메뉴 건너뛰기




Volumn 216, Issue 2, 2008, Pages 486-497

Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PHENYLEPHRINE; PRAZOSIN; RGS2 PROTEIN; STAT3 PROTEIN; STEROID RECEPTOR COACTIVATOR 1;

EID: 46049097373     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21420     Document Type: Article
Times cited : (30)

References (69)
  • 1
    • 0026318020 scopus 로고
    • G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity
    • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S. 1991. G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci USA 88:11354-11358.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11354-11358
    • Allen, L.F.1    Lefkowitz, R.J.2    Caron, M.G.3    Cotecchia, S.4
  • 2
    • 1342304124 scopus 로고    scopus 로고
    • Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: Implications for epithelial secretory responses
    • Bertelsen LS, Barrett KE, Keely SJ. 2004. Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: Implications for epithelial secretory responses. J Biol Chem 279:6271-6279.
    • (2004) J Biol Chem , vol.279 , pp. 6271-6279
    • Bertelsen, L.S.1    Barrett, K.E.2    Keely, S.J.3
  • 4
    • 0030807080 scopus 로고    scopus 로고
    • Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase
    • Boluyt MO, Zheng JS, Younes A, Long X, O'Neill L, Silverman H, Lakatta EG, Crow MT. 1997. Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase. Circ Res 81:176-186.
    • (1997) Circ Res , vol.81 , pp. 176-186
    • Boluyt, M.O.1    Zheng, J.S.2    Younes, A.3    Long, X.4    O'Neill, L.5    Silverman, H.6    Lakatta, E.G.7    Crow, M.T.8
  • 7
    • 0027081142 scopus 로고
    • Pharmacological characteristics of alpha 2-adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning
    • Bylund DB, Blaxall HS, Iversen LJ, Caron MG, Lefkowitz RJ, Lomasney JW. 1992. Pharmacological characteristics of alpha 2-adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol Pharmacol 42:1-5.
    • (1992) Mol Pharmacol , vol.42 , pp. 1-5
    • Bylund, D.B.1    Blaxall, H.S.2    Iversen, L.J.3    Caron, M.G.4    Lefkowitz, R.J.5    Lomasney, J.W.6
  • 10
    • 0029584895 scopus 로고
    • Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ
    • Chen L, Xin X, Eckhart AD, Yang N, Faber JE. 1995. Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ. J Biol Chem 270:30980-30988.
    • (1995) J Biol Chem , vol.270 , pp. 30980-30988
    • Chen, L.1    Xin, X.2    Eckhart, A.D.3    Yang, N.4    Faber, J.E.5
  • 12
    • 0021868220 scopus 로고
    • Norepinephrine and epidermal growth factor: Dynamics of their interaction in the stimulation of hepatocyte DNA synthesis
    • Cruise JL, Michalopoulos G. 1985. Norepinephrine and epidermal growth factor: Dynamics of their interaction in the stimulation of hepatocyte DNA synthesis. J Cell Physiol 125: 45-50.
    • (1985) J Cell Physiol , vol.125 , pp. 45-50
    • Cruise, J.L.1    Michalopoulos, G.2
  • 13
    • 0022005066 scopus 로고
    • Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine
    • Cruise JL, Houck KA, Michalopoulos GK. 1985. Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine. Science 227:749-751.
    • (1985) Science , vol.227 , pp. 749-751
    • Cruise, J.L.1    Houck, K.A.2    Michalopoulos, G.K.3
  • 15
    • 3843121101 scopus 로고    scopus 로고
    • Hepatocytes from alpha1B-adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution
    • Deighan C, Woollhead AM, Colston JF, McGrath JC. 2004. Hepatocytes from alpha1B-adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution. Br J Pharmacol 142:1031-1037.
