Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor α

Journal of Cellular Physiology

Volumn 166, Issue 3, 1996, Pages 512-522

  Reddy, Cartikeya C ^a   Wells, Alan ^b,c   Lauffenburger, Douglas A ^d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; HORMONE RESPONSE; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM;

ANIMALS; BINDING, COMPETITIVE; CELL DIVISION; CELL LINE; CULTURE MEDIA; EPIDERMAL GROWTH FACTOR; FIBROBLASTS; HUMANS; LIGANDS; MICE; MITOGENS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE DELETION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0029976245     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199603)166:3<512::AID-JCP6>3.0.CO;2-S     Document Type: Article

References (37)

1. Aharonov, A., Pruss, R.M., and Herschman, H.R (1978) Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells. J. Biol. Chem., 253:3970-3977.
2. Anzano, M.A., Roberts, A.B., Smith, J.M., Sporn, M.B., and De Larco, J.E. (1983) Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type α and type βtransforming growth factors. Proc. Natl. Acad. Sci. U.S.A., 80:6264-6268.
3. Barrandon, Y., and Green, H. (1987) Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor. Cell, 50:1131-1137.
4. Brenner, D.A., Koch, K.S., and Leffert, H.L. (1989) Transforming growth factor-α stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. DNA, 8:279-285.
5. Campbell, I.D., Baron, M., Cooke, R.M., Dudgeon, T.J., Fallon, A., Harvey, T.S., and Tappin, M.J. (1990) Structure-function relationships in epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α). Biochem. Pharmacol., 40:35-40.
6. Carpenter, G., and Wahl, M.I. (1990) The epidermal growth factor family. In: Peptide Growth Factors and Their Receptors. M.B. Sporn and A.B. Roberts, eds. Springer-Verlag, Berlin, Heidelberg, pp. 69-71.
7. Carpenter, G., Stoschek, C.M., Preston, Y.A., and De Larco, J.E. (1983) Antibodies to the epidermal growth factor receptor block the biological activities. Proc. Natl. Acad. Sci. U.S.A., 80:5627-5630.
8. Chen, P., Gupta, K., and Wells, A. (1994) Cell movement elicited by the epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J. Cell Biol., 124:547-555.
9. Chen, W.S., Lazar, C.S., Lund, K.A , Welsh, J.B., Chang, C.P., Walton, G.M., Der, C.J., Wiley, H.S., Gill, G.N., and Rosenfeld, M G (1989) Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell, 59.33-43.
10. Cutry, A F., Kinniburgh, A.J., Twardzik, D.R., and Wenner, C.E. (1988) Transforming growth factor alpha (TGFα) induction of c-fos and c-myc expression in C3H 10T1/2 cells. Biochem. Biophys. Res. Commun., 152.216-222.
11. Decker, S.J. (1990) Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor. Biochem. Biophys. Res. Commun., 166:615-621.
12. Decker, S.J., Alexander, C., and Habib, T. (1992) Epidermal growth factor (EGF) stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing receptors truncated at residue 973. J. Biol. Chem., 267:1104-1108.
13. De Larco, J.E., and Todaro, G.J. (1978) Growth factors from murine sarcoma virus-transformed cells. Proc. Natl. Acad. Sci. U.S.A., 75:4001-4005.
14. Derynck, R. (1992) The physiology of the transforming growth factor-α. Adv. Cancer Res., 58:27-52.
15. Ebner, R., and Derynck, R. (1991) Epidermal growth factor and transforming growth factor-α: Differential intracellular routing and processing of ligand receptor complexes. Cell Regul., 2:599-612.
16. French, A.R., Sudlow, G.P., Wiley, H.S., and Lauffenburger, D.A. (1994) Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J. Biol. Chem., 263:15749-15755.
17. French, A.R., Tadaki, D.K., Niyogi, S.K., and Lauffenburger, D.A. (1995) Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ ligand interaction. J. Biol. Chem., 270:4334-4340.
18. Gan, B.S., Hollenberg, M.D., MacCannell, K.L., Lederis, K., Winkler, M.E., and Derynck, R. (1987) Distinct vascular actions epidermal growth factor-uragastrone and transforming growth factor-α. J. Pharmacol. Exp. Ther., 242:331-337.
