메뉴 건너뛰기




Volumn 1, Issue 4, 2012, Pages 1261-1292

Signals and cells involved in regulating liver regeneration

Author keywords

Epidermal growth factor; Hepatocyte; Hepatocyte growth factor; Liver regeneration; Oval cell; Partial hepatectomy; Transdifferentitation

Indexed keywords

ACTIVIN; AMPHIREGULIN; BETA CATENIN; BILE ACID; CARBON TETRACHLORIDE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOKINE; DIAZEPAM; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; GLYPICAN 3; INSULIN; INTEGRIN LINKED KINASE; INTERLEUKIN 6; MESSENGER RNA; NEUROTRANSMITTER; NORADRENALIN; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHENOBARBITAL; PHENYTOIN; SCATTER FACTOR; SEROTONIN; SEROTONIN TRANSPORTER; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR YAP1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; WNT PROTEIN;

EID: 84881522730     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells1041261     Document Type: Review
Times cited : (112)

References (229)
  • 1
    • 0036462410 scopus 로고    scopus 로고
    • Thrombopoietin: The novel hepatic hormone
    • Wolber, E.M.; Jelkmann, W. Thrombopoietin: The novel hepatic hormone. News Physiol. Sci. 2002, 17, 6-10.
    • (2002) News Physiol. Sci. , vol.17 , pp. 6-10
    • Wolber, E.M.1    Jelkmann, W.2
  • 2
    • 73949091032 scopus 로고    scopus 로고
    • Liver regeneration after partial hepatectomy: Critical analysis of mechanistic dilemmas
    • Michalopoulos, G.K. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am. J. Pathol. 2010, 176, 2-13.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2-13
    • Michalopoulos, G.K.1
  • 3
    • 85027935727 scopus 로고    scopus 로고
    • Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration
    • Miyaoka, Y.; Ebato, K.; Kato, H.; Arakawa, S.; Shimizu, S.; Miyajima, A. Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Curr. Biol. 2012, 22, 1166-1175.
    • (2012) Curr. Biol. , vol.22 , pp. 1166-1175
    • Miyaoka, Y.1    Ebato, K.2    Kato, H.3    Arakawa, S.4    Shimizu, S.5    Miyajima, A.6
  • 4
    • 54549119175 scopus 로고    scopus 로고
    • The global impact of hepatic fibrosis and end-stage liver disease
    • Lim, Y.S.; Kim, W.R. The global impact of hepatic fibrosis and end-stage liver disease. Clin. Liver Dis. 2008, 12, 733-746, vii.
    • (2008) Clin. Liver Dis. , vol.12
    • Lim, Y.S.1    Kim, W.R.2
  • 5
    • 84858754943 scopus 로고    scopus 로고
    • Immune functioning in non lymphoid organs: The liver
    • Parker, G.A.; Picut, C.A. Immune functioning in non lymphoid organs: The liver. Toxicol. Pathol. 2012, 40, 237-247.
    • (2012) Toxicol. Pathol. , vol.40 , pp. 237-247
    • Parker, G.A.1    Picut, C.A.2
  • 6
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman, S.L. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 2008, 88, 125-172.
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 7
    • 0001276586 scopus 로고
    • Experimental pathology of the liver-Restoration of the liver of the white rat following partial surgical removal
    • Higgins, G.M.; Anderson, R.M. Experimental pathology of the liver-Restoration of the liver of the white rat following partial surgical removal. Arch. Pathol. 1931, 12, 186-202.
    • (1931) Arch. Pathol. , vol.12 , pp. 186-202
    • Higgins, G.M.1    Anderson, R.M.2
  • 8
    • 50249150340 scopus 로고    scopus 로고
    • A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
    • Mitchell, C.; Willenbring, H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat. Protoc. 2008, 3, 1167-1170.
    • (2008) Nat. Protoc. , vol.3 , pp. 1167-1170
    • Mitchell, C.1    Willenbring, H.2
  • 9
    • 0017805623 scopus 로고
    • Carbon tetrachloride activation, lipid peroxidation and liver necrosis in different strains of mice
    • de Toranzo, E.G.; Gomez, M.I.; Castro, J.A. Carbon tetrachloride activation, lipid peroxidation and liver necrosis in different strains of mice. Res. Commun. Chem. Pathol. Pharmacol. 1978, 19, 347-352.
    • (1978) Res. Commun. Chem. Pathol. Pharmacol. , vol.19 , pp. 347-352
    • de Toranzo, E.G.1    Gomez, M.I.2    Castro, J.A.3
  • 10
    • 0032169127 scopus 로고    scopus 로고
    • Serum and liver concentrations of tumor necrosis factor alpha and interleukin-1beta following administration of carbon tetrachloride to male rats
    • DeCicco, L.A.; Rikans, L.E.; Tutor, C.G.; Hornbrook, K.R. Serum and liver concentrations of tumor necrosis factor alpha and interleukin-1beta following administration of carbon tetrachloride to male rats. Toxicol. Lett. 1998, 98, 115-121.
    • (1998) Toxicol. Lett. , vol.98 , pp. 115-121
    • DeCicco, L.A.1    Rikans, L.E.2    Tutor, C.G.3    Hornbrook, K.R.4
  • 11
    • 79954615800 scopus 로고    scopus 로고
    • Current issues with acetaminophen hepatotoxicity a clinically relevant model to test the efficacy of natural products
    • Jaeschke, H.; McGill, M.R.; Williams, C.D.; Ramachandran, A. Current issues with acetaminophen hepatotoxicity a clinically relevant model to test the efficacy of natural products. Life Sci. 2011, 88, 737-745.
    • (2011) Life Sci. , vol.88 , pp. 737-745
    • Jaeschke, H.1    McGill, M.R.2    Williams, C.D.3    Ramachandran, A.4
  • 13
    • 30344461594 scopus 로고    scopus 로고
    • The molecular toxicology of acetaminophen
    • David Josephy, P. The molecular toxicology of acetaminophen. Drug Metab. Rev. 2005, 37, 581-594.
    • (2005) Drug Metab. Rev. , vol.37 , pp. 581-594
    • David Josephy, P.1
  • 14
    • 0029976478 scopus 로고    scopus 로고
    • Cell kinetics of repair after allyl alcohol-induced liver necrosis in mice
    • Lee, J.H.; Ilic, Z.; Sell, S. Cell kinetics of repair after allyl alcohol-induced liver necrosis in mice. Int. J. Exp. Pathol. 1996, 77, 63-72.
    • (1996) Int. J. Exp. Pathol. , vol.77 , pp. 63-72
    • Lee, J.H.1    Ilic, Z.2    Sell, S.3
  • 15
    • 0017821480 scopus 로고
    • Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats
    • Pound, A.W.; McGuire, L.J. Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats. Br. J. Cancer. 1978, 37, 585-594.
    • (1978) Br. J. Cancer. , vol.37 , pp. 585-594
    • Pound, A.W.1    McGuire, L.J.2
  • 16
    • 79952008241 scopus 로고    scopus 로고
    • Secretory phospholipase A(2)-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2
    • Bhave, V.S.; Donthamsetty, S.; Latendresse, J.R.; Cunningham, M.L.; Mehendale, H.M. Secretory phospholipase A(2)-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2. Toxicol. Appl. Pharmacol. 2011, 251, 173-180.
    • (2011) Toxicol. Appl. Pharmacol. , vol.251 , pp. 173-180
    • Bhave, V.S.1    Donthamsetty, S.2    Latendresse, J.R.3    Cunningham, M.L.4    Mehendale, H.M.5
  • 17
    • 41549131209 scopus 로고    scopus 로고
    • Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2
    • Bhave, V.S.; Donthamsetty, S.; Latendresse, J.R.; Muskhelishvili, L.; Mehendale, H.M. Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2. Toxicol. Appl. Pharmacol. 2008, 228, 225-238.
    • (2008) Toxicol. Appl. Pharmacol. , vol.228 , pp. 225-238
    • Bhave, V.S.1    Donthamsetty, S.2    Latendresse, J.R.3    Muskhelishvili, L.4    Mehendale, H.M.5
  • 19
    • 84859440714 scopus 로고    scopus 로고
    • Once initiated, how does toxic tissue injury expand?
    • Mehendale, H.M. Once initiated, how does toxic tissue injury expand? Trends Pharmacol. Sci. 2012, 33, 200-206.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 200-206
    • Mehendale, H.M.1
  • 20
    • 13444269608 scopus 로고    scopus 로고
    • Tissue repair: An important determinant of final outcome of toxicant-induced injury
    • Mehendale, H.M. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol. Pathol. 2005, 33, 41-51.
    • (2005) Toxicol. Pathol. , vol.33 , pp. 41-51
    • Mehendale, H.M.1
  • 21
    • 0037277270 scopus 로고    scopus 로고
    • Mitogenesis by ligands of nuclear receptors: An attractive model for the study of the molecular mechanisms implicated in liver growth
    • Columbano, A.; Ledda-Columbano, G.M. Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth. Cell Death Differ. 2003, 10 (Suppl. 1), S19-S21.
