Induction of IκBα mRNA expression in the brain by glucocorticoids: A negative feedback mechanism for immune-to-brain signaling

Journal of Neuroscience

Volumn 20, Issue 17, 2000, Pages 6473-6477

  Quan, Ning ^a   He, Lingli ^a   Lai, Wenmin ^a   Shen, Tiansheng ^a   Herkenham, Miles ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Brain; Glucocorticoid; Inflammatory cytokines; Interleukin 1; I B ; Lipopolysaccharide

Indexed keywords

DEXAMETHASONE; ENDOTOXIN; GLUCOCORTICOID; INTERLEUKIN 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MIFEPRISTONE; TUMOR NECROSIS FACTOR ALPHA; DNA BINDING PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; GENE EXPRESSION; GENE INDUCTION; IMMEDIATE EARLY GENE; IMMOBILIZATION; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; MALE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNE SYSTEM; IMMUNOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; DEXAMETHASONE; DNA-BINDING PROTEINS; FEEDBACK; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; I-KAPPA B PROTEINS; IMMUNE SYSTEM; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0034257924     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-17-06473.2000     Document Type: Article

References (27)

1. Repeated immobilization stress increases total cytosolic glucocorticoid receptor in rat liver
2. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
3. Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
4. Dexamethasone suppression of corticosteroid secretion: Evaluation of the site of action by receptor measures and functional studies
5. Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus
6. Rel/NF-κB/I κB story
7. Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor κ B activity in the brain during endotoxemia
8. The effect of repeated immobilization on the level of plasma corticosterone and on the activity of several liver enzymes in rats
9. Exposure to acute stress induces brain interleukin-1β protein in the rat
10. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress
11. Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse
12. Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1β
13. Neither acute nor chronic exposure to a naturalistic (predator) stressor influences the interleukin-1β system, tumor necrosis factor-α, transforming growth factor-β1, and neuropeptide mRNAs in specific brain regions
14. Brain cytokine expression in response to peripheral infection
15. Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat
16. Time course and localization patterns of interleukin-1β messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide
17. In vivo control of NF-kappa B activation by I kappa B alpha
18. Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
19. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
20. Stress-induced neuroendocrine modulation of viral pathogenesis and immunity
21. Hypothalamic PGE2 and cAMP production and adrenocortical activation following intraperitoneal endotoxin injection: In vivo microdialysis studies in Lewis and Fischer rats
22. Dexamethasone attenuates NF-kappa B DNA binding activity without inducing I kappa B levels in rat brain in vivo
23. Induction of pituitary cytokine transcripts by peripheral lipopolysaccharide
24. Optimization of cRNA probe in situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: A detailed protocol
25. Interleukin.(IL) 1β, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications
26. Induction of interleukin-1 beta mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paws