaton DL: In vivo biological effects of various forms of thrombopoietin in a marine model of transient pancytopenia. Stem Cells 14:244, 1996 (suppl 1)
-
(1996)
Stem Cells
, vol.14
, pp. 244
-
-
Thomas, G.R.1
Thibodeaux, H.2
Erret, C.J.3
Mathias, J.4
Marian, M.5
Meng, G.6
Vandlen, R.L.7
Eaton, D.L.8
-
14
-
-
0029150347
-
Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
-
Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
-
(1995)
J Clin Invest
, vol.96
, pp. 1683
-
-
Kaushansky, K.1
Broudy, V.C.2
Grossmann, A.3
Humes, J.4
Lin, N.5
Ren, H.P.6
Bailey, M.C.7
Papayannopoulou, T.8
Forstrom, J.W.9
Sprugel, K.H.10
-
15
-
-
0029864161
-
Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and rnyelosuppressed mice
-
Kaushansky K, Lin N, Grossman A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and rnyelosuppressed mice. Exp Hematol 24:265, 1996
-
(1996)
Exp Hematol
, vol.24
, pp. 265
-
-
Kaushansky, K.1
Lin, N.2
Grossman, A.3
Humes, J.4
Sprugel, K.H.5
Broudy, V.C.6
-
16
-
-
0030799430
-
The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys
-
Neelis KJ, Hartong SCC, Egeland T, Thomas GR, Eaton DL, Wagemaker G: The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 90:2565, 1997
-
(1997)
Blood
, vol.90
, pp. 2565
-
-
Neelis, K.J.1
Hartong, S.C.C.2
Egeland, T.3
Thomas, G.R.4
Eaton, D.L.5
Wagemaker, G.6
-
17
-
-
0000231829
-
The prolonged hematologic effects of a single injection of PEG-rHuMGDF in normal and thrombocytopenic mice
-
abstr
-
Ulich TR, Castillo JD, Cheung E, Roskos L, Young J, Molineux G, Senaldi G, Guo J, Toombs CF, Kaufman S, Yin S, Nelson AG, Sheridan WP: The prolonged hematologic effects of a single injection of PEG-rHuMGDF in normal and thrombocytopenic mice. Blood 88: 1399a, 1996 (abstr)
-
(1996)
Blood
, vol.88
-
-
Ulich, T.R.1
Castillo, J.D.2
Cheung, E.3
Roskos, L.4
Young, J.5
Molineux, G.6
Senaldi, G.7
Guo, J.8
Toombs, C.F.9
Kaufman, S.10
Yin, S.11
Nelson, A.G.12
Sheridan, W.P.13
-
18
-
-
3543032289
-
Single injection of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) promotes hemato-logic recovery in irradiated mice
-
abstr
-
Shibuya K. Takahashi K, Tahara E, Kato T, Akahori H, Miyazaki H: Single injection of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) promotes hemato-logic recovery in irradiated mice. Blood 88:1400a, 1996 (abstr)
-
(1996)
Blood
, vol.88
-
-
Shibuya, K.1
Takahashi, K.2
Tahara, E.3
Kato, T.4
Akahori, H.5
Miyazaki, H.6
-
19
-
-
0003293589
-
Effect of delayed administration of recombinant human megakaryocyte growth and development factor on hematopoietic reconstitution in nonhuman primates following radiation induced marrow aplasia
-
abstr
-
MacVittie TJ, Farese AM, Grab LB, Hunt P: Effect of delayed administration of recombinant human megakaryocyte growth and development factor on hematopoietic reconstitution in nonhuman primates following radiation induced marrow aplasia. Exp Hematol 23:311a, 1995 (abstr)
-
(1995)
Exp Hematol
, vol.23
-
-
MacVittie, T.J.1
Farese, A.M.2
Grab, L.B.3
Hunt, P.4
-
21
-
-
0025234915
-
Murine macrophage precursor characterization II. Monoclonal antibodies against macrophage precursor antigens
-
Leenen PJM, Melis M, Slieker WAT, Van Ewijk W: Murine macrophage precursor characterization II. Monoclonal antibodies against macrophage precursor antigens. Eur J Immunol 20:27, 1990
-
(1990)
Eur J Immunol
, vol.20
, pp. 27
-
-
Leenen, P.J.M.1
Melis, M.2
Slieker, W.A.T.3
Van Ewijk, W.4
-
22
-
-
0028955581
-
