Human platelets as a model for the binding and degradation of thrombopoietin

Blood

Volumn 89, Issue 8, 1997, Pages 2782-2788

  Fielder, Paul J ^a   Hass, Philip ^a   Nagel, Mark ^a   Stefanich, Eric ^a   Widmer, Ramon ^a   Bennett, Gregory L ^a   Keller, Gilbert André ^a   De Sauvage, Frederic J ^a   Eaton, Dan ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; RECOMBINANT THROMBOPOIETIN; THROMBOPOIETIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; MEGAKARYOPOIESIS; PRIORITY JOURNAL; RECEPTOR AFFINITY; THROMBOCYTE; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 0030901558     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.8.2782     Document Type: Article

References (15)

1. Yamamoto S: Mechanisms of the development of thrombocytosis due to bleeding. Acta Haematol Jpn 20:163, 1957
2. Kelemen E, Cserhati I, Tanos B: Demonstration and some thrombocythemic sera. Acta Haematol 20:350, 1958
3. Gordon MS, Hoffman R: Growth factors affecting thrombocytopoiesis: Potential agents for the treatment of thrombocytopenia (Editorial). Blood 80:302, 1992
4. de Sauvage FJ, Mass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LA, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
5. Wendung F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius, Cosman D, Vainchenker W: Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
6. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie, Shutter J, Shute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu M C-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
7. Lok S, Kaushansky K, Holly RD, Kuijper JF, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara FS, Rothe GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
8. Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin P, Giddelbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
9. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li Y-S, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P: Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95:2973, 1995
10. Chang M, Suen Y, Meng G, Buzby J, Williams S, Shen V, Knoppel A, Fernandez G, Cairo MS: Regulation of TPO mRNA expression and protein production: TPO gene regulation appears post transcriptional, and endogenous levels are inversely correlated to megakaryocyte mass and circulating platelet count. Blood 86:368a, 1995 (abstr, suppl 1)
11. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
12. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
13. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
14. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage FJ: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
15. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara, N: Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89:244, 1992