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Volumn , Issue , 2010, Pages 139-167

Uncoupling of Endothelial Nitric Oxide Synthase in Cardiovascular Disease and its Pharmacological Reversal

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EID: 84882544755     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-373866-0.00005-8     Document Type: Chapter
Times cited : (6)

References (178)
  • 1
    • 0027525273 scopus 로고
    • Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer
    • Abu-Soud H.M., Stuehr D.J. Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proc. Natl. Acad Sci. U S A 1993, 90:10769-10772.
    • (1993) Proc. Natl. Acad Sci. U S A , vol.90 , pp. 10769-10772
    • Abu-Soud, H.M.1    Stuehr, D.J.2
  • 2
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition
    • Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J. 2001, 357:593-615.
    • (2001) Biochem J. , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 3
    • 0023200353 scopus 로고
    • Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets
    • Alheid U., Frölich J.C., Förstermann U. Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb. Res. 1987, 47:561-571.
    • (1987) Thromb. Res. , vol.47 , pp. 561-571
    • Alheid, U.1    Frölich, J.C.2    Förstermann, U.3
  • 4
    • 0027467495 scopus 로고
    • Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats
    • Arndt H., Smith C.W., Granger D.N. Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. Hypertension 1993, 21:667-673.
    • (1993) Hypertension , vol.21 , pp. 667-673
    • Arndt, H.1    Smith, C.W.2    Granger, D.N.3
  • 5
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    • Aviram M., Rosenblat M., Bisgaier C.L., Newton R.S., Primo-Parmo S.L., La Du B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J. Clin. Invest. 1998, 101:1581-1590.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4    Primo-Parmo, S.L.5    La Du, B.N.6
  • 7
    • 0027441142 scopus 로고
    • Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme
    • Baek K.J., Thiel B.A., Lucas S., Stuehr D.J. Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J. Biol. Chem. 1993, 268:21120-21129.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21120-21129
    • Baek, K.J.1    Thiel, B.A.2    Lucas, S.3    Stuehr, D.J.4
  • 12
    • 0034816774 scopus 로고    scopus 로고
    • Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction
    • Bivalacqua T.J., Hellstrom W.J., Kadowitz P.J., Champion H.C. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. Biochem. Biophys. Res. Commun. 2001, 283:923-927.
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , pp. 923-927
    • Bivalacqua, T.J.1    Hellstrom, W.J.2    Kadowitz, P.J.3    Champion, H.C.4
  • 14
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases
    • Böger R.H., Sydow K., Borlak J., Thum T., Lenzen H., Schubert B., Tsikas D., Bode-Böger S.M. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res. 2000, 87:99-105.
    • (2000) Circ Res. , vol.87 , pp. 99-105
    • Böger, R.H.1    Sydow, K.2    Borlak, J.3    Thum, T.4    Lenzen, H.5    Schubert, B.6    Tsikas, D.7    Bode-Böger, S.M.8
  • 16
    • 0032535511 scopus 로고    scopus 로고
    • Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization
    • Brunner K., Tortschanoff A., Hemmens B., Andrew P.J., Mayer B., Kungl A.J. Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization. Biochemistry 1998, 37:17545-17553.
    • (1998) Biochemistry , vol.37 , pp. 17545-17553
    • Brunner, K.1    Tortschanoff, A.2    Hemmens, B.3    Andrew, P.J.4    Mayer, B.5    Kungl, A.J.6
  • 19
    • 0034065857 scopus 로고    scopus 로고
    • Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension
    • Butler R., Morris A.D., Belch J.J., Hill A., Struthers A.D. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 2000, 35:746-751.
    • (2000) Hypertension , vol.35 , pp. 746-751
    • Butler, R.1    Morris, A.D.2    Belch, J.J.3    Hill, A.4    Struthers, A.D.5
  • 20
    • 0030750723 scopus 로고    scopus 로고
    • Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients
    • Cardillo C., Kilcoyne C.M., Cannon R.O., Quyyumi A.A., Panza J.A. Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients. Hypertension 1997, 30:57-63.
    • (1997) Hypertension , vol.30 , pp. 57-63
    • Cardillo, C.1    Kilcoyne, C.M.2    Cannon, R.O.3    Quyyumi, A.A.4    Panza, J.A.5
  • 21
    • 0033986606 scopus 로고    scopus 로고
    • Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters
    • Closs E.I., Scheld J.S., Sharafi M., Forstermann U. Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol. Pharmacol. 2000, 57:68-74.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 68-74
    • Closs, E.I.1    Scheld, J.S.2    Sharafi, M.3    Forstermann, U.4
  • 22
    • 0028813306 scopus 로고
    • Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries
    • Cosentino F., Katusic Z.S. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 1995, 91:139-144.
    • (1995) Circulation , vol.91 , pp. 139-144
    • Cosentino, F.1    Katusic, Z.S.2
  • 23
    • 0031874893 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and endothelial function
    • Cosentino F., Luscher T.F. Tetrahydrobiopterin and endothelial function. Eur Heart J. 1998, 19(Suppl G):G3-G8.
    • (1998) Eur Heart J. , vol.19 , Issue.SUPPL.G
    • Cosentino, F.1    Luscher, T.F.2
  • 25
    • 0029823037 scopus 로고    scopus 로고
    • Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease
    • Diet F., Pratt R.E., Berry G.J., Momose N., Gibbons G.H., Dzau V.J. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation 1996, 94:2756-2767.
    • (1996) Circulation , vol.94 , pp. 2756-2767
    • Diet, F.1    Pratt, R.E.2    Berry, G.J.3    Momose, N.4    Gibbons, G.H.5    Dzau, V.J.6
  • 27
    • 0026338964 scopus 로고
    • Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
    • Drexler H., Zeiher A.M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991, 338:1546-1550.