Identification of hematopoietic stem cell subsets on the basis of their primitiveness using antibody ER-MP12
-
van der Loo JCM, Slieker WAT, Kieboom D, Ploemacher RE: Identification of hematopoietic stem cell subsets on the basis of their primitiveness using antibody ER-MP12. Blood 85:952, 1995
-
(1995)
Blood
, vol.85
, pp. 952
-
-
Van der Loo, J.C.M.1
Slieker, W.A.T.2
Kieboom, D.3
Ploemacher, R.E.4
-
23
-
-
0021723276
-
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
-
Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldmann H: Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548, 1984
-
(1984)
Nature
, vol.312
, pp. 548
-
-
Cobbold, S.P.1
Jayasuriya, A.2
Nash, A.3
Prospero, T.D.4
Waldmann, H.5
-
24
-
-
0029865443
-
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
-
Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
-
(1996)
Blood
, vol.87
, pp. 2154
-
-
Fielder, P.J.1
Gurney, A.L.2
Stefanich, E.3
Marian, M.4
Moore, M.W.5
Carver-Moore, K.6
De Sauvage, F.J.7
-
25
-
-
0017192861
-
Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoietic cell cultures
-
Guilbert LJ, Iscove NN: Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoietic cell cultures. Nature 263:594, 1976
-
(1976)
Nature
, vol.263
, pp. 594
-
-
Guilbert, L.J.1
Iscove, N.N.2
-
26
-
-
0021714809
-
Detection of murine bone marrow granulocyte/macrophage progenitor cells (GM-CFU) in serum-free cultures stimulated with purified M-CSF or GM-CSF
-
Merchav S, Wagemaker G: Detection of murine bone marrow granulocyte/macrophage progenitor cells (GM-CFU) in serum-free cultures stimulated with purified M-CSF or GM-CSF. Int J Cell Cloning 2:356, 1984
-
(1984)
Int J Cell Cloning
, vol.2
, pp. 356
-
-
Merchav, S.1
Wagemaker, G.2
-
27
-
-
0018964859
-
Erythropoietin-independent regeneration of erythroid progenitor cells following multiple injections of hydroxyurea
-
Wagemaker G, Visser TP: Erythropoietin-independent regeneration of erythroid progenitor cells following multiple injections of hydroxyurea. Cell Tissue Kinet 13:505, 1980
-
(1980)
Cell Tissue Kinet
, vol.13
, pp. 505
-
-
Wagemaker, G.1
Visser, T.P.2
-
28
-
-
0015194695
-
Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro
-
Bradley TR, Stanley ER, Summer MS: Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 49:595, 1971
-
(1971)
Aust J Exp Biol Med Sci
, vol.49
, pp. 595
-
-
Bradley, T.R.1
Stanley, E.R.2
Summer, M.S.3
-
29
-
-
84982574649
-
Quantitative in vitro studies on stimulation of murine haemopoietic cells by colony stimulating factor
-
van den Engh GJ: Quantitative in vitro studies on stimulation of murine haemopoietic cells by colony stimulating factor. Cell Tissue Kinet 7:537, 1974
-
(1974)
Cell Tissue Kinet
, vol.7
, pp. 537
-
-
Van den Engh, G.J.1
-
30
-
-
0023580293
-
Light scatter and cell surface properties of murine megakaryocyte progenitor cells
-
Bauman JG, Chen MG: Light scatter and cell surface properties of murine megakaryocyte progenitor cells. Exp Hematol 15:1074, 1987
-
(1987)
Exp Hematol
, vol.15
, pp. 1074
-
-
Bauman, J.G.1
Chen, M.G.2
-
31
-
-
0015694434
-
Cholinesterase as a possible marker for early cells of the megakaryocytic series
-
Jackson CW: Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 42:413, 1973
-
(1973)
Blood
, vol.42
, pp. 413
-
-
Jackson, C.W.1
-
32
-
-
78651153462
-
A direct-coloring thiocholine method for cholinesterases
-
Karnovsky MJ, Roots L: A direct-coloring thiocholine method for cholinesterases. J Histochem Cytochem 12:219, 1964
-
(1964)
J Histochem Cytochem
, vol.12
, pp. 219
-
-
