Cytokine-induced sickness behavior and depression

The Neuroimmunological Basis of Behavior and Mental Disorders

Volumn , Issue , 2009, Pages 145-181

  Chang, Q ^a   Szegedi, S S ^a   O'Connor, J C ^a   Dantzer, R ^a   Kelley, K W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

3 dioxygenase; Cytokines; Depression; Indoleamine 2; Inflammation; Kynurenine; Sickness behavior; Tryptophan

Indexed keywords

EID: 84882192753     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-84851-8_9     Document Type: Chapter

References (273)

1. Abraham E (2000) NF-kappaB activation. Crit Care Med 28:N100-104
2. Allan SM, Rothwell NJ (2003) Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci 358:1669-1677
3. Anisman H, Merali Z (2003) Cytokines, stress and depressive illness: brain-immune interactions. Ann Med 35:2-11
4. Aubert A (1999) Sickness and behaviour in animals: a motivational perspective. Neurosci Biobehav Rev 23: 1029-1036
5. Aubert A, Goodall G, Dantzer R (1995a) Compared effects of cold ambient temperature and cytokines on macronutrient intake in rats. Physiol Behav 57:869-873
6. Aubert A, Kelley KW, Dantzer R (1997a) Differential effect of lipopolysaccharide on food hoarding behavior and food consumption in rats. Brain Behav Immun 11:229-238
7. Aubert A, Vega C, Dantzer R, Goodall G (1995b) Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain Behav Immun 9:129-148
8. Aubert A, Goodall G, Dantzer R, Gheusi G (1997b) Differential effects of lipopolysaccharide on pup retrieving and nest building in lactating mice. Brain Behav Immun 11:107-118
9. Babcock TA, Carlin JM (2000) Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells. Cytokine 12:588-594
10. Bailey SL, Schreiner B, McMahon EJ, Miller SD (2007) CNS myeloid DCs presenting endogenous myelin peptides preferentially polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol 8:172-180
11. Banks WA (2006) The blood-brain barrier in psychoneuroimmunology. Neurol Clin 24:413-419
12. Banks WA, Plotkin SR, Kastin AJ (1995) Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunomodulation 2:161-165
13. Banks WA, Farr SA, Morley JE (2002) Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes. Neuroimmunomodulation 10:319-327
14. Barton GM, Medzhitov R (2003) Toll-like receptor signaling pathways. Science 300:1524-1525
15. Bernardino L, Xapelli S, Silva AP, Jakobsen B, Poulsen FR, Oliveira CR, Vezzani A, Malva JO, Zimmer J (2005) Modulator effects of interleukin-1beta and tumor necrosis factor-Alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci 25:6734-6744
16. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868
17. Besedovsky HO, Rey AD (2007) Physiology of psychoneuroimmunology: a personal view. Brain Behav Immun 21:34-44
18. Blake GJ, Ridker PM (2000) Are statins anti-inflammatory? Curr Control Trials Cardiovasc Med 1:161-165
19. Blatteis CM (1992) Role of the OVLT in the febrile response to circulating pyrogens. Prog Brain Res 91:409-412
20. Bluthe RM, Dantzer R, Kelley KW (1991) Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor alpha in mice. Eur J Pharmacol 209:281-283
21. Bluthe RM, Dantzer R, Kelley KW (1997) Central mediation of the effects of interleukin-1 on social exploration and body weight in mice. Psychoneuroendocrinology 22:1-11
22. Bluthe RM, Kelley KW, Dantzer R (2006) Effects of insulin-like growth factor-I on cytokineinduced sickness behavior in mice. Brain Behav Immun 20:57-63
23. Bluthe RM, Beaudu C, Kelley KW, Dantzer R (1995) Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Res 677:171-176
24. Bluthe RM, Frenois F, Kelley KW, Dantzer R (2005) Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice. J Neuroimmunol 169:50-58
25. Bluthe RM, Bristow A, Lestage J, Imbs C, Dantzer R (2001) Central injection of interleukin-13 potentiates LPS-induced sickness behavior in rats. Neuroreport 12:3979-3983
26. Bluthe RM, Lestage J, Rees G, Bristow A, Dantzer R (2002) Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in rats. Neuropsychopharmacology 26:86-93
27. Bluthe RM, Castanon N, Pousset F, Bristow A, Ball C, Lestage J, Michaud B, Kelley KW, Dantzer R (1999) Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Psychoneuroendocrinology 24:301-311
28. Bluthe RM, Walter V, Parnet P, Laye S, Lestage J, Verrier D, Poole S, Stenning BE, Kelley KW, Dantzer R (1994) Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad Sci III 317:499-503
29. Bonaccorso S, Puzella A, Marino V, Pasquini M, Biondi M, Artini M, Almerighi C, Levrero M, Egyed B, Bosmans E, Meltzer HY, Maes M (2001) Immunotherapy with interferon-Alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms. Psychiatry Res 105:45-55
30. Bornstein SR, Schuppenies A, Wong ML, Licinio J (2006) Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions. Mol Psychiatry 11:892-902
31. Borsini F, Meli A (1988) Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl) 94:147-160