    • (1991) Lancet , vol.338 , pp. 1546-1550
    • Drexler, H.1    Zeiher, A.M.2    Meinzer, K.3    Just, H.4
  • 28
    • 0033952940 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide
    • Drummond G.R., Cai H., Davis M.E., Ramasamy S., Harrison D.G. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res. 2000, 86:347-354.
    • (2000) Circ Res. , vol.86 , pp. 347-354
    • Drummond, G.R.1    Cai, H.2    Davis, M.E.3    Ramasamy, S.4    Harrison, D.G.5
  • 30
    • 0037216768 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
    • Fleming I., Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 284:R1-R12.
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.284
    • Fleming, I.1    Busse, R.2
  • 31
    • 44449162751 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
    • Förstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat. Clin. Pract. Cardiovasc. Med. 2008, 5:338-349.
    • (2008) Nat. Clin. Pract. Cardiovasc. Med. , vol.5 , pp. 338-349
    • Förstermann, U.1
  • 32
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    • Förstermann U., Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006, 113:1708-1714.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Förstermann, U.1    Münzel, T.2
  • 33
    • 0022607081 scopus 로고
    • Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries
    • Förstermann U., Mülsch A., Böhme E., Busse R. Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ Res. 1986, 58:531-538.
    • (1986) Circ Res. , vol.58 , pp. 531-538
    • Förstermann, U.1    Mülsch, A.2    Böhme, E.3    Busse, R.4
  • 34
    • 0042330455 scopus 로고    scopus 로고
    • Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    • Fox K.M. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003, 362:782-788.
    • (2003) Lancet , vol.362 , pp. 782-788
    • Fox, K.M.1
  • 35
    • 0036182797 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
    • Fukuda Y., Teragawa H., Matsuda K., Yamagata T., Matsuura H., Chayama K. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002, 87:264-269.
    • (2002) Heart , vol.87 , pp. 264-269
    • Fukuda, Y.1    Teragawa, H.2    Matsuda, K.3    Yamagata, T.4    Matsuura, H.5    Chayama, K.6
  • 37
    • 0024553336 scopus 로고
    • Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
    • Garg U.C., Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 1989, 83:1774-1777.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1774-1777
    • Garg, U.C.1    Hassid, A.2
  • 38
    • 0035657643 scopus 로고    scopus 로고
    • Protein kinase C inhibitors as novel anticancer drugs
    • Goekjian P.G., Jirousek M.R. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin. Investig. Drugs 2001, 10:2117-2140.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 2117-2140
    • Goekjian, P.G.1    Jirousek, M.R.2
  • 40
    • 0035705640 scopus 로고    scopus 로고
    • Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase
    • Gorren A.C., Kungl A.J., Schmidt K., Werner E.R., Mayer B. Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. Nitric Oxide 2001, 5:176-186.
    • (2001) Nitric Oxide , vol.5 , pp. 176-186
    • Gorren, A.C.1    Kungl, A.J.2    Schmidt, K.3    Werner, E.R.4    Mayer, B.5
  • 41
    • 0030464496 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites
    • Gorren A.C., List B.M., Schrammel A., Pitters E., Hemmens B., Werner E.R., Schmidt K., Mayer B. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 1996, 35:16735-16745.
    • (1996) Biochemistry , vol.35 , pp. 16735-16745
    • Gorren, A.C.1    List, B.M.2    Schrammel, A.3    Pitters, E.4    Hemmens, B.5    Werner, E.R.6    Schmidt, K.7    Mayer, B.8
  • 42
    • 1942468123 scopus 로고    scopus 로고
    • Novel NAD(P)H oxidases in the cardiovascular system
    • Griendling K.K. Novel NAD(P)H oxidases in the cardiovascular system. Heart 2004, 90:491-493.
    • (2004) Heart , vol.90 , pp. 491-493
    • Griendling, K.K.1
  • 43
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: role in cardiovascular biology and disease
    • Griendling K.K., Sorescu D., Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000, 86:494-501.
    • (2000) Circ Res. , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 44
    • 0038718531 scopus 로고    scopus 로고
    • Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species
    • Grote K., Flach I., Luchtefeld M., Akin E., Holland S.M., Drexler H., Schieffer B. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circ. Res. 2003, 92:e80-e86.
    • (2003) Circ. Res. , vol.92
    • Grote, K.1    Flach, I.2    Luchtefeld, M.3    Akin, E.4    Holland, S.M.5    Drexler, H.6    Schieffer, B.7
  • 45
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • Guzik T.J., Mussa S., Gastaldi D., Sadowski J., Ratnatunga C., Pillai R., Channon K.M. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002, 105:1656-1662.
    • (2002) Circulation , vol.105 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 46
    • 0025018196 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine
    • Hecker M., Sessa W.C., Harris H.J., Anggard E.E., Vane J.R. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. U S A 1990, 87:8612-8616.
    • (1990) Proc. Natl. Acad. Sci. U S A , vol.87 , pp. 8612-8616
    • Hecker, M.1    Sessa, W.C.2    Harris, H.J.3    Anggard, E.E.4    Vane, J.R.5
  • 47
    • 4744365177 scopus 로고    scopus 로고
    • Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase
    • Hein T.W., Zhang C., Wang W., Chang C.I., Thengchaisri N., Kuo L. Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. FASEB J. 2003, 17:2328-2330.
    • (2003) FASEB J. , vol.17 , pp. 2328-2330
    • Hein, T.W.1    Zhang, C.2    Wang, W.3    Chang, C.I.4    Thengchaisri, N.5    Kuo, L.6
  • 48
    • 0026584089 scopus 로고
    • 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
    • 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. Biochem. J. 1992, 281(Pt 3):627-630.