Karnovsky, M.J.1
Roots, L.2
-
33
-
-
84956427297
-
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
-
Till JE, McCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213, 1961
-
(1961)
Radiat Res
, vol.14
, pp. 213
-
-
Till, J.E.1
McCulloch, E.A.2
-
34
-
-
0022375359
-
Multiparameter analysis of transplantable hemopoietic stem cells: I. the separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence
-
Bertoncello I, Hodgson GS, Bradley TR: Multiparameter analysis of transplantable hemopoietic stem cells: I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence. Exp Hematol 13:999, 1985
-
(1985)
Exp Hematol
, vol.13
, pp. 999
-
-
Bertoncello, I.1
Hodgson, G.S.2
Bradley, T.R.3
-
35
-
-
0029858989
-
Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro
-
Borge OJ, Ramsfjell V, Veiby OP, Murphy Jr MJ, Lok S, Jacobsen SEW: Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood 88:2859, 1996
-
(1996)
Blood
, vol.88
, pp. 2859
-
-
Borge, O.J.1
Ramsfjell, V.2
Veiby, O.P.3
Murphy Jr., M.J.4
Lok, S.5
Jacobsen, S.E.W.6
-
36
-
-
0030014681
-
The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
-
Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K: The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998, 1996
-
(1996)
Blood
, vol.87
, pp. 4998
-
-
Sitnicka, E.1
Lin, N.2
Priestley, G.V.3
Fox, N.4
Broudy, V.C.5
Wolf, N.S.6
Kaushansky, K.7
-
37
-
-
0029900227
-
Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3
-
Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3. Blood 88:429, 1996
-
(1996)
Blood
, vol.88
, pp. 429
-
-
Kobayashi, M.1
Laver, J.H.2
Kato, T.3
Miyazaki, H.4
Ogawa, M.5
-
38
-
-
0031157028
-
Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+CD38-) human bone marrow progenitor cells
-
Ramsfjell V, Borge OJ, Cui L, Jacobsen SEW: Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+CD38-) human bone marrow progenitor cells. J Immunol 158:5169, 1997
-
(1997)
J Immunol
, vol.158
, pp. 5169
-
-
Ramsfjell, V.1
Borge, O.J.2
Cui, L.3
Jacobsen, S.E.W.4
-
39
-
-
0029121283
-
Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand
-
Banu N, Wang JF, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 86:1331, 1995
-
(1995)
Blood
, vol.86
, pp. 1331
-
-
Banu, N.1
Wang, J.F.2
Deng, B.3
Groopman, J.E.4
Avraham, H.5
-
40
-
-
0028114123
-
In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
-
Zeigler FC, de Sauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass P, Eaton D, Matthews W: In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045, 1994
-
(1994)
Blood
, vol.84
, pp. 4045
-
-
Zeigler, F.C.1
De Sauvage, F.2
Widmer, H.R.3
Keller, G.A.4
Donahue, C.5
Schreiber, R.D.6
Malloy, B.7
Hass, P.8
Eaton, D.9
Matthews, W.10
-
41
-
-
0029819701
-
Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Linprimitive progenitor cells
-
Young JC, Bruno E, Luens KM, Wu S, Backer M, Murray LJ: Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Linprimitive progenitor cells. Blood 88:1619, 1996
-
(1996)
Blood
, vol.88
, pp. 1619
-
-
Young, J.C.1
Bruno, E.2
Luens, K.M.3
Wu, S.4
Backer, M.5
Murray, L.J.6
-
42
-
-
0030884466
-
Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro
-
Tanimukai S, Kimura T, Sakabe H, Ohmizono Y, Kato T, Miyazaki H, Yamagishi H, Sonoda Y: Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro. Exp Hematol 25:1025, 1997
-
(1997)
Exp Hematol
, vol.25
, pp. 1025
-
-
Tanimukai, S.1
Kimura, T.2
Sakabe, H.3
Ohmizono, Y.4
Kato, T.5
Miyazaki, H.6
Yamagishi, H.7
Sonoda, Y.8
-
43
-
-
0028985440
-
Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes
-
Wickenhauser C, Lorenzen J, Thiele J, Hillienhof A, Jungheim K, Schmitz B, Hansmann ML, Fischer R: Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood 85:685, 1995
-
(1995)
Blood
, vol.85
, pp. 685
-
-
Wickenhauser, C.1
Lorenzen, J.2
Thiele, J.3
Hillienhof, A.4
Jungheim, K.5
Schmitz, B.6
Hansmann, M.L.7
Fischer, R.8
-
44
-
-
0028114126
-
Cytokine production by primary bone marrow megakaryocytes
-
Jiang S, Levine JD, Fu Y, Deng B, London R, Groopman JE, Avraham H: Cytokine production by primary bone marrow megakaryocytes. Blood 84:4151, 1994
-
(1994)
Blood
, vol.84
, pp. 4151
-
-
Jiang, S.1
Levine, J.D.2
Fu, Y.3
Deng, B.4
London, R.5
Groopman, J.E.6
Avraham, H.7
-
45
-
-
0031019748
-
Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor
-
Harker LA, Marzec UM, Kelly AB, Tomer A, Nichol JL, Hanson SR, Stead RB: Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor. Blood 89:155, 1997
-
(1997)
Blood
, vol.89
, pp. 155
-
-
Harker, L.A.1
Marzec, U.M.2
Kelly, A.B.3
Tomer, A.4
Nichol, J.L.5
Hanson, S.R.6
Stead, R.B.7
-
46
-
-
0029035989
-
Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor
-
Hunt P, Li YS, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C, Merewether LA, Johnson MJ, Parker V, Knudten A, Farese A, Hsu RY, Garcia A, Stead R, Bosselman RA, Bartley TD: Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86:540, 1995
-
(1995)
Blood
, vol.86
, pp. 540
-
-
Hunt, P.1
Li, Y.S.2
Nichol, J.L.3
Hokom, M.M.4
Bogenberger, J.M.5
Swift, S.E.6
Skrine, J.D.7
Hornkohl, A.C.8
Lu, H.9
Clogston, C.10
Merewether, L.A.11
Johnson, M.J.12
Parker, V.13
Knudten, A.14
Farese, A.15
Hsu, R.Y.16
Garcia, A.17
Stead, R.18
Bosselman, R.A.19
Bartley, T.D.20
more..
-
47
-
-
0030970642
-
Metabolism of thrombopoietin (TPO) in vivo: Determination of the binding dynamics for TPO in mice
-
Stefanich E, Senn T, Widmer R, Fratino C, Keller G-A, Fielder PJ: Metabolism of thrombopoietin (TPO) in vivo: Determination of the binding dynamics for TPO in mice. Blood 89:4063, 1997
-
(1997)
Blood
, vol.89
, pp. 4063
-
-
Stefanich, E.1
Senn, T.2
Widmer, R.3
Fratino, C.4
Keller, G.-A.5
Fielder, P.J.6
-
48
-
-
0344192545
-
Dose-dependent kinetics of rmTPO in mice: Influence of receptor-mediated clearance
-
abstr
-
Marian M, Mallett P, Senn T, Stefanich E, Fielder P: Dose-dependent kinetics of rmTPO in mice: Influence of receptor-mediated clearance. Blood 88:2166a, 1996 (abstr)
-
(1996)
Blood
, vol.88
-
-
Marian, M.1
Mallett, P.2
Senn, T.3
Stefanich, E.4
Fielder, P.5
-
49
-
-
0020052387
-
Transient nature of early haematopoietic spleen colonies
-
Magli MC, Iscove NN, Odartchenko N: Transient nature of early haematopoietic spleen colonies. Nature 295:527, 1982
-
(1982)
Nature
, vol.295
, pp. 527
-
-
Magli, M.C.1
Iscove, N.N.2
Odartchenko, N.3
-
50
-
-
0028351506
-
Stable multilineage hematopoietic chimerism in alpha-thalassemic mice induced by a bone marrow subpopulation that excludes the majority of day-12 spleen colony-forming units
-
van der Loo JC, van den Bos C, Baert MR, Wagemaker G, Ploemacher RE: Stable multilineage hematopoietic chimerism in alpha-thalassemic mice induced by a bone marrow subpopulation that excludes the majority of day-12 spleen colony-forming units. Blood 83:1769, 1994
-
(1994)
Blood
, vol.83
, pp. 1769
-
-
Van der Loo, J.C.1
Van den Bos, C.2
Baert, M.R.3
Wagemaker, G.4
Ploemacher, R.E.5
-
51
-
-
0021341845
-
Studies of hematopoietic stem cells spared by 5-fluorouracil
-