    • (2004) Br J Pharmacol , vol.142 , pp. 1031-1037
    • Deighan, C.1    Woollhead, A.M.2    Colston, J.F.3    McGrath, J.C.4
  • 16
    • 0018882356 scopus 로고
    • Mechanisms involved in alpha-adrenergic phenomena: Role of calcium ions in actions of catecholamines in liver and other tissues
    • Exton JH. 1980. Mechanisms involved in alpha-adrenergic phenomena: Role of calcium ions in actions of catecholamines in liver and other tissues. Am J Physiol 238:E3-E12.
    • (1980) Am J Physiol , vol.238
    • Exton, J.H.1
  • 17
    • 32944463507 scopus 로고    scopus 로고
    • Cytokines, STATs and liver disease
    • Gao B. 2005. Cytokines, STATs and liver disease. Cell Mol Immunol 2:92-100.
    • (2005) Cell Mol Immunol , vol.2 , pp. 92-100
    • Gao, B.1
  • 18
    • 0028985690 scopus 로고
    • Characterization of the human liver alpha 1-adrenoceptors: Predominance of the alpha 1A subtype
    • Garcia-Sainz JA, Romero-Avila MT, Torres-Marquez ME. 1995. Characterization of the human liver alpha 1-adrenoceptors: Predominance of the alpha 1A subtype. Eur J Pharmacol 289:81-86.
    • (1995) Eur J Pharmacol , vol.289 , pp. 81-86
    • Garcia-Sainz, J.A.1    Romero-Avila, M.T.2    Torres-Marquez, M.E.3
  • 19
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G, Waris G, Tanveer R, Siddiqui A. 2001. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci USA 98:9599-9604.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 20
    • 0035952656 scopus 로고    scopus 로고
    • Cell communication networks: Epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission
    • Gschwind A, Zwick E, Prenzel N, Leserer M, Ullrich A. 2001. Cell communication networks: Epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 20:1594-1600.
    • (2001) Oncogene , vol.20 , pp. 1594-1600
    • Gschwind, A.1    Zwick, E.2    Prenzel, N.3    Leserer, M.4    Ullrich, A.5
  • 22
    • 33747677468 scopus 로고    scopus 로고
    • Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2- controlled prostaglandin E2 signaling pathway
    • Han C, Demetris AJ, Stolz DB, Xu L, Lim K, Wu T. 2006a. Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2- controlled prostaglandin E2 signaling pathway. J Biol Chem 281:24831-24846.
    • (2006) J Biol Chem , vol.281 , pp. 24831-24846
    • Han, C.1    Demetris, A.J.2    Stolz, D.B.3    Xu, L.4    Lim, K.5    Wu, T.6
  • 23
    • 33644898889 scopus 로고    scopus 로고
    • Prostaglandin E2 receptor EPI transactivates EGFR/ MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells
    • Han C, Michalopoulos GK, Wu T. 2006b. Prostaglandin E2 receptor EPI transactivates EGFR/ MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. J Cell Physiol 207:261-270.
    • (2006) J Cell Physiol , vol.207 , pp. 261-270
    • Han, C.1    Michalopoulos, G.K.2    Wu, T.3
  • 24
    • 0034695506 scopus 로고    scopus 로고
    • OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
    • Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massague J. 2000. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100:229-240.
    • (2000) Cell , vol.100 , pp. 229-240
    • Hata, A.1    Seoane, J.2    Lagna, G.3    Montalvo, E.4    Hemmati-Brivanlou, A.5    Massague, J.6
  • 25
    • 33947178331 scopus 로고    scopus 로고
    • Signal transduction and regulation: Are all alpha1-adrenergic receptor subtypes created equal?
    • Hein P, Michel MC. 2007. Signal transduction and regulation: Are all alpha1-adrenergic receptor subtypes created equal? Biochem Pharmacol 73:1097-1106.
