Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells

Immunopharmacology

Volumn 34, Issue 1, 1996, Pages 27-37

  Xia, Zhenlei ^a   DePierre, Joseph W ^a   Nässberger, Lennart ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

cAMP; Cytokine; In vitro; Monocyte; T cell; Tricyclic antidepressant

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; CYCLIC AMP; CYTOKINE; GAMMA INTERFERON; IMIPRAMINE; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; TRICYCLIC ANTIDEPRESSANT AGENT; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030220185     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00111-7     Document Type: Article

References (26)

1. Bøyum A. Separation of leucocytes from blood and bone marrow, Scand. J. Clin. Lab. Invest. 1968; 21: suppl 97, 9-108.
2. Carroll BJ. Clinical application of neuroendocrine research in depression. In: van Praag HM, Lader MH, Rafaelsen OJ, Sachar EJ. Eds. Handbook of Biological Psychiatry. Part 3: Brain mechanisms and abnormal behavior genetics and neuroendocrinology. New York: Marcel Dekker. 1980: 179-193.
3. Cavaillon JM, Fitting C, Haeffner-Cavaillon N, Kirsch SJ, Warren HS. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide. Infect. Immunol. 1990; 58: 2375-2382.
4. Chaplin DD, Wedner HJ, Parker CW. Protein phosphorylation and lymphocyte activation. In: Gelfand EW, Dosch HM. Eds. Biological Basis of Immunodeficiency. New York: Raven Press. 1980: 269-281.
5. Darko DF, Lucas AH, Gillin JC, Risch SC, Golshan S, Hamburger RN, Silverman MB, Janowsky DS. Cellular immunity and the hypothalamic-pituitary axis in major affective disorder: a preliminary study. Psychiatr. Res. 1988; 25: 1-10.
6. Duch DS, Woolf JH, Nichol CA, Davidson JR, Garbutt JC. Urinary excretion of biopterin and neopterin in psychiatric disorders. Psychiatr. Res. 1984; 11: 83-89.
7. Dunbar PR, Hill J, Neale TJ, Mellsop GW. Neopterin measurement provides evidence of altered cell-mediated immunity in patients with depression, but not with schizoprenia. Psychol. Med. 1992; 22: 1051-1057.
8. Eisenhut T, Sinha B, Gröttup-Wolfers E, Semmler J, Siess W, Endres S. Prostacyclin analogs suppress the synthesis of tumor necrosis factor-alpha in LPS-stimulated human peripheral blood mononuclear cells. Immunopharmacology 1993; 26: 259-264.
9. Fuchs D, Weiss G, Reibnegger G, Wachter H. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases, Crit. Rev. Clin. Lab. Sci. 1992; 29: 307-341.
10. Irwin M, Caldwell C, Smith TL. Brown S, Schuckit MA, Gillin JC. Major depressive disorder, alcoholism and reduced natural killer cell cytotoxicity. Arch. Gen. Psychiatry 1990; 47: 713-718.
11. Kronfol Z, House DJ. Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls. Acta Psychiatr. Scand. 1989; 80: 142-147.
12. Macs M, Smith R, Scharpe S. The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology 1995; 20: 111-116.
13. Macs M, Lambrechts J, Bosmans E, Jacobs J, Suy E, Vandervorst C, DeJonckheere C, Minner B, Raus J. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol. Med. 1992; 22: 45-53.
14. Maes M, Stevens WJ, Declerck LS, Bridts CH, Peeters D, Schotte C, Cosyns P. Significantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: further evidence for an inflammatory process during that illness. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 1993a; 17: 241-255.
15. Maes M, Bosmans E, Suy E, Vandervorst C, DeJonckheere C, Raus J. Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1-beta and soluble interleukin-2 receptor production. Acta Psychiatr. Scand. 1991; 84: 327-386.
16. Maes M, Scharpé S, Meltzer HY, Bosmans E, Suy E, Calabrese J, Cosyns P. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitaryadrenal axis in severe depression. Psychiatr. Res. 1993b; 49: 11-27.
17. Maes M, Scharpé S, Meltzer HY, Okayli G, Bosnians E, D'Hondt P, Bossche BV, Cosyns P. Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response. Psychiatr. Res. 1994; 54: 143-160.
18. Mary D, Aussie C, Ferrua B, Fehlmann M. Regulation of interleukin 2 synthesis by cAMP in human T cells. J. Immunol. 1987; 139: 1179-1184.
19. Mårtensson U, Nässberger L. Influence of antidepressants on mitogen stimulation of human lymphocytes. Toxic. in Vitro 1993; 7: 241-245.
20. Nässberger L, Traskman-Bendz L. Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiatr. Scand. 1993; 88: 48-52.
21. Ocklind G. Stimulation of human lymphocytes by phytohemagglutinin(PHA) in a new ultra-microtest plate. Immunobiology 1986; 171: 339-344.
22. Plata-Salamán C.R. Immunoregulators in the nervous system. Neurosci. Biobehav. Rev. 1991; 15: 185-215.
23. 2 differentially modulates cytokine secretion profiles of human T helper lymphocyte. J. Immunol. 1993; 150: 5312-5329.
24. Tondo L, Pani PP, Pellegrini-Bettoli R, Milia G, Mancoli PE. T-lymphocytes in depressive disorder. Med. Sci. Res. 1988; 16: 867-868.
25. Viherluoto J, Palkama T, Silvennoinen O, Hurme M. Cyclic adenosine monophosphate decreases the secretion, but not the cell-associated levels, of interleukin-1-beta in lipopolysaccharide-activated human monocytes. Scand. J. Immunol. 1991; 34: 121-125.
26. Wachter H, Fuchs D, Hausen A, Reibnegger G, Werner ER. Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application. Adv. Clin. Chem. 1989; 27: 81-141.