van Zant G: Studies of hematopoietic stem cells spared by 5-fluorouracil. J Exp Med 159:679, 1984
-
(1984)
J Exp Med
, vol.159
, pp. 679
-
-
Zant, G.1
-
52
-
-
0024544497
-
Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: Evidence for a pre-CFU-S cell
-
Ploemacher RE, Brons RH: Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: Evidence for a pre-CFU-S cell. Exp Hematol 17:263, 1989
-
(1989)
Exp Hematol
, vol.17
, pp. 263
-
-
Ploemacher, R.E.1
Brons, R.H.2
-
53
-
-
0031965018
-
Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice
-
Shibuya K, Akahori H, Takahashi K, Tahara E, Kato T, Miyazaki H: Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice. Blood 91:37, 1998
-
(1998)
Blood
, vol.91
, pp. 37
-
-
Shibuya, K.1
Akahori, H.2
Takahashi, K.3
Tahara, E.4
Kato, T.5
Miyazaki, H.6
-
54
-
-
3543034097
-
-
submitted for publication
-
Mouthon MA, Van der Meeren A, Gaugler MH, Visser TP, Squiban C, Gourmelon P, Wagemaker G: Thrombopoietin promotes hematopoietic recovery and survival after high dose whole body irradiation. (submitted for publication)
-
Thrombopoietin Promotes Hematopoietic Recovery and Survival after High Dose Whole Body Irradiation
-
-
Mouthon, M.A.1
Van der Meeren, A.2
Gaugler, M.H.3
Visser, T.P.4
Squiban, C.5
Gourmelon, P.6
Wagemaker, G.7
-
55
-
-
0029853230
-
In vivo effects of pegylated recombinant human megakaryocyte growth and development factor on hematopoiesis in normal mice
-
Kabaya K, Akahori H, Shibuya K, Nitta Y, Ida M, Kusaka M, Kato T, Miyazaki H: In vivo effects of pegylated recombinant human megakaryocyte growth and development factor on hematopoiesis in normal mice. Stem Cells 14:651, 1996
-
(1996)
Stem Cells
, vol.14
, pp. 651
-
-
Kabaya, K.1
Akahori, H.2
Shibuya, K.3
Nitta, Y.4
Ida, M.5
Kusaka, M.6
Kato, T.7
Miyazaki, H.8
-
56
-
-
0030068687
-
Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates
-
Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87:1833, 1996
-
(1996)
Blood
, vol.87
, pp. 1833
-
-
Harker, L.A.1
Hunt, P.2
Marzec, U.M.3
Kelly, A.B.4
Tomer, A.5
Hanson, S.R.6
Stead, R.B.7
-
57
-
-
0029807901
-
Recombinant human ligand for MPL, Megakaryocyte growth and development factor (MGDF), stimulates thrombopoiesis in vivo in normal and myelosuppressed baboons
-
Andrews RG, Winkler A, Myerson D, Briddell RA, Knitter GH, McNiece IK, Hunt P: Recombinant human ligand for MPL, Megakaryocyte growth and development factor (MGDF), stimulates thrombopoiesis in vivo in normal and myelosuppressed baboons. Stem Cells 14:661, 1996
-
(1996)
Stem Cells
, vol.14
, pp. 661
-
-
Andrews, R.G.1
Winkler, A.2
Myerson, D.3
Briddell, R.A.4
Knitter, G.H.5
McNiece, I.K.6
Hunt, P.7
-
58
-
-
0030942587
-
A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size, and ploidization
-
Arnold JT, Daw NC, Stenberg PE, Jayawardene D, Srivastava DK, Jackson CW: A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size, and ploidization. Blood 89:823, 1997
-
(1997)
Blood
, vol.89
, pp. 823
-
-
Arnold, J.T.1
Daw, N.C.2
Stenberg, P.E.3
Jayawardene, D.4
Srivastava, D.K.5
Jackson, C.W.6
-
59
-
-
0031973576
-
A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration
-
Daw NC, Arnold JT, Abushullaih BA, Stenberg PE, White MM, Jayawardene D, Srivastava DK, Jackson CW: A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration. Blood 91:466, 1998
-
(1998)
Blood
, vol.91
, pp. 466
-
-
Daw, N.C.1
Arnold, J.T.2
Abushullaih, B.A.3
Stenberg, P.E.4
White, M.M.5
Jayawardene, D.6
Srivastava, D.K.7
Jackson, C.W.8
-
60
-
-
0028803099
-
Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
-
Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
-
(1995)
Blood
, vol.86
, pp. 4486
-
-
Hokom, M.M.1
Lacey, D.2
Kinstler, O.B.3
Choi, E.4
Kaufman, S.5
Faust, J.6
Rowan, C.7
Dwyer, E.8
Nichol, J.L.9
Grasel, T.10
Wilson, J.11
Steinbrink, R.12
Hecht, R.13
Winters, D.14
Boone, T.15
Hunt, P.16
-
61
-
-
0029992540
-
Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelo-suppressed mice
-
Grossmann A, Lenox J, Deisher TA, Ren HP, Humes JM, Kaushansky K, Sprugel KH: Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelo-suppressed mice. Blood 88:3363, 1996
-
(1996)
Blood
, vol.88
, pp. 3363
-
-
Grossmann, A.1
Lenox, J.2
Deisher, T.A.3
Ren, H.P.4
Humes, J.M.5
Kaushansky, K.6
Sprugel, K.H.7
-
62
-
-
0030929124
-
Lack of efficacy of thrombopoietin and granulocyte colony-stimulating factor after high dose total body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys
-
Neelis KJ, Dubbelman YD, Wognum AW, Thomas GR, Eaton DL, Egeland T, Wagemaker G: Lack of efficacy of thrombopoietin and granulocyte colony-stimulating factor after high dose total body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys. Exp Hematol 25:1094, 1997
-
(1997)
Exp Hematol
, vol.25
, pp. 1094
-
-
Neelis, K.J.1
Dubbelman, Y.D.2
Wognum, A.W.3
Thomas, G.R.4
Eaton, D.L.5
Egeland, T.6
Wagemaker, G.7
-
63
-
-
0344073862
-
A randomised, double-blind, placebo- controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with de-novo acuter myeloid leukaemia (AML): Early results
-
abstr
-
Archimbaud E, Ottman O, Liu Yin JA, Lechner K, Sanz MA, Herrmann F, Gruss H, Fenaux P, Ganser A, Heil G, Kanz L, Brugger W, Sims T, Olsen K, Hoelzer D: A randomised, double-blind, placebo- controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with de-novo acuter myeloid leukaemia (AML): Early results. Blood 88:1778a, 1996 (abstr)
-
(1996)
Blood
, vol.88
-
-
Archimbaud, E.1
Ottman, O.2
Liu Yin, J.A.3
Lechner, K.4
Sanz, M.A.5
Herrmann, F.6
Gruss, H.7
Fenaux, P.8
Ganser, A.9
Heil, G.10
Kanz, L.11
Brugger, W.12
Sims, T.13
Olsen, K.14
Hoelzer, D.15
-
64
-
-
0031049879
-
Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
-
Fanucchi M, Glaspy J, Crawford J, Garst J, Figlin R, Sheridan W, Menchaca D, Tomita D, Ozer H, Harker L: Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 336:404, 1997
-
(1997)
N Engl J Med
, vol.336
, pp. 404
-
-
Fanucchi, M.1
Glaspy, J.2
Crawford, J.3
Garst, J.4
Figlin, R.5
Sheridan, W.6
Menchaca, D.7
Tomita, D.8
Ozer, H.9
Harker, L.10
-
65
-
-
0004522568
-
Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I)
-
abstr
-
Vadhan-Raj S, Patel S, Broxmeyer HE, Bueso-Ramos C, Reddy SP, Papadopolous N, Burgess A, Johnston T, Yang T, Paton V, Hellman S, Benjamin RS: Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I). Blood 88:1779a, 1996 (abstr)
-
(1996)
Blood
, vol.88
-
-
Vadhan-Raj, S.1
Patel, S.2
Broxmeyer, H.E.3
Bueso-Ramos, C.4
Reddy, S.P.5
Papadopolous, N.6
Burgess, A.7
Johnston, T.8
Yang, T.9
Paton, V.10
Hellman, S.11
Benjamin, R.S.12
-
66
-
-
17944389931
-
Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
-
Basser RL, Rasko JEJ, Clarke K, Cebon J, Green MD, Grigg AP, Zalcberg J, Cohen B, O'Byrne J, Menchaca DM, Fox RM, Begley CG: Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 89:3118, 1997
-
(1997)
Blood
, vol.89
, pp. 3118
-
-
Basser, R.L.1
Rasko, J.E.J.2
Clarke, K.3
Cebon, J.4
Green, M.D.5
Grigg, A.P.6
Zalcberg, J.7
Cohen, B.8
O'Byrne, J.9
Menchaca, D.M.10
Fox, R.M.11
Begley, C.G.12
|