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Volumn 19, Issue 27, 2013, Pages 4913-4929

Pioglitazone and cancer: Angel or demon?

Author keywords

Bladder; Cancer; Pioglitazone; Safety; Type 2 diabetes

Indexed keywords

ANGIOGENIC FACTOR; CYCLIN D1; CYCLOOXYGENASE 2; EXENDIN 4; FATTY ACID BINDING PROTEIN; GELATINASE A; GELATINASE B; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INCRETIN; LIRAGLUTIDE; MATRILYSIN; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PROSTAGLANDIN E2; PROTEIN P53; ROSIGLITAZONE; SITAGLIPTIN; SULFONYLUREA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRIACYLGLYCEROL; TROGLITAZONE;

EID: 84881339060     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990294     Document Type: Article
Times cited : (36)

References (245)
  • 1
    • 33746461855 scopus 로고    scopus 로고
    • Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002
    • Cowie CC, Rust KF, Byrd-Holt DD, et al. Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002. Diabetes Care 2006; 29: 1263-8.
    • (2006) Diabetes Care , vol.29 , pp. 1263-1268
    • Cowie, C.C.1    Rust, K.F.2    Byrd-Holt, D.D.3
  • 2
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21: 1414-31.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 4
    • 79952260576 scopus 로고    scopus 로고
    • Diabetes mellitus, fasting glucose, and risk of cause-specific death
    • Seshasai SR, Kaptoge S, Thompson A, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 2011; 364: 829-41.
    • (2011) N Engl J Med , vol.364 , pp. 829-841
    • Seshasai, S.R.1    Kaptoge, S.2    Thompson, A.3
  • 5
    • 84855182612 scopus 로고    scopus 로고
    • Diabetes and cancer: Is diabetes causally related to cancer?
    • Suh S, Kim KW. Diabetes and cancer: is diabetes causally related to cancer? Diabetes Metab J 2011; 35: 193-8.
    • (2011) Diabetes Metab J , vol.35 , pp. 193-198
    • Suh, S.1    Kim, K.W.2
  • 6
    • 58049192725 scopus 로고    scopus 로고
    • Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis
    • Barone BB, Yeh HC, Snyder CF, et al. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA 2008; 300: 2754-64.
    • (2008) JAMA , vol.300 , pp. 2754-2764
    • Barone, B.B.1    Yeh, H.C.2    Snyder, C.F.3
  • 7
    • 0036517099 scopus 로고    scopus 로고
    • Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes
    • Miyazaki Y, Matsuda M, DeFronzo RA. Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care 2002; 25: 517-23.
    • (2002) Diabetes Care , vol.25 , pp. 517-523
    • Miyazaki, Y.1    Matsuda, M.2    DeFronzo, R.A.3
  • 9
    • 22644440448 scopus 로고    scopus 로고
    • Beta-cell preservation: A potential role for thiazolidinediones to improve clinical care in Type 2 diabetes
    • Leiter LA. Beta-cell preservation: a potential role for thiazolidinediones to improve clinical care in Type 2 diabetes. Diabet Med 2005; 22: 963-72.
    • (2005) Diabet Med , vol.22 , pp. 963-972
    • Leiter, L.A.1
  • 10
    • 33947149143 scopus 로고    scopus 로고
    • Beta-cell preservation with thiazolidinediones
    • Campbell IW, Mariz S. Beta-cell preservation with thiazolidinediones. Diabetes Res Clin Pract 2007; 76: 163-76.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 163-176
    • Campbell, I.W.1    Mariz, S.2
  • 11
    • 77957710722 scopus 로고    scopus 로고
    • Efficacy and tolerability of pioglitazone in patients with type 2 diabetes mellitus: Comparison with other oral antihyperglycaemic agents
    • Derosa G. Efficacy and tolerability of pioglitazone in patients with type 2 diabetes mellitus: comparison with other oral antihyperglycaemic agents. Drugs 2010; 70: 1945-61.
    • (2010) Drugs , vol.70 , pp. 1945-1961
    • Derosa, G.1
  • 13
    • 0037259315 scopus 로고    scopus 로고
    • Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone
    • Graham DJ, Drinkard CR, Shatin D. Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone. Am J Gastroenterol 2003; 98: 175-9.
    • (2003) Am J Gastroenterol , vol.98 , pp. 175-179
    • Graham, D.J.1    Drinkard, C.R.2    Shatin, D.3
  • 14
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-71.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 15
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 2007; 298: 1189-95.
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 16
    • 45849141431 scopus 로고    scopus 로고
    • Division of Metabolism and Endocrine Products and Offi ce of Surveillance and Epidemiology, US Food and Drug Administration, July 30, Available from
    • Division of Metabolism and Endocrine Products and Offi ce of Surveillance and Epidemiology, US Food and Drug Administration. FDA Briefing Document: joint meeting of the Endocrinologic and Metabolic Drugs Advisory Committee. July 30, 2007. Available from: http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4308b1-02-fda-backgrounder.pdf.
    • (2007) FDA Briefing Document: Joint meeting of the Endocrinologic and Metabolic Drugs Advisory Committee
  • 17
    • 34248663609 scopus 로고    scopus 로고
    • Available at
    • The U.S. Food and Drug Administration. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021071 s040lbl.pdf.
    • The U.S. Food and Drug Administration
  • 18
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/000268/WC500029109.pdf.
    • European Medicines Agency
  • 19
    • 37149034178 scopus 로고    scopus 로고
    • Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    • Lipscombe LL, Gomes T, Levesque LE, et al. Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA 2007; 298: 2634-43.
    • (2007) JAMA , vol.298 , pp. 2634-2643
    • Lipscombe, L.L.1    Gomes, T.2    Levesque, L.E.3
  • 20
    • 41649084422 scopus 로고    scopus 로고
    • Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: The PERISCOPE randomized controlled trial
    • Nissen SE, Nicholls SJ, Wolski K, et al. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. JAMA 2008; 299: 1561-73.
    • (2008) JAMA , vol.299 , pp. 1561-1573
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3
  • 21
    • 33845400193 scopus 로고    scopus 로고
    • Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: A randomized trial
    • Mazzone T, Meyer PM, Feinstein SB, et al. Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA 2006; 296: 2572-81.
