Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 29525-29531

  Littlejohn, Tamantha K ^a   Takikawa, Osamu ^a,b   Truscott, Roger J W ^a   Walker, Mark J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CONFORMATIONS; ENZYMES; GENES; METABOLISM; MUTAGENESIS; PHYSIOLOGY; TISSUE;

HEME BINDING;

BIOCHEMISTRY;

CYTOKINE; GAMMA INTERFERON; HEME; INDOLEAMINE 2,3 DIOXYGENASE; TRYPTOPHAN; ALANINE; ASPARTIC ACID; HISTIDINE; LIGAND; TRYPTOPHAN 2,3 DIOXYGENASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY; ANIMAL; BIOSYNTHESIS; CATALYSIS; CELL DIVISION; CHEMISTRY; ELECTRON SPIN RESONANCE; KINETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN CONFORMATION; RAT; ULTRAVIOLET RADIATION; UPREGULATION; WESTERN BLOTTING;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; BLOTTING, WESTERN; CATALYSIS; CELL DIVISION; CIRCULAR DICHROISM; CYTOKINES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEME; HISTIDINE; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON TYPE II; KINETICS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN; TRYPTOPHAN OXYGENASE; ULTRAVIOLET RAYS; UP-REGULATION;

EID: 0043032808     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301700200     Document Type: Article

References (46)