    • (2007) Biochem Pharmacol , vol.73 , pp. 1097-1106
    • Hein, P.1    Michel, M.C.2
  • 27
    • 0035815180 scopus 로고    scopus 로고
    • Regulation of subcellular localization of alpha1-adrenoceptor subtypes
    • Hirasawa A, Awaji T, Xu Z, Shinoura H, Tsujimoto G. 2001. Regulation of subcellular localization of alpha1-adrenoceptor subtypes. Life Sci 68:2259-2267.
    • (2001) Life Sci , vol.68 , pp. 2259-2267
    • Hirasawa, A.1    Awaji, T.2    Xu, Z.3    Shinoura, H.4    Tsujimoto, G.5
  • 28
    • 0037011992 scopus 로고    scopus 로고
    • Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of Bcl-2 and Bcl-x(L) proteins
    • Hong F, Kim WH, Tian Z, Jaruga B, Ishac E, Shen X, Gao B. 2002. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21:32-43.
    • (2002) Oncogene , vol.21 , pp. 32-43
    • Hong, F.1    Kim, W.H.2    Tian, Z.3    Jaruga, B.4    Ishac, E.5    Shen, X.6    Gao, B.7
  • 29
    • 4644237206 scopus 로고    scopus 로고
    • Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    • Hong F, Radaeva S, Pan HN, Tian Z, Veech R, Gao B. 2004. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 40:933-941.
    • (2004) Hepatology , vol.40 , pp. 933-941
    • Hong, F.1    Radaeva, S.2    Pan, H.N.3    Tian, Z.4    Veech, R.5    Gao, B.6
  • 30
    • 0029664629 scopus 로고    scopus 로고
    • Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis
    • Hu ZW, Shi XY, Lin RZ, Hoffman BB. 1996. Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem 271:8977-8982.
    • (1996) J Biol Chem , vol.271 , pp. 8977-8982
    • Hu, Z.W.1    Shi, X.Y.2    Lin, R.Z.3    Hoffman, B.B.4
  • 33
  • 34
    • 0035854780 scopus 로고    scopus 로고
    • Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL
    • Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G, Taub R. 2001. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem 276:26605-26613.
    • (2001) J Biol Chem , vol.276 , pp. 26605-26613
    • Kovalovich, K.1    Li, W.2    DeAngelis, R.3    Greenbaum, L.E.4    Ciliberto, G.5    Taub, R.6
  • 35
    • 0041822007 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: Evidence for Akt inhibition in celecoxib-induced apoptosis
    • Leng J, Han C, Demetris AJ, Michalopoulos GK, Wu T. 2003. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: Evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 38:756-768.
    • (2003) Hepatology , vol.38 , pp. 756-768
    • Leng, J.1    Han, C.2    Demetris, A.J.3    Michalopoulos, G.K.4    Wu, T.5
  • 36
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell JE, Jr. 2002. Stats: Transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 37
    • 0037047360 scopus 로고    scopus 로고
    • STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    • Li W, Liang X, Kellendonk C, Poli V, Taub R. 2002. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 277:28411-28417.
    • (2002) J Biol Chem , vol.277 , pp. 28411-28417
    • Li, W.1    Liang, X.2    Kellendonk, C.3    Poli, V.4    Taub, R.5
  • 38
    • 0033538452 scopus 로고    scopus 로고
    • Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells
    • Liang H, Venema VJ, Wang X, Ju H, Venema RC, Marrero MB. 1999. Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. J Biol Chem 274:19846-19851.
    • (1999) J Biol Chem , vol.274 , pp. 19846-19851
    • Liang, H.1    Venema, V.J.2    Wang, X.3    Ju, H.4    Venema, R.C.5    Marrero, M.B.6
  • 39
    • 0025758192 scopus 로고
    • Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration
    • Lindroos PM, Zarnegar R, Michalopoulos GK. 1991. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 13:743-750.
