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Volumn 86, Issue 11, 2000, Pages 1129-1134

Folic acid reverts dysfunction of endothelial nitric oxide synthase

Author keywords

Electron spin resonance; Folic acid; Nitric oxide; Nitric oxide synthase; Tetrahydrobiopterin

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ARGININE; CITRULLINE; FOLIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SUPEROXIDE; TETRAHYDROBIOPTERIN;

EID: 0034625532     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.11.1129     Document Type: Article
Times cited : (275)

References (46)
  • 1
    • 0028966599 scopus 로고
    • Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis
    • Gimbrone MA. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol. 1995;75:67B-70B.
    • (1995) Am J Cardiol , vol.75
    • Gimbrone, M.A.1
  • 2
    • 0027687479 scopus 로고
    • The endothelium as target and mediator of cardiovascular disease
    • Luscher TF. The endothelium as target and mediator of cardiovascular disease. Eur J Clin Invest. 1993;23:670-685.
    • (1993) Eur J Clin Invest , vol.23 , pp. 670-685
    • Luscher, T.F.1
  • 3
    • 0028939363 scopus 로고
    • The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion
    • Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 1995;332:488-493.
    • (1995) N Engl J Med , vol.332 , pp. 488-493
    • Anderson, T.J.1    Meredith, I.T.2    Yeung, A.C.3    Frei, B.4    Selwyn, A.P.5    Ganz, P.6
  • 6
    • 0028939151 scopus 로고
    • Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion
    • Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol. 1995;75:75B-81B.
    • (1995) Am J Cardiol , vol.75
    • Harrison, D.G.1    Ohara, Y.2
  • 8
    • 0010689908 scopus 로고    scopus 로고
    • Ca/calmodulin dependent superoxide generation by endothelial nitric oxide synthase
    • Xia Y, Tsai HL, Zweier JL. Ca/calmodulin dependent superoxide generation by endothelial nitric oxide synthase. Circulation. 1997;96:1281A.
    • (1997) Circulation , vol.96
    • Xia, Y.1    Tsai, H.L.2    Zweier, J.L.3
  • 10
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 1996;271:C1424-C1437.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 12
    • 0027367617 scopus 로고
    • Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    • Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88:2149-2155.
    • (1993) Circulation , vol.88 , pp. 2149-2155
    • Celermajer, D.S.1    Sorensen, K.E.2    Georgakopoulos, D.3    Bull, C.4    Thomas, O.5    Robinson, J.6    Deanfield, J.E.7
  • 13
    • 0027429948 scopus 로고
    • Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries
    • Seiler C, Hess OM, Buechi M, Suter TM, Krayenbuehl HP. Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries. Circulation. 1993;88: 2139-2148.
    • (1993) Circulation , vol.88 , pp. 2139-2148
    • Seiler, C.1    Hess, O.M.2    Buechi, M.3    Suter, T.M.4    Krayenbuehl, H.P.5
  • 14
    • 0029121091 scopus 로고
    • Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication
    • Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 1995;346:467-471.
    • (1995) Lancet , vol.346 , pp. 467-471
    • Stroes, E.S.1    Koomans, H.A.2    De Bruin, T.W.3    Rabelink, T.J.4
  • 15
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88:2510-2516.
    • (1993) Circulation , vol.88 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 16
    • 0030007350 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1996;27:567-574.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 567-574
    • Williams, S.B.1    Cusco, J.A.2    Roddy, M.A.3    Johnstone, M.T.4    Creager, M.A.5
  • 17
    • 0028821021 scopus 로고
    • Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension: Different responses to acetylcholine and substance P