    • (1992) Biochem. J. , vol.281 , Issue.PT 3 , pp. 627-630
    • Heinzel, B.1    John, M.2    Klatt, P.3    Bohme, E.4    Mayer, B.5
  • 49
    • 0034602878 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase
    • Heitzer T., Brockhoff C., Mayer B., Warnholtz A., Mollnau H., Henne S., Meinertz T., Munzel T. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ. Res. 2000, 86:E36-E41.
    • (2000) Circ. Res. , vol.86
    • Heitzer, T.1    Brockhoff, C.2    Mayer, B.3    Warnholtz, A.4    Mollnau, H.5    Henne, S.6    Meinertz, T.7    Munzel, T.8
  • 50
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T., Krohn K., Albers S., Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 2000, 43:1435-1438.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 51
    • 0035960677 scopus 로고    scopus 로고
    • Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    • Heitzer T., Schlinzig T., Krohn K., Meinertz T., Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104:2673-2678.
    • (2001) Circulation , vol.104 , pp. 2673-2678
    • Heitzer, T.1    Schlinzig, T.2    Krohn, K.3    Meinertz, T.4    Munzel, T.5
  • 53
    • 0032227694 scopus 로고    scopus 로고
    • Enzymology of nitric oxide synthases
    • Hemmens B., Mayer B. Enzymology of nitric oxide synthases. Methods Mol. Biol. 1998, 100:1-32.
    • (1998) Methods Mol. Biol. , vol.100 , pp. 1-32
    • Hemmens, B.1    Mayer, B.2
  • 54
    • 0034680914 scopus 로고    scopus 로고
    • Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase
    • Hemmens B., Goessler W., Schmidt K., Mayer B. Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. J. Biol. Chem. 2000, 275:35786-35791.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35786-35791
    • Hemmens, B.1    Goessler, W.2    Schmidt, K.3    Mayer, B.4
  • 55
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • Higashi Y., Sasaki S., Nakagawa K., Fukuda Y., Matsuura H., Oshima T., Chayama K. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am. J. Hypertens. 2002, 15:326-332.
    • (2002) Am. J. Hypertens. , vol.15 , pp. 326-332
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3    Fukuda, Y.4    Matsuura, H.5    Oshima, T.6    Chayama, K.7
  • 58
    • 3543040601 scopus 로고    scopus 로고
    • Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury
    • Ho Y.S., Xiong Y., Ma W., Spector A., Ho D.S. Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J. Biol. Chem. 2004, 279:32804-32812.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32804-32812
    • Ho, Y.S.1    Xiong, Y.2    Ma, W.3    Spector, A.4    Ho, D.S.5
  • 59
    • 3843090635 scopus 로고    scopus 로고
    • Protective role of heme oxygenase in the blood vessel wall during atherogenesis
    • Hoekstra K.A., Godin D.V., Cheng K.M. Protective role of heme oxygenase in the blood vessel wall during atherogenesis. Biochem. Cell. Biol. 2004, 82:351-359.
    • (2004) Biochem. Cell. Biol. , vol.82 , pp. 351-359
    • Hoekstra, K.A.1    Godin, D.V.2    Cheng, K.M.3
  • 60
    • 0026713726 scopus 로고
    • Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus
    • Hogan M., Cerami A., Bucala R. Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus. J. Clin. Invest. 1992, 90:1110-1115.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1110-1115
    • Hogan, M.1    Cerami, A.2    Bucala, R.3
  • 61
    • 0035726142 scopus 로고    scopus 로고
    • Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats
    • Hong H.-J., Hsiao G., Cheng T.-H., Yen M.-H. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 2001, 38:1044-1048.
    • (2001) Hypertension , vol.38 , pp. 1044-1048
    • Hong, H.-J.1    Hsiao, G.2    Cheng, T.-H.3    Yen, M.-H.4
  • 63
    • 34247213490 scopus 로고    scopus 로고
    • Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation
    • Horke S., Witte I., Wilgenbus P., Kruger M., Strand D., Forstermann U. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation 2007, 115:2055-2064.
    • (2007) Circulation , vol.115 , pp. 2055-2064
    • Horke, S.1    Witte, I.2    Wilgenbus, P.3    Kruger, M.4    Strand, D.5    Forstermann, U.6
  • 64
    • 0035852775 scopus 로고    scopus 로고
    • Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase
    • Hornig B., Landmesser U., Kohler C., Ahlersmann D., Spiekermann S., Christoph A., Tatge H., Drexler H. Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation 2001, 103:799-805.
    • (2001) Circulation , vol.103 , pp. 799-805
    • Hornig, B.1    Landmesser, U.2    Kohler, C.3    Ahlersmann, D.4    Spiekermann, S.5    Christoph, A.6    Tatge, H.7    Drexler, H.8
  • 65
    • 0022461711 scopus 로고
    • Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid
    • Ignarro L.J., Harbison R.G., Wood K.S., Kadowitz P.J. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J. Pharmacol. Exp. Ther. 1986, 237:893-900.
    • (1986) J. Pharmacol. Exp. Ther. , vol.237 , pp. 893-900
    • Ignarro, L.J.1    Harbison, R.G.2    Wood, K.S.3    Kadowitz, P.J.4
  • 68
    • 33750260791 scopus 로고    scopus 로고
    • NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells
    • Jiang F., Roberts S.J., Datla S., Dusting G.J. NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells. Hypertension 2006, 48:950-957.
