Activation of protein kinase Cα and/or ε enhances transcription of the human endothelial nitric oxide synthase gene

Molecular Pharmacology

Volumn 53, Issue 4, 1998, Pages 630-637

  Li, Huige ^a   Oehrlein, Silke A ^a   Wallerath, Thomas ^a   Ihrig Biedert, Irmgard ^a   Wohlfart, Paulus ^b   Ulshöfer, Thomas ^b   Jessen, Timm ^b   Herget, Thomas ^a   Förstermann, Ulrich ^a   Kleinert, Hartmut ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4ALPHA PHORBOL DIDECANOATE; ARGININE; BISINDOLYLMALEIMIDE; BRADYKININ; CHELERYTHRINE; CITRULLINE; ISOENZYME; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; UMBILICAL VEIN;

EID: 18544392083     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.4.630     Document Type: Article

References (40)

1. Brown CA, Patel V, Wilkinson G, and Boarder MR (1996) P2 purinoceptor-stimulated conversion of arginine to citrulline in bovine endothelial cells is reduced by inhibition of protein kinase C. Biochem Pharmacol 52:1849-1854.
2. Busse R and Fleming I (1995) Regulation and functional consequences of endothelial nitric oxide formation. Ann Med 27:331-340.
3. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
4. Edgell CJ, McDonald CC, and Graham JB (1983) Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 80:3734-3737.
5. Förstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, and Kleinert H (1994) Nitric oxide synthase isozymes: characterization, molecular cloning, and functions. Hypertension 23:1121-1131.
6. Förstermann U and Kleinert H (1995) Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch Pharmacol 352:351-364.
7. Förstermann U, Pollock JS, Schmidt HHHW, Heller M, and Murad F (1991) Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the paniculate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:1788-1792.
8. Gibbons GH and Dzau VJ (1996) Molecular therapies for vascular diseases. Science (Washington DC) 272:689-693.
9. Graff JM, Stumpo DJ, and Blackshear PJ (1989) Characterization of the phosphorylation sites in the chicken and bovine myristoyiated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C. J Biol Chem 264:11912-11919.
10. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, and F-J Johannes (1996) Inhibition of protein kinase C mu by various inhibitors: differentiation from protein kinase c isoenzymes. FEBS Lett 392:77-80.
11. Harrison DG, Inoue N, Ohara Y, and Fukai T (1996) Modulation of endothelial cell nitric oxide synthase expression. Jpn Circ J 60:815-821.
12. Hecker M, Lückhoff A, and Busse R (1993) Modulation of endothelial autacoid release by protein kinase C: feedback inhibition or non-specific attenuation of receptor-dependent cell activation? J Cell Physiol 156:571-578.
13. Huang PL, Huang ZH, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, and Fishman MC (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (Lond) 377:239-242.
14. Hug H and Sarre TF (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:329-343.
15. Kleinert H, Euchenhofer C, Ihrig-Biedert I, and Förstermann U (1996) Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokineinduced activity of transcription factor nuclear factor. Mol Pharmacol 49:15-21.
16. Marsden PA, Heng HHQ, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, and Schappert KT (1993) Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268:17478-17488.
17. Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, and Michel T (1992) Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 307:287-293.
18. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, and Schächtele C (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268:9194-9197.
19. Mochly-Rosen D (1995) Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science (Washington DC) 268:247-251.
20. Moncada S and Higgs EA (1995) Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 9:1319-1330.
21. Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (Lond) 308:693-698.
22. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond) 334:661-665.
23. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (Washington DC) 258:607-614.
24. Nishikawa K, Toker A, Johannes F-J, Zhou SY, and Cantley LC (1997) Determination of the specific substrate sequence motifs of protein kinase c isozymes. J Biol Chem 272:952-960.
25. Ohara Y, Sayegh HS, Yamin JJ, and Harrison DG (1995) Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25:415-420.
26. Pollock JS, Förstermann U, Mitchell JA, Warner TD, Schmidt HH, Nakane M, and Murad F (1991) Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:10480-10484.
27. Rees DD, Palmer RM, and Moncada S (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86:3375-3378.
28. Rubanyi GM, Desiderio D, Luisi A, Johns A, and Sybertz EJ (1989) Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels. J Pharmacol Exp Ther 249:858-863.
29. Saito S, Hirata Y, Emori T, Imai T, and Marumo F (1996) Angiotensin II activates endothelial constitutive nitric oxide synthase via AT1 receptors. Hypertens Res 19:201-206.
30. Sakai M, Sawada T, Nishimura T, and Nagatsu I (1996) Expression of nitric oxide synthases in the mouse and human nasal mucosa. Acta Histochem Cytochem 29:177-179.
31. Sakata K and Karaki H (1990) Phorbol ester-induced release of endothelium-derived relaxing factor. Eur J Pharmacol 179:207-210.
32. Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Shaul PW, North AJ, Wu LC, Wells LB, Brannon TS, Lau KS, Michel T, Margraf LR, and Star RA (1994) Endothelial nitric oxide expressed in cultured human bronchiolar epithelium. J Clin Invest 94:2231-2236.
34. Stanwell C, Denning MF, Rutberg SE, Cheng C, Yuspa SH, and Dlugosz AA (1996a) Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes. J Invest Dermatol 106:482-489.
35. Stanwell C, Dlugosz AA, and Yuspa SH (1996b) Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C. Carcinogenesis 17:1259-1265.
36. Takahashi K, Sawasaki Y, Hata J, Mukai K, and Goto T (1990) Spontaneous transformation and immortalization of human endothelial cells. In Vitro Cell Dev Biol 26:265-274.
37. Tracey WR, Pollock JS, Murad F, Nakane M, and Förstermann U (1994) Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells. Am J Physiol 266:C22-C28.
38. Wallerath T, Gath I, Aulitzky WE, Pollock JS, Kleinen H, and Förstermann U (1997) Identification of the no synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets. Thromb Haemost 77:163-167.
39. Wohlfart P, Dedio J, Wirth K, Schölkens BA, and Wiemer G (1997) Different B1 kinin receptor expression and pharmacology in endothelial cells of different origins and species. J Pharmacol Exp Ther 280:1109-1116.
40. Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, and Nesher R (1997) Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta cells. J Biol Chem 272:1417-1420.