32. Bourin M, Chenu F, Ripoll N, David DJ (2005) A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests. Behav Brain Res 164:266-269
33. Bret-Dibat JL, Creminon C, Couraud JY, Kelley KW, Dantzer R, Kent S (1997) Systemic capsaicin pretreatment fails to block the decrease in food-motivated behavior induced by lipopolysaccharide and interleukin-1beta. Brain Res Bull 42:443-449
34. Byerley WF, Risch SC (1985) Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. J Clin Psychopharmacol 5:191-206
35. Cancello R, Clement K (2006) Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. Bjog 113:1141-1147
36. Capuron L, Ravaud A (1999) Prediction of the depressive effects of interferon alfa therapy by the patients initial affective state. N Engl J Med 340:1370
37. Capuron L, Dantzer R (2003) Cytokines and depression: the need for a new paradigm. Brain Behav Immun 17 Suppl 1:S119-124
38. Capuron L, Ravaud A, Dantzer R (2000) Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy. J Clin Oncol 18:2143-2151
39. Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB, Miller AH (2002) Neurobehavioral effects of interferon-Alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26:643-652
40. Carlsson A (1976) The contribution of drug research to investigating the nature of endogenous depression. Pharmakopsychiatr Neuropsychopharmakol 9:2-10
41. Carpentier PA, Duncan DS, Miller SD (2008) Glial toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav Immun 22:140-147
42. Castanon N, Bluthe RM, Dantzer R (2001) Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat. Psychopharmacology (Berl) 154:50-60
43. Chang Q, Gold PE (2003) Switching memory systems during learning: changes in patterns of brain acetylcholine release in the hippocampus and striatum in rats. J Neurosci 23:3001-3005
44. Chang Q, Gold PE (2004) Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Hippocampus 14:170-179
45. Chang Q, Gold PE (2008) Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol Learn Mem 89:167-177
46. Chang Q, Savage LM, Gold PE (2006) Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate. J Neurochem 97:697-706
47. Connor TJ, Harkin A, Kelly JP, Leonard BE (2000) Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-Alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment. Neuroimmunomodulation 7:27-35
48. Craft TK, DeVries AC (2006) Role of IL-1 in poststroke depressive-like behavior in mice. Biol Psychiatry 60:812-818
49. Crestani F, Seguy F, Dantzer R (1991) Behavioural effects of peripherally injected interleukin-1: role of prostaglandins. Brain Res 542:330-335
50. Crowley JJ, Jones MD, OLeary OF, Lucki I (2004) Automated tests for measuring the effects of antidepressants in mice. Pharmacol Biochem Behav 78:269-274
51. Cryan JF, Mombereau C (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9:326-357
52. Cryan JF, Markou A, Lucki I (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23:238-245
53. Dalvi A, Lucki I (1999) Murine models of depression. Psychopharmacology (Berl) 147:14-16
54. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R (2005) Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111:1448-1454
55. Dantzer R (2001) Cytokine-induced sickness behavior: where do we stand? Brain Behav Immun 15:7-24
56. Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500:399-411
57. Dantzer R (2006) Cytokine, sickness behavior, and depression. Neurol Clin 24:441-460
58. Dantzer R, Kelley KW (1989) Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci 44:1995-2008
59. Dantzer R, Kelley KW (2007) Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 21:153-160
60. Dantzer R, Bluthe RM, Kelley KW (1991) Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior. Brain Res 557:115-120
61. Dantzer R, Gheusi G, Johnson RW, Kelley KW (1999) Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice. Neuroreport 10:289-292
62. Dantzer R, Konsman JP, Bluthe RM, Kelley KW (2000) Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent? Auton Neurosci 85:60-65
63. Dantzer R, OConnor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46-56
64. De La Garza R, 2nd (2005) Endotoxin-or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia. Neurosci Biobehav Rev 29:761-770
65. Denicoff KD, Rubinow DR, Papa MZ, Simpson C, Seipp CA, Lotze MT, Chang AE, Rosenstein D, Rosenberg SA (1987) The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-Activated killer cells. Ann Intern Med 107:293-300
66. Dilsaver SC (1986a) Pharmacologic induction of cholinergic system up-regulation and supersensitivity in affective disorders research. J Clin Psychopharmacol 6:65-74
67. Dilsaver SC (1986b) Cholinergic mechanisms in depression. Brain Res 396:285-316
68. Dinarello CA (2007) Historical insights into cytokines. Eur J Immunol 37 Suppl 1:S34-45
69. Dunn AL, Trivedi MH, ONeal HA (2001) Physical activity dose-response effects on outcomes of depression and anxiety. Med Sci Sports Exerc 33:S587-597; discussion 609-510
70. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005) Exercise treatment for depression: efficacy and dose response. Am J Prev Med 28:1-8
71. Eison MS (1990) Serotonin: a common neurobiologic substrate in anxiety and depression. J Clin Psychopharmacol 10:26S-30S
72. El Yacoubi M, Vaugeois JM (2007) Genetic rodent models of depression. Curr Opin Pharmacol 7:3-7
73. Faith MS, Matz PE, Jorge MA (2002) Obesity-depression associations in the population. J Psychosom Res 53:935-942
74. Ferrante AW, Jr. (2007) Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 262:408-414
75. Ferri CC, Yuill EA, Ferguson AV (2005) Interleukin-1beta depolarizes magnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductance. Regul Pept 129:63-71
76. Ferroni P, Basili S, Falco A, Davi G (2004) Inflammation, insulin resistance, and obesity. Curr Atheroscler Rep 6:424-431
77. Forrester JS, Libby P (2007) The inflammation hypothesis and its potential relevance to statin therapy. Am J Cardiol 99:732-738
78. Frenois F, Moreau M, OConnor J, Lawson M, Micon C, Lestage J, Kelley KW, Dantzer R, Castanon N (2007) Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 32:516-531
79. Fuchs D, Moller AA, Reibnegger G, Stockle E, Werner ER, Wachter H (1990) Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J Acquir Immune Defic Syndr 3:873-876
80. Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, Seishima M (2006) The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-Activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J Biochem 139:655-662
81. Gaykema RP, Goehler LE, Hansen MK, Maier SF, Watkins LR (2000) Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation. Auton Neurosci 85:72-77
82. Getting SJ (2006) Targeting melanocortin receptors as potential novel therapeutics. Pharmacol Ther 111:1-15
83. Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW (2005b) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. Faseb J 19:1329-1331
84. Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O'Connor JC, Castanon N, Kelley KW, Dantzer R, Johnson RW (2007, Sep) Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System. Neuropsychopharmacology 33(10):2341-51
85. Goeb JL, Even C, Nicolas G, Gohier B, Dubas F, Garre JB (2006) Psychiatric side effects of interferon-beta in multiple sclerosis. Eur Psychiatry 21:186-193
86. Goehler LE, Erisir A, Gaykema RP. (2006, Jul 21) Neural-immune interface in the rate area postrema. Neuroscience 140(4):1415-34
87. Goehler LE, Lyte M, Gaykema RP (2007) Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology. Brain Behav Immun 21:721-726
88. Goehler LE, Gaykema RP, Hammack SE, Maier SF, Watkins LR (1998) Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res 804:306-310
89. Goehler LE, Gaykema RP, Hansen MK, Anderson K, Maier SF, Watkins LR (2000) Vagal immuneto-brain communication: a visceral chemosensory pathway. Auton Neurosci 85:49-59
90. Goehler LE, Relton JK, Dripps D, Kiechle R, Tartaglia N, Maier SF, Watkins LR (1997) Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Res Bull 43:357-364
91. Goehler LE, Gaykema RP, Nguyen KT, Lee JE, Tilders FJ, Maier SF, Watkins LR (1999) Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J Neurosci 19:2799-2806
92. Gourine AV, Rudolph K, Korsak AS, Kubatko J, Tesfaigzi J, Kozak W, Kluger MJ (2001) Role of capsaicin-sensitive afferents in fever and cytokine responses during systemic and local inflammation in rats. Neuroimmunomodulation 9:13-22
93. Greenberg AS, Obin MS (2006) Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 83:461S-465S
94. Greenwood BN, Strong PV, Dorey AA, Fleshner M (2007a) Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape. Behav Neurosci 121:992-1000
95. Greenwood BN, Strong PV, Foley TE, Thompson RS, Fleshner M (2007b) Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience 144:1193-1208
96. Greenwood BN, Foley TE, Day HE, Campisi J, Hammack SH, Campeau S, Maier SF, Fleshner M (2003) Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci 23:2889-2898
97. Grohmann U, Fallarino F, Puccetti P (2003) Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24:242-248
98. Hachinski V (1999) Post-stroke depression, not to be underestimated. Lancet 353:1728
99. Harden LM, du Plessis I, Poole S, Laburn HP (2006) Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior. Physiol Behav 89:146-155
100. Harden LM, Plessis ID, Poole S, Laburn HP (2008, Aug) Interleukin (IL)-6 and IL-1beta act synergistically within the brain to induce sickness behavior and fever in rats. Brain Behav Immun. 22(6):838-49
101. Hart BL (1988) Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 12:123-137
102. Hasday JD, Garrison A (2000) Antipyretic therapy in patients with sepsis. Clin Infect Dis 31 Suppl 5:S234-241
103. Hasday JD, Fairchild KD, Shanholtz C (2000) The role of fever in the infected host. Microbes Infect 2:1891-1904
104. Hauser P, Soler R, Reed S, Kane R, Gulati M, Khosla J, Kling MA, Valentine AD, Meyers CA (2000) Prophylactic treatment of depression induced by interferon-Alpha. Psychosomatics 41:439-441