    • (2003) Cell Death Differ. , vol.10 , Issue.SUPPL. 1
    • Columbano, A.1    Ledda-Columbano, G.M.2
  • 23
    • 22844445140 scopus 로고    scopus 로고
    • Exogenous thyroid hormone induces liver enlargement, whilst maintaining regenerative potential a study relevant to donor preconditioning
    • Malik, R.; Habib, M.; Tootle, R.; Hodgson, H. Exogenous thyroid hormone induces liver enlargement, whilst maintaining regenerative potential a study relevant to donor preconditioning. Am. J. Transplant. 2005, 5, 1801-1807.
    • (2005) Am. J. Transplant. , vol.5 , pp. 1801-1807
    • Malik, R.1    Habib, M.2    Tootle, R.3    Hodgson, H.4
  • 25
    • 77954987061 scopus 로고    scopus 로고
    • PPARalpha: Energy combustion, hypolipidemia, inflammation and cancer
    • Pyper, S.R.; Viswakarma, N.; Yu, S.; Reddy, J.K. PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nucl. Recept. Signal. 2010, 8, e002.
    • (2010) Nucl. Recept. Signal. , vol.8
    • Pyper, S.R.1    Viswakarma, N.2    Yu, S.3    Reddy, J.K.4
  • 26
    • 23144447140 scopus 로고    scopus 로고
    • CAR, the continuously advancing receptor, in drug metabolism and disease
    • Qatanani, M.; Moore, D.D. CAR, the continuously advancing receptor, in drug metabolism and disease. Curr. Drug Metab. 2005, 6, 329-339.
    • (2005) Curr. Drug Metab. , vol.6 , pp. 329-339
    • Qatanani, M.1    Moore, D.D.2
  • 27
    • 0027817570 scopus 로고
    • Compensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis
    • Ledda-Columbano, G.M.; Coni, P.; Simbula, G.; Zedda, I.; Columbano, A. Compensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis. Environ. Health Perspect. 1993, 101 (Suppl. 5), 163-168.
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 163-168
    • Ledda-Columbano, G.M.1    Coni, P.2    Simbula, G.3    Zedda, I.4    Columbano, A.5
  • 28
    • 0022411742 scopus 로고
    • Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia
    • Bursch, W.; Taper, H.S.; Lauer, B.; Schulte-Hermann, R. Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 1985, 50, 153-166.
    • (1985) Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. , vol.50 , pp. 153-166
    • Bursch, W.1    Taper, H.S.2    Lauer, B.3    Schulte-Hermann, R.4
  • 30
    • 0029845271 scopus 로고    scopus 로고
    • Liver regeneration versus direct hyperplasia
    • Columbano, A.; Shinozuka, H. Liver regeneration versus direct hyperplasia. FASEB J. 1996, 10, 1118-1128.
    • (1996) FASEB J. , vol.10 , pp. 1118-1128
    • Columbano, A.1    Shinozuka, H.2
  • 32
    • 77956635388 scopus 로고    scopus 로고
    • Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice
    • Liu, B.; Bell, A.W.; Paranjpe, S.; Bowen, W.C.; Khillan, J.S.; Luo, J.H.; Mars, W.M.; Michalopoulos, G.K. Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology 2010, 52, 1060-1067.
    • (2010) Hepatology , vol.52 , pp. 1060-1067
    • Liu, B.1    Bell, A.W.2    Paranjpe, S.3    Bowen, W.C.4    Khillan, J.S.5    Luo, J.H.6    Mars, W.M.7    Michalopoulos, G.K.8
  • 33
    • 75249102027 scopus 로고    scopus 로고
    • Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration
    • Donthamsetty, S.; Bowen, W.; Mars, W.; Bhave, V.; Luo, J.H.; Wu, C.; Hurd, J.; Orr, A.; Bell, A.; Michalopoulos, G. Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration. Toxicol. Sci. 2010, 113, 358-366.
    • (2010) Toxicol. Sci. , vol.113 , pp. 358-366
    • Donthamsetty, S.1    Bowen, W.2    Mars, W.3    Bhave, V.4    Luo, J.H.5    Wu, C.6    Hurd, J.7    Orr, A.8    Bell, A.9    Michalopoulos, G.10
  • 34
    • 79251511172 scopus 로고    scopus 로고
    • Excessive hepatomegaly of mice with hepatocytetargeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene
    • Donthamsetty, S.; Bhave, V.S.; Kliment, C.S.; Bowen, W.C.; Mars, W.M.; Bell, A.W.; Stewart, R.E.; Orr, A.; Wu, C.; Michalopoulos, G.K. Excessive hepatomegaly of mice with hepatocytetargeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology 2011, 53, 587-595.
    • (2011) Hepatology , vol.53 , pp. 587-595
    • Donthamsetty, S.1    Bhave, V.S.2    Kliment, C.S.3    Bowen, W.C.4    Mars, W.M.5    Bell, A.W.6    Stewart, R.E.7    Orr, A.8    Wu, C.9    Michalopoulos, G.K.10
  • 35
    • 79960719528 scopus 로고    scopus 로고
    • Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice
    • Lin, C.W.; Mars, W.M.; Paranjpe, S.; Donthamsetty, S.; Bhave, V.S.; Kang, L.I.; Orr, A.; Bowen, W.C.; Bell, A.W.; Michalopoulos, G.K. Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology 2011, 54, 620-630.
    • (2011) Hepatology , vol.54 , pp. 620-630
    • Lin, C.W.1    Mars, W.M.2    Paranjpe, S.3    Donthamsetty, S.4    Bhave, V.S.5    Kang, L.I.6    Orr, A.7    Bowen, W.C.8    Bell, A.W.9    Michalopoulos, G.K.10
  • 36
    • 33646713469 scopus 로고    scopus 로고
    • Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car
    • Kodama, S.; Negishi, M. Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car. Drug. Metab. Rev. 2006, 38, 75-87.
    • (2006) Drug. Metab. Rev. , vol.38 , pp. 75-87
    • Kodama, S.1    Negishi, M.2
  • 39
    • 0030874711 scopus 로고    scopus 로고
    • Extracellular matrix remodeling at the early stages of liver regeneration in the rat
    • Kim, T.H.; Mars, W.M.; Stolz, D.B.; Petersen, B.E.; Michalopoulos, G.K. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology 1997, 26, 896-904.
    • (1997) Hepatology , vol.26 , pp. 896-904
    • Kim, T.H.1    Mars, W.M.2    Stolz, D.B.3    Petersen, B.E.4    Michalopoulos, G.K.5
  • 40
    • 0033971360 scopus 로고    scopus 로고
    • Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration
    • Kim, T.H.; Mars, W.M.; Stolz, D.B.; Michalopoulos, G.K. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 2000, 31, 75-82.
    • (2000) Hepatology , vol.31 , pp. 75-82
    • Kim, T.H.1    Mars, W.M.2    Stolz, D.B.3    Michalopoulos, G.K.4
  • 41
    • 0027761342 scopus 로고
    • Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA
    • Mars, W.M.; Zarnegar, R.; Michalopoulos, G.K. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am. J. Pathol. 1993, 143, 949-958.
    • (1993) Am. J. Pathol. , vol.143 , pp. 949-958
    • Mars, W.M.1    Zarnegar, R.2    Michalopoulos, G.K.3
  • 42
    • 0029929227 scopus 로고    scopus 로고
    • Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor
    • Mars, W.M.; Kim, T.H.; Stolz, D.B.; Liu, M.L.; Michalopoulos, G.K. Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res. 1996, 56, 2837-2843.
    • (1996) Cancer Res. , vol.56 , pp. 2837-2843
    • Mars, W.M.1    Kim, T.H.2    Stolz, D.B.3    Liu, M.L.4    Michalopoulos, G.K.5
  • 43
    • 0029058462 scopus 로고
    • Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration
    • Mars, W.M.; Liu, M.L.; Kitson, R.P.; Goldfarb, R.H.; Gabauer, M.K.; Michalopoulos, G.K. Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration. Hepatology 1995, 21, 1695-1701.
    • (1995) Hepatology , vol.21 , pp. 1695-1701
    • Mars, W.M.1    Liu, M.L.2    Kitson, R.P.3    Goldfarb, R.H.4    Gabauer, M.K.5    Michalopoulos, G.K.6
  • 44
    • 1842480002 scopus 로고    scopus 로고
    • Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration
    • Kohler, C.; Bell, A.W.; Bowen, W.C.; Monga, S.P.; Fleig, W.; Michalopoulos, G.K. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 2004, 39, 1056-1065.
    • (2004) Hepatology , vol.39 , pp. 1056-1065
    • Kohler, C.1    Bell, A.W.2    Bowen, W.C.3    Monga, S.P.4    Fleig, W.5    Michalopoulos, G.K.6
  • 45
    • 0035032989 scopus 로고    scopus 로고
    • Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration
    • Monga, S.P.; Pediaditakis, P.; Mule, K.; Stolz, D.B.; Michalopoulos, G.K. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology. 2001, 33, 1098-1109.