    • (2006) JAMA , vol.296 , pp. 2572-2581
    • Mazzone, T.1    Meyer, P.M.2    Feinstein, S.B.3
  • 22
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366: 1279-89.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 23
    • 84858281382 scopus 로고    scopus 로고
    • Pioglitazone and bladder cancer in human studies: Is it diabetes itself, diabetes drugs, flawed analyses or different ethnicities?
    • Tseng CH. Pioglitazone and bladder cancer in human studies: is it diabetes itself, diabetes drugs, flawed analyses or different ethnicities? J Formos Med Assoc 2012; 111: 123-31.
    • (2012) J Formos Med Assoc , vol.111 , pp. 123-131
    • Tseng, C.H.1
  • 24
    • 84862991650 scopus 로고    scopus 로고
    • Association Between Pioglitazone and Urothelial Bladder Cancer
    • Barbalat Y, Dombrovskiy VY, Weiss RE. Association Between Pioglitazone and Urothelial Bladder Cancer. Urology 2012; 80: 1-4.
    • (2012) Urology , vol.80 , pp. 1-4
    • Barbalat, Y.1    Dombrovskiy, V.Y.2    Weiss, R.E.3
  • 29
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 30
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 31
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358: 2545-59.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 32
    • 0029082033 scopus 로고
    • Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes
    • Abraira C, Colwell JA, Nuttall FQ, et al. Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes. Diabetes Care 1995; 18: 1113-23.
    • (1995) Diabetes Care , vol.18 , pp. 1113-1123
    • Abraira, C.1    Colwell, J.A.2    Nuttall, F.Q.3
  • 33
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: A meta-analysis of major trials
    • Johnson JA, Bowker SL. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 2011; 54: 25-31.
    • (2011) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 34
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358: 2560-72.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Patel, A.1    McMahon, S.2    Chalmers, J.3
  • 35
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009; 373: 2125-35.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 36
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006; 29: 254-8.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 37
    • 70449533135 scopus 로고    scopus 로고
    • Sulphonylureas and cancer: A case-control study
    • Monami M, Lamanna C, Balzi D, et al. Sulphonylureas and cancer: a case-control study. Acta Diabetol 2009; 46: 279-84.
    • (2009) Acta Diabetol , vol.46 , pp. 279-284
    • Monami, M.1    Lamanna, C.2    Balzi, D.3
  • 38
    • 34948847587 scopus 로고    scopus 로고
    • Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality
    • Monami M, Balzi D, Lamanna C, et al. Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality. Diabetes Metab Res Rev 2007; 23: 479-84.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 479-484
    • Monami, M.1    Balzi, D.2    Lamanna, C.3
  • 39
    • 5144234027 scopus 로고    scopus 로고
    • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    • Yang YX, Hennessy S, Lewis JD. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology 2004; 127: 1044-50.
    • (2004) Gastroenterology , vol.127 , pp. 1044-1050
    • Yang, Y.X.1    Hennessy, S.2    Lewis, J.D.3
  • 40
    • 68449104156 scopus 로고    scopus 로고
    • Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: A cohort study
    • Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 2009; 52: 1732-44.
    • (2009) Diabetologia , vol.52 , pp. 1732-1744
    • Hemkens, L.G.1    Grouven, U.2    Bender, R.3
  • 41
    • 68449088664 scopus 로고    scopus 로고
    • Does diabetes therapy influence the risk of cancer?
    • Smith U, Gale EA. Does diabetes therapy influence the risk of cancer? Diabetologia 2009; 52: 1699-708.
    • (2009) Diabetologia , vol.52 , pp. 1699-1708
    • Smith, U.1    Gale, E.A.2
  • 42
    • 84860388926 scopus 로고    scopus 로고
    • Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study: Proceedings from a meeting of a European Insulin Safety Consensus Panel, convened and sponsored by Novo Nordisk, held Tuesday October 5, 2010 at The Radisson Edwardian Heathrow Hotel, Hayes, Middlesex, UK
    • Gough SC, Belda-Iniesta C, Poole C, et al. Insulin therapy in diabetes and cancer risk: current understanding and implications for future study: proceedings from a meeting of a European Insulin Safety Consensus Panel, convened and sponsored by Novo Nordisk, held Tuesday October 5, 2010 at The Radisson Edwardian Heathrow Hotel, Hayes, Middlesex, UK. Adv Ther 2011; 28 Suppl 5: 1-18.
    • (2011) Adv Ther , vol.28 , Issue.SUPPL. 5 , pp. 1-18
    • Gough, S.C.1    Belda-Iniesta, C.2    Poole, C.3
  • 43
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis
    • Decensi A, Puntoni M, Goodwin P, et al. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010; 3: 1451-61.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 44
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT, et al. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009; 32: 1620-5.
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3
  • 45
    • 84855443186 scopus 로고    scopus 로고
    • Cancer mortality reduction and metformin: A retrospective cohort study in type 2 diabetic patients
    • Bo S, Ciccone G, Rosato R, et al. Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients. Diabetes Obes Metab 2011.
    • (2011) Diabetes Obes Metab
    • Bo, S.1    Ciccone, G.2    Rosato, R.3
  • 46
    • 77955558076 scopus 로고    scopus 로고
    • Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials
    • Home PD, Kahn SE, Jones NP, et al. Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials. Diabetologia 2010; 53: 1838-45.
    • (2010) Diabetologia , vol.53 , pp. 1838-1845
    • Home, P.D.1    Kahn, S.E.2    Jones, N.P.3
  • 47
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011; 141: 150-6.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3
  • 48
    • 81855194761 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Martelli D, Mannucci E. Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr Med Res Opin 2011; 27 Suppl 3: 57-64.
    • (2011) Curr Med Res Opin , vol.27 , Issue.SUPPL. 3 , pp. 57-64
    • Monami, M.1    Dicembrini, I.2    Martelli, D.3    Mannucci, E.4
  • 49
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide-the FDA's review of a new antidiabetic therapy
    • Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide-the FDA's review of a new antidiabetic therapy. N Engl J Med 2010; 362: 774-7.
    • (2010) N Engl J Med , vol.362 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 50
    • 34248663609 scopus 로고    scopus 로고
    • Available at
    • The U.S. Food and Drug Administration. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAl ertsforHumanMedicalProducts/ucm258826.htm.