105. Heyen JR, Ye S, Finck BN, Johnson RW (2000) Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB. Brain Res Mol Brain Res 77:138-147
106. Holmes TE, Miller NE (1963) Effects of bacterial endotoxin on water intake, food intake and body temperature in the albino rat. J Exp Med 118: 649-658
107. Hopkins SJ (2007) Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration. Acta Biomed 78 Suppl 1:231-247
108. Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS (2007, Dec). Antidepressant actions of the exercise-regulated gene VGF. Nat Med 13(12):1476-82
109. Intiso D, Zarrelli MM, Lagioia G, Di Rienzo F, Checchia De Ambrosio C, Simone P, Tonali P, Cioffi Dagger RP (2004) Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 24:390-396
110. Irwin MR, Miller AH (2007) Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun 21:374-383
111. Jesberger JA, Richardson JS (1988) Brain output dysregulation induced by olfactory bulbectomy: an approximation in the rat of major depressive disorder in humans? Int J Neurosci 38: 241-265
112. Johnson RW, Gheusi G, Segreti S, Dantzer R, Kelley KW (1997) C3H/HeJ mice are refractory to lipopolysaccharide in the brain. Brain Res 752:219-226
113. Katsuura G, Arimura A, Koves K, Gottschall PE. (1990, Jan) Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. Am J Physiol 258(1 Pt 1):E163-71
114. Katz RJ (1982) Animal model of depression: pharmacological sensitivity of a hedonic deficit. Pharmacol Biochem Behav 16:965-968
115. Kelley KW, Bluthe RM, Dantzer R, Zhou JH, Shen WH, Johnson RW, Broussard SR (2003) Cytokine-induced sickness behavior. Brain Behav Immun 17 Suppl 1:S112-118
116. Kenis G, Maes M (2002) Effects of antidepressants on the production of cytokines. Int J Neuropsychopharmacol 5:401-412
117. Kent S, Kelley KW, Dantzer R (1992a) Effects of lipopolysaccharide on food-motivated behavior in the rat are not blocked by an interleukin-1 receptor antagonist. Neurosci Lett 145:83-86
118. Kent S, Bluthe RM, Kelley KW, Dantzer R (1992b) Sickness behavior as a new target for drug development. Trends Pharmacol Sci 13:24-28
119. Kent S, Rodriguez F, Kelley KW, Dantzer R (1994) Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat. Physiol Behav 56:1031-1036
120. Kent S, Bluthe RM, Dantzer R, Hardwick AJ, Kelley KW, Rothwell NJ, Vannice JL (1992c) Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc Natl Acad Sci USA 89:9117-9120
121. Kim L, Butcher BA, Denkers EY (2004) Toxoplasma gondii interferes with lipopolysaccharideinduced mitogen-Activated protein kinase activation by mechanisms distinct from endotoxin tolerance. J Immunol 172:3003-3010
122. Kinder LS, Carnethon MR, Palaniappan LP, King AC, Fortmann SP (2004) Depression and the metabolic syndrome in young adults: findings from the Third National Health and Nutrition Examination Survey. Psychosom Med 66:316-322
123. King NJ, Thomas SR (2007) Molecules in focus: indoleamine 2,3-dioxygenase. Int J Biochem Cell Biol 39:2167-2172
124. Kluger MJ (1979) Temperature regulation, fever, and disease. Int Rev Physiol 20:209-251
125. Kluger MJ (1986) Is fever beneficial? Yale J Biol Med 59:89-95
126. Kluger MJ (1991) Fever: role of pyrogens and cryogens. Physiol Rev 71:93-127
127. Komaki G, Arimura A, Koves K (1992) Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis. Am J Physiol 262:E246-251
128. Konsman JP, Kelley K, Dantzer R (1999) Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain. Neuroscience 89:535-548
129. Konsman JP, Tridon V, Dantzer R (2000) Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS. Neuroscience 101:957-967
130. Larson SJ, Dunn AJ (2001) Behavioral effects of cytokines. Brain Behav Immun 15:371-387
131. Laye S, Gheusi G, Cremona S, Combe C, Kelley K, Dantzer R, Parnet P (2000) Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am J Physiol Regul Integr Comp Physiol 279:R93-98
132. Laye S, Bluthe RM, Kent S, Combe C, Medina C, Parnet P, Kelley K, Dantzer R (1995) Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS. Am J Physiol 268:R1327-1331
133. Lee YH, Pratley RE (2005) The evolving role of inflammation in obesity and the metabolic syndrome. Curr Diab Rep 5:70-75
134. Lenczowski MJ, Bluthe RM, Roth J, Rees GS, Rushforth DA, van Dam AM, Tilders FJ, Dantzer R, Rothwell NJ, Luheshi GN (1999) Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. Am J Physiol 276:R652-658
135. Leon LR, Kozak W, Rudolph K, Kluger MJ (1999) An antipyretic role for interleukin-10 in LPS fever in mice. Am J Physiol 276:R81-89
136. Lestage J, Verrier D, Palin K, Dantzer R (2002) The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen. Brain Behav Immun 16:596-601
137. Linthorst AC, Flachskamm C, Muller-Preuss P, Holsboer F, Reul JM (1995) Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study. J Neurosci 15: 2920-2934
138. Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ (2003) Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. J Biol Chem 278:29525-29531