    • (2001) Hepatology. , vol.33 , pp. 1098-1109
    • Monga, S.P.1    Pediaditakis, P.2    Mule, K.3    Stolz, D.B.4    Michalopoulos, G.K.5
  • 46
    • 79958146175 scopus 로고    scopus 로고
    • Role of Wnt/beta-catenin signaling in liver metabolism and cancer
    • Monga, S.P. Role of Wnt/beta-catenin signaling in liver metabolism and cancer. Int. J. Biochem. Cell Biol. 2011, 43, 1021-1029.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 1021-1029
    • Monga, S.P.1
  • 47
    • 0027159088 scopus 로고
    • Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration
    • Haber, B.A.; Mohn, K.L.; Diamond, R.H.; Taub, R. Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. J. Clin. Invest. 1993, 91, 1319-1326.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1319-1326
    • Haber, B.A.1    Mohn, K.L.2    Diamond, R.H.3    Taub, R.4
  • 48
    • 0025679002 scopus 로고
    • Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/c 3T3 cells. Liverspecific induction patterns of gene 33, phosphoenolpyruvate carboxykinase, and the jun, fos, and egr families
    • Mohn, K.L.; Laz, T.M.; Melby, A.E.; Taub, R. Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/c 3T3 cells. Liverspecific induction patterns of gene 33, phosphoenolpyruvate carboxykinase, and the jun, fos, and egr families. J. Biol. Chem. 1990, 265, 21914-21921.
    • (1990) J. Biol. Chem. , vol.265 , pp. 21914-21921
    • Mohn, K.L.1    Laz, T.M.2    Melby, A.E.3    Taub, R.4
  • 49
  • 50
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: From myth to mechanism
    • Taub, R. Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell Biol. 2004, 5, 836-847.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 836-847
    • Taub, R.1
  • 52
    • 0024356856 scopus 로고
    • Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes
    • Zarnegar, R.; Michalopoulos, G. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res. 1989, 49, 3314-3320.
    • (1989) Cancer Res. , vol.49 , pp. 3314-3320
    • Zarnegar, R.1    Michalopoulos, G.2
  • 53
    • 0000975548 scopus 로고
    • Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures
    • Nakamura, T.; Teramoto, H.; Ichihara, A. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc. Natl. Acad. Sci. USA 1986, 83, 6489-6493.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6489-6493
    • Nakamura, T.1    Teramoto, H.2    Ichihara, A.3
  • 55
    • 0024473902 scopus 로고
    • NH2-terminal amino acid sequence of rabbit hepatopoietin A, a heparin-binding polypeptide growth factor for hepatocytes
    • Zarnegar, R.; Muga, S.; Enghild, J.; Michalopoulos, G. NH2-terminal amino acid sequence of rabbit hepatopoietin A, a heparin-binding polypeptide growth factor for hepatocytes. Biochem Biophys. Res. Commun. 1989, 163, 1370-1376.
    • (1989) Biochem Biophys. Res. Commun. , vol.163 , pp. 1370-1376
    • Zarnegar, R.1    Muga, S.2    Enghild, J.3    Michalopoulos, G.4
  • 57
    • 84856113332 scopus 로고    scopus 로고
    • A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
    • Fafalios, A.; Ma, J.; Tan, X.; Stoops, J.; Luo, J.; Defrances, M.C.; Zarnegar, R. A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nat. Med. 2011, 17, 1577-1584.
    • (2011) Nat. Med. , vol.17 , pp. 1577-1584
    • Fafalios, A.1    Ma, J.2    Tan, X.3    Stoops, J.4    Luo, J.5    Defrances, M.C.6    Zarnegar, R.7
  • 58
    • 0028678042 scopus 로고
    • Hepatocyte growth factor as mitogen, motogen and morphogen, and its roles in organ regeneration
    • Nakamura, T. Hepatocyte growth factor as mitogen, motogen and morphogen, and its roles in organ regeneration. Princess Takamatsu Symp. 1994, 24, 195-213.
    • (1994) Princess Takamatsu Symp. , vol.24 , pp. 195-213
    • Nakamura, T.1
  • 59
    • 34250312451 scopus 로고    scopus 로고
    • Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference
    • Paranjpe, S.; Bowen, W.C.; Bell, A.W.; Nejak-Bowen, K.; Luo, J.H.; Michalopoulos, G.K. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology. 2007, 45, 1471-1477.
    • (2007) Hepatology. , vol.45 , pp. 1471-1477
    • Paranjpe, S.1    Bowen, W.C.2    Bell, A.W.3    Nejak-Bowen, K.4    Luo, J.H.5    Michalopoulos, G.K.6
  • 60
    • 21844433508 scopus 로고    scopus 로고
    • C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes
    • Wang, B.; Gao, C.; Ponder, K.P. C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes. J. Hepatol. 2005, 43, 294-302.
    • (2005) J. Hepatol. , vol.43 , pp. 294-302
    • Wang, B.1    Gao, C.2    Ponder, K.P.3
  • 62
    • 0028343007 scopus 로고
    • Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver
    • Liu, M.L.; Mars, W.M.; Zarnegar, R.; Michalopoulos, G.K. Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver. Am. J. Pathol. 1994, 144, 129-140.
    • (1994) Am. J. Pathol. , vol.144 , pp. 129-140
    • Liu, M.L.1    Mars, W.M.2    Zarnegar, R.3    Michalopoulos, G.K.4
  • 63
    • 0033567002 scopus 로고    scopus 로고
    • Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat
    • Stolz, D.B.; Mars, W.M.; Petersen, B.E.; Kim, T.H.; Michalopoulos, G.K. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Cancer Res. 1999, 59, 3954-3960.
    • (1999) Cancer Res. , vol.59 , pp. 3954-3960
    • Stolz, D.B.1    Mars, W.M.2    Petersen, B.E.3    Kim, T.H.4    Michalopoulos, G.K.5
  • 64
    • 0034807926 scopus 로고    scopus 로고
    • The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat
    • Pediaditakis, P.; Lopez-Talavera, J.C.; Petersen, B.; Monga, S.P.; Michalopoulos, G.K. The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology 2001, 34, 688-693.
    • (2001) Hepatology , vol.34 , pp. 688-693
    • Pediaditakis, P.1    Lopez-Talavera, J.C.2    Petersen, B.3    Monga, S.P.4    Michalopoulos, G.K.5
  • 65
    • 0025758192 scopus 로고
    • Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration
    • Lindroos, P.M.; Zarnegar, R.; Michalopoulos, G.K. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991, 13, 743-750.
    • (1991) Hepatology , vol.13 , pp. 743-750
    • Lindroos, P.M.1    Zarnegar, R.2    Michalopoulos, G.K.3
  • 66
    • 0026593063 scopus 로고
    • Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells
    • Schirmacher, P.; Geerts, A.; Pietrangelo, A.; Dienes, H.P.; Rogler, C.E. Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells. Hepatology 1992, 15, 5-11.
    • (1992) Hepatology , vol.15 , pp. 5-11
    • Schirmacher, P.1    Geerts, A.2    Pietrangelo, A.3    Dienes, H.P.4    Rogler, C.E.5
  • 68
    • 0027264871 scopus 로고
    • Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride
    • Maher, J.J. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J. Clin. Invest. 1993, 91, 2244-2252.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2244-2252
    • Maher, J.J.1
  • 70
    • 0027129823 scopus 로고
    • Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organs
    • Kono, S.; Nagaike, M.; Matsumoto, K.; Nakamura, T. Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organs. Biochem. Biophys. Res. Commun. 1992, 186, 991-998.
    • (1992) Biochem. Biophys. Res. Commun. , vol.186 , pp. 991-998
    • Kono, S.1    Nagaike, M.2    Matsumoto, K.3    Nakamura, T.4
  • 71
    • 0026567275 scopus 로고
    • Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs
    • Yanagita, K.; Nagaike, M.; Ishibashi, H.; Niho, Y.; Matsumoto, K.; Nakamura, T. Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs. Biochem. Biophys. Res. Commun. 1992, 182, 802-809.
    • (1992) Biochem. Biophys. Res. Commun. , vol.182 , pp. 802-809
    • Yanagita, K.1    Nagaike, M.2    Ishibashi, H.3    Niho, Y.4    Matsumoto, K.5    Nakamura, T.6
  • 73
    • 0030830203 scopus 로고    scopus 로고
    • Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells
    • Skrtic, S.; Wallenius, V.; Ekberg, S.; Brenzel, A.; Gressner, A.M.; Jansson, J.O. Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells. Endocrinology 1997, 138, 4683-4689.
    • (1997) Endocrinology , vol.138 , pp. 4683-4689
    • Skrtic, S.1    Wallenius, V.2    Ekberg, S.3    Brenzel, A.4    Gressner, A.M.5    Jansson, J.O.6
  • 74
    • 0019458617 scopus 로고
    • DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP
    • McGowan, J.A.; Strain, A.J.; Bucher, N.L. DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP. J. Cell. Physiol. 1981, 108, 353-363.
    • (1981) J. Cell. Physiol. , vol.108 , pp. 353-363
    • McGowan, J.A.1    Strain, A.J.2    Bucher, N.L.3
  • 75
    • 0017730941 scopus 로고
    • Hormonal factors concerned with liver regeneration
    • Bucher, N.L.; Patel, U.; Cohen, S. Hormonal factors concerned with liver regeneration. Ciba Found. Symp. 1977, 95-107.
