Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation

Biochemical and Biophysical Research Communications

Volumn 353, Issue 3, 2007, Pages 638-643

  Gkretsi, Vasiliki ^a   Bowen, William C ^a   Yang, Yu ^a   Wu, Chuanyue ^a   Michalopoulos, George K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Differentiation; Hepatocytes; ILK; Matrix; Mig 2; Parvin; PINCH

Indexed keywords

ALBUMIN; ALPHA PARVIN; INTEGRIN LINKED KINASE; PROTEIN DERIVATIVE; PROTEIN MIG 2; PROTEIN PINCH; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; EXTRACELLULAR MATRIX; HEPATOCYTES; LAMININ; LIVER; MALE; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; RATS; RATS, INBRED F344;

EID: 33845989065     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.091     Document Type: Article

References (25)

1. Kleinman H., McGarvey M.L., Hassell J.R., Star V.L., Cannon F.B., Laurie G.W., and Martin G.R. Basement membrane complexes with biological activity. Biochemistry 25 (1986) 312-318
2. Block G.D., Locker J., Bowen W.C., Petersen B.E., Katyal S., Strom S.C., Riley T., Howard T.A., and Michalopoulos G.K. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J. Cell Biol. 132 (1996) 1133-1149
3. Kim T.H., Bowen W.C., Stolz D.B., Runge D., Mars W.M., and Michalopoulos G.K. Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocyte differentiation. Exp. Cell Res. 244 (1998) 93-104
4. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
5. Hannigan G., Troussard A., and Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat. Rev. Cancer 5 (2005) 51-63
6. Legate K.R., Montanez E., Kudlacek O., and Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat. Rev. Mol. Cell Biol. 7 (2006) 20-31
7. Wu C. PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. Trends Cell Biol. 15 (2005) 460-466
8. Huang Y., Li J., Zhang Y., and Wu C. The roles of integrin-linked kinase in the regulation of myogenic differentiation. J. Cell Biol. 150 (2000) 861-872
9. Li Y., Yang J., Dai C., Wu C., and Liu Y. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J. Clin. Invest. 112 (2003) 503-516
10. Terpstra L., Prud'homme J., Arabian A., Takeda S., Karsenty G., Dedhar S., and St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J. Cell Biol. 162 (2003) 139-148
11. Persad S., and Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metast. Rev. 22 (2003) 375-384
12. Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., and Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379 (1996) 91-96
13. Radeva G., Petrocelli T., Behrend E., Leung-Hagesteijn C., Filmus J., Slingerland J., and Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J. Biol. Chem. 272 (1997) 13937-13944
14. Attwell S., Roskelley C., and Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19 (2000) 3811-3815
15. Sepulveda J.L., Gkretsi V., and Wu C. Assembly and signaling of adhesion complexes. Curr. Top. Dev. Biol. 68 (2005) 183-225
16. Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim. Biophys. Acta 1692 (2004) 55-62
17. Zhang Y., Chen K., Tu Y., Velyvis A., Yang Y., Qin J., and Wu C. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell Sci. 115 (2002) 4777-4786
18. Fukuda T., Chen K., Shi X., and Wu C. PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. J. Biol. Chem. 278 (2003) 51324-51333
19. Fukuda T., Guo L., Shi X., and Wu C. CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. J. Cell Biol. 160 (2003) 1001-1008
20. Mackinnon A.C., Qadota H., Norman K.R., Moerman D.G., and Williams B.D. C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Curr. Biol. 12 (2002) 787-797
21. Tu Y., Wu S., Shi X., Chen K., and Wu C. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113 (2003) 37-47
22. Clark K.A., McGrail M., and Beckerle M.C. Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development 130 (2003) 2611-2621
23. Monga S., Micsenyi A., Germinaro M., Apte U., and Bell A. β-Catenin regulation during matrigel-induced rat hepatocyte differentiation. Cell Tissue Res. 323 (2006) 71-79
24. Kim T.H., Mars W.M., Stolz D.B., and Michalopoulos G.K. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 31 (2000) 75-82
25. Li F., Zhang Y., and Wu C. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. 112 (1999) 4589-4599