139. Loftis JM, Huckans M, Ruimy S, Hinrichs DJ, Hauser P (2008) Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1beta and tumor necrosis factor-Alpha. Neurosci Lett 430:264-268
140. Lowe B, Hochlehnert A, Nikendei C (2006) [Metabolic syndrome and depression]. Ther Umsch 63:521-527
141. Lyketsos CG, Olin J (2002) Depression in Alzheimers disease: overview and treatment. Biol Psychiatry 52:243-252
142. Lyketsos CG, Lee HB (2004) Diagnosis and treatment of depression in Alzheimers disease. A practical update for the clinician. Dement Geriatr Cogn Disord 17:55-64
143. Maes M, Smith R, Scharpe S (1995) The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology 20:111-116
144. Maes M, Bosmans E, Suy E, Vandervorst C, DeJonckheere C, Raus J (1991) Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1 beta and soluble interleukin-2 receptor production. Acta Psychiatr Scand 84:379-386
145. Maes M, Lambrechts J, Bosmans E, Jacobs J, Suy E, Vandervorst C, de Jonckheere C, Minner B, Raus J (1992) Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med 22:45-53
146. Maier SF. (1984) Learned helplessness and animal models of depression. Prog neuropsychopharmacol Biol Psychiatry 8(3):435-46
147. Maness LM, Kastin AJ, Banks WA (1998) Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1alpha to the brain. Am J Physiol 275:E207-212
148. Martinsen EW (1994) Physical activity and depression: clinical experience. Acta Psychiatr Scand Suppl 377:23-27
149. Massol J, Martin P, Belon JP, Puech AJ, Soubrie P (1989) Helpless behavior (escape deficits) in streptozotocin-diabetic rats: resistance to antidepressant drugs. Psychoneuroendocrinology 14:145-153
150. McArthur R, Borsini F (2006) Animal models of depression in drug discovery: a historical perspective. Pharmacol Biochem Behav 84:436-452
151. McCaffery JM, Frasure-Smith N, Dube MP, Theroux P, Rouleau GA, Duan Q, Lesperance F (2006) Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin. Psychosom Med 68:187-200
152. McCusker RH, McCrea K, Zunich S, Dantzer R, Broussard SR, Johnson RW, Kelley KW (2006) Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons. J Neuroimmunol 179:186-190
153. McElroy SL, Kotwal R, Malhotra S, Nelson EB, Keck PE, Nemeroff CB (2004) Are mood disorders and obesity related? A review for the mental health professional. J Clin Psychiatry 65:634-651
154. McIntyr RS, Soczynska JK, Konarski JZ, Woldeyohannes HO, Law C, Miranda A, Fulgosi D, Kennedy SH (2007, Oct-Dec). Should Depressive Syndromes Be Reclassified as Metabolic Syndrome Type II? Ann Clin Psychiatry 19(4):257-64
155. McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD (2005) Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 11:335-339
156. Mellor AL, Munn DH (1999) Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 20:469-473
157. Mensah GA, Mokdad AH, Ford E, Narayan KM, Giles WH, Vinicor F, Deedwania PC (2004) Obesity, metabolic syndrome, and type 2 diabetes: emerging epidemics and their cardiovascular implications. Cardiol Clin 22:485-504
158. Merali Z, Lacosta S, Anisman H (1997) Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study. Brain Res 761:225-235
159. Meyers CA (1999) Mood and cognitive disorders in cancer patients receiving cytokine therapy. Adv Exp Med Biol 461:75-81
160. Meyers CA, Valentine AD (1995) Neurologic and psychiatric adverse effects of immunological therapy. CNS Drugs 3: 56-68
161. Miller NE (1964), Some psychophysiological studies of motivation and the behavioral effects of illness. Bull Br Psychol Soc 17:1-20
162. Miller SD, McMahon EJ, Schreiner B, Bailey SL (2007) Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann NY Acad Sci 1103:179-191
163. Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ (2006) Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol 2:293-308
164. Miyaoka H, Otsubo T, Kamijima K, Ishii M, Onuki M, Mitamura K (1999) Depression from interferon therapy in patients with hepatitis C. Am J Psychiatry 156:1120
165. Moreau M, Andr C, OConnor JC, Dumich SA, Woods JA, Kelley KW, Dantzer R, Lestage J, Castanon N (2008), Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior, Brain Behav Immun (submitted)
166. Monleon S, DAquila P, Parra A, Simon VM, Brain PF, Willner P (1995) Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology (Berl) 117:453-457
167. Mormde C, Castanon N, Mdina C, Moze E, Lestage J, Neveu PJ, Dantzer R (2002-2003). Chronic mild stress in mice decreases peripheral cytikine and increases central cytokine expression independently of IL-10 regulation of the cytokine network. Neuroimmunomodulation 10(6):359-66
168. Moraska A, Fleshner M (2001) Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression. Am J Physiol Regul Integr Comp Physiol 281:R484-489
169. Morikawa O, Sakai N, Obara H, Saito N (1998) Effects of interferon-Alpha, interferon-gamma and cAMP on the transcriptional regulation of the serotonin transporter. Eur J Pharmacol 349:317-324