    • (1977) Ciba Found. Symp. , vol.95 , pp. 107
    • Bucher, N.L.1    Patel, U.2    Cohen, S.3
  • 76
    • 1842347836 scopus 로고
    • Hepatic sequestration and biliary secretion of epidermal growth factor: Evidence for a high-capacity uptake system
    • St Hilaire, R.J.; Hradek, G.T.; Jones, A.L. Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system. Proc. Natl. Acad. Sci. USA 1983, 80, 3797-3801.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3797-3801
    • St Hilaire, R.J.1    Hradek, G.T.2    Jones, A.L.3
  • 77
    • 0020448840 scopus 로고
    • Epidermal growth factor: Its biologic and metabolic effects with emphasis on the hepatocyte
    • St Hilaire, R.J.; Jones, A.L. Epidermal growth factor: its biologic and metabolic effects with emphasis on the hepatocyte. Hepatology 1982, 2, 601-613.
    • (1982) Hepatology , vol.2 , pp. 601-613
    • St Hilaire, R.J.1    Jones, A.L.2
  • 78
    • 0021994628 scopus 로고
    • Adrenergic effects on secretion of epidermal growth factor from Brunner's glands
    • Olsen, P.S.; Poulsen, S.S.; Kirkegaard, P. Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. Gut 1985, 26, 920-927.
    • (1985) Gut , vol.26 , pp. 920-927
    • Olsen, P.S.1    Poulsen, S.S.2    Kirkegaard, P.3
  • 80
    • 0029976245 scopus 로고    scopus 로고
    • Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha
    • Reddy, C.C.; Wells, A.; Lauffenburger, D.A. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. J. Cell. Physiol. 1996, 166, 512-522.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 512-522
    • Reddy, C.C.1    Wells, A.2    Lauffenburger, D.A.3
  • 81
    • 0027331503 scopus 로고
    • Transforming growth factor-alpha expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-alpha and hepatocyte growth factor
    • Webber, E.M.; FitzGerald, M.J.; Brown, P.I.; Bartlett, M.H.; Fausto, N. Transforming growth factor-alpha expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-alpha and hepatocyte growth factor. Hepatology 1993, 18, 1422-1431.
    • (1993) Hepatology , vol.18 , pp. 1422-1431
    • Webber, E.M.1    FitzGerald, M.J.2    Brown, P.I.3    Bartlett, M.H.4    Fausto, N.5
  • 82
    • 0025476771 scopus 로고
    • Transforming growth factor alpha: Expression, regulation and biological action of its integral membrane precursor
    • Luetteke, N.C.; Lee, D.C. Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor. Semin. Cancer Biol. 1990, 1, 265-275.
    • (1990) Semin. Cancer Biol. , vol.1 , pp. 265-275
    • Luetteke, N.C.1    Lee, D.C.2
  • 84
    • 0041531109 scopus 로고
    • Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism
    • Mead, J.E.; Fausto, N. Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. Proc. Natl. Acad. Sci. USA 1989, 86, 1558-1562.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1558-1562
    • Mead, J.E.1    Fausto, N.2
  • 85
    • 0029871253 scopus 로고    scopus 로고
    • Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice
    • Russell, W.E.; Kaufmann, W.K.; Sitaric, S.; Luetteke, N.C.; Lee, D.C. Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice. Mol. Carcinog. 1996, 15, 183-189.
    • (1996) Mol. Carcinog. , vol.15 , pp. 183-189
    • Russell, W.E.1    Kaufmann, W.K.2    Sitaric, S.3    Luetteke, N.C.4    Lee, D.C.5
  • 87
    • 14944361776 scopus 로고    scopus 로고
    • Liver regeneration, growth factors, and amphiregulin
    • Michalopoulos, G.K.; Khan, Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology 2005, 128, 503-506.
    • (2005) Gastroenterology , vol.128 , pp. 503-506
    • Michalopoulos, G.K.1    Khan, Z.2
  • 88
    • 0028807924 scopus 로고
    • Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy
    • Kiso, S.; Kawata, S.; Tamura, S.; Higashiyama, S.; Ito, N.; Tsushima, H.; Taniguchi, N.; Matsuzawa, Y. Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy. Hepatology 1995, 22, 1584-1590.
    • (1995) Hepatology , vol.22 , pp. 1584-1590
    • Kiso, S.1    Kawata, S.2    Tamura, S.3    Higashiyama, S.4    Ito, N.5    Tsushima, H.6    Taniguchi, N.7    Matsuzawa, Y.8
  • 90
    • 13244295639 scopus 로고    scopus 로고
    • Heparinbinding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration
    • Mitchell, C.; Nivison, M.; Jackson, L.F.; Fox, R.; Lee, D.C.; Campbell, J.S.; Fausto, N. Heparinbinding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J. Biol. Chem. 2005, 280, 2562-2568.
    • (2005) J. Biol. Chem. , vol.280 , pp. 2562-2568
    • Mitchell, C.1    Nivison, M.2    Jackson, L.F.3    Fox, R.4    Lee, D.C.5    Campbell, J.S.6    Fausto, N.7
  • 92
    • 77953202698 scopus 로고    scopus 로고
    • RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats
    • Paranjpe, S.; Bowen, W.C.; Tseng, G.C.; Luo, J.H.; Orr, A.; Michalopoulos, G.K. RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. Am. J. Pathol. 2010, 176, 2669-2681.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2669-2681
    • Paranjpe, S.1    Bowen, W.C.2    Tseng, G.C.3    Luo, J.H.4    Orr, A.5    Michalopoulos, G.K.6
  • 93
    • 36048973747 scopus 로고    scopus 로고
    • The EGF receptor is required for efficient liver regeneration
    • Natarajan, A.; Wagner, B.; Sibilia, M. The EGF receptor is required for efficient liver regeneration. Proc. Natl. Acad. Sci. USA 2007, 104, 17081-17086.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17081-17086
    • Natarajan, A.1    Wagner, B.2    Sibilia, M.3
  • 95
    • 0034745222 scopus 로고    scopus 로고
    • NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha-and Fas-mediated apoptosis
    • Hatano, E.; Bennett, B.L.; Manning, A.M.; Qian, T.; Lemasters, J.J.; Brenner, D.A. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha-and Fas-mediated apoptosis. Gastroenterology 2001, 120, 1251-1262.
    • (2001) Gastroenterology , vol.120 , pp. 1251-1262
    • Hatano, E.1    Bennett, B.L.2    Manning, A.M.3    Qian, T.4    Lemasters, J.J.5    Brenner, D.A.6
  • 96
    • 0035658389 scopus 로고    scopus 로고
    • Akt protects mouse hepatocytes from TNF-alpha-and Fas-mediated apoptosis through NK-kappa B activation
    • Hatano, E.; Brenner, D.A. Akt protects mouse hepatocytes from TNF-alpha-and Fas-mediated apoptosis through NK-kappa B activation. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 281, G1357-G1368.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.281
    • Hatano, E.1    Brenner, D.A.2
  • 97
    • 0028999453 scopus 로고
    • Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
    • Leist, M.; Gantner, F.; Bohlinger, I.; Tiegs, G.; Germann, P.G.; Wendel, A. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 1995, 146, 1220-1234.
    • (1995) Am. J. Pathol. , vol.146 , pp. 1220-1234
    • Leist, M.1    Gantner, F.2    Bohlinger, I.3    Tiegs, G.4    Germann, P.G.5    Wendel, A.6
  • 98
    • 0028895940 scopus 로고
    • Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release
    • Leist, M.; Gantner, F.; Jilg, S.; Wendel, A. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J. Immunol. 1995, 154, 1307-1316.
    • (1995) J. Immunol. , vol.154 , pp. 1307-1316
    • Leist, M.1    Gantner, F.2    Jilg, S.3    Wendel, A.4
  • 99
    • 0029669189 scopus 로고    scopus 로고
    • The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure
    • Leist, M.; Gantner, F.; Kunstle, G.; Bohlinger, I.; Tiegs, G.; Bluethmann, H.; Wendel, A. The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol. Med. 1996, 2, 109-124.
    • (1996) Mol. Med. , vol.2 , pp. 109-124
    • Leist, M.1    Gantner, F.2    Kunstle, G.3    Bohlinger, I.4    Tiegs, G.5    Bluethmann, H.6    Wendel, A.7
  • 100
    • 0026801421 scopus 로고
    • Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy
    • Akerman, P.; Cote, P.; Yang, S.Q.; McClain, C.; Nelson, S.; Bagby, G.J.; Diehl, A.M. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J. Physiol. 1992, 263, G579-G585.
    • (1992) Am J. Physiol. , vol.263
    • Akerman, P.1    Cote, P.2    Yang, S.Q.3    McClain, C.4    Nelson, S.5    Bagby, G.J.6    Diehl, A.M.7
  • 101
    • 0031688717 scopus 로고    scopus 로고
    • Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor
    • Yamada, Y.; Webber, E.M.; Kirillova, I.; Peschon, J.J.; Fausto, N. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor. Hepatology 1998, 28, 959-970.
    • (1998) Hepatology , vol.28 , pp. 959-970
    • Yamada, Y.1    Webber, E.M.2    Kirillova, I.3    Peschon, J.J.4    Fausto, N.5
  • 103
    • 0031787394 scopus 로고    scopus 로고
    • Tumor necrosis factor primes hepatocytes for DNA replication in the rat
    • Webber, E.M.; Bruix, J.; Pierce, R.H.; Fausto, N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 1998, 28, 1226-1234.