    • (2006) Hypertension , vol.48 , pp. 950-957
    • Jiang, F.1    Roberts, S.J.2    Datla, S.3    Dusting, G.J.4
  • 70
    • 33847046763 scopus 로고    scopus 로고
    • Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension
    • Jung O., Marklund S.L., Xia N., Busse R., Brandes R.P. Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension. Arterioscler. Thromb. Vasc. Biol. 2007, 27:470-477.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 470-477
    • Jung, O.1    Marklund, S.L.2    Xia, N.3    Busse, R.4    Brandes, R.P.5
  • 71
    • 0033021938 scopus 로고    scopus 로고
    • Superoxide anion production is increased in a model of genetic hypertension : role of the endothelium
    • Kerr S., Brosnan M.J., McIntyre M., Reid J.L., Dominiczak A.F., Hamilton C.A. Superoxide anion production is increased in a model of genetic hypertension : role of the endothelium. Hypertension 1999, 33:1353-1358.
    • (1999) Hypertension , vol.33 , pp. 1353-1358
    • Kerr, S.1    Brosnan, M.J.2    McIntyre, M.3    Reid, J.L.4    Dominiczak, A.F.5    Hamilton, C.A.6
  • 72
    • 0029929385 scopus 로고    scopus 로고
    • Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin
    • Klatt P., Pfeiffer S., List B.M., Lehner D., Glatter O., Bachinger H.P., Werner E.R., Schmidt K., Mayer B. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. J. Biol. Chem. 1996, 271:7336-7342.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7336-7342
    • Klatt, P.1    Pfeiffer, S.2    List, B.M.3    Lehner, D.4    Glatter, O.5    Bachinger, H.P.6    Werner, E.R.7    Schmidt, K.8    Mayer, B.9
  • 74
    • 0034654022 scopus 로고    scopus 로고
    • Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
    • Kotsonis P., Frohlich L.G., Shutenko Z.V., Horejsi R., Pfleiderer W., Schmidt H.H. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochem. J. 2000, 346(Pt 3):767-776.
    • (2000) Biochem. J. , vol.346 , Issue.PT 3 , pp. 767-776
    • Kotsonis, P.1    Frohlich, L.G.2    Shutenko, Z.V.3    Horejsi, R.4    Pfleiderer, W.5    Schmidt, H.H.6
  • 75
    • 0025731835 scopus 로고
    • Nitric oxide: an endogenous modulator of leukocyte adhesion
    • Kubes P., Suzuki M., Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U S A 1991, 88:4651-4655.
    • (1991) Proc. Natl. Acad. Sci. U S A , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 76
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D.J., Sessa W.C., Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat. Med. 2000, 6:1004-1010.
    • (2000) Nat. Med. , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6    Sessa, W.C.7    Walsh, K.8
  • 77
    • 0038604446 scopus 로고    scopus 로고
    • Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    • Kuzkaya N., Weissmann N., Harrison D.G., Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J. Biol. Chem. 2003, 278:22546-22554.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22546-22554
    • Kuzkaya, N.1    Weissmann, N.2    Harrison, D.G.3    Dikalov, S.4
  • 81
    • 0034673949 scopus 로고    scopus 로고
    • Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation
    • Landmesser U., Merten R., Spiekermann S., Buttner K., Drexler H., Hornig B. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation 2000, 101:2264-2270.
    • (2000) Circulation , vol.101 , pp. 2264-2270
    • Landmesser, U.1    Merten, R.2    Spiekermann, S.3    Buttner, K.4    Drexler, H.5    Hornig, B.6
  • 82
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U., Liao J.K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J. Biol. Chem. 1998, 273:24266-24271.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 83
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen J.B., Somers M., Kurz S., McCann L., Warnholtz A., Freeman B.A., Tarpey M., Fukai T., Harrison D.G. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001, 103:1282-1288.
    • (2001) Circulation , vol.103 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 84
    • 0035864342 scopus 로고    scopus 로고
    • PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients
    • Leus F.R., Zwart M., Kastelein J.J., Voorbij H.A. PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients. Atherosclerosis 2001, 154:641-649.
    • (2001) Atherosclerosis , vol.154 , pp. 641-649
    • Leus, F.R.1    Zwart, M.2    Kastelein, J.J.3    Voorbij, H.A.4
  • 85
    • 0343114388 scopus 로고    scopus 로고
    • Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene
    • Li H., Forstermann U. Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene. Mol. Pharmacol. 2000, 57:427-435.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 427-435
    • Li, H.1    Forstermann, U.2
  • 87
    • 0037159279 scopus 로고    scopus 로고
    • Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase
    • Li H., Junk P., Huwiler A., Burkhardt C., Wallerath T., Pfeilschifter J., Forstermann U. Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase. Circulation 2002, 106:2250-2256.
    • (2002) Circulation , vol.106 , pp. 2250-2256
    • Li, H.1    Junk, P.2    Huwiler, A.3    Burkhardt, C.4    Wallerath, T.5    Pfeilschifter, J.6    Forstermann, U.7
  • 89
    • 0033597930 scopus 로고    scopus 로고
    • Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase
    • Li H., Raman C.S., Glaser C.B., Blasko E., Young T.A., Parkinson J.F., Whitlow M., Poulos T.L. Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. J Biol Chem. 1999, 274:21276-21284.
    • (1999) J Biol Chem. , vol.274 , pp. 21276-21284
    • Li, H.1    Raman, C.S.2    Glaser, C.B.3    Blasko, E.4    Young, T.A.5    Parkinson, J.F.6    Whitlow, M.7    Poulos, T.L.8
  • 90
    • 33745009958 scopus 로고    scopus 로고
    • Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
    • Li H., Witte K., August M., Brausch I., Godtel-Armbrust U., Habermeier A., Closs E.I., Oelze M., Munzel T., Förstermann U. Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 2006, 47:2536-2544.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2536-2544
    • Li, H.1    Witte, K.2    August, M.3    Brausch, I.4    Godtel-Armbrust, U.5    Habermeier, A.6    Closs, E.I.7    Oelze, M.8    Munzel, T.9    Förstermann, U.10
  • 92
    • 0036829777 scopus 로고    scopus 로고
    • Beyond lipid lowering: the role of statins in vascular protection
    • Liao J.K. Beyond lipid lowering: the role of statins in vascular protection. Int. J. Cardiol. 2002, 86:5-18.
