Dual effect of ceramide on human endothelial cells: Induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase

Circulation

Volumn 106, Issue 17, 2002, Pages 2250-2256

  Li, Huige ^a   Junk, Peter ^a   Huwiler, Andrea ^a   Burkhardt, Christian ^a   Wallerath, Thomas ^a   Pfeilschifter, Josef ^a   Förstermann, Ulrich ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Endothelium derived factors; Nitric oxide synthase; Signal transduction

Indexed keywords

5(6) CHLOROMETHYL 2',7' DICHLORODIHYDROFLUORESCEIN DIACETATE; CERAMIDE; FLUORESCEIN DIACETATE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHOSPHOPROTEIN PHOSPHATASE 2A; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELL LINE; CELLS, CULTURED; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; KINETICS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHOPROTEIN PHOSPHATASE; PROMOTER REGIONS (GENETICS); REACTIVE OXYGEN SPECIES; RNA STABILITY; SPHINGOMYELIN PHOSPHODIESTERASE; TRANS-ACTIVATION (GENETICS); UP-REGULATION;

EID: 0037159279     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000035650.05921.50     Document Type: Article

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