    • (1998) Hepatology , vol.28 , pp. 1226-1234
    • Webber, E.M.1    Bruix, J.2    Pierce, R.H.3    Fausto, N.4
  • 104
    • 0028040336 scopus 로고
    • In vivo response of hepatocytes to growth factors requires an initial priming stimulus
    • Webber, E.M.; Godowski, P.J.; Fausto, N. In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994, 19, 489-497.
    • (1994) Hepatology , vol.19 , pp. 489-497
    • Webber, E.M.1    Godowski, P.J.2    Fausto, N.3
  • 105
    • 0025311421 scopus 로고
    • IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6
    • Gauldie, J.; Northemann, W.; Fey, G.H. IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6. J. Immunol. 1990, 144, 3804-3808.
    • (1990) J. Immunol. , vol.144 , pp. 3804-3808
    • Gauldie, J.1    Northemann, W.2    Fey, G.H.3
  • 106
    • 0025228036 scopus 로고
    • Acutephase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin
    • Castell, J.V.; Gomez-Lechon, M.J.; David, M.; Fabra, R.; Trullenque, R.; Heinrich, P.C. Acutephase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-Hepatology 1990, 12, 1179-1186.
    • (1990) Hepatology , vol.12 , pp. 1179-1186
    • Castell, J.V.1    Gomez-Lechon, M.J.2    David, M.3    Fabra, R.4    Trullenque, R.5    Heinrich, P.C.6
  • 108
    • 0032533949 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis
    • Peters, M.; Muller, A.M.; Rose-John, S. Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis. Blood 1998, 92, 3495-3504.
    • (1998) Blood , vol.92 , pp. 3495-3504
    • Peters, M.1    Muller, A.M.2    Rose-John, S.3
  • 109
    • 0026499123 scopus 로고
    • Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130
    • Wang, Y.; Nesbitt, J.E.; Fuentes, N.L.; Fuller, G.M. Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130. Genomics 1992, 14, 666-672.
    • (1992) Genomics , vol.14 , pp. 666-672
    • Wang, Y.1    Nesbitt, J.E.2    Fuentes, N.L.3    Fuller, G.M.4
  • 111
    • 0028025345 scopus 로고
    • Structural and functional characterization of the mouse hepatocyte growth factor gene promoter
    • Liu, Y.; Michalopoulos, G.K.; Zarnegar, R. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter. J. Biol. Chem. 1994, 269, 4152-4160.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4152-4160
    • Liu, Y.1    Michalopoulos, G.K.2    Zarnegar, R.3
  • 112
    • 27844465896 scopus 로고    scopus 로고
    • IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: Regulation by SOCS3
    • Sun, R.; Jaruga, B.; Kulkarni, S.; Sun, H.; Gao, B. IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3. Biochem. Biophys. Res. Commun. 2005, 338, 1943-1949.
    • (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 1943-1949
    • Sun, R.1    Jaruga, B.2    Kulkarni, S.3    Sun, H.4    Gao, B.5
  • 113
    • 0142124723 scopus 로고    scopus 로고
    • Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line
    • Kariv, R.; Enden, A.; Zvibel, I.; Rosner, G.; Brill, S.; Shafritz, D.A.; Halpern, Z.; Oren, R. Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line. Liver Int. 2003, 23, 187-193.
    • (2003) Liver Int. , vol.23 , pp. 187-193
    • Kariv, R.1    Enden, A.2    Zvibel, I.3    Rosner, G.4    Brill, S.5    Shafritz, D.A.6    Halpern, Z.7    Oren, R.8
  • 114
    • 78149492010 scopus 로고    scopus 로고
    • Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: Implications for inflammatory mediated diseases
    • Coudriet, G.M.; He, J.; Trucco, M.; Mars, W.M.; Piganelli, J.D. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: Implications for inflammatory mediated diseases. PLoS One 2010, 5, e15384.
    • (2010) PLoS One , vol.5
    • Coudriet, G.M.1    He, J.2    Trucco, M.3    Mars, W.M.4    Piganelli, J.D.5
  • 115
    • 54949091994 scopus 로고    scopus 로고
    • Multi-target anti-inflammatory action of hepatocyte growth factor
    • Gong, R. Multi-target anti-inflammatory action of hepatocyte growth factor. Curr. Opin. Investig. Drugs 2008, 9, 1163-1170.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 1163-1170
    • Gong, R.1
  • 117
    • 0025356905 scopus 로고
    • Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat
    • Gruppuso, P.A.; Mead, J.E.; Fausto, N. Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat. Cancer Res. 1990, 50, 1464-1469.
    • (1990) Cancer Res. , vol.50 , pp. 1464-1469
    • Gruppuso, P.A.1    Mead, J.E.2    Fausto, N.3
  • 118
    • 0028835609 scopus 로고
    • Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration
    • discussion 131-122
    • Chari, R.S.; Price, D.T.; Sue, S.R.; Meyers, W.C.; Jirtle, R.L. Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration. Am. J. Surg. 1995, 169, 126-131; discussion 131-122.
    • (1995) Am. J. Surg. , vol.169 , pp. 126-131
    • Chari, R.S.1    Price, D.T.2    Sue, S.R.3    Meyers, W.C.4    Jirtle, R.L.5
  • 119
    • 0029159792 scopus 로고
    • Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation
    • Bissell, D.M.; Wang, S.S.; Jarnagin, W.R.; Roll, F.J. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J. Clin. Invest. 1995, 96, 447-455.
    • (1995) J. Clin. Invest. , vol.96 , pp. 447-455
    • Bissell, D.M.1    Wang, S.S.2    Jarnagin, W.R.3    Roll, F.J.4
  • 120
    • 0032578596 scopus 로고    scopus 로고
    • Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor beta1 expression and DNA synthesis
    • Ikeda, H.; Nagoshi, S.; Ohno, A.; Yanase, M.; Maekawa, H.; Fujiwara, K. Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor beta1 expression and DNA synthesis. Biochem. Biophys. Res. Commun. 1998, 250, 769-775.
    • (1998) Biochem. Biophys. Res. Commun. , vol.250 , pp. 769-775
    • Ikeda, H.1    Nagoshi, S.2    Ohno, A.3    Yanase, M.4    Maekawa, H.5    Fujiwara, K.6
  • 121
    • 0025050821 scopus 로고
    • Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver
    • Nakatsukasa, H.; Evarts, R.P.; Hsia, C.C.; Thorgeirsson, S.S. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab. Invest. 1990, 63, 171-180.
    • (1990) Lab. Invest. , vol.63 , pp. 171-180
    • Nakatsukasa, H.1    Evarts, R.P.2    Hsia, C.C.3    Thorgeirsson, S.S.4
  • 122
    • 0024382102 scopus 로고
    • TGF beta gene transcription in normal and neoplastic liver growth
    • Carr, B.I.; Huang, T.H.; Itakura, K.; Noel, M.; Marceau, N. TGF beta gene transcription in normal and neoplastic liver growth. J. Cell. Biochem. 1989, 39, 477-487.
    • (1989) J. Cell. Biochem. , vol.39 , pp. 477-487
    • Carr, B.I.1    Huang, T.H.2    Itakura, K.3    Noel, M.4    Marceau, N.5
  • 123
    • 0038045136 scopus 로고    scopus 로고
    • HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures
    • Michalopoulos, G.K.; Bowen, W.C.; Mule, K.; Luo, J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr. 2003, 11, 55-75.
    • (2003) Gene Expr. , vol.11 , pp. 55-75
    • Michalopoulos, G.K.1    Bowen, W.C.2    Mule, K.3    Luo, J.4
  • 124
    • 0022519967 scopus 로고
    • Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture
    • McMahon, J.B.; Richards, W.L.; del Campo, A.A.; Song, M.K.; Thorgeirsson, S.S. Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res. 1986, 46, 4665-4671.
    • (1986) Cancer Res. , vol.46 , pp. 4665-4671
    • McMahon, J.B.1    Richards, W.L.2    del Campo, A.A.3    Song, M.K.4    Thorgeirsson, S.S.5
  • 125
    • 0023758570 scopus 로고
    • Norepinephrine modulates the growth-inhibitory effect of transforming growth factor-beta in primary rat hepatocyte cultures
    • Houck, K.A.; Cruise, J.L.; Michalopoulos, G. Norepinephrine modulates the growth-inhibitory effect of transforming growth factor-beta in primary rat hepatocyte cultures. J. Cell. Physiol. 1988, 135, 551-555.
    • (1988) J. Cell. Physiol. , vol.135 , pp. 551-555
    • Houck, K.A.1    Cruise, J.L.2    Michalopoulos, G.3
  • 126
    • 0024040124 scopus 로고
    • Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat
    • Russell, W.E.; Coffey, R.J., Jr.; Ouellette, A.J.; Moses, H.L. Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc. Natl. Acad. Sci. USA 1988, 85, 5126-5130.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5126-5130
    • Russell, W.E.1    Coffey Jr., R.J.2    Ouellette, A.J.3    Moses, H.L.4
  • 127
    • 0025888301 scopus 로고
    • Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration
    • Jirtle, R.L.; Carr, B.I.; Scott, C.D. Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration. J. Biol. Chem. 1991, 266, 22444-22450.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22444-22450
    • Jirtle, R.L.1    Carr, B.I.2    Scott, C.D.3
  • 129
    • 0024818405 scopus 로고
    • Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type beta
    • Houck, K.A.; Michalopoulos, G.K. Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type beta. J. Cell. Physiol. 1989, 141, 503-509.