    • The U.S. Food and Drug Administration
  • 51
    • 78650936018 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonist pioglitazone inhibits beta-cateninmediated glioma cell growth and invasion
    • Wan Z, Shi W, Shao B, et al. Peroxisome proliferator-activated receptor gamma agonist pioglitazone inhibits beta-cateninmediated glioma cell growth and invasion. Mol Cell Biochem 2011; 349: 1-10.
    • (2011) Mol Cell Biochem , vol.349 , pp. 1-10
    • Wan, Z.1    Shi, W.2    Shao, B.3
  • 52
    • 34248192254 scopus 로고    scopus 로고
    • Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes
    • Govindarajan R, Ratnasinghe L, Simmons DL, et al. Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol 2007; 25: 1476-81.
    • (2007) J Clin Oncol , vol.25 , pp. 1476-1481
    • Govindarajan, R.1    Ratnasinghe, L.2    Simmons, D.L.3
  • 53
    • 34547815173 scopus 로고    scopus 로고
    • Association between cancer prevalence and use of thiazolidinediones: Results from the Vermont Diabetes Information System
    • Ramos-Nino ME, MacLean CD, Littenberg B. Association between cancer prevalence and use of thiazolidinediones: results from the Vermont Diabetes Information System. BMC Med 2007; 5: 17.
    • (2007) BMC Med , vol.5 , pp. 17
    • Ramos-Nino, M.E.1    McLean, C.D.2    Littenberg, B.3
  • 54
    • 49649107776 scopus 로고    scopus 로고
    • Rosiglitazone and risk of cancer: A meta-analysis of randomized clinical trials
    • Monami M, Lamanna C, Marchionni N, Mannucci E. Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials. Diabetes Care 2008; 31: 1455-60.
    • (2008) Diabetes Care , vol.31 , pp. 1455-1460
    • Monami, M.1    Lamanna, C.2    Marchionni, N.3    Mannucci, E.4
  • 55
    • 79956217900 scopus 로고    scopus 로고
    • Risk of bladder cancer among diabetic patients treated with pioglitazone: Interim report of a longitudinal cohort study
    • Lewis JD, Ferrara A, Peng T, et al. Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care 2011; 34: 916-22.
    • (2011) Diabetes Care , vol.34 , pp. 916-922
    • Lewis, J.D.1    Ferrara, A.2    Peng, T.3
  • 58
    • 62949147825 scopus 로고    scopus 로고
    • Available at
    • European Medicines Agency. Available at: www.ema.eu/docs/eu_GB/document_library/Press_release/2011/07/WC500109176.pdf.
    • European Medicines Agency
  • 59
    • 84881358259 scopus 로고    scopus 로고
    • Available at
    • AFDSSDPD. Available at: http://www.afssaps.fr/Infos-desecurite/Communiques-Points-presse/Suspension-de-l-utilisationdes-medicaments-contenant-de-la-pioglitazone-Actos-RCompetact-R-Communique.
    • AFDSSDPD
  • 60
    • 84895067345 scopus 로고    scopus 로고
    • BFARM http://www.bfarm.de/EN/vigilance/riskinfo/2011/rhbpioglitazon2. html;jsessionid=531EA537F7AB715D533CE467CA4 C2628.1_cid103.
    • BFARM
  • 61
    • 79956226830 scopus 로고    scopus 로고
    • Cohort study of pioglitazone and cancer incidence in patients with diabetes
    • Ferrara A, Lewis JD, Quesenberry CP Jr., et al. Cohort study of pioglitazone and cancer incidence in patients with diabetes. Diabetes Care 2011; 34: 923-9.
    • (2011) Diabetes Care , vol.34 , pp. 923-929
    • Ferrara, A.1    Lewis, J.D.2    Quesenberry Jr., C.P.3
  • 62
    • 66149157824 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma in bladder cancer: A promising therapeutic target
    • Mansure JJ, Nassim R, Kassouf W. Peroxisome proliferatoractivated receptor gamma in bladder cancer: a promising therapeutic target. Cancer Biol Ther 2009; 8: 6-15.
    • (2009) Cancer Biol Ther , vol.8 , pp. 6-15
    • Mansure, J.J.1    Nassim, R.2    Kassouf, W.3
  • 63
    • 0037401046 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
    • Yoshimura R, Matsuyama M, Segawa Y, et al. Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer 2003; 104: 597-602.
    • (2003) Int J Cancer , vol.104 , pp. 597-602
    • Yoshimura, R.1    Matsuyama, M.2    Segawa, Y.3
  • 64
    • 0033206336 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death
    • Guan YF, Zhang YH, Breyer RM, et al. Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia 1999; 1: 330-9.
    • (1999) Neoplasia , vol.1 , pp. 330-339
    • Guan, Y.F.1    Zhang, Y.H.2    Breyer, R.M.3
  • 65
    • 10144222646 scopus 로고    scopus 로고
    • Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas
    • Celis JE, Ostergaard M, Basse B, et al. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas. Cancer Res 1996; 56: 4782-90.
    • (1996) Cancer Res , vol.56 , pp. 4782-4790
    • Celis, J.E.1    Ostergaard, M.2    Basse, B.3
  • 66
    • 0034581527 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma in bladder cancer in relation to angiogenesis and progression
    • Possati L, Rocchetti R, Talevi S, et al. The role of peroxisome proliferator-activated receptor gamma in bladder cancer in relation to angiogenesis and progression. Gen Pharmacol 2000; 35: 269-75.
    • (2000) Gen Pharmacol , vol.35 , pp. 269-275
    • Possati, L.1    Rocchetti, R.2    Talevi, S.3
  • 67
    • 24944558497 scopus 로고    scopus 로고
    • Polymorphisms in inflammation genes and bladder cancer: From initiation to recurrence, progression, and survival
    • Leibovici D, Grossman HB, Dinney CP, et al. Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival. J Clin Oncol 2005; 23: 5746-56.
    • (2005) J Clin Oncol , vol.23 , pp. 5746-5756
    • Leibovici, D.1    Grossman, H.B.2    Dinney, C.P.3
  • 68
    • 15744368845 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells
    • Huang JW, Shiau CW, Yang YT, et al. Peroxisome proliferatoractivated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells. Mol Pharmacol 2005; 67: 1342-8.
    • (2005) Mol Pharmacol , vol.67 , pp. 1342-1348
    • Huang, J.W.1    Shiau, C.W.2    Yang, Y.T.3
  • 69
    • 75249084816 scopus 로고    scopus 로고
    • Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    • Suzuki S, Arnold LL, Pennington KL, et al. Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol Sci 2010; 113: 349-57.
