Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 8, 2006, Pages 2611-2616

  Sugimoto, Hiroshi ^a   Oda, Shun Ichiro ^a,b   Otsuki, Takashi ^a,b   Hino, Tomoya ^a   Yoshida, Tadashi ^c   Shiro, Yoshitsugu ^a,b  

^a Harima Institute ^*  (Japan)

^b UNIVERSITY OF HYOGO   (Japan)

^c YAMAGATA UNIVERSITY   (Japan)

Author keywords

Iron; Kynurenine; Tryptophan; X ray crystallography

Indexed keywords

2 CYCLOHEXYLAMINOETHANESULFONIC ACID; 4 PHENYLIMIDAZOLE; AMINO ACID; CYANIDE; CYTOCHROME P450; DIOXYGENASE; HEME; INDOLEAMINE 2,3 DIOXYGENASE; IRON; OXYGEN; PEROXIDASE; PYRROLE DERIVATIVE; SULFONIC ACID DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYANIDES; HEME; HEMEPROTEINS; HUMANS; IMIDAZOLES; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 33644511372     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508996103     Document Type: Article

References (33)

1. Hayaishi, O. & Nozaki, M. (1969) Science 164, 389-396.
2. Yamamoto, S. & Hayaishi, O. (1967) J. Biol. Chem. 242, 5260-5266.
3. Hayaishi, O., Rothberg, S., Mehler, A. H. & Saito, Y. (1957) J. Biol. Chem. 229, 889-896.
4. Knox, W. E. & Mehler, A. H. (1950) J. Biol. Chem. 187, 419-430.
5. Takikawa, O., Truscott, R. J., Fukao, M. & Miwa, S. (2003) Adv. Exp. Med. Biol. 527, 277-285.
6. Shimizu, T., Nomiyama, S., Hirata, F. & Hayaishi, O. (1978) J. Biol. Chem. 253, 4700-4706.
7. Mellor, A. L. & Munn, D. H. (2004) Nat. Rev. Immunol. 4, 762-774.
8. Davydov, R., Makris, T. M., Kofman, V., Werst, D. E., Sugar, S. G. & Hoffman, B. M. (2001) J. Am. Chem. Soc. 123, 1403-1415.
9. Schlichting, I., Berendzen, J., Chu, K., Stock, A. M., Maves, S. A., Benson, D. E., Sweet, R. M., Ringe, D., Petsko, G. A. & Sligar, S. G. (2000) Science 287, 1615-1622.
10. Baek, H. K. & Van Wart, H. E. (1989) Biochemistry 28, 5714-5719.
11. Sono, M., Roach, M. P., Coulter, E. D. & Dawson, J. H. (1996) Chem. Rev. 96, 2841-2888.
12. Karlsson, A., Parales, J. V., Parales, R. E., Gibson, D. T., Eklund, H. & Ramaswamy, S. (2003) Science 299, 1039-1042.
13. Senda, T., Sugiyama, K., Narita, H., Yamamoto, T., Kimbara, K., Fukuda, M., Sato, M., Yano, K. & Mitsui, Y. (1996) J. Mol. Biol. 255, 735-752.
14. Sono, M. (1990) Biochemistry 29, 1451-1460.
15. Holm, L. & Sander, C. (1994) Nucleic Acids Res. 22, 3600-3609.
16. Littlejohn, T. K., Takikawa, O., Truscott, R. J. & Walker, M. J. (2003) J. Biol. Chem. 278, 29525-29531.
17. Terentis, A. C., Thomas, S. R., Takikawa, O., Littlejohn, T. K., Truscott, R. J., Armstrong, R. S., Yeh, S. R. & Stocker, R. (2002) J. Biol. Chem. 277, 15788-15794.
18. Sono, M. & Dawson, J. H. (1984) Biochim. Biophys. Acta 789, 170-187.
19. Yeh, S. R., Couture, M., Quellet, Y., Guertin, M. & Rousseau, D. L. (2000) J. Biol. Chem. 275, 1679-1684.
20. Gunsalus, I. C., Meek, J. R., Lipscomb, J. D., Debrunner, P. & Munk, E. (1974) in Molecular Mechanisms of Oxygen Activation, ed. Hayashi, O. (Academic, New York), pp. 559-613.
21. White, R. E. & Coon, M. J. (1980) Annu. Rev. Biochem. 49, 315-356.
22. Sevrioukova, I. F., Li, H., Zhang, H., Peterson, J. A. & Poulos, T. L. (1999) Proc. Natl. Acad. Sci. USA 96, 1863-1868.
23. Han, S., Eltis, L. D., Timmis, K. N., Muchmore, S. W. & Bolin, J. T. (1995) Science 270, 976-980.
24. Kudo, Y. & Boyd, C. A. (2000) Biochim. Biophys. Acta 1500, 119-124.
25. Fortelle, E. D. L. & Bricogne, G. (1997) Methods Enzymol. 276, 472-494.
26. Lamzin, V. S. & Wilson, K. S. (1997) Methods Enzymol. 277, 269-305.
27. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
28. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
29. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
30. Merritt, E. A. & Bacon, D. J. (1997) Methods Enzymol. 277, 505-524.
31. DeLano, W. L. (2002) The PYMOL Molecular Graphics System (DeLano Scientific, San Carlos, CA).
32. Nicholls, A., Sharp, K. A. & Honig, B. (1991) Proteins 11, 281-296.
33. Dobrovolsky, V. N., Bowyer, J. F., Pabarcus, M. K., Heflich, R. H., Williams, L. D., Doerge, D. R., Arvidsson, B., Bergquist, J. & Casida, J. E. (2005) Biochim. Biophys. Acta 1724, 163-172.