    • (1989) J. Cell. Physiol. , vol.141 , pp. 503-509
    • Houck, K.A.1    Michalopoulos, G.K.2
  • 130
    • 0023193194 scopus 로고
    • Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin
    • O'Connor-McCourt, M.D.; Wakefield, L.M. Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin. J. Biol. Chem. 1987, 262, 14090-14099.
    • (1987) J. Biol. Chem. , vol.262 , pp. 14090-14099
    • O'Connor-McCourt, M.D.1    Wakefield, L.M.2
  • 131
    • 0000742819 scopus 로고
    • Transforming growth factor beta mRNA increases during liver regeneration: A possible paracrine mechanism of growth regulation
    • Braun, L.; Mead, J.E.; Panzica, M.; Mikumo, R.; Bell, G.I.; Fausto, N. Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc. Natl. Acad. Sci. USA 1988, 85, 1539-1543.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1539-1543
    • Braun, L.1    Mead, J.E.2    Panzica, M.3    Mikumo, R.4    Bell, G.I.5    Fausto, N.6
  • 132
    • 7044228192 scopus 로고    scopus 로고
    • Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice
    • Oe, S.; Lemmer, E.R.; Conner, E.A.; Factor, V.M.; Leveen, P.; Larsson, J.; Karlsson, S.; Thorgeirsson, S.S. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004, 40, 1098-1105.
    • (2004) Hepatology , vol.40 , pp. 1098-1105
    • Oe, S.1    Lemmer, E.R.2    Conner, E.A.3    Factor, V.M.4    Leveen, P.5    Larsson, J.6    Karlsson, S.7    Thorgeirsson, S.S.8
  • 136
    • 0021868220 scopus 로고
    • Norepinephrine and epidermal growth factor: Dynamics of their interaction in the stimulation of hepatocyte DNA synthesis
    • Cruise, J.L.; Michalopoulos, G. Norepinephrine and epidermal growth factor: dynamics of their interaction in the stimulation of hepatocyte DNA synthesis. J. Cell. Physiol. 1985, 125, 45-50.
    • (1985) J. Cell. Physiol. , vol.125 , pp. 45-50
    • Cruise, J.L.1    Michalopoulos, G.2
  • 137
    • 0022005066 scopus 로고
    • Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine
    • Cruise, J.L.; Houck, K.A.; Michalopoulos, G.K. Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine. Science 1985, 227, 749-751.
    • (1985) Science , vol.227 , pp. 749-751
    • Cruise, J.L.1    Houck, K.A.2    Michalopoulos, G.K.3
  • 139
    • 46049097373 scopus 로고    scopus 로고
    • Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes
    • Han, C.; Bowen, W.C.; Michalopoulos, G.K.; Wu, T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. J. Cell. Physiol. 2008, 216, 486-497.
    • (2008) J. Cell. Physiol. , vol.216 , pp. 486-497
    • Han, C.1    Bowen, W.C.2    Michalopoulos, G.K.3    Wu, T.4
  • 145
    • 79959503376 scopus 로고    scopus 로고
    • TGR5 in the biliary tree
    • Keitel, V.; Haussinger, D. TGR5 in the biliary tree. Dig. Dis. 2011, 29, 45-47.
    • (2011) Dig. Dis. , vol.29 , pp. 45-47
    • Keitel, V.1    Haussinger, D.2
  • 146
    • 0345425112 scopus 로고    scopus 로고
    • Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: A review
    • Holeek, M. Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review. Nutrition 1999, 15, 784-788.
    • (1999) Nutrition , vol.15 , pp. 784-788
    • Holeek, M.1
  • 147
    • 84867175770 scopus 로고    scopus 로고
    • Functional Relationships between Lipid Metabolism and Liver Regeneration
    • 549241
    • Rudnick, D.A.; Davidson, N.O. Functional Relationships between Lipid Metabolism and Liver Regeneration. Int. J. Hepatol. 2012, 549241.
    • (2012) Int. J. Hepatol.
    • Rudnick, D.A.1    Davidson, N.O.2
  • 148
    • 0016710260 scopus 로고
    • Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations
    • Michalopoulos, G.; Pitot, H.C. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp. Cell Res. 1975, 94, 70-78.
    • (1975) Exp. Cell Res. , vol.94 , pp. 70-78
    • Michalopoulos, G.1    Pitot, H.C.2
  • 149
    • 0026493720 scopus 로고
    • Rat liver regeneration after partial hepatectomy: Effects of insulin, glucagon and epidermal growth factor
    • Lai, H.S.; Chung, Y.C.; Chen, W.J.; Chen, K.M. Rat liver regeneration after partial hepatectomy: effects of insulin, glucagon and epidermal growth factor. J. Formos. Med. Assoc. 1992, 91, 685-690.
    • (1992) J. Formos. Med. Assoc. , vol.91 , pp. 685-690
    • Lai, H.S.1    Chung, Y.C.2    Chen, W.J.3    Chen, K.M.4
  • 152
    • 0022496273 scopus 로고
    • Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy
    • Caruana, J.A.; Whalen, D.A.; Anthony, W.P.; Sunby, C.R.; Ciechoski, M.P. Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy. Endocrine Res. 1986, 12, 147-156.
    • (1986) Endocrine Res , vol.12 , pp. 147-156
    • Caruana, J.A.1    Whalen, D.A.2    Anthony, W.P.3    Sunby, C.R.4    Ciechoski, M.P.5
  • 153
    • 0018765225 scopus 로고
    • Effects of protein-deprivation on the regeneration of rat liver after partial hepatectomy
    • McGowan, J.; Atryzek, V.; Fausto, N. Effects of protein-deprivation on the regeneration of rat liver after partial hepatectomy. Biochem. J. 1979, 180, 25-35.
    • (1979) Biochem. J , vol.180 , pp. 25-35
    • McGowan, J.1    Atryzek, V.2    Fausto, N.3
  • 154
    • 0025887744 scopus 로고
    • Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats
    • Holeček, M.; Šimek, J.; Palička, V.; Zadák, Z. Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats. J. Hepatol. 1991, 13, 14-20.
    • (1991) J. Hepatol , vol.13 , pp. 14-20
    • Holeček, M.1    Šimek, J.2    Palička, V.3    Zadák, Z.4
  • 155
    • 0014271008 scopus 로고
    • Alteration in liver lipid and lipid fatty acid composition after partial hepatectomy in the rat
    • Glende, E.A.; Morgan, W.S. Alteration in liver lipid and lipid fatty acid composition after partial hepatectomy in the rat. Exp. Mol. Path. 1968, 8, 190-200.
    • (1968) Exp. Mol. Path , vol.8 , pp. 190-200
    • Glende, E.A.1    Morgan, W.S.2
  • 157
    • 0026710464 scopus 로고
    • Liver regeneration in partially hepatectomized rats infused with carnitine and lipids
    • Blaha, V.; Simek, J.; Zadak, Z. Liver regeneration in partially hepatectomized rats infused with carnitine and lipids. Exp. Toxicol. Pathol. 1992, 44, 158, 165-168.
    • (1992) Exp. Toxicol. Pathol. , vol.44
    • Blaha, V.1    Simek, J.2    Zadak, Z.3
  • 158
    • 0019519930 scopus 로고
    • Differences in predominant energy substrate in relation to the resected hepatic mass in the phase immediately after hepatectomy
    • Nakatani, T.; Ozawa, K.; Asano, M. Differences in predominant energy substrate in relation to the resected hepatic mass in the phase immediately after hepatectomy. J. Lab. Clin. Med. 1981, 97, 887-898.
    • (1981) J. Lab. Clin. Med. , vol.97 , pp. 887-898
    • Nakatani, T.1    Ozawa, K.2    Asano, M.3
  • 161
    • 0036531819 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    • Monga, S.P.; Mars, W.M.; Pediaditakis, P.; Bell, A.; Mule, K.; Bowen, W.C.; Wang, X.; Zarnegar, R.; Michalopoulos, G.K. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res. 2002, 62, 2064-2071.
    • (2002) Cancer Res. , vol.62 , pp. 2064-2071
    • Monga, S.P.1    Mars, W.M.2    Pediaditakis, P.3    Bell, A.4    Mule, K.5    Bowen, W.C.6    Wang, X.7    Zarnegar, R.8    Michalopoulos, G.K.9
  • 162
    • 20444408343 scopus 로고    scopus 로고
    • Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration
    • Sodhi, D.; Micsenyi, A.; Bowen, W.C.; Monga, D.K.; Talavera, J.C.; Monga, S.P. Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration. J. Hepatol. 2005, 43, 132-141.
    • (2005) J. Hepatol. , vol.43 , pp. 132-141
    • Sodhi, D.1    Micsenyi, A.2    Bowen, W.C.3    Monga, D.K.4    Talavera, J.C.5    Monga, S.P.6
  • 163
    • 33750726092 scopus 로고    scopus 로고
    • Conditional deletion of betacatenin reveals its role in liver growth and regeneration
    • Tan, X.; Behari, J.; Cieply, B.; Michalopoulos, G.K.; Monga, S.P. Conditional deletion of betacatenin reveals its role in liver growth and regeneration. Gastroenterology 2006, 131, 1561-1572.
