Nf-κb stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-α- and fas-mediated apoptosis

Gastroenterology

Volumn 120, Issue 5, 2001, Pages 1251-1262

  Hatano, Etsuro ^a   Bennett, Brydon L ^b   Manning, Anthony M ^b   Qian, Ting ^c   Lemasters, John J ^c   Brenner, David A ^a,b  

^a Department of Medicine ^*  (United States)

^b CELGENE CORPORATION   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BID PROTEIN, MOUSE; CARRIER PROTEIN; CASP3 PROTEIN, MOUSE; CASP8 PROTEIN, MOUSE; CASP9 PROTEIN, MOUSE; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DRUG DERIVATIVE; FAS ANTIGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; PENICILLAMINE; PROTEIN BID; S NITRO N ACETYLPENICILLAMINE; S-NITRO-N-ACETYLPENICILLAMINE; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B KINASE BETA; MESSENGER RNA; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE ACETATE; UNCLASSIFIED DRUG;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LIVER CELL; MALE; METABOLISM; MITOCHONDRION; MOUSE; MUTAGENESIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; ANIMAL CELL; ANIMAL TISSUE; CELL ACTIVATION; CELL DEATH; CELL KILLING; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; ANTIBODIES; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CYTOCHROME C GROUP; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; I-KAPPA B PROTEINS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MUTAGENESIS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PENICILLAMINE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034745222     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.23239     Document Type: Article

References (63)

1. The Fas death factor
2. Apoptosis by death factor
3. Dissection of TNF receptor I effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
4. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
5. Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkap-paB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase
6. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
7. IKK-1 and IKK-2: Cytokine-activated IkappaB kinases essential for NF-kappaB activation
8. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
9. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
10. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
11. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
12. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
13. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
14. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
15. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-lAP1 and c-lAP2 to suppress caspase-8 activation
16. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
17. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor
18. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
19. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis
20. The CD95(APO-1/Fas)/CD95L system
21. Fas-mediated apoptosis of hepatic cells
22. CD95-induced apoptosis in human liver disease
23. Fas and Fas ligand in gut and liver
24. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes
25. Nitric oxide and mitochondrial respiration
26. S-nitrosylation regulates apoptosis
27. Nitric oxide mediates hepatocyte injury
28. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
29. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression
30. Inducible nitric oxide synthase in the liver: Regulation and function
31. Isolation and use of liver cells
32. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
33. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release
34. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration
35. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases
36. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
37. Co-stimulatory effect of nitric oxide on endothelial NF-kappaB implies a physiological self-amplifying mechanism
38. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
39. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
40. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
41. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
42. How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
43. IKAP is a scaffold protein of the IkappaB kinase complex
44. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
45. The CD95 (APO-1/Fas) receptor activates NF-kappaB independently of its cytotoxic function
46. NF-kappaB activation by tumour necrosis factor requires the Akt serinethreonine kinase
47. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
48. Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters
49. Nuclear factor kappaB is required for the transcriptional control of type II NO synthase in regenerating liver
50. Cloning and sequencing of the proximal promoter of the rat iNOS gene: Activation of NFkappaB is not sufficient for transcription of the iNOS gene in rat mesangial cells
51. Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells
52. Apoptotic cell death and nitric oxide: Activating and antagonistic transducing pathways
53. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
54. Nitric oxide inhibits Fas-incduced apoptosis
55. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting ehzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
56. Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression
57. Impaired liver regeneration in inducible nitric oxide synthase deficient mice
58. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
59. The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L)
60. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and bcl-X(L) levels in vivo
61. Nitric oxide inhibits APO-1/Fas-mediated cell death
62. Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide
63. Mechanisms of hepatic toxicity. I. TNF-induced liver injury