    • (2010) Toxicol Sci , vol.113 , pp. 349-357
    • Suzuki, S.1    Arnold, L.L.2    Pennington, K.L.3
  • 70
    • 24944463432 scopus 로고    scopus 로고
    • Effects of PPARgamma and combined agonists on the urinary tract of rats and other species
    • Cohen SM. Effects of PPARgamma and combined agonists on the urinary tract of rats and other species. Toxicol Sci 2005; 87: 322-7.
    • (2005) Toxicol Sci , vol.87 , pp. 322-327
    • Cohen, S.M.1
  • 71
    • 34447547778 scopus 로고    scopus 로고
    • Rodent carcinogenicity profile of the antidiabetic dual PPAR alpha and gamma agonist muraglitazar
    • Tannehill-Gregg SH, Sanderson TP, Minnema D, et al. Rodent carcinogenicity profile of the antidiabetic dual PPAR alpha and gamma agonist muraglitazar. Toxicol Sci 2007; 98: 258-70.
    • (2007) Toxicol Sci , vol.98 , pp. 258-270
    • Tannehill-Gregg, S.H.1    Sanderson, T.P.2    Minnema, D.3
  • 72
    • 33845789088 scopus 로고    scopus 로고
    • Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: Evidence for urolithiasis as the inciting event in the mode of action
    • Dominick MA, White MR, Sanderson TP, et al. Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: Evidence for urolithiasis as the inciting event in the mode of action. Toxicol Pathol 2006; 34: 903-20.
    • (2006) Toxicol Pathol , vol.34 , pp. 903-920
    • Dominick, M.A.1    White, M.R.2    Sanderson, T.P.3
  • 73
    • 0034880165 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma and its ligands in nonneoplastic and neoplastic human urothelial cells
    • Nakashiro KI, Hayashi Y, Kita A, et al. Role of peroxisome proliferator-activated receptor gamma and its ligands in nonneoplastic and neoplastic human urothelial cells. Am J Pathol 2001; 159: 591-7.
    • (2001) Am J Pathol , vol.159 , pp. 591-597
    • Nakashiro, K.I.1    Hayashi, Y.2    Kita, A.3
  • 74
    • 0023098226 scopus 로고
    • Eicosanoid synthesis by human urinary bladder mucosa: Pathological implications
    • Jeremy JY, Tsang V, Mikhailidis DP, et al. Eicosanoid synthesis by human urinary bladder mucosa: pathological implications. Br J Urol 1987; 59: 36-9.
    • (1987) Br J Urol , vol.59 , pp. 36-39
    • Jeremy, J.Y.1    Tsang, V.2    Mikhailidis, D.P.3
  • 75
    • 0023119161 scopus 로고
    • Urinary bladder prostanoids--their synthesis, function and possible role in the pathogenesis and treatment of disease
    • Mikhailidis DP, Jeremy JY, Dandona P. Urinary bladder prostanoids--their synthesis, function and possible role in the pathogenesis and treatment of disease. J Urol 1987; 137: 577-82.
    • (1987) J Urol , vol.137 , pp. 577-582
    • Mikhailidis, D.P.1    Jeremy, J.Y.2    Dandona, P.3
  • 76
    • 34347353320 scopus 로고    scopus 로고
    • Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase
    • Hazra S, Batra RK, Tai HH, et al. Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase. Mol Pharmacol 2007; 71: 1715-20.
    • (2007) Mol Pharmacol , vol.71 , pp. 1715-1720
    • Hazra, S.1    Batra, R.K.2    Tai, H.H.3
  • 77
    • 84866358522 scopus 로고    scopus 로고
    • Pioglitazone and risk of bladder cancer among diabetic patients in France: A populationbased cohort study
    • Neumann A, Weill A, Ricordeau P, et al. Pioglitazone and risk of bladder cancer among diabetic patients in France: a populationbased cohort study. Diabetologia 2012; 55: 1953-62.
    • (2012) Diabetologia , vol.55 , pp. 1953-1962
    • Neumann, A.1    Weill, A.2    Ricordeau, P.3
  • 78
    • 80051975559 scopus 로고    scopus 로고
    • Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting
    • Piccinni C, Motola D, Marchesini G, Poluzzi E. Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting. Diabetes Care 2011; 34: 1369-71.
    • (2011) Diabetes Care , vol.34 , pp. 1369-1371
    • Piccinni, C.1    Motola, D.2    Marchesini, G.3    Poluzzi, E.4
  • 79
    • 84859053613 scopus 로고    scopus 로고
    • Pioglitazone and bladder cancer: A population-based study of Taiwanese
    • Tseng CH. Pioglitazone and bladder cancer: a population-based study of Taiwanese. Diabetes Care 2012; 35: 278-80.
    • (2012) Diabetes Care , vol.35 , pp. 278-280
    • Tseng, C.H.1
  • 80
    • 84871113059 scopus 로고    scopus 로고
    • Pioglitazone and bladder cancer: A propensity score matched cohort study
    • Li W, Macdonald TM, Mackenzie IS. Pioglitazone and bladder cancer: A propensity score matched cohort study. Br J Clin Pharmacol 2012; 75: 254-9.
    • (2012) Br J Clin Pharmacol , vol.75 , pp. 254-259
    • Li, W.1    Macdonald, T.M.2    Mackenzie, I.S.3
  • 81
    • 80051723862 scopus 로고    scopus 로고
    • Association between smoking and risk of bladder cancer among men and women
    • Freedman ND, Silverman DT, Hollenbeck AR, et al. Association between smoking and risk of bladder cancer among men and women. JAMA 2011; 306: 737-45.
    • (2011) JAMA , vol.306 , pp. 737-745
    • Freedman, N.D.1    Silverman, D.T.2    Hollenbeck, A.R.3
  • 82
    • 72349086941 scopus 로고    scopus 로고
    • Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract
    • Colin P, Koenig P, Ouzzane A, et al. Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract. BJU Int 2009; 104: 1436-40.
    • (2009) BJU Int , vol.104 , pp. 1436-1440
    • Colin, P.1    Koenig, P.2    Ouzzane, A.3
  • 83
    • 53149111914 scopus 로고    scopus 로고
    • A meta-analysis on the association between bladder cancer and occupation
    • Reulen RC, Kellen E, Buntinx F, et al. A meta-analysis on the association between bladder cancer and occupation. Scand J Urol Nephrol Suppl 2008: 64-78.