1. Takikawa, O., Yoshida, R., Kido, R., and Hayaishi, O. (1986) J. Biol. Chem. 261, 3648-3653
2. Botting, N. P. (1995) Chem. Soc. Rev. 24, 401-412
3. Stone, T. W., and Connick, J. H. (1985) Neuroscience 15, 597-617
4. Yoshida, R., Urade, Y., Takuda, M., and Hayaishi, O. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 4084-4086
5. Saito, K., Nagamura, Y., Ohta, Y., Sasaki, E., and Ishiguro, I. (1991) Life Sci. 49, 527-534
6. Reinhard, J. F., Jr. (1998) Neurochem. Res. 23, 661-665
7. Heyes, M. P., Saito, K., Jacobowitz, K., Markey, S. P., Takikawa, O., and Vickers, J. H. (1992) FASEB J. 6, 2977-2989
8. Yoshida, R., and Hayaishi, O. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 3998-4000
9. Sanni, L. A., Thomas, S. R., Tattam, B. N., Moore, D. E., Chaudhri, G., Stocker, R., and Hunt, N. H. (1998) Am. J. Pathol. 152, 611-619
10. Burke, F., Knowles, R. G., East, N., and Balkwill, F. R. (1995) Int. J. Cancer 60, 115-122
11. Dias, S., Thomas, H., and Balkwill, F. R. (1998) Int. J. Cancer 75, 151-157
12. Yu, W. G., Yamamoto, N., Takenaka, H., Mu, J., Tai, X.-G., Zou, J.-P., Ogawa, M., Tsutsui, T., Wijesuriya, T., Yoshida, R., Hermann, S., Fujiwara, H., and Hamaoka, T. (1996) Int. Immunol. 8, 855-865
13. Takikawa, O., Habara-Ohkubo, A., and Yoshida, R. (1990) J. Immunol. 145, 1246-1250
14. Sardar, A. M., and Reynolds, G. P. (1995) Neurosci. Lett. 187, 9-12
15. Heyes, M. P., Brew, B. J., Martin, A., Price, R. W., Salazar, A. M., Sidtis, J. J., Yergey, J. A., Mouradian, M. M., Salder, A. E., Keilp, J., Rebinow, D., and Markey, S. P. (1991) Ann. Neurol. 29, 202-209
16. Brew, B. J., Evans, L., Byrne, C., Pemberton, L., and Hurren, L. (1996) J Neurovirol. 2, 152-157
17. Okuda, S., Nishiyama, N., Saito, H., and Katsuki, H. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12553-12558
18. Widner, B., Leblhuber, F., Walli, J., Tilz, G. P., Demel, U., and Fuchs, D. (2000) J. Neural Transm. 107, 343-353
19. Truscott, R. J. W. (2000) Ophthalmic Res. 32, 185-194
20. Stutchbury, G. M., and Truscott, R. J. W. (1993) Exp. Eye Res. 57, 149-155
21. Aquilina, J. A., Carver, J. A., and Truscott, R. J. W. (1997) Exp. Eye Res. 64, 727-735
22. Dai, W., and Gupta, S. L. (1990) Biochem. Biophys. Res. Comm. 168, 1-8
23. Tone, S., Takikawa, O., Habara-Ohkubo, A., Kadoya, A., Yoshida, R., and Kido, R. (1989) Nucleic Acids Res. 18, 367
24. Ishimura, Y., Nozaki, M., and Hayaishi, O. (1970) J. Biol. Chem. 245, 3593-3602
25. Hirata, F., Ohnishi, T., and Hayaishi, O. (1977) J. Biol. Chem. 252, 4637-4642
26. Sono, M., Taniguchi, T., Watanabe, Y., and Hayaishi, O. (1980) J. Biol. Chem. 255, 1339-1345
27. Sono, M., and Dawson, J. H. (1984) Biochim. Biophys. Acta 789, 170-187
28. Uchida, K., Shimizu, T., Makino, R., Sakaguchi, K., Iisuka, T., and Ishimura, Y. (1983) J. Biol. Chem. 258, 2526-2533
29. Uchida, K., Shimizus, T., Makino, R., Sakaguchi, K., Iisuka, T., and Ishimura, Y. (1983) J. Biol. Chem. 258, 2519-2525
30. Sono, M. (1990) Biochem. 29, 1451-1460
31. Shimizu, T., Nomiyama, S., Hirata, F., and Hayaishi, O. (1978) J. Biol. Chem. 253, 4700-4706
32. Littlejohn, T. K., Takikawa, O., Skylas, D., Jamie, J. F., Walker, M. J., and Truscott, R. J. W. (2000) Protein. Expr. Purif. 19, 22-29
33. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
34. Laemmli, U. K. (1970) Nature 227, 680-685
35. Burnette, W. N. (1981) Anal. Biochem. 112, 195-203
36. Takikawa, O., Kuroiwa, T., Yamazaki, F., and Kido, R. (1988) J. Biol. Chem. 263, 2041-2048
37. Andrade, M. A., Chacón, P., Merelo, J. J., and Morán, F. (1993) Protein Eng. 6, 383-390
38. Merelo, J. J., Andrade, M. A., Prieto, A., and Morán, F. (1994) Neurocomputing 6, 443-454
39. Suzuki, T., and Takagi, T. (1992) J. Mol. Biol. 228, 698-700
40. Saito, K., Lankner, A., Markey, S. P., and Heyes, M. P. (1991) Brain Res. 540, 353-356
41. Widner, B., Lebihuber, F., Walli, J., Tilz, G. P., Demel, U., and Fuchs, D. (1999) Adv. Exp. Med. Biol. 467, 133-138
42. Habara-Ohkubo, A., Takikawa, O., and Yoshida, R. (1991) Gene 105, 221-227
43. Pan, T., Lin, C., Chen, C., Lin, Y., Gojo, S., Lee, T., Wang, Y., Lord, R., Lai, C., Tsu, L., Tseng, H., Wu, M., Iwashita, Y., Kitano, S., Chiang, K., Hashimoto, T., Sugioka, A., and Goto, S. (2000) Transpl. Immunol. 8, 189-194
44. Suzuki, T. (1994) J. Protein Chem. 13, 9-13
45. Suzuki, T., Kawamichi, H., and Imai, K. (1998) J. Protein Chem. 17, 817-826
46. Kawamichi, H., and Suzuki, T. (1998) J. Protein Chem. 17, 651-656