    • (2002) Int. J. Cardiol. , vol.86 , pp. 5-18
    • Liao, J.K.1
  • 93
    • 0037143637 scopus 로고    scopus 로고
    • Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase
    • Lin K.Y., Ito A., Asagami T., Tsao P.S., Adimoolam S., Kimoto M., Tsuji H., Reaven G.M., Cooke J.P. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002, 106:987-992.
    • (2002) Circulation , vol.106 , pp. 987-992
    • Lin, K.Y.1    Ito, A.2    Asagami, T.3    Tsao, P.S.4    Adimoolam, S.5    Kimoto, M.6    Tsuji, H.7    Reaven, G.M.8    Cooke, J.P.9
  • 94
    • 0242666181 scopus 로고    scopus 로고
    • Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
    • Lin M.I., Fulton D., Babbitt R., Fleming I., Busse R., Pritchard K.A., Sessa W.C. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J. Biol. Chem. 2003, 278:44719-44726.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44719-44726
    • Lin, M.I.1    Fulton, D.2    Babbitt, R.3    Fleming, I.4    Busse, R.5    Pritchard, K.A.6    Sessa, W.C.7
  • 95
    • 0030948345 scopus 로고    scopus 로고
    • Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization
    • List B.M., Klosch B., Volker C., Gorren A.C., Sessa W.C., Werner E.R., Kukovetz W.R., Schmidt K., Mayer B. Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem. J. 1997, 323(Pt 1):159-165.
    • (1997) Biochem. J. , vol.323 , Issue.PT 1 , pp. 159-165
    • List, B.M.1    Klosch, B.2    Volker, C.3    Gorren, A.C.4    Sessa, W.C.5    Werner, E.R.6    Kukovetz, W.R.7    Schmidt, K.8    Mayer, B.9
  • 98
    • 0029966119 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal
    • Masters B.S., McMillan K., Sheta E.A., Nishimura J.S., Roman L.J., Martasek P. Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal. FASEB J. 1996, 10:552-558.
    • (1996) FASEB J. , vol.10 , pp. 552-558
    • Masters, B.S.1    McMillan, K.2    Sheta, E.A.3    Nishimura, J.S.4    Roman, L.J.5    Martasek, P.6
  • 102
    • 0039129150 scopus 로고    scopus 로고
    • Zinc content of Escherichia coli-expressed constitutive isoforms of nitric-oxide synthase. Enzymatic activity and effect of pterin
    • Miller R.T., Martasek P., Raman C.S., Masters B.S. Zinc content of Escherichia coli-expressed constitutive isoforms of nitric-oxide synthase. Enzymatic activity and effect of pterin. J Biol Chem. 1999, 274:14537-14540.
    • (1999) J Biol Chem. , vol.274 , pp. 14537-14540
    • Miller, R.T.1    Martasek, P.2    Raman, C.S.3    Masters, B.S.4
  • 103
    • 0343990001 scopus 로고    scopus 로고
    • Involvement of the reductase domain of neuronal nitric oxide synthase in superoxide anion production
    • Miller R.T., Martasek P., Roman L.J., Nishimura J.S., Masters B.S. Involvement of the reductase domain of neuronal nitric oxide synthase in superoxide anion production. Biochemistry 1997, 36:15277-15284.
    • (1997) Biochemistry , vol.36 , pp. 15277-15284
    • Miller, R.T.1    Martasek, P.2    Roman, L.J.3    Nishimura, J.S.4    Masters, B.S.5
  • 104
    • 0033527413 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function
    • Milstien S., Katusic Z. Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochem. Biophys. Res. Commun. 1999, 263:681-684.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 681-684
    • Milstien, S.1    Katusic, Z.2
  • 106
    • 30444458698 scopus 로고    scopus 로고
    • Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis
    • Moat S.J., Clarke Z.L., Madhavan A.K., Lewis M.J., Lang D. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. Eur. J. Pharmacol. 2006, 530:250-258.
    • (2006) Eur. J. Pharmacol. , vol.530 , pp. 250-258
    • Moat, S.J.1    Clarke, Z.L.2    Madhavan, A.K.3    Lewis, M.J.4    Lang, D.5
  • 108
    • 24144476577 scopus 로고    scopus 로고
    • Heme oxygenase and atherosclerosis
    • Morita T. Heme oxygenase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2005, 25:1786-1795.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1786-1795
    • Morita, T.1
  • 111
    • 0025204692 scopus 로고
    • Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells
    • Nakaki T., Nakayama M., Kato R. Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells. Eur. J. Pharmacol. 1990, 189:347-353.
    • (1990) Eur. J. Pharmacol. , vol.189 , pp. 347-353
    • Nakaki, T.1    Nakayama, M.2    Kato, R.3
  • 112
    • 33749544927 scopus 로고    scopus 로고
    • Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2
    • Ng C.J., Bourquard N., Grijalva V., Hama S., Shih D.M., Navab M., Fogelman A.M., Lusis A.J., Young S., Reddy S.T. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J. Biol. Chem. 2006, 281:29491-29500.
    • (2006) J. Biol. Chem. , vol.281 , pp. 29491-29500
    • Ng, C.J.1    Bourquard, N.2    Grijalva, V.3    Hama, S.4    Shih, D.M.5    Navab, M.6    Fogelman, A.M.7    Lusis, A.J.8    Young, S.9    Reddy, S.T.10
  • 113
    • 0037154324 scopus 로고    scopus 로고
    • The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis
    • Nickenig G., Harrison D.G. The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis. Circulation 2002, 105:393-396.