    • (2008) Scand J Urol Nephrol Suppl , pp. 64-78
    • Reulen, R.C.1    Kellen, E.2    Buntinx, F.3
  • 84
    • 79960915935 scopus 로고    scopus 로고
    • Diabetes and risk of bladder cancer: A study using the National Health Insurance database in Taiwan
    • Tseng CH. Diabetes and risk of bladder cancer: a study using the National Health Insurance database in Taiwan. Diabetologia 2011; 54: 2009-15.
    • (2011) Diabetologia , vol.54 , pp. 2009-2015
    • Tseng, C.H.1
  • 85
    • 44449155990 scopus 로고    scopus 로고
    • Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer
    • Reddy RC, Srirangam A, Reddy K, et al. Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer. Neoplasia 2008; 10: 597-603.
    • (2008) Neoplasia , vol.10 , pp. 597-603
    • Reddy, R.C.1    Srirangam, A.2    Reddy, K.3
  • 86
    • 45349107287 scopus 로고    scopus 로고
    • Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptorgamma Ligands in Lung Cancer
    • Nemenoff RA, Weiser-Evans M, Winn RA. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptorgamma Ligands in Lung Cancer. PPAR Res 2008; 2008: 156875.
    • (2008) PPAR Res , vol.2008 , pp. 156875
    • Nemenoff, R.A.1    Weiser-Evans, M.2    Winn, R.A.3
  • 87
    • 0036123548 scopus 로고    scopus 로고
    • Decreased perioxisome proliferator-activated receptor gamma gene expression was correlated with poor prognosis in patients with lung cancer
    • Sasaki H, Tanahashi M, Yukiue H, et al. Decreased perioxisome proliferator-activated receptor gamma gene expression was correlated with poor prognosis in patients with lung cancer. Lung Cancer 2002; 36: 71-6.
    • (2002) Lung Cancer , vol.36 , pp. 71-76
    • Sasaki, H.1    Tanahashi, M.2    Yukiue, H.3
  • 88
    • 0942268713 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer
    • Keshamouni VG, Reddy RC, Arenberg DA, et al. Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer. Oncogene 2004; 23: 100-8.
    • (2004) Oncogene , vol.23 , pp. 100-108
    • Keshamouni, V.G.1    Reddy, R.C.2    Arenberg, D.A.3
  • 89
    • 15744396059 scopus 로고    scopus 로고
    • PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer
    • Keshamouni VG, Arenberg DA, Reddy RC, et al. PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer. Neoplasia 2005; 7: 294-301.
    • (2005) Neoplasia , vol.7 , pp. 294-301
    • Keshamouni, V.G.1    Arenberg, D.A.2    Reddy, R.C.3
  • 90
    • 33644978143 scopus 로고    scopus 로고
    • Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgammaindependent signal pathways
    • Han S, Roman J. Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgammaindependent signal pathways. Mol Cancer Ther 2006; 5: 430-7.
    • (2006) Mol Cancer Ther , vol.5 , pp. 430-437
    • Han, S.1    Roman, J.2
  • 91
    • 0037192702 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells
    • Satoh T, Toyoda M, Hoshino H, et al. Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. Oncogene 2002; 21: 2171-80.
    • (2002) Oncogene , vol.21 , pp. 2171-2180
    • Satoh, T.1    Toyoda, M.2    Hoshino, H.3
  • 92
    • 14844316288 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma (PPAR(gamma) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC)
    • Bren-Mattison Y, Van Putten V, Chan D, et al. Peroxisome proliferator-activated receptor-gamma (PPAR(gamma) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC). Oncogene 2005; 24: 1412-22.
    • (2005) Oncogene , vol.24 , pp. 1412-1422
    • Bren-Mattison, Y.1    Van Putten, V.2    Chan, D.3
  • 93
    • 70450253169 scopus 로고    scopus 로고
    • Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists
    • Kusakabe M, Watanabe K, Emoto N, et al. Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. Biochem Biophys Res Commun 2009; 390: 1283-7.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 1283-1287
    • Kusakabe, M.1    Watanabe, K.2    Emoto, N.3
  • 94
    • 80155129711 scopus 로고    scopus 로고
    • Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
    • Fu H, Zhang J, Pan J, et al. Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. Mol Carcinog 2011; 50: 913-21.
    • (2011) Mol Carcinog , vol.50 , pp. 913-921
    • Fu, H.1    Zhang, J.2    Pan, J.3
  • 95
    • 78649668811 scopus 로고    scopus 로고
    • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    • Wang Y, James M, Wen W, et al. Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Mol Cancer Ther 2010; 9: 3074-82.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3074-3082
    • Wang, Y.1    James, M.2    Wen, W.3
  • 96
    • 78649740044 scopus 로고    scopus 로고
    • Roles of peroxisome proliferatoractivated receptor-alpha and-gamma in the development of nonsmall cell lung cancer
    • Li MY, Yuan H, Ma LT, et al. Roles of peroxisome proliferatoractivated receptor-alpha and-gamma in the development of nonsmall cell lung cancer. Am J Respir Cell Mol Biol 2010; 43: 674-83.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 674-683
    • Li, M.Y.1    Yuan, H.2    Ma, L.T.3
  • 97
    • 33644685228 scopus 로고    scopus 로고
    • The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts
    • Ihle NT, Paine-Murrieta G, Berggren MI, et al. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther 2005; 4: 1349-57.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1349-1357
    • Ihle, N.T.1    Paine-Murrieta, G.2    Berggren, M.I.3
  • 98
    • 58149505585 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
    • Ihle NT, Lemos R, Schwartz D, et al. Peroxisome proliferatoractivated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. Mol Cancer Ther 2009; 8: 94-100.
    • (2009) Mol Cancer Ther , vol.8 , pp. 94-100
    • Ihle, N.T.1    Lemos, R.2    Schwartz, D.3
  • 99
    • 21244432740 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptorgamma ligands for the treatment of breast cancer
    • Fenner MH, Elstner E. Peroxisome proliferator-activated receptorgamma ligands for the treatment of breast cancer. Expert Opin Investig Drugs 2005; 14: 557-68.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 557-568
    • Fenner, M.H.1    Elstner, E.2
  • 100
    • 79957603975 scopus 로고    scopus 로고
    • Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells
    • Park BH, Lee SB, Stolz DB, et al. Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells. J Biol Chem 2011; 286: 20087-99.