    • Egashira K, Suzuki S, Hirooka Y, Kai H, Sugimachi M, Imaizumi T, Takeshita A. Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension: different responses to acetylcholine and substance P. Hypertension. 1995;25:201-206.
    • (1995) Hypertension , vol.25 , pp. 201-206
    • Egashira, K.1    Suzuki, S.2    Hirooka, Y.3    Kai, H.4    Sugimachi, M.5    Imaizumi, T.6    Takeshita, A.7
  • 19
    • 0027255291 scopus 로고
    • Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
    • Celermajer DS, Sorensen K, Ryalls M, Robinson J, Thomas O, Leonard JV, Deanfield JE. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol. 1993;22:854-858.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 854-858
    • Celermajer, D.S.1    Sorensen, K.2    Ryalls, M.3    Robinson, J.4    Thomas, O.5    Leonard, J.V.6    Deanfield, J.E.7
  • 21
    • 0029118174 scopus 로고
    • Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production
    • Ohara Y, Peterson TE, Sayegh HS, Subramanian RR, Wilcox JN, Harrison DG. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation. 1995; 92:898-903.
    • (1995) Circulation , vol.92 , pp. 898-903
    • Ohara, Y.1    Peterson, T.E.2    Sayegh, H.S.3    Subramanian, R.R.4    Wilcox, J.N.5    Harrison, D.G.6
  • 22
    • 0028939151 scopus 로고
    • Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion
    • Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol. 1995;75:75B-81B.
    • (1995) Am J Cardiol , vol.75
    • Harrison, D.G.1    Ohara, Y.2
  • 23
    • 0027242030 scopus 로고
    • Hypercholesterolemia increases endothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 1993;91: 2546-2551.
    • (1993) J Clin Invest , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 25
    • 0032570254 scopus 로고    scopus 로고
    • 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
    • Verhaar MC, Wever R, Kastelein J, Dam T, Koomans HA, Rabelink TJ. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation. 1998;97: 237-241.
    • (1998) Circulation , vol.97 , pp. 237-241
    • Verhaar, M.C.1    Wever, R.2    Kastelein, J.3    Dam, T.4    Koomans, H.A.5    Rabelink, T.J.6
  • 27
    • 0029013876 scopus 로고
    • 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: A new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen centered radicals
    • Frejaville C, Karoui H, Tuccio B, Le Moigne F, Culcasi M, Pietri S, Lauricella R, Tordo P. 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen centered radicals. J Med Chem. 1995;38: 258-265.
    • (1995) J Med Chem , vol.38 , pp. 258-265
    • Frejaville, C.1    Karoui, H.2    Tuccio, B.3    Le Moigne, F.4    Culcasi, M.5    Pietri, S.6    Lauricella, R.7    Tordo, P.8
  • 28
    • 0025063772 scopus 로고
    • Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene
    • Montesano R, Pepper MS, Mohle-Steinlein U, Riseau W, Wagner EF, Orci L. Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene. Cell. 1990;62:435-445.
    • (1990) Cell , vol.62 , pp. 435-445
    • Montesano, R.1    Pepper, M.S.2    Mohle-Steinlein, U.3    Riseau, W.4    Wagner, E.F.5    Orci, L.6
  • 32
    • 0032416666 scopus 로고    scopus 로고
    • Crystal structure of constitutive endothelial nitric oxide synthase: A paradigm for pterin function involving a novel metal center
    • Raman CS, Li H, Martasek P, Krai V, Masters BSS, Poulos TL. Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell. 1998;95:939-950.
    • (1998) Cell , vol.95 , pp. 939-950
    • Raman, C.S.1    Li, H.2    Martasek, P.3    Krai, V.4    Masters, B.S.S.5    Poulos, T.L.6
  • 33
    • 0032227694 scopus 로고    scopus 로고
    • Enzymology of nitric oxide synthases