170. Mossner R, Daniel S, Albert D, Heils A, Okladnova O, Schmitt A, Lesch KP (2000) Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochem Int 36:197-202
171. Muller N, Schwarz MJ (2007) The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 12:988-1000
172. Muller N, Schwarz MJ, Dehning S, Douhe A, Cerovecki A, Goldstein-Muller B, Spellmann I, Hetzel G, Maino K, Kleindienst N, Moller HJ, Arolt V, Riedel M (2006) The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 11:680-684
173. Muscat R, Papp M, Willner P (1992) Antidepressant-like effects of dopamine agonists in an animal model of depression. Biol Psychiatry 31:937-946
174. Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S, Goodkin RS, Greiner K, Nemeroff CB, Miller AH (2001) Paroxetine for the prevention of depression induced by highdose interferon alfa. N Engl J Med 344:961-966
175. Musso T, Gusella GL, Brooks A, Longo DL, Varesio L (1994) Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes. Blood 83:1408-1411
176. Nakamura S (1991) Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment. Prog Brain Res 88:587-598
177. Neveu PJ, Bluthe RM, Liege S, Moya S, Michaud B, Dantzer R (1998) Interleukin-1-induced sickness behavior depends on behavioral lateralization in mice. Physiol Behav 63:587-590
178. Nutt DJ (2002) The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 17 Suppl 1:S1-12
179. Nys GM, van Zandvoort MJ, van der Worp HB, de Haan EH, de Kort PL, Kappelle LJ (2005) Early depressive symptoms after stroke: neuropsychological correlates and lesion characteristics. J Neurol Sci 228:27-33
180. OConnor JC, Lawson MA, Andr C, Moreau M, Lestage J, Castanon N, Kelley KW, Dantzer R (2008, Jan 15) Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry. [Epub ahead of print]
181. Owe-Young R, Webster NL, Mukhtar M, Pomerantz RJ, Smythe G, Walker D, Armati PJ, Crowe SM, Brew BJ (2008, May) Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance & neurotoxicity. J Neurochem. 105(4):1346-57
182. Palin K, Bluthe RM, McCusker RH, Moos F, Dantzer R, Kelley KW (2007) TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I. J Neuroimmunol 187:55-60
183. Palin K, Moreau MM, Orcel H, Duvoid-Guillou A, Rabie A, Kelley KW, Moos F (2008) Age impaired fluid homeostasis depends on the balance of IL-6/IGF-1 in the supraoptic nuclei of rats. Neurobiology of Aging. (Epub ahead of print)
184. Pan W, Kastin AJ (2001) Upregulation of the transport system for TNFalpha at the blood-brain barrier. Arch Physiol Biochem 109:350-353
185. Peruzzo B, Pastor FE, Blazquez JL, Schobitz K, Pelaez B, Amat P, Rodriguez EM (2000) A second look at the barriers of the medial basal hypothalamus. Exp Brain Res 132:10-26
186. Plotkin SR, Banks WA, Kastin AJ (1996) Comparison of saturable transport and extracellular pathways in the passage of interleukin-1 alpha across the blood-brain barrier. J Neuroimmunol 67:41-47
187. Pohjasvaara T, Leppavuori A, Siira I, Vataja R, Kaste M, Erkinjuntti T (1998) Frequency and clinical determinants of poststroke depression. Stroke 29:2311-2317
188. Pollak Y, Ovadia H, Goshen I, Gurevich R, Monsa K, Avitsur R, Yirmiya R (2000, Apr 3). Behavioral aspects of experimental autoimmune encephalomyelitis. J Neuroimmunol 104(1):31-6
189. Pollak Y, Yirmiya R (2002) Cytokine-induced changes in mood and behaviour: implications for depression due to a general medical condition, immunotherapy and antidepressive treatment. Int J Neuropsychopharmacol 5:389-399
190. Porsolt RD, Bertin A, Jalfre M (1977a) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327-336
191. Porsolt RD, Le Pichon M, Jalfre M (1977b) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732
192. Quan N, Banks WA (2007) Brain-immune communication pathways. Brain Behav Immun 21:727-735
193. Quan N, Whiteside M, Herkenham M (1998) Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide. Neuroscience 83:281-293
194. Quan N, Whiteside M, Kim L, Herkenham M (1997) Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the rat. Proc Natl Acad Sci USA 94:10985-10990
195. Quan N, Stern EL, Whiteside MB, Herkenham M (1999) Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol 93:72-80
196. Quan N, He L, Lai W, Shen T, Herkenham M (2000) Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling. J Neurosci 20:6473-6477
197. Quan N, Herkenham M (2002) Connecting cytokines and brain: a review of current issues. Histol Histopathol 17:273-288
198. Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27:24-31
199. Renault PF, Hoofnagle JH, Park Y, Mullen KD, Peters M, Jones DB, Rustgi V, Jones EA (1987) Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med 147:1577-1580
200. Rhodes JS, Ryabinin AE, Crabbe JC (2005) Patterns of brain activation associated with contextual conditioning to methamphetamine in mice. Behav Neurosci 119:759-771
201. Ridker PM, Hennekens CH, Buring JE, Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843