    • (2011) J Biol Chem , vol.286 , pp. 20087-20099
    • Park, B.H.1    Lee, S.B.2    Stolz, D.B.3
  • 101
    • 77954763598 scopus 로고    scopus 로고
    • Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells
    • Rashid-Kolvear F, Taboski MA, Nguyen J, et al. Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer 2010; 10: 390.
    • (2010) BMC Cancer , vol.10 , pp. 390
    • Rashid-Kolvear, F.1    Taboski, M.A.2    Nguyen, J.3
  • 102
    • 47349108152 scopus 로고    scopus 로고
    • Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligand
    • Yu HN, Lee YR, Noh EM, et al. Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligand. Cell Biol Int 2008; 32: 906-12.
    • (2008) Cell Biol Int , vol.32 , pp. 906-912
    • Yu, H.N.1    Lee, Y.R.2    Noh, E.M.3
  • 103
    • 70349257304 scopus 로고    scopus 로고
    • Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells
    • Bonofiglio D, Cione E, Qi H, et al. Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells. Am J Pathol 2009; 175: 1270-80.
    • (2009) Am J Pathol , vol.175 , pp. 1270-1280
    • Bonofiglio, D.1    Cione, E.2    Qi, H.3
  • 104
    • 33746716146 scopus 로고    scopus 로고
    • Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells
    • Kim KY, Kim SS, Cheon HG. Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells. Biochem Pharmacol 2006; 72: 530-40.
    • (2006) Biochem Pharmacol , vol.72 , pp. 530-540
    • Kim, K.Y.1    Kim, S.S.2    Cheon, H.G.3
  • 105
    • 79953709985 scopus 로고    scopus 로고
    • EGR1 expression: A calcium and ERK1/2 mediated PPARgamma-independent event involved in the antiproliferative effect of 15-deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells
    • Chbicheb S, Yao X, Rodeau JL, et al. EGR1 expression: a calcium and ERK1/2 mediated PPARgamma-independent event involved in the antiproliferative effect of 15-deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells. Biochem Pharmacol 2011; 81: 1087-97.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1087-1097
    • Chbicheb, S.1    Yao, X.2    Rodeau, J.L.3
  • 106
    • 78649416421 scopus 로고    scopus 로고
    • Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer
    • Reynolds AR. Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer. Dose Response 2009; 8: 253-84.
    • (2009) Dose Response , vol.8 , pp. 253-284
    • Reynolds, A.R.1
  • 107
    • 75649133232 scopus 로고    scopus 로고
    • Alpha-eleostearic acid suppresses proliferation of MCF-7 breast cancer cells via activation of PPARgamma and inhibition of ERK 1/2
    • Moon HS, Guo DD, Lee HG, et al. Alpha-eleostearic acid suppresses proliferation of MCF-7 breast cancer cells via activation of PPARgamma and inhibition of ERK 1/2. Cancer Sci 2010; 101: 396-402.
    • (2010) Cancer Sci , vol.101 , pp. 396-402
    • Moon, H.S.1    Guo, D.D.2    Lee, H.G.3
  • 108
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPAR gamma
    • Mueller E, Sarraf P, Tontonoz P, et al. Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1998; 1: 465-70.
    • (1998) Mol Cell , vol.1 , pp. 465-470
    • Mueller, E.1    Sarraf, P.2    Tontonoz, P.3
  • 110
    • 20044372348 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest
    • Lu M, Kwan T, Yu C, et al. Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest. J Biol Chem 2005; 280: 6742-51.
    • (2005) J Biol Chem , vol.280 , pp. 6742-6751
    • Lu, M.1    Kwan, T.2    Yu, C.3
  • 111
    • 0035990751 scopus 로고    scopus 로고
    • Novel therapeutic approach: Ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells
    • Elstner E, Williamson EA, Zang C, et al. Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells. Breast Cancer Res Treat 2002; 74: 155-65.
    • (2002) Breast Cancer Res Treat , vol.74 , pp. 155-165
    • Elstner, E.1    Williamson, E.A.2    Zang, C.3
  • 112
    • 0036771776 scopus 로고    scopus 로고
    • PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
    • Panigrahy D, Singer S, Shen LQ, et al. PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest 2002; 110: 923-32.
    • (2002) J Clin Invest , vol.110 , pp. 923-932
    • Panigrahy, D.1    Singer, S.2    Shen, L.Q.3
  • 113
    • 6344235259 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510
    • Huang H, Campbell SC, Bedford DF, et al. Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. Mol Cancer Res 2004; 2: 541-50.
    • (2004) Mol Cancer Res , vol.2 , pp. 541-550
    • Huang, H.1    Campbell, S.C.2    Bedford, D.F.3
  • 114
    • 0034654120 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible implications for breast cancer therapy
    • Rubin GL, Zhao Y, Kalus AM, Simpson ER. Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. Cancer Res 2000; 60: 1604-8.
    • (2000) Cancer Res , vol.60 , pp. 1604-1608
    • Rubin, G.L.1    Zhao, Y.2    Kalus, A.M.3    Simpson, E.R.4
  • 115
    • 0033571433 scopus 로고    scopus 로고
    • A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis
    • Suh N, Wang Y, Williams CR, et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res 1999; 59: 5671-3.
    • (1999) Cancer Res , vol.59 , pp. 5671-5673
    • Suh, N.1    Wang, Y.2    Williams, C.R.3
  • 116
    • 18144384743 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis
    • Yin Y, Russell RG, Dettin LE, et al. Peroxisome proliferatoractivated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Res 2005; 65: 3950-7.
    • (2005) Cancer Res , vol.65 , pp. 3950-3957
    • Yin, Y.1    Russell, R.G.2    Dettin, L.E.3
  • 117
    • 65749084405 scopus 로고    scopus 로고
    • Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats
    • Tikoo K, Kumar P, Gupta J. Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats. BMC Cancer 2009; 9: 107.
    • (2009) BMC Cancer , vol.9 , pp. 107
    • Tikoo, K.1    Kumar, P.2    Gupta, J.3
  • 118
    • 18344364890 scopus 로고    scopus 로고
    • Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone
    • Yee LD, Young DC, Rosol TJ, et al. Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone. J Nutr 2005; 135: 983-8.