    • (2002) Circulation , vol.105 , pp. 393-396
    • Nickenig, G.1    Harrison, D.G.2
  • 114
    • 0344541709 scopus 로고    scopus 로고
    • Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men
    • Nickenig G., Baumer A.T., Temur Y., Kebben D., Jockenhovel F., Bohm M. Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. Circulation 1999, 100:2131-2134.
    • (1999) Circulation , vol.100 , pp. 2131-2134
    • Nickenig, G.1    Baumer, A.T.2    Temur, Y.3    Kebben, D.4    Jockenhovel, F.5    Bohm, M.6
  • 116
    • 0026441233 scopus 로고
    • Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation
    • Nunokawa Y., Tanaka S. Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation. Biochem. Biophys. Res. Commun. 1992, 188:409-415.
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 409-415
    • Nunokawa, Y.1    Tanaka, S.2
  • 117
    • 0032883768 scopus 로고    scopus 로고
    • Nitric oxide-dependent endothelial function is unaffected by allopurinol in hypercholesterolaemic subjects
    • O'Driscoll J.G., Green D.J., Rankin J.M., Taylor R.R. Nitric oxide-dependent endothelial function is unaffected by allopurinol in hypercholesterolaemic subjects. Clin. Exp. Pharmacol. Physiol. 1999, 26:779-783.
    • (1999) Clin. Exp. Pharmacol. Physiol. , vol.26 , pp. 779-783
    • O'Driscoll, J.G.1    Green, D.J.2    Rankin, J.M.3    Taylor, R.R.4
  • 118
    • 0027242030 scopus 로고
    • Hypercholesterolemia increases endothelial superoxide anion production
    • Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 1993, 91:2546-2551.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 120
    • 0030659486 scopus 로고    scopus 로고
    • Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans
    • Ohishi M., Ueda M., Rakugi H., Naruko T., Kojima A., Okamura A., Higaki J., Ogihara T. Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans. J. Hypertens. 1997, 15:1295-1302.
    • (1997) J. Hypertens. , vol.15 , pp. 1295-1302
    • Ohishi, M.1    Ueda, M.2    Rakugi, H.3    Naruko, T.4    Kojima, A.5    Okamura, A.6    Higaki, J.7    Ogihara, T.8
  • 121
    • 85048379125 scopus 로고    scopus 로고
    • Antioxidant vitamins for prevention of cardiovascular disease
    • author reply 921
    • Paolini M., Sapone A., Canistro D., Chieco P., Valgimigli L. Antioxidant vitamins for prevention of cardiovascular disease. Lancet 2003, 362:920. author reply 921.
    • (2003) Lancet , vol.362 , pp. 920
    • Paolini, M.1    Sapone, A.2    Canistro, D.3    Chieco, P.4    Valgimigli, L.5
  • 122
    • 0031033321 scopus 로고    scopus 로고
    • Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin
    • Pieper G.M. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J. Cardiovasc. Pharmacol. 1997, 29:8-15.
    • (1997) J. Cardiovasc. Pharmacol. , vol.29 , pp. 8-15
    • Pieper, G.M.1
  • 123
    • 0025750850 scopus 로고
    • Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
    • Pollock J.S., Forstermann U., Mitchell J.A., Warner T.D., Schmidt H.H., Nakane M., Murad F. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc. Natl. Acad. Sci. U. S. A 1991, 88:10480-10484.
    • (1991) Proc. Natl. Acad. Sci. U. S. A , vol.88 , pp. 10480-10484
    • Pollock, J.S.1    Forstermann, U.2    Mitchell, J.A.3    Warner, T.D.4    Schmidt, H.H.5    Nakane, M.6    Murad, F.7
  • 124
    • 0026470180 scopus 로고
    • Generation of superoxide by purified brain nitric oxide synthase
    • Pou S., Pou W.S., Bredt D.S., Snyder S.H., Rosen G.M. Generation of superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 1992, 267:24173-24176.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24173-24176
    • Pou, S.1    Pou, W.S.2    Bredt, D.S.3    Snyder, S.H.4    Rosen, G.M.5
  • 126
    • 0023446425 scopus 로고
    • The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
    • Radomski M.W., Palmer R.M., Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol. 1987, 92:639-646.
    • (1987) Br. J. Pharmacol. , vol.92 , pp. 639-646
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 128
    • 0032416666 scopus 로고    scopus 로고
    • Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center
    • Raman C.S., Li H., Martasek P., Kral V., Masters B.S., Poulos T.L. Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell 1998, 95:939-950.
    • (1998) Cell , vol.95 , pp. 939-950
    • Raman, C.S.1    Li, H.2    Martasek, P.3    Kral, V.4    Masters, B.S.5    Poulos, T.L.6
  • 129
    • 0021063422 scopus 로고
    • Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation
    • Rapoport R.M., Draznin M.B., Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983, 306:174-176.
    • (1983) Nature , vol.306 , pp. 174-176
    • Rapoport, R.M.1    Draznin, M.B.2    Murad, F.3
  • 130
    • 0028196891 scopus 로고
    • Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity
    • Rosenkranz-Weiss P., Sessa W.C., Milstien S., Kaufman S., Watson C.A., Pober J.S. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest. 1994, 93:2236-2243.
    • (1994) J Clin Invest. , vol.93 , pp. 2236-2243
    • Rosenkranz-Weiss, P.1    Sessa, W.C.2    Milstien, S.3    Kaufman, S.4    Watson, C.A.5    Pober, J.S.6
  • 131
    • 0025906819 scopus 로고
    • L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits
    • Rossitch E., Alexander E., Black P.M., Cooke J.P. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J. Clin. Invest. 1991, 87:1295-1299.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1295-1299
    • Rossitch, E.1    Alexander, E.2    Black, P.M.3    Cooke, J.P.4
  • 132
    • 20444419056 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice
    • Rozenberg O., Shih D.M., Aviram M. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice. Atherosclerosis 2005, 181:9-18.