    • (1991) Hepatology , vol.13 , pp. 743-750
    • Lindroos, P.M.1    Zarnegar, R.2    Michalopoulos, G.K.3
  • 41
    • 33947362780 scopus 로고    scopus 로고
    • The alpha1b-adrenoceptor exists as a higher-order oligomer: Effective oligomerization is required for receptor maturation, surface delivery, and function
    • Lopez-Gimenez JF, Canals M, Pediani JD, Milligan G. 2007. The alpha1b-adrenoceptor exists as a higher-order oligomer: Effective oligomerization is required for receptor maturation, surface delivery, and function. Mol Pharmacol 71:1015-1029.
    • (2007) Mol Pharmacol , vol.71 , pp. 1015-1029
    • Lopez-Gimenez, J.F.1    Canals, M.2    Pediani, J.D.3    Milligan, G.4
  • 42
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • Ma YC, Huang J, Ali S, Lowry W, Huang XY. 2000. Src tyrosine kinase is a novel direct effector of G proteins. Cell 102:635-646.
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1    Huang, J.2    Ali, S.3    Lowry, W.4    Huang, X.Y.5
  • 45
    • 0024265224 scopus 로고
    • Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+
    • Minneman KP. 1988. Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+. Pharmacol Rev 40:87-119.
    • (1988) Pharmacol Rev , vol.40 , pp. 87-119
    • Minneman, K.P.1
  • 47
    • 0033544914 scopus 로고    scopus 로고
    • Cross-talk between alpha(1B)-adrenergic receptor (alpha(1B)AR) and interleukin-6 (IL-6) signaling pathways. Activation of alpha(1b)AR inhibits il-6-activated STAT3 in hepatic cells by a p42/44 mitogen-activated protein kinase-dependent mechanism
    • Nguyen VA, Gao B. 1999. Cross-talk between alpha(1B)-adrenergic receptor (alpha(1B)AR) and interleukin-6 (IL-6) signaling pathways. Activation of alpha(1b)AR inhibits il-6-activated STAT3 in hepatic cells by a p42/44 mitogen-activated protein kinase-dependent mechanism. J Biol Chem 274:35492-35498.
    • (1999) J Biol Chem , vol.274 , pp. 35492-35498
    • Nguyen, V.A.1    Gao, B.2
  • 49
    • 0021994628 scopus 로고
    • Adrenergic effects on secretion of epidermal growth factor from Brunner's glands
    • Olsen PS, Poulsen SS, Kirkegaard P. 1985. Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. Gut 26:920-927.
    • (1985) Gut , vol.26 , pp. 920-927
    • Olsen, P.S.1    Poulsen, S.S.2    Kirkegaard, P.3
  • 50
    • 33947244972 scopus 로고    scopus 로고
    • Structure-function of alpha1-adrenergic receptors
    • Perez DM. 2007. Structure-function of alpha1-adrenergic receptors. Biochem Pharmacol 73:1051-1062.
    • (2007) Biochem Pharmacol , vol.73 , pp. 1051-1062
    • Perez, D.M.1
  • 51
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B. 2004. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39:1332-1342.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 52
    • 0031933949 scopus 로고    scopus 로고
    • Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: Inhibition by protein kinase A
    • Ruan Y, Kan H, Parmentier JH, Fatima S, Allen LF, Malik KU. 1998. Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: Inhibition by protein kinase A. J Pharmacol Exp Ther 284:576-585.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 576-585
    • Ruan, Y.1    Kan, H.2    Parmentier, J.H.3    Fatima, S.4    Allen, L.F.5    Malik, K.U.6
  • 54
    • 34548183625 scopus 로고    scopus 로고
    • Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    • Rybin VO, Guo J, Gertsberg Z, Elouardighi H, Steinberg SF. 2007. Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes. J Biol Chem 282:23631-23638.
    • (2007) J Biol Chem , vol.282 , pp. 23631-23638
    • Rybin, V.O.1    Guo, J.2    Gertsberg, Z.3    Elouardighi, H.4    Steinberg, S.F.5
  • 55
    • 0029658495 scopus 로고    scopus 로고
    • Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways
    • Sah VP, Hoshijima M, Chien KR, Brown JH. 1996. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem 271:31185-31190.