    • (2006) Gastroenterology , vol.131 , pp. 1561-1572
    • Tan, X.1    Behari, J.2    Cieply, B.3    Michalopoulos, G.K.4    Monga, S.P.5
  • 167
    • 43049097898 scopus 로고    scopus 로고
    • Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
    • Capurro, M.I.; Xu, P.; Shi, W.; Li, F.; Jia, A.; Filmus, J. Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev. Cell. 2008, 14, 700-711.
    • (2008) Dev. Cell. , vol.14 , pp. 700-711
    • Capurro, M.I.1    Xu, P.2    Shi, W.3    Li, F.4    Jia, A.5    Filmus, J.6
  • 168
    • 0032985184 scopus 로고    scopus 로고
    • Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase
    • Kan, M.; Wu, X.; Wang, F.; McKeehan, W.L. Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase. J. Biol. Chem. 1999, 274, 15947-15952.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15947-15952
    • Kan, M.1    Wu, X.2    Wang, F.3    McKeehan, W.L.4
  • 169
    • 0025309633 scopus 로고
    • Acidic fibroblast growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocyte cultures
    • Houck, K.A.; Zarnegar, R.; Muga, S.J.; Michalopoulos, G.K. Acidic fibroblast growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocyte cultures. J. Cell. Physiol. 1990, 143, 129-132.
    • (1990) J. Cell. Physiol. , vol.143 , pp. 129-132
    • Houck, K.A.1    Zarnegar, R.2    Muga, S.J.3    Michalopoulos, G.K.4
  • 170
    • 0028290799 scopus 로고
    • Keratinocyte growth factor and fibroblast growth factor action on DNA synthesis in rat and human hepatocytes: Modulation by heparin
    • Strain, A.J.; McGuinness, G.; Rubin, J.S.; Aaronson, S.A. Keratinocyte growth factor and fibroblast growth factor action on DNA synthesis in rat and human hepatocytes: Modulation by heparin. Exp. Cell Res. 1994, 210, 253-259.
    • (1994) Exp. Cell Res. , vol.210 , pp. 253-259
    • Strain, A.J.1    McGuinness, G.2    Rubin, J.S.3    Aaronson, S.A.4
  • 172
    • 84961054225 scopus 로고
    • A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3
    • Grisham, J.W. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res. 1962, 22, 842-849.
    • (1962) Cancer Res. , vol.22 , pp. 842-849
    • Grisham, J.W.1
  • 173
    • 0016759038 scopus 로고
    • Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver. A light and electron microscopic cytochemical study
    • Widmann, J.J.; Fahimi, H.D. Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver. A light and electron microscopic cytochemical study. Am. J. Pathol. 1975, 80, 349-366.
    • (1975) Am. J. Pathol. , vol.80 , pp. 349-366
    • Widmann, J.J.1    Fahimi, H.D.2
  • 174
    • 0025177272 scopus 로고
    • Immunohistochemical detection of proliferating lipocytes in regenerating rat liver
    • Tanaka, Y.; Mak, K.M.; Lieber, C.S. Immunohistochemical detection of proliferating lipocytes in regenerating rat liver. J. Pathol. 1990, 160, 129-134.
    • (1990) J. Pathol. , vol.160 , pp. 129-134
    • Tanaka, Y.1    Mak, K.M.2    Lieber, C.S.3
  • 175
    • 0015177131 scopus 로고
    • Regeneration of liver parenchyma under normal and pathological conditions
    • Stocker, E.; Heine, W.D. Regeneration of liver parenchyma under normal and pathological conditions. Beitr. Pathol. 1971, 144, 400-408.
    • (1971) Beitr. Pathol. , vol.144 , pp. 400-408
    • Stocker, E.1    Heine, W.D.2
  • 176
    • 0015193398 scopus 로고
    • Proliferation and regeneration in liver and kidney of juvenile rats. Autoradiographic studies after continuous infusion of 3H-thymidine (author's transl)
    • Stocker, E.; Heine, W.D. Proliferation and regeneration in liver and kidney of juvenile rats. Autoradiographic studies after continuous infusion of 3H-thymidine (author's transl). Verh. Dtsch. Ges. Pathol. 1971, 55, 483-488.
    • (1971) Verh. Dtsch. Ges. Pathol. , vol.55 , pp. 483-488
    • Stocker, E.1    Heine, W.D.2
  • 177
    • 0015259648 scopus 로고
    • Growth and regeneration in parenchymatous organs of the rat. Autoradiographic investigations with 3 H-thymidin
    • Stocker, E.; Schultze, B.; Heine, W.D.; Liebscher, H. Growth and regeneration in parenchymatous organs of the rat. Autoradiographic investigations with 3 H-thymidin. Z. Zellforsch. Mikrosk. Anat. 1972, 125, 306-331.
    • (1972) Z. Zellforsch. Mikrosk. Anat. , vol.125 , pp. 306-331
    • Stocker, E.1    Schultze, B.2    Heine, W.D.3    Liebscher, H.4
  • 178
    • 81555221816 scopus 로고    scopus 로고
    • Liver regeneration and aging: A current perspective
    • Schmucker, D.L.; Sanchez, H. Liver regeneration and aging: a current perspective. Curr. Gerontol. Geriatr. Res. 2011, 2011, 526379.
    • (2011) Curr. Gerontol. Geriatr. Res. , vol.2011 , pp. 526379
    • Schmucker, D.L.1    Sanchez, H.2
  • 179
    • 52449141463 scopus 로고
    • Capacity of regeneration in liver epithelia of juvenile, repeated partially hepatectomized rats. Autoradiographic studies after continous infusion of 3Hthymidine (author's transl)
    • Stocker, E.; Wullstein, H.K.; Brau, G. Capacity of regeneration in liver epithelia of juvenile, repeated partially hepatectomized rats. Autoradiographic studies after continous infusion of 3Hthymidine (author's transl). Virchows Arch. B Cell. Pathol. 1973, 14, 93-103.
    • (1973) Virchows Arch. B Cell. Pathol. , vol.14 , pp. 93-103
    • Stocker, E.1    Wullstein, H.K.2    Brau, G.3
  • 180
    • 0030715611 scopus 로고    scopus 로고
    • Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
    • Overturf, K.; al-Dhalimy, M.; Ou, C.N.; Finegold, M.; Grompe, M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am. J. Pathol. 1997, 151, 1273-1280.
    • (1997) Am. J. Pathol. , vol.151 , pp. 1273-1280
    • Overturf, K.1    al-Dhalimy, M.2    Ou, C.N.3    Finegold, M.4    Grompe, M.5
  • 181
    • 80053327098 scopus 로고    scopus 로고
    • Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo
    • Bhave, V.S.; Paranjpe, S.; Bowen, W.C.; Donthamsetty, S.; Bell, A.W.; Khillan, J.S.; Michalopoulos, G.K. Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology 2011, 54, 1360-1370.
    • (2011) Hepatology , vol.54 , pp. 1360-1370
    • Bhave, V.S.1    Paranjpe, S.2    Bowen, W.C.3    Donthamsetty, S.4    Bell, A.W.5    Khillan, J.S.6    Michalopoulos, G.K.7
  • 182
    • 0344913663 scopus 로고
    • Heparinbinding growth factor type 1 (acidic fibroblast growth factor): A potential biphasic autocrine and paracrine regulator of hepatocyte regeneration
    • Kan, M.; Huang, J.S.; Mansson, P.E.; Yasumitsu, H.; Carr, B.; McKeehan, W.L. Heparinbinding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration. Proc. Natl. Acad. Sci. USA 1989, 86, 7432-7436.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7432-7436
    • Kan, M.1    Huang, J.S.2    Mansson, P.E.3    Yasumitsu, H.4    Carr, B.5    McKeehan, W.L.6
  • 184
    • 0035190838 scopus 로고    scopus 로고
    • Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver
    • Ross, M.A.; Sander, C.M.; Kleeb, T.B.; Watkins, S.C.; Stolz, D.B. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Hepatology 2001, 34, 1135-1148.
    • (2001) Hepatology , vol.34 , pp. 1135-1148
    • Ross, M.A.1    Sander, C.M.2    Kleeb, T.B.3    Watkins, S.C.4    Stolz, D.B.5
  • 185
    • 0028789311 scopus 로고
    • The extracellular matrix in hepatic regeneration
    • Martinez-Hernandez, A.; Amenta, P.S. The extracellular matrix in hepatic regeneration. FASEB J. 1995, 9, 1401-1410.
    • (1995) FASEB J. , vol.9 , pp. 1401-1410
    • Martinez-Hernandez, A.1    Amenta, P.S.2
  • 186
    • 0035144232 scopus 로고    scopus 로고
    • Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver
    • Wack, K.E.; Ross, M.A.; Zegarra, V.; Sysko, L.R.; Watkins, S.C.; Stolz, D.B. Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology 2001, 33, 363-378.