    • (2005) Atherosclerosis , vol.181 , pp. 9-18
    • Rozenberg, O.1    Shih, D.M.2    Aviram, M.3
  • 133
    • 0342424181 scopus 로고    scopus 로고
    • Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    • Schächinger V., Britten M.B., Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000, 101:1899-1906.
    • (2000) Circulation , vol.101 , pp. 1899-1906
    • Schächinger, V.1    Britten, M.B.2    Zeiher, A.M.3
  • 134
    • 0033512422 scopus 로고    scopus 로고
    • Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta
    • Shinozaki K., Kashiwagi A., Nishio Y., Okamura T., Yoshida Y., Masada M., Toda N., Kikkawa R. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta. Diabetes 1999, 48:2437-2445.
    • (1999) Diabetes , vol.48 , pp. 2437-2445
    • Shinozaki, K.1    Kashiwagi, A.2    Nishio, Y.3    Okamura, T.4    Yoshida, Y.5    Masada, M.6    Toda, N.7    Kikkawa, R.8
  • 135
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
    • Shinozaki K., Nishio Y., Okamura T., Yoshida Y., Maegawa H., Kojima H., Masada M., Toda N., Kikkawa R., Kashiwagi A. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ. Res. 2000, 87:566-573.
    • (2000) Circ. Res. , vol.87 , pp. 566-573
    • Shinozaki, K.1    Nishio, Y.2    Okamura, T.3    Yoshida, Y.4    Maegawa, H.5    Kojima, H.6    Masada, M.7    Toda, N.8    Kikkawa, R.9    Kashiwagi, A.10
  • 136
    • 0242298632 scopus 로고    scopus 로고
    • Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells
    • Simon A., Plies L., Habermeier A., Martine U., Reining M., Closs E.I. Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells. Circ. Res. 2003, 93:813-820.
    • (2003) Circ. Res. , vol.93 , pp. 813-820
    • Simon, A.1    Plies, L.2    Habermeier, A.3    Martine, U.4    Reining, M.5    Closs, E.I.6
  • 138
    • 0025340170 scopus 로고
    • Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP
    • Southgate K., Newby A.C. Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP. Atherosclerosis 1990, 82:113-123.
    • (1990) Atherosclerosis , vol.82 , pp. 113-123
    • Southgate, K.1    Newby, A.C.2
  • 139
    • 4344691399 scopus 로고    scopus 로고
    • A review of the epidemiological evidence for the 'antioxidant hypothesis'
    • Stanner S.A., Hughes J., Kelly C.N., Buttriss J. A review of the epidemiological evidence for the 'antioxidant hypothesis'. Public Health Nutr. 2004, 7:407-422.
    • (2004) Public Health Nutr. , vol.7 , pp. 407-422
    • Stanner, S.A.1    Hughes, J.2    Kelly, C.N.3    Buttriss, J.4
  • 140
    • 33750969074 scopus 로고    scopus 로고
    • Heme oxygenase-1: a novel drug target for atherosclerotic diseases?
    • Stocker R., Perrella M.A. Heme oxygenase-1: a novel drug target for atherosclerotic diseases?. Circulation 2006, 114:2178-2189.
    • (2006) Circulation , vol.114 , pp. 2178-2189
    • Stocker, R.1    Perrella, M.A.2
  • 143
    • 0035805555 scopus 로고    scopus 로고
    • Oxygen reduction by nitric-oxide synthases
    • Stuehr D., Pou S., Rosen G.M. Oxygen reduction by nitric-oxide synthases. J. Biol. Chem. 2001, 276:14533-14536.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14533-14536
    • Stuehr, D.1    Pou, S.2    Rosen, G.M.3
  • 145
    • 3142581994 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability
    • Taille C., El-Benna J., Lanone S., Dang M.C., Ogier-Denis E., Aubier M., Boczkowski J. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J. Biol. Chem. 2004, 279:28681-28688.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28681-28688
    • Taille, C.1    El-Benna, J.2    Lanone, S.3    Dang, M.C.4    Ogier-Denis, E.5    Aubier, M.6    Boczkowski, J.7
  • 147
    • 0037783377 scopus 로고    scopus 로고
    • C-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    • Touyz R.M., Yao G., Schiffrin E.L. c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 2003, 23:981-987.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 981-987
    • Touyz, R.M.1    Yao, G.2    Schiffrin, E.L.3
  • 148
    • 0021996572 scopus 로고
    • Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
    • Turrens J.F., Alexandre A., Lehninger A.L. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 1985, 237:408-414.
    • (1985) Arch. Biochem. Biophys. , vol.237 , pp. 408-414
    • Turrens, J.F.1    Alexandre, A.2    Lehninger, A.L.3
  • 150
    • 0036020286 scopus 로고    scopus 로고
    • Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate
    • van Etten R.W., de Koning E.J., Verhaar M.C., Gaillard C.A., Rabelink T.J. Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate. Diabetologia 2002, 45:1004-1010.
    • (2002) Diabetologia , vol.45 , pp. 1004-1010
    • van Etten, R.W.1    de Koning, E.J.2    Verhaar, M.C.3    Gaillard, C.A.4    Rabelink, T.J.5
  • 151
    • 0031840214 scopus 로고    scopus 로고
    • Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats
    • Vaziri N.D., Ni Z., Oveisi F. Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 1998, 31:1248-1254.
    • (1998) Hypertension , vol.31 , pp. 1248-1254
    • Vaziri, N.D.1    Ni, Z.2    Oveisi, F.3
  • 152
    • 0034696681 scopus 로고    scopus 로고
    • Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability
    • Vergnani L., Hatrik S., Ricci F., Passaro A., Manzoli N., Zuliani G., Brovkovych V., Fellin R., Malinski T. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation 2000, 101:1261-1266.
