Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR

Drug Metabolism Reviews

Volumn 38, Issue 1-2, 2006, Pages 75-87

  Kodama, Susumu ^a   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

CAR; Cytochrome P450; Gene transcription; Gluconeogenesis; Hepatic metabolism; Hepatocellular carcinoma; Liver; Nuclear receptors

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B2; ORPHAN RECEPTOR; PHENOBARBITAL; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

BILE ACID SYNTHESIS; DRUG ACTIVITY; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GLUCONEOGENESIS; LIGAND BINDING; LIVER CELL CARCINOMA; LIVER FUNCTION; LIVER METABOLISM; MOLECULAR MECHANICS; PLEIOTROPY; RECEPTOR UPREGULATION; REVIEW; STEROID METABOLISM; THYROID HORMONE METABOLISM; TRANSCRIPTION REGULATION; TUMOR PROMOTION;

ANIMALS; BIOTRANSFORMATION; HUMANS; HYPNOTICS AND SEDATIVES; LIVER; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 33646713469     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530600569851     Document Type: Review

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