    • (2005) J Nutr , vol.135 , pp. 983-988
    • Yee, L.D.1    Young, D.C.2    Rosol, T.J.3
  • 119
    • 0037899628 scopus 로고    scopus 로고
    • Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: A phase II study
    • Burstein HJ, Demetri GD, Mueller E, et al. Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study. Breast Cancer Res Treat 2003; 79: 391-7.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 391-397
    • Burstein, H.J.1    Demetri, G.D.2    Mueller, E.3
  • 120
    • 33846334043 scopus 로고    scopus 로고
    • Pilot study of rosiglitazone therapy in women with breast cancer: Effects of short-term therapy on tumor tissue and serum markers
    • Yee LD, Williams N, Wen P, et al. Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers. Clin Cancer Res 2007; 13: 246-52.
    • (2007) Clin Cancer Res , vol.13 , pp. 246-252
    • Yee, L.D.1    Williams, N.2    Wen, P.3
  • 121
    • 0038703477 scopus 로고    scopus 로고
    • PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro
    • Liu H, Zang C, Fenner MH, et al. PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat 2003; 79: 63-74.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 63-74
    • Liu, H.1    Zang, C.2    Fenner, M.H.3
  • 122
    • 77955277303 scopus 로고    scopus 로고
    • Pioglitazone in chemically induced mammary carcinogenesis in rats
    • Bojkova B, Garajova M, Kajo K, et al. Pioglitazone in chemically induced mammary carcinogenesis in rats. Eur J Cancer Prev 2010; 19: 379-84.
    • (2010) Eur J Cancer Prev , vol.19 , pp. 379-384
    • Bojkova, B.1    Garajova, M.2    Kajo, K.3
  • 123
    • 34548069753 scopus 로고    scopus 로고
    • Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
    • Su W, Bush CR, Necela BM, et al. Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon. Physiol Genomics 2007; 30: 342-53.
    • (2007) Physiol Genomics , vol.30 , pp. 342-353
    • Su, W.1    Bush, C.R.2    Necela, B.M.3
  • 124
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARgamma
    • Sarraf P, Mueller E, Jones D, et al. Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 1998; 4: 1046-52.
    • (1998) Nat Med , vol.4 , pp. 1046-1052
    • Sarraf, P.1    Mueller, E.2    Jones, D.3
  • 125
    • 16644393169 scopus 로고    scopus 로고
    • Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects
    • Yoshizumi T, Ohta T, Ninomiya I, et al. Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects. Int J Oncol 2004; 25: 631-9.
    • (2004) Int J Oncol , vol.25 , pp. 631-639
    • Yoshizumi, T.1    Ohta, T.2    Ninomiya, I.3
  • 126
    • 0037109043 scopus 로고    scopus 로고
    • APC-dependent suppression of colon carcinogenesis by PPARgamma
    • Girnun GD, Smith WM, Drori S, et al. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci USA 2002; 99: 13771-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13771-13776
    • Girnun, G.D.1    Smith, W.M.2    Drori, S.3
  • 127
    • 0035497756 scopus 로고    scopus 로고
    • PPARgamma agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells
    • Kitamura S, Miyazaki Y, Hiraoka S, et al. PPARgamma agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells. Int J Cancer 2001; 94: 335-42.
    • (2001) Int J Cancer , vol.94 , pp. 335-342
    • Kitamura, S.1    Miyazaki, Y.2    Hiraoka, S.3
  • 128
    • 13844306722 scopus 로고    scopus 로고
    • Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR
    • Chen A, Xu J. Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. Am J Physiol Gastrointest Liver Physiol 2005; 288: G447-56.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Chen, A.1    Xu, J.2
  • 129
    • 14844354335 scopus 로고    scopus 로고
    • Ciglitazone-induced cellular antiproliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation
    • Chen F, Harrison LE. Ciglitazone-induced cellular antiproliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. Cell Signal 2005; 17: 809-16.
    • (2005) Cell Signal , vol.17 , pp. 809-816
    • Chen, F.1    Harrison, L.E.2
  • 130
    • 4344568552 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators
    • Theocharis S, Margeli A, Vielh P, Kouraklis G. Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators. Cancer Treat Rev 2004; 30: 545-54.
    • (2004) Cancer Treat Rev , vol.30 , pp. 545-554
    • Theocharis, S.1    Margeli, A.2    Vielh, P.3    Kouraklis, G.4
  • 131
    • 24344441541 scopus 로고    scopus 로고
    • Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway
    • Chen F, Kim E, Wang CC, Harrison LE. Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway. Cell Signal 2005; 17: 1572-7.
    • (2005) Cell Signal , vol.17 , pp. 1572-1577
    • Chen, F.1    Kim, E.2    Wang, C.C.3    Harrison, L.E.4
  • 132
    • 0242363581 scopus 로고    scopus 로고
    • 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway
    • Chen GG, Xu H, Lee JF, et al. 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. Int J Cancer 2003; 107: 837-43.
    • (2003) Int J Cancer , vol.107 , pp. 837-843
    • Chen, G.G.1    Xu, H.2    Lee, J.F.3
  • 133
    • 0037134255 scopus 로고    scopus 로고
    • Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer
    • Chen GG, Lee JF, Wang SH, et al. Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. Life Sci 2002; 70: 2631-46.
    • (2002) Life Sci , vol.70 , pp. 2631-2646
    • Chen, G.G.1    Lee, J.F.2    Wang, S.H.3
  • 134
    • 33646387693 scopus 로고    scopus 로고
    • Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells
    • Lee CJ, Han JS, Seo CY, et al. Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. Apoptosis 2006; 11: 401-11.
    • (2006) Apoptosis , vol.11 , pp. 401-411
    • Lee, C.J.1    Han, J.S.2    Seo, C.Y.3
  • 135
    • 22444435396 scopus 로고    scopus 로고
    • Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells
    • Yasui Y, Hosokawa M, Sahara T, et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 2005; 73: 113-9.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.73 , pp. 113-119
    • Yasui, Y.1    Hosokawa, M.2    Sahara, T.3
  • 136
    • 0036117576 scopus 로고    scopus 로고
    • Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells
    • Shimada T, Kojima K, Yoshiura K, et al. Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. Gut 2002; 50: 658-64.