    • (1996) J Biol Chem , vol.271 , pp. 31185-31190
    • Sah, V.P.1    Hoshijima, M.2    Chien, K.R.3    Brown, J.H.4
  • 56
    • 0032985306 scopus 로고    scopus 로고
    • Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    • Sakamoto T, Liu Z, Murase N, Ezure T, Yokomuro S, Poli V, Demetris AJ. 1999. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 29:403-411.
    • (1999) Hepatology , vol.29 , pp. 403-411
    • Sakamoto, T.1    Liu, Z.2    Murase, N.3    Ezure, T.4    Yokomuro, S.5    Poli, V.6    Demetris, A.J.7
  • 58
    • 0030890352 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/ APRF transcription factor in human hepatoma cells and hepatocytes
    • Schaper F, Siewert E, Gomez-Lechon MJ, Gatsios P, Sachs M, Birchmeier W, Heinrich PC, Castell J. 1997. Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/ APRF transcription factor in human hepatoma cells and hepatocytes. FEBS Lett 405:99-103.
    • (1997) FEBS Lett , vol.405 , pp. 99-103
    • Schaper, F.1    Siewert, E.2    Gomez-Lechon, M.J.3    Gatsios, P.4    Sachs, M.5    Birchmeier, W.6    Heinrich, P.C.7    Castell, J.8
  • 59
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen PO. 1976. Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83.
    • (1976) Methods Cell Biol , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 60
    • 0030989153 scopus 로고    scopus 로고
    • Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes
    • Spector MS, Auer KL, Jarvis WD, Ishac EJ, Gao B, Kunos G, Dent P. 1997. Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Mol Cell Biol 17:3556-3565.
    • (1997) Mol Cell Biol , vol.17 , pp. 3556-3565
    • Spector, M.S.1    Auer, K.L.2    Jarvis, W.D.3    Ishac, E.J.4    Gao, B.5    Kunos, G.6    Dent, P.7
  • 61
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13:513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 63
    • 0031928143 scopus 로고    scopus 로고
    • The inhibitory effect of interleukin 1 beta on rat hepatocyte DNA synthesis is mediated by nitric oxide
    • Wang Z, Wang M, Carr BI. 1998. The inhibitory effect of interleukin 1 beta on rat hepatocyte DNA synthesis is mediated by nitric oxide. Hepatology 28:430-435.
    • (1998) Hepatology , vol.28 , pp. 430-435
    • Wang, Z.1    Wang, M.2    Carr, B.I.3
  • 64
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
    • Waris G, Huh KW, Siddiqui A. 2001. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 21:7721-7730.
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.W.2    Siddiqui, A.3
  • 65
    • 0032544233 scopus 로고    scopus 로고
    • Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells
    • Williams NG, Zhong H, Minneman KP. 1998. Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells. J Biol Chem 273:24624-24632.
    • (1998) J Biol Chem , vol.273 , pp. 24624-24632
    • Williams, N.G.1    Zhong, H.2    Minneman, K.P.3
  • 66
    • 0036083322 scopus 로고    scopus 로고
    • Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes
    • Xiao L, Pimentel DR, Wang J, Singh K, Colucci WS, Sawyer DB. 2002. Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol 282:C926-C934.
    • (2002) Am J Physiol Cell Physiol , vol.282
    • Xiao, L.1    Pimentel, D.R.2    Wang, J.3    Singh, K.4    Colucci, W.S.5    Sawyer, D.B.6
  • 67
    • 0029928112 scopus 로고    scopus 로고
    • Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells
    • Xing M, Insel PA. 1996. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells. J Clin Invest 97:1302-1310.
    • (1996) J Clin Invest , vol.97 , pp. 1302-1310
    • Xing, M.1    Insel, P.A.2
  • 69
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6    Jove, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.