19. Guiterrez, G.E., Mundy, G.R., Derynck, R., Hewlett, E.L., and Katz, M.S. (1987) Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor α and epidermal growth factor. J. Biol. Chem., 262:15845-15850.
20. Herbst, J.J., Opresko, L.K., Walsh, B.J., Lauffenburger, D.A., and Wiley, H. S. (1994) Regulation of postendocytic trafficking of the epidermal growth factor through endosomal retention. J. Biol. Chem., 269:12865-12873.
21. Ibbotson, K.J., Harrod, J., Gowen, M., D'Souza, S., Smith, D.D., Winkler, M.E., Derynck, R., and Mundy, G.R. (1986) Human recombinant transforming growth factor α stimulates bone resorption and inhibits formation in vitro. Proc. Natl. Acad. Sci. U.S.A., 83:2228-2232.
22. Korc, M., and Finman, J.E. (1989) Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor-α. J. Biol. Chem., 264:14990-14999.
23. Korc, M., Haussler, C.A., and Trookman, N.S. (1987) Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line. Cancer Res., 47:4909-4914.
24. Lax, I., Johnson, A., Howk, R., Sap, J., Bellot, F., Winkler, M., Ullrich, A., Vennstrom, B., Schlessinger, J., and Givol, D. (1988) Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells and differential binding of EGP and transforming growth factor alpha. Mol. Cell. Biol., 8:1970-1978.
25. Massague, J. (1983) Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J. Biol. Chem., 258:13614-13620.
26. 1H NMR assignments and identification of two antiparallel β-sheets in the solution structure of recombinant hTGF-α. Proc. Natl. Acad. Sci. U.S.A., 86:1519-1523.
27. Myrdal, S.E., Twardzik, D.R., and Auspenberg, N. (1986) Cell-mediated co-action of transforming growth factors: Incubation of type β with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type α. J. Cell Biol., 102:1230-1234.
28. Pruss, R.M., and Herschman, H.R. (1977) Variants of 3T3 cells lacking mitogenic response to epidermal growth factor Proc. Natl. Acad. Sci. U.S.A., 74:3918-3921.
29. Reddy, C.G., Wells, A., and Lauffenburger, D.A. (1994) Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect. Biotechnol. Prog., 10.377-384.
30. Schreiber, A.B., Winkler, M.E., and Derynck, R. (1986) Transforming growth factor-α: A more potent angiogenic mediator than epidermal growth factor. Science, 232:1250-1253.
31. Schultz, G.S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D.R., and Todaro, G. J. (1987) Epithelial wound healing enhanced by transforming growth factor-α and vaccinia growth factor. Science, 235:350-352.
32. Smith, J.J., Derynck, R., and Korc, M. (1987) Production of transforming growth factor α in human pancreatic cancer cells: Evidence for a superagonist autocrine cycle. Proc. Natl. Acad. Sci. U S.A., 84:7567-7570.
33. Smith, J.M., Sporn, M.B., Roberts, A.B., Derynck, R., Winkler, M.E., and Gregory, H. (1985) Human transforming growth factor-α causes precocious eyelid opening in newborn mice. Nature, 315:515-516.
34. Sorkin, A.D., Teslenko, L.V., and Nikolsky, N.N. (1988) The endocytosis of epidermal growth factor in A431 cells: A pH of microenvironment and dynamics of receptor complex dissociation. Exp. Cell Res., 175:192-205.
35. Stern, P.H., Krieger, N.S., Nissenson, R.A., Williams, R.D., Winkler, M.E., Derynck, R., and Strewler, G.J. (1985) Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin. Invest., 76:2016-2019.
36. Wells, A., Welsh, J.B., Lazar, C.S., Wiley, H.S., Gill, G.N., and Rosenfeld, M.G. (1990) Ligand-induced transformation by a non-internalizing epidermal growth factor receptor. Science, 247:962-964.
37. Wiley, H.S., Herbst, J.J., Walsh, J.B., Lauffenburger, D.A., Rosenfeld, M.G., and Gill, G.N. (1991) The role of tyrosine kinase activity in endocytosis, eompartmentation and down-regulation of the epidermal growth factor receptor. J. Biol. Chem., 266:11083-11094.