    • (2000) Circulation , vol.101 , pp. 1261-1266
    • Vergnani, L.1    Hatrik, S.2    Ricci, F.3    Passaro, A.4    Manzoli, N.5    Zuliani, G.6    Brovkovych, V.7    Fellin, R.8    Malinski, T.9
  • 154
    • 0032570254 scopus 로고    scopus 로고
    • 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
    • Verhaar M.C., Wever R.M., Kastelein J.J., van Dam T., Koomans H.A., Rabelink T.J. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 1998, 97:237-241.
    • (1998) Circulation , vol.97 , pp. 237-241
    • Verhaar, M.C.1    Wever, R.M.2    Kastelein, J.J.3    van Dam, T.4    Koomans, H.A.5    Rabelink, T.J.6
  • 156
    • 0343048978 scopus 로고    scopus 로고
    • Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation
    • Wagner A.H., Kohler T., Ruckschloss U., Just I., Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler. Thromb. Vasc. Biol. 2000, 20:61-69.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 61-69
    • Wagner, A.H.1    Kohler, T.2    Ruckschloss, U.3    Just, I.4    Hecker, M.5
  • 158
    • 0035569562 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    • Wassmann S., Laufs U., Baumer A.T., Muller K., Ahlbory K., Linz W., Itter G., Rosen R., Bohm M., Nickenig G. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 2001, 37:1450-1457.
    • (2001) Hypertension , vol.37 , pp. 1450-1457
    • Wassmann, S.1    Laufs, U.2    Baumer, A.T.3    Muller, K.4    Ahlbory, K.5    Linz, W.6    Itter, G.7    Rosen, R.8    Bohm, M.9    Nickenig, G.10
  • 159
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • Wassmann S., Laufs U., Baumer A.T., Muller K., Konkol C., Sauer H., Bohm M., Nickenig G. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol 2001, 59:646-654.
    • (2001) Mol Pharmacol , vol.59 , pp. 646-654
    • Wassmann, S.1    Laufs, U.2    Baumer, A.T.3    Muller, K.4    Konkol, C.5    Sauer, H.6    Bohm, M.7    Nickenig, G.8
  • 160
  • 164
    • 33646555780 scopus 로고    scopus 로고
    • Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution
    • Whitsett J., Martasek P., Zhao H., Schauer D.W., Hatakeyama K., Kalyanaraman B., Vasquez-Vivar J. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic. Biol. Med. 2006, 40:2056-2068.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 2056-2068
    • Whitsett, J.1    Martasek, P.2    Zhao, H.3    Schauer, D.W.4    Hatakeyama, K.5    Kalyanaraman, B.6    Vasquez-Vivar, J.7
  • 167
    • 0032475865 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
    • 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J. Biol. Chem. 1998, 273:25804-25808.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25804-25808
    • Xia, Y.1    Tsai, A.L.2    Berka, V.3    Zweier, J.L.4
  • 170
    • 0344875019 scopus 로고    scopus 로고
    • Thioredoxin: a key regulator of cardiovascular homeostasis
    • Yamawaki H., Haendeler J., Berk B.C. Thioredoxin: a key regulator of cardiovascular homeostasis. Circ. Res. 2003, 93:1029-1033.
    • (2003) Circ. Res. , vol.93 , pp. 1029-1033
    • Yamawaki, H.1    Haendeler, J.2    Berk, B.C.3
  • 171
    • 9344240424 scopus 로고    scopus 로고
    • Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E
    • Yang H., Roberts L.J., Shi M.J., Zhou L.C., Ballard B.R., Richardson A., Guo Z.M. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ. Res. 2004, 95:1075-1081.
    • (2004) Circ. Res. , vol.95 , pp. 1075-1081
    • Yang, H.1    Roberts, L.J.2    Shi, M.J.3    Zhou, L.C.4    Ballard, B.R.5    Richardson, A.6    Guo, Z.M.7
  • 172
    • 0027521236 scopus 로고
    • Nitric Oxide Synthase-Immunoreactive Nerve Fibers in Dog Cerebral and Peripheral Arteries
    • Yoshida K., Okamura T., Kimura H., Bredt D.S., Snyder S.H., Toda N. Nitric Oxide Synthase-Immunoreactive Nerve Fibers in Dog Cerebral and Peripheral Arteries. Brain Res. 1993, 629:67-72.
    • (1993) Brain Res. , vol.629 , pp. 67-72
    • Yoshida, K.1    Okamura, T.2    Kimura, H.3    Bredt, D.S.4    Snyder, S.H.5    Toda, N.6
  • 174
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S., Sleight P., Pogue J., Bosch J., Davies R., Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl. J. Med. 2000, 342:145-153.
    • (2000) N Engl. J. Med. , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 176
    • 0035347173 scopus 로고    scopus 로고
    • Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function
    • Zhang C., Hein T.W., Wang W., Chang C.I., Kuo L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J. 2001, 15:1264-1266.
    • (2001) FASEB J. , vol.15 , pp. 1264-1266
    • Zhang, C.1    Hein, T.W.2    Wang, W.3    Chang, C.I.4    Kuo, L.5
  • 177
    • 9644282852 scopus 로고    scopus 로고
    • Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles
    • Zhang C., Hein T.W., Wang W., Miller M.W., Fossum T.W., McDonald M.M., Humphrey J.D., Kuo L. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension 2004, 44:935-943.
    • (2004) Hypertension , vol.44 , pp. 935-943
    • Zhang, C.1    Hein, T.W.2    Wang, W.3    Miller, M.W.4    Fossum, T.W.5    McDonald, M.M.6    Humphrey, J.D.7    Kuo, L.8


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