    • Hemmens B, Mayer B. Enzymology of nitric oxide synthases. Methods Mol Biol. 1997;100:1-32.
    • (1997) Methods Mol Biol , vol.100 , pp. 1-32
    • Hemmens, B.1    Mayer, B.2
  • 37
    • 0026072264 scopus 로고
    • Some metabolic relationships between biopterin and folate: Implications for the methyl trap hypothesis
    • Kaufman S. Some metabolic relationships between biopterin and folate: implications for the methyl trap hypothesis. Neurochem Res. 1991;16: 1031-1036.
    • (1991) Neurochem Res , vol.16 , pp. 1031-1036
    • Kaufman, S.1
  • 38
    • 0030894594 scopus 로고    scopus 로고
    • Thiols and neuronal nitric oxide synthase: Complex formation, competitive inhibition and enzyme stabilization
    • Gorren ACF, Schrammel A, Schmidt K, Mayer B. Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition and enzyme stabilization. Biochemistry. 1997;36:4360-4366.
    • (1997) Biochemistry , vol.36 , pp. 4360-4366
    • Gorren, A.C.F.1    Schrammel, A.2    Schmidt, K.3    Mayer, B.4
  • 39
    • 0032577582 scopus 로고    scopus 로고
    • Reaction of neuronal nitric oxide synthase with oxygen at low temperature: Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin
    • Bee N, Gorren AC, Voelker C, Mayer B, Lange R. Reaction of neuronal nitric oxide synthase with oxygen at low temperature: evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin. J Biol Chem. 1998;273:13502-13508.
    • (1998) J Biol Chem , vol.273 , pp. 13502-13508
    • Bee, N.1    Gorren, A.C.2    Voelker, C.3    Mayer, B.4    Lange, R.5
  • 40
    • 0039550848 scopus 로고    scopus 로고
    • L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells
    • Heller R, Munscher-Paulig F, Grabner R, Till U. L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem. 1999;274: 8254-8260.
    • (1999) J Biol Chem , vol.274 , pp. 8254-8260
    • Heller, R.1    Munscher-Paulig, F.2    Grabner, R.3    Till, U.4
  • 41
    • 0026501460 scopus 로고
    • Insight into the nature and site of oxygen-centered free radical generation by endothelial monolayers using a novel spin trapping technique
    • Britigan BE, Roedar TL, Shasby DM. Insight into the nature and site of oxygen-centered free radical generation by endothelial monolayers using a novel spin trapping technique. Blood. 1992;3:699-707.
    • (1992) Blood , vol.3 , pp. 699-707
    • Britigan, B.E.1    Roedar, T.L.2    Shasby, D.M.3
  • 42
    • 0000452931 scopus 로고
    • Nitroxide radical adducts in biology: Chemistry, applications, and pitfalls
    • Chapter 10. New York, NY: Plenum Press
    • Mottley C, Mason PM. Nitroxide radical adducts in biology: chemistry, applications, and pitfalls. In: Spin Labeling: Biological Magnetic Resonance. Vol 8, Chapter 10. New York, NY: Plenum Press; 1989:543-568.
    • (1989) Spin Labeling: Biological Magnetic Resonance , vol.8 , pp. 543-568
    • Mottley, C.1    Mason, P.M.2
  • 44
    • 0242502758 scopus 로고    scopus 로고
    • Superoxide anion formation from lucigenin: An electron spin resonance spin-trapping study
    • Vasquez-Vivar J, Hogg N, Pritchard KA, Martasek P, Kalyanaraman B. Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett. 1997;403:127-130.
    • (1997) FEBS Lett , vol.403 , pp. 127-130
    • Vasquez-Vivar, J.1    Hogg, N.2    Pritchard, K.A.3    Martasek, P.4    Kalyanaraman, B.5
  • 46
    • 33847087667 scopus 로고
    • Spin trapping: Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones
    • Finkelstein E, Rosen GM, Rauckman EJ. Spin trapping: kinetics of the reaction of superoxide and hydroxyl radicals with nitrones. J Am Chem Soc. 1980;102:4994-4999.
    • (1980) J Am Chem Soc , vol.102 , pp. 4994-4999
    • Finkelstein, E.1    Rosen, G.M.2    Rauckman, E.J.3


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