Cytokine production and function in c-mpl-deficient mice: No physiologic role for interleukin-3 in residual megakaryocyte and platelet production

Blood

Volumn 91, Issue 8, 1998, Pages 2745-2752

  Gainsford, Timothy ^b   Roberts, Andrew W ^b   Kimura, Shinya ^b   Metcalf, Donald ^b   Dranoff, Glenn ^b   Mulligan, Richard C ^b   Begley, C Glenn ^b   Robb, Lorraine ^b   Alexander, Warren S ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENETIC DISORDER; HEMATOPOIETIC STEM CELL; MEGAKARYOPOIESIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS;

EID: 0032522963     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.8.2745.2745_2745_2752     Document Type: Article

References (35)

1. Gordon MS, Huffman R: Growth factors affecting human thrombopoiesis: Potential agents for treatment of thrombocytopenia. Blood 80:302, 1992
2. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
3. Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
4. Hunt P, Li Y-S, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C, Merewether LA, Johnson MJ, Parker V, Knudten A, Farese A, Hsu RY, Garcia A, Stead R, Bosselman RA, Bartley TD: Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86:540, 1995
5. Banu N, Wang JF, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 86:1331, 1995
6. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369: 568, 1994
7. Zeigler FC, deSauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass P, Eaton D, Matthews W: In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045, 1994
8. Choi ES, Hokom M, Bartley T, Li Y-S, Ohashi H, Kato T, Nichol JL, Skrine J, Knudten A, Chen J, Homkohl A, Grampp G, Sleeman L, Cole S, Trail G, Hunt P: Recombinant human megakaryocyte growth and development factor (MGDF), a ligand for c-Mpl, produces functional human platelets in vitro. Stem Cells 13:317, 1995
9. Debili N, Wendling F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl ligand or thrombopoietin or megakaryocyte growth and differentiation factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
10. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Marhewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
11. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennen L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86:971, 1995
12. Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 86:54, 1995
13. Basser RL, Rasko JEJ, Clarke K, Cebon J, Green MD, Hussein S, Alt C, Menchaca D, Tomita D, Marty J, Fox RM, Begley CG: Thrombopoietic effects of pegylated recominant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 348:1279, 1996
14. Rasko JEJ, Basser RL, Boyd J, Mansfield R, O'Malley CJ, Hussein S, Berndt MC, Clarke K, O'Byrne J, Sheridan WP, Grigg AP, Begley CG: Multilineage mobilisation of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF. Br J Haematol 97:871, 1997
15. Metcalf D, Begley CG, Johnson GR, Nicola NA, Lopez AF, Williamson DJ: Effects of bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood 68:46, 1986
16. Hill RJ, Warren MK, Levin J: Stimulation of thrombopoiesis in mice by human recombinant interleukin 6. J Clin Invest 85:1242, 1990
17. Metcalf D, Nicola NA, Gearing DP: Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood 76:50, 1990
18. Neben TY, Loebelenz J, Hayes L, McCarthy K, Stoudemire J, Schaub R, Goldman SJ: Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Blood 81:901, 1993
19. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
20. Alexander WS, Roberts AR, Nicola NA, Li R, Metcalf D: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162, 1996
21. deSauvage FJ, Carver-Moore K, Luoh S-M, Ryan A, Dowd M, Eaton DL, Moore MW: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183:651, 1996
22. Carver-Moore K, Broxmeyer HE, Luoh S-M, Cooper S, Peng J, Burstein SA, Moore MW, deSauvage FJ: Low levels of erythroid and myeloid progenitors in thrombopoietin and c-mpl-deficient mice. Blood 88:803, 1996
23. Ichihara M, Hara T, Takagi M, Cho LC, Gorman DM, Miyajima A: Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor a subunit gene. EMBO J 14:939, 1995
24. Mach N, Lantz CS, Galli SJ, Reznikoff G, Mihm M, Small C, Granstein R, Beissert S, Sadelain M, Mulligan RC, Dranoff G: Involvement of interleukin-3 in delayed type hypersensitivity. Blood (in press)
25. Metcalf D, Willson TA, Hilton DJ, DiRago L, Mifsud S: Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: Measurement by specific bioassay. Leukemia 9:1556, 1995
26. Alexander WS, Metcalf D, Dunn AR: Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J 14:5569, 1995
27. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
28. Escary J-L, Perreau J, Dumenil D, Ezine S, Brulet P: Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 363:361, 1993
29. Bemad A, Kopf M, Kulbacki R, Weich N, Koehler G, Gutierrez-Ramos JC: Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1:725, 1994
30. Nishinakamura R, Miyajima A, Mee PJ, Tybulewicz VLJ, Murray R: Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Blood 88:2458, 1996
31. Nandurkar HH, Robb L, Tarlinton D, Barnett L, Kontgen F, Begley CG: Adult mice with targeted mutation of the IL-11 receptor (I111Ra) display normal hematopoiesis. Blood 90:2148, 1997
32. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-macrophage and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 23:265, 1996
33. Cheng J, Baumhueter S, Cacalano G, Thibodeaux H, Thomas R, Broxmeyer HE, Cooper S, Hague N, Moore M, Lasky LA: Hematopoietic defects in mice lacking the sialomucin CD34. Blood 87:479, 1996
34. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995
35. Ebbe S, Levin J, Miller K, Yee T, Levin F, Phalen E: Thrombocytopoietic response to immunothrombocytopenia in nude mice. Blood 69:192, 1987