Molecular insights on the cerebral innate immune system

Brain, Behavior, and Immunity

Volumn 17, Issue 1, 2003, Pages 13-19

  Rivest, Serge ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Blood brain barrier; CD14; Cerebral capillaries; Infection; Microglia; NF B; PAMPs; Pro inflammatory cytokines; Toll like receptors

Indexed keywords

ANTIGEN; CD14 ANTIGEN; ENDOTOXIN; GLUCOCORTICOID; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

BACTERIAL INFECTION; BRAIN; BRAIN INJURY; BRAIN REGION; CELL ACTIVATION; CELL KILLING; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC CODE; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; MEDIATOR; MENINX; MICROBIAL IMMUNITY; MICROGLIA; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NEUROIMMUNOLOGY; NONHUMAN; PARENCHYMA; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION; SURVIVAL; TRANSCRIPTION INITIATION;

ANIMALS; BRAIN; CYTOKINES; GENE EXPRESSION; GLUCOCORTICOIDS; INFLAMMATION MEDIATORS; SIGNAL TRANSDUCTION;

EID: 0037320253     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-1591(02)00055-7     Document Type: Short Survey

References (22)

1. Anderson K.V. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12:2000;13-19.
2. Dalpke A.H., Schafer M.K., Frey M., Zimmermann S., Tebbe J., Weihe E., Heeg K. Immunostimulatory CpG-DNA activates murine microglia. J. Immunol. 168:2002;4854-4863.
3. Delhase M., Hayakawa M., Chen Y., Karin M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science. 284:1999;309-313.
4. Herx L.M., Rivest S., Yong V.W. Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1β is required for the production of ciliary neurotrophic factor. J. Immunol. 165:2000;2232-2239.
5. Hirschfeld M., Ma Y., Weis J.H., Vogel S.N., Weis J.J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165:2000;618-622.
6. Kakimura J., Kitamura Y., Takata K., Umeki M., Suzuki S., Shibagaki K., Taniguchi T., Nomura Y., Gebicke-Haerter P.J., Smith M.A., Perry G., Shimohama S. Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J. 16:2002;601-603.
7. Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 20:2000;6309-6316.
8. Lacroix S., Feinstein D., Rivest S. The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations. Brain Pathol. 8:1998;625-640.
9. Laflamme N., Rivest S. Effects of systemic immunogenic insults and circulating pro-inflammatory cytokines on the transcription of the IκBα within specific cellular populations of the rat brain. J. Neurochem. 73:1999;309-321.
10. Laflamme N., Rivest S. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating Gram-negative bacterial cell wall components. FASEB J. 15:2001;155-163.
11. Laflamme N., Lacroix S., Rivest S. An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain barrier in response to systemic and localized inflammation, but not during endotoxemia. J. Neurosci. 19:1999;10923-10930.
12. Laflamme N., Souci G., Rivest S. Circulating cell wall components derived from Gram-negative and not Gram-positive bacteria cause a profound transcriptional activation of the gene encoding Toll-like receptor 2 in the CNS. J. Neurochem. 70:2001;648-657.
13. Mason J.L., Suzuki K., Chaplin D.D., Matsushima G.K. Interleukin-1β promotes repair of the CNS. J. Neurosci. 21:2001;7046-7052.
14. Nadeau S., Rivest S. Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and NF-κB activity in the brain during endotoxemia. J. Neurosci. 20:2000;3456-3468.
15. Nadeau S., Rivest S. Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal LPS injection: role of glucocorticoids and CD14. J. Immunol. 169:2002;3370-3381.
16. Nguyen M.D., Julien J.P., Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration. Nat. Rev. Neurosci. 3:2002;216-227.
17. Owens T., Wekerle H., Antel J. Genetic models for CNS inflammation. Nat. Med. 7:2001;161-166.
18. Quan N., Whiteside M., Kim L., Herkenham M. Induction of IκBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the rat. Proc. Natl. Acad. Sci. USA. 94:1997;10985-10990.
19. Quan N., He L., Lai W., Shen T., Herkenham M. Induction of IκBα mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling. J. Neurosci. 20:2000;6473-6477.
20. Vallières L., Rivest S. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the pro-inflammatory cytokine interleukin-1β J. Neurochem. 69:1997;1668-1683.
21. Wright S.D. Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189:1999;605-609.
22. Zheng H., Fletcher D., Kozak W., Jiang M., Hofmann K.J., Conn C.A., Soszynski D., Grabiec C., Trumbauer M.E., Shaw A., Kostura M.J., Stevens K., Rosen H., North R.J., Chen H.Y., Tocci M.J., Kluger M.J., VanDerPloeg L.H.T. Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice. Immunity. 3:1995;9-19.