202. Rivest S (2001) How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-Adrenal axis. Psychoneuroendocrinology 26:761-788
203. Rivest S (2003) Molecular insights on the cerebral innate immune system. Brain Behav Immun 17:13-19
204. Rodriguez EM, Blazquez JL, Pastor FE, Pelaez B, Pena P, Peruzzo B, Amat P (2005) Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 247:89-164
205. Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN (2001) The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol 115:91-100
206. Rosenberg PB (2005) Clinical aspects of inflammation in Alzheimers disease. Int Rev Psychiatry 17:503-514
207. Roth J, De Souza GE (2001) Fever induction pathways: evidence from responses to systemic or local cytokine formation. Braz J Med Biol Res 34:301-314
208. Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L (2005, Mar 1). The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol 45(5):637-51
209. Rudisch B, Nemeroff CB (2003) Epidemiology of comorbid coronary artery disease and depression. Biol Psychiatry 54:227-240
210. Rupniak NM (2003) Animal models of depression: challenges from a drug development perspective. Behav Pharmacol 14:385-390
211. Schiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol. Biol Psychiatry 29:201-217
212. Schrocksnadel K, Wirleitner B, Winkler C, Fuchs D (2006) Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 364:82-90
213. Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1-10
214. Selye, H (1936), A syndrome produced by diverse nocuous agents. Nature 138 (4, July)
215. Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE (1999) Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Sci 65:1773-1786
216. Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD (2000) Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 275:6628-6635
217. Sherwin CM (1998) Voluntary wheel running: a review and novel interpretation. Anim Behav 56:11-27
218. Shimbo D, Chaplin W, Crossman D, Haas D, Davidson KW (2005) Role of depression and inflammation in incident coronary heart disease events. Am J Cardiol 96:1016-1021
219. Siegert RJ, Abernethy DA (2005) Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry 76:469-475
220. Skilton MR, Moulin P, Terra JL, Bonnet F (2007) Associations between anxiety, depression, and the metabolic syndrome. Biol Psychiatry 62:1251-1257
221. Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35:298-306
222. Song C, Leonard BE (2005). The olfactory bulbectomised rat as a model of depression. Neurosci Biobehav Rev 29(4-5):627-47
223. Sola S, Mir MQ, Lerakis S, Tandon N, Khan BV (2006) Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 47:332-337
224. Spalletta G, Bossu P, Ciaramella A, Bria P, Caltagirone C, Robinson RG (2006) The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry 11:984-991
225. Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW (2006) Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci 26:10709-10716
226. Starkstein SE, Mizrahi R (2006) Depression in Alzheimers disease. Expert Rev Neurother 6:887-895
227. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85:367-370
228. Stone TW, Forrest CM, Mackay GM, Stoy N, Darlington LG (2007) Tryptophan, adenosine, neurodegeneration and neuroprotection. Metab Brain Dis 22:337-352
229. Strine TW, Mokdad AH, Dube SR, Balluz LS, Gonzalez O, Berry JT, Manderscheid R, Kroenke K (2008) The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. Gen Hosp Psychiatry 30:127-137
230. Strle K, McCusker RH, Johnson RW, Zunich SM, Dantzer R, Kelley KW (2008, Apr) The Prototypical Anti-Inflammatory Cytokine, IL-10, Prevents Loss of IGF-I-Induced Myogenin Protein Expression Caused by IL-1beta. Am J Physiol Endocrinol Metab 294(4):E709-18
231. Strle K, Zhou JH, Shen WH, Broussard SR, Johnson RW, Freund GG, Dantzer R, Kelley KW (2001) Interleukin-10 in the brain. Crit Rev Immunol 21:427-449
232. Stunkard AJ, Faith MS, Allison KC (2003) Depression and obesity. Biol Psychiatry 54:330-337
233. Sugimoto H, Oda S, Otsuki T, Hino T, Yoshida T, Shiro Y (2006) Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci USA 103:2611-2616
234. Sutherland JP, McKinley B, Eckel RH (2004) The metabolic syndrome and inflammation. Metab Syndr Relat Disord 2:82-104
235. Swiergiel AH, Smagin GN, Dunn AJ (1997) Influenza virus infection of mice induces anorexia: comparison with endotoxin and interleukin-1 and the effects of indomethacin. Pharmacol Biochem Behav 57:389-396
236. Takikawa O, Yoshida R, Kido R, Hayaishi O (1986) Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem 261:3648-3653
237. Taniguchi T, Sono M, Hirata F, Hayaishi O, Tamura M, Hayashi K, Iizuka T, Ishimura Y (1979) Indoleamine 2,3-dioxygenase. Kinetic studies on the binding of superoxide anion and molecular oxygen to enzyme. J Biol Chem 254:3288-3294
238. Tayal V, Kalra BS (2008) Cytokines and anti-cytokines as therapeutics -An update. Eur J Pharmacol 579:1-12
239. Taylor MW, Feng GS (1991) Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. Faseb J 5:2516-2522