    • (2001) Hepatology , vol.33 , pp. 363-378
    • Wack, K.E.1    Ross, M.A.2    Zegarra, V.3    Sysko, L.R.4    Watkins, S.C.5    Stolz, D.B.6
  • 187
  • 189
    • 84859723288 scopus 로고    scopus 로고
    • Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
    • Wang, L.; Wang, X.; Xie, G.; Hill, C.K.; DeLeve, L.D. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J. Clin. Invest. 2012, 122, 1567-1573.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1567-1573
    • Wang, L.1    Wang, X.2    Xie, G.3    Hill, C.K.4    DeLeve, L.D.5
  • 190
    • 84869743329 scopus 로고    scopus 로고
    • Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells
    • Wang, L.; Wang, X.; Chiu, J.D.; van de Ven, G.; Gaarde, W.A.; Deleve, L.D. Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells. Gastroenterology 2012, 143, 1555-1563.
    • (2012) Gastroenterology , vol.143 , pp. 1555-1563
    • Wang, L.1    Wang, X.2    Chiu, J.D.3    van de Ven, G.4    Gaarde, W.A.5    Deleve, L.D.6
  • 198
    • 0033547424 scopus 로고    scopus 로고
    • 2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression
    • Trautwein, C.; Will, M.; Kubicka, S.; Rakemann, T.; Flemming, P.; Manns, M.P. 2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression. Oncogene 1999, 18, 6443-6453.
    • (1999) Oncogene , vol.18 , pp. 6443-6453
    • Trautwein, C.1    Will, M.2    Kubicka, S.3    Rakemann, T.4    Flemming, P.5    Manns, M.P.6
  • 199
    • 48749116279 scopus 로고    scopus 로고
    • Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    • Limaye, P.B.; Alarcon, G.; Walls, A.L.; Nalesnik, M.A.; Michalopoulos, G.K.; Demetris, A.J.; Ochoa, E.R. Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab. Invest. 2008, 88, 865-872.
    • (2008) Lab. Invest. , vol.88 , pp. 865-872
    • Limaye, P.B.1    Alarcon, G.2    Walls, A.L.3    Nalesnik, M.A.4    Michalopoulos, G.K.5    Demetris, A.J.6    Ochoa, E.R.7
  • 200
    • 0031938718 scopus 로고    scopus 로고
    • Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat
    • Petersen, B.E.; Goff, J.P.; Greenberger, J.S.; Michalopoulos, G.K. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology 1998, 27, 433-445.
    • (1998) Hepatology , vol.27 , pp. 433-445
    • Petersen, B.E.1    Goff, J.P.2    Greenberger, J.S.3    Michalopoulos, G.K.4
  • 201
    • 0027636320 scopus 로고
    • Activation of hepatic stem cell compartment in the rat: Role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation
    • Evarts, R.P.; Hu, Z.; Fujio, K.; Marsden, E.R.; Thorgeirsson, S.S. Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. Cell Growth Differ. 1993, 4, 555-561.
    • (1993) Cell Growth Differ. , vol.4 , pp. 555-561
    • Evarts, R.P.1    Hu, Z.2    Fujio, K.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 203
    • 77950602936 scopus 로고    scopus 로고
    • Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver
    • Thenappan, A.; Li, Y.; Kitisin, K.; Rashid, A.; Shetty, K.; Johnson, L.; Mishra, L. Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver. Hepatology 2010, 51, 1373-1382.
    • (2010) Hepatology , vol.51 , pp. 1373-1382
    • Thenappan, A.1    Li, Y.2    Kitisin, K.3    Rashid, A.4    Shetty, K.5    Johnson, L.6    Mishra, L.7
  • 204
    • 44249105872 scopus 로고    scopus 로고
    • Signaling networks in hepatic oval cell activation
    • Erker, L.; Grompe, M. Signaling networks in hepatic oval cell activation. Stem Cell Res. 2007, 1, 90-102.
    • (2007) Stem Cell Res. , vol.1 , pp. 90-102
    • Erker, L.1    Grompe, M.2
  • 206
    • 9644275633 scopus 로고    scopus 로고
    • Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat
    • Mavier, P.; Martin, N.; Couchie, D.; Preaux, A.M.; Laperche, Y.; Zafrani, E.S. Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat. Am. J. Pathol. 2004, 165, 1969-1977.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1969-1977
    • Mavier, P.1    Martin, N.2    Couchie, D.3    Preaux, A.M.4    Laperche, Y.5    Zafrani, E.S.6
  • 208
    • 0028291370 scopus 로고
    • Expression of hepatic transcription factors during liver development and oval cell differentiation
    • Nagy, P.; Bisgaard, H.C.; Thorgeirsson, S.S. Expression of hepatic transcription factors during liver development and oval cell differentiation. J. Cell. Biol. 1994, 126, 223-233.
    • (1994) J. Cell. Biol. , vol.126 , pp. 223-233
    • Nagy, P.1    Bisgaard, H.C.2    Thorgeirsson, S.S.3
  • 209
    • 0030874842 scopus 로고    scopus 로고
    • Bile ductular damage induced by methylene dianiline inhibits oval cell activation
    • Petersen, B.E.; Zajac, V.F.; Michalopoulos, G.K. Bile ductular damage induced by methylene dianiline inhibits oval cell activation. Am. J. Pathol. 1997, 151, 905-909.
    • (1997) Am. J. Pathol. , vol.151 , pp. 905-909
    • Petersen, B.E.1    Zajac, V.F.2    Michalopoulos, G.K.3
  • 210
    • 0030055904 scopus 로고    scopus 로고
    • Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes
    • Demetris, A.J.; Seaberg, E.C.; Wennerberg, A.; Ionellie, J.; Michalopoulos, G. Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am. J. Pathol. 1996, 149, 439-448.
    • (1996) Am. J. Pathol. , vol.149 , pp. 439-448
    • Demetris, A.J.1    Seaberg, E.C.2    Wennerberg, A.3    Ionellie, J.4    Michalopoulos, G.5
  • 211
    • 14244252656 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
    • Michalopoulos, G.K.; Barua, L.; Bowen, W.C. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005, 41, 535-544.
    • (2005) Hepatology , vol.41 , pp. 535-544
    • Michalopoulos, G.K.1    Barua, L.2    Bowen, W.C.3
  • 214
    • 84864582837 scopus 로고    scopus 로고
    • Analysis of the role of the integrin signaling pathway in hepatocytes during rat liver regeneration
    • Xu, C.; Yang, Y.; Yang, J.; Chen, X.; Wang, G. Analysis of the role of the integrin signaling pathway in hepatocytes during rat liver regeneration. Cell Mol Biol Lett. 2012, 17, 274-288.
    • (2012) Cell Mol Biol Lett. , vol.17 , pp. 274-288
    • Xu, C.1    Yang, Y.2    Yang, J.3    Chen, X.4    Wang, G.5
  • 221
    • 0034756105 scopus 로고    scopus 로고
    • Transforming growth factor beta and activin tonically inhibit DNA synthesis in the rat liver
    • Ichikawa, T.; Zhang, Y.Q.; Kogure, K.; Hasegawa, Y.; Takagi, H.; Mori, M.; Kojima, I. Transforming growth factor beta and activin tonically inhibit DNA synthesis in the rat liver. Hepatology 2001, 34, 918-925.
    • (2001) Hepatology , vol.34 , pp. 918-925
    • Ichikawa, T.1    Zhang, Y.Q.2    Kogure, K.3    Hasegawa, Y.4    Takagi, H.5    Mori, M.6    Kojima, I.7
  • 222
    • 78650674666 scopus 로고    scopus 로고
    • Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels
    • Buraschi, S.; Pal, N.; Tyler-Rubinstein, N.; Owens, R.T.; Neill, T.; Iozzo, R.V. Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J. Biol. Chem. 2010, 285, 42075-42085.
    • (2010) J. Biol. Chem. , vol.285 , pp. 42075-42085
    • Buraschi, S.1    Pal, N.2    Tyler-Rubinstein, N.3    Owens, R.T.4    Neill, T.5    Iozzo, R.V.6
  • 223
    • 25444503249 scopus 로고    scopus 로고
    • Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis
    • Zhu, J.X.; Goldoni, S.; Bix, G.; Owens, R.T.; McQuillan, D.J.; Reed, C.C.; Iozzo, R.V. Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J. Biol. Chem. 2005, 280, 32468-32479.
    • (2005) J. Biol. Chem. , vol.280 , pp. 32468-32479
    • Zhu, J.X.1    Goldoni, S.2    Bix, G.3    Owens, R.T.4    McQuillan, D.J.5    Reed, C.C.6    Iozzo, R.V.7
  • 224
    • 78650885839 scopus 로고    scopus 로고
    • Mst1/2 signalling to Yap: Gatekeeper for liver size and tumour development
    • Avruch, J.; Zhou, D.; Fitamant, J.; Bardeesy, N. Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br. J. Cancer. 2011, 104, 24-32.
    • (2011) Br. J. Cancer. , vol.104 , pp. 24-32
    • Avruch, J.1    Zhou, D.2    Fitamant, J.3    Bardeesy, N.4
  • 228
    • 33746253919 scopus 로고    scopus 로고
    • Prometheus' challenge: Molecular, cellular and systemic aspects of liver regeneration
    • Pahlavan, P.S.; Feldmann, R.E., Jr.; Zavos, C.; Kountouras, J. Prometheus' challenge: molecular, cellular and systemic aspects of liver regeneration. J. Surg. Res. 2006, 134, 238-251.
    • (2006) J. Surg. Res. , vol.134 , pp. 238-251
    • Pahlavan, P.S.1    Feldmann Jr., R.E.2    Zavos, C.3    Kountouras, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.