240. Tazi A, Dantzer R, Crestani F, Le Moal M (1988) Interleukin-1 induces conditioned taste aversion in rats: a possible explanation for its pituitary-Adrenal stimulating activity. Brain Res 473:369-371
241. Telner JI, Singhal RL (1981) Effects of nortriptyline treatment on learned helplessness in the rat. Pharmacol Biochem Behav 14:823-826
242. Telner JI, Singhal RL, Lapierre YD (1981) Reversal of learned helplessness by nortriptyline. Prog Neuropsychopharmacol 5:587-590
243. Teste JF, Pelsy-Johann I, Decelle T, Boulu RG (1993) Anti-immobility activity of different antidepressant drugs using the tail suspension test in normal or reserpinized mice. Fundam Clin Pharmacol 7:219-226
244. Thomas WE (1999) Brain macrophages: on the role of pericytes and perivascular cells. Brain Res Brain Res Rev 31:42-57
245. Tune LE (1998) Depression and Alzheimers disease. Depress Anxiety 8 Suppl 1:91-95
246. Tuppo EE, Arias HR (2005) The role of inflammation in Alzheimers disease. Int J Biochem Cell Biol 37:289-305
247. van der Bruggen T, Nijenhuis S, van Raaij E, Verhoef J, van Asbeck BS (1999) Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/ MEK1-MEK2/ERK1-ERK2 pathway. Infect Immun 67:3824-3829
248. Vargas-Perez H, Borrelli E, Diaz JL (2004) Wheel running use in dopamine D2L receptor knockout mice. Neurosci Lett 366:172-175
249. Vila N, Castillo J, Davalos A, Chamorro A (2000) Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke 31:2325-2329
250. Vitkovic L, Konsman JP, Bockaert J, Dantzer R, Homburger V, Jacque C (2000) Cytokine signals propagate through the brain. Mol Psychiatry 5:604-615
251. Watkins LR, Maier SF (2000) The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 51:29-57
252. Watkins LR, Maier SF, Goehler LE (1995a) Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci 57:1011-1026
253. Watkins LR, Maier SF, Goehler LE (1995b) Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 63:289-302
254. Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF (2007) Norman Cousins Lecture. Glia as the bad guys: implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun 21:131-146
255. Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D, Maier SF (1995c) Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 183:27-31
256. Weinstock-Guttman B, Ransohoff RM, Kinkel RP, Rudick RA (1995) The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann Neurol 37:7-15
257. Weisman D, Hakimian E, Ho GJ (2006) Interleukins, inflammation, and mechanisms of Alzheimers disease. Vitam Horm 74:505-530
258. Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharpe S, Maes M (2005) IDO and interferonalpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 10:538-544
259. Wichers MC, Maes M (2004, Jan). The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-Alpha-induced depression. J Psychiatry Neurosci. 29(1):11-7
260. Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D (2002) Neopterin production, tryptophan degradation, and mental depression -what is the link? Brain Behav Immun 16:590-595
261. Willner P (1995) Animal models of depression: validity and applications. Adv Biochem Psychopharmacol 49:19-41
262. Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52:90-110
263. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93(3):358-64
264. Xia Z, DePierre JW, Nassberger L (1996) Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-Alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells. Immunopharmacology 34:27-37
265. Yirmiya R (1996) Endotoxin produces a depressive-like episode in rats. Brain Res 711:163-174
266. Yirmiya R, Barak O, Avitsur R, Gallily R, Weidenfeld J (1997) Intracerebral administration of Mycoplasma fermentans produces sickness behavior: role of prostaglandins. Brain Res 749:71-81
267. Yirmiya R, Pollak Y, Barak O, Avitsur R, Ovadia H, Bette M, Weihe E, Weidenfeld J (2001) Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 24:531-544
268. Yirmiya R, Pollak Y, Morag M, Reichenberg A, Barak O, Avitsur R, Shavit Y, Ovadia H, Weidenfeld J, Morag A, Newman ME, Pollmacher T (2000) Illness, cytokines, and depression. Ann NY Acad Sci 917:478-487
269. Young-Xu Y, Chan KA, Liao JK, Ravid S, Blatt CM (2003) Long-term statin use and psychological well-being. J Am Coll Cardiol 42:690-697
270. Yuan W, Collado-Hidalgo A, Yufit T, Taylor M, Varga J (1998) Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-beta: selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression. J Cell Physiol 177:174-186
271. Yudkin JS (2007) Inflammation, obesity, and the metabolic syndrome. Horm Metab Res 39:707-709
272. Zaremba J, Losy J (2001) Early TNF-Alpha levels correlate with ischaemic stroke severity. Acta Neurol Scand 104:288-295
273. Zaremba J, Skrobanski P, Losy J (2001) Tumour necrosis factor-Alpha is increased in the cerebrospinal fluid and serum of ischaemic stroke patients and correlates with the volume of evolving brain infarct. Biomed Pharmacother 55:258-263.