    • (2002) Gut , vol.50 , pp. 658-664
    • Shimada, T.1    Kojima, K.2    Yoshiura, K.3
  • 137
    • 84862296372 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and colorectal cancer
    • Dai Y, Wang WH. Peroxisome proliferator-activated receptor gamma and colorectal cancer. World J Gastrointest Oncol 2010; 2: 159-64.
    • (2010) World J Gastrointest Oncol , vol.2 , pp. 159-164
    • Dai, Y.1    Wang, W.H.2
  • 138
    • 33746218695 scopus 로고    scopus 로고
    • Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer
    • Cesario RM, Stone J, Yen WC, et al. Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. Cancer Lett 2006; 240: 225-33.
    • (2006) Cancer Lett , vol.240 , pp. 225-233
    • Cesario, R.M.1    Stone, J.2    Yen, W.C.3
  • 139
    • 45349092527 scopus 로고    scopus 로고
    • Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment
    • Shimizu M, Moriwaki H. Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment. PPAR Res 2008; 2008: 181047.
    • (2008) PPAR Res , vol.2008 , pp. 181047
    • Shimizu, M.1    Moriwaki, H.2
  • 140
    • 0035999424 scopus 로고    scopus 로고
    • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone
    • Sunami E, Tsuno NH, Kitayama J, et al. Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. Surg Today 2002; 32: 343-50.
    • (2002) Surg Today , vol.32 , pp. 343-350
    • Sunami, E.1    Tsuno, N.H.2    Kitayama, J.3
  • 141
    • 0035866756 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats
    • Tanaka T, Kohno H, Yoshitani S, et al. Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res 2001; 61: 2424-8.
    • (2001) Cancer Res , vol.61 , pp. 2424-2428
    • Tanaka, T.1    Kohno, H.2    Yoshitani, S.3
  • 142
    • 0031667938 scopus 로고    scopus 로고
    • Activators of the nuclear receptor PPARgamma enhance colon polyp formation
    • Saez E, Tontonoz P, Nelson MC, et al. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 1998; 4: 1058-61.
    • (1998) Nat Med , vol.4 , pp. 1058-1061
    • Saez, E.1    Tontonoz, P.2    Nelson, M.C.3
  • 143
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre AM, Chen I, Desreumaux P, et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998; 4: 1053-7.
    • (1998) Nat Med , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1    Chen, I.2    Desreumaux, P.3
  • 144
    • 0036730017 scopus 로고    scopus 로고
    • A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer
    • Kulke MH, Demetri GD, Sharpless NE, et al. A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J 2002; 8: 395-9.
    • (2002) Cancer J , vol.8 , pp. 395-399
    • Kulke, M.H.1    Demetri, G.D.2    Sharpless, N.E.3
  • 145
    • 77956229623 scopus 로고    scopus 로고
    • RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells
    • Papi A, Rocchi P, Ferreri AM, Orlandi M. RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. Cancer Lett 2010; 297: 65-74.
    • (2010) Cancer Lett , vol.297 , pp. 65-74
    • Papi, A.1    Rocchi, P.2    Ferreri, A.M.3    Orlandi, M.4
  • 146
    • 58149173507 scopus 로고    scopus 로고
    • Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis
    • Takano S, Kubota T, Nishibori H, et al. Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. Anticancer Res 2008; 28: 3593-9.
    • (2008) Anticancer Res , vol.28 , pp. 3593-3599
    • Takano, S.1    Kubota, T.2    Nishibori, H.3
  • 147
    • 34250773317 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells
    • Shen D, Deng C, Zhang M. Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells. Postgrad Med J 2007; 83: 414-9.
    • (2007) Postgrad Med J , vol.83 , pp. 414-419
    • Shen, D.1    Deng, C.2    Zhang, M.3
  • 148
    • 42549146102 scopus 로고    scopus 로고
    • PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo
    • Choi IK, Kim YH, Kim JS, Seo JH. PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. Invest New Drugs 2008; 26: 283-8.
    • (2008) Invest New Drugs , vol.26 , pp. 283-288
    • Choi, I.K.1    Kim, Y.H.2    Kim, J.S.3    Seo, J.H.4
  • 149
    • 33745491465 scopus 로고    scopus 로고
    • Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice
    • Mutoh M, Niho N, Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. Biol Chem 2006; 387: 381-5.
    • (2006) Biol Chem , vol.387 , pp. 381-385
    • Mutoh, M.1    Niho, N.2    Wakabayashi, K.3
  • 150
    • 0141842617 scopus 로고    scopus 로고
    • Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands
    • Niho N, Takahashi M, Kitamura T, et al. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res 2003; 63: 6090-5.
    • (2003) Cancer Res , vol.63 , pp. 6090-6095
    • Niho, N.1    Takahashi, M.2    Kitamura, T.3
  • 151
    • 0345099451 scopus 로고    scopus 로고
    • Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand
    • Niho N, Takahashi M, Shoji Y, et al. Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand. Cancer Sci 2003; 94: 960-4.
    • (2003) Cancer Sci , vol.94 , pp. 960-964
    • Niho, N.1    Takahashi, M.2    Shoji, Y.3
  • 152
    • 0037309496 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice
    • Osawa E, Nakajima A, Wada K, et al. Peroxisome proliferatoractivated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 2003; 124: 361-7.
    • (2003) Gastroenterology , vol.124 , pp. 361-367
    • Osawa, E.1    Nakajima, A.2    Wada, K.3
  • 153
    • 77956795473 scopus 로고    scopus 로고
    • PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study
    • Takahashi H, Hosono K, Uchiyama T, et al. PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study. PPAR Res 2010; 2010.
    • (2010) PPAR Res 2010
    • Takahashi, H.1    Hosono, K.2    Uchiyama, T.3
  • 154
    • 0034307161 scopus 로고    scopus 로고
    • 17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes
    • Wu GJ, Sinclair CS, Paape J, et al. 17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes. Cancer Res 2000; 60: 5371-5.
    • (2000) Cancer Res , vol.60 , pp. 5371-5375
    • Wu, G.J.1    Sinclair, C.S.2    Paape, J.3
  • 155
    • 0038622077 scopus 로고    scopus 로고
    • Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells
    • Xu Y, Iyengar S, Roberts RL, et al. Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells. J Cell Physiol 2003; 196: 131-43.
    • (2003) J Cell Physiol , vol.196 , pp. 131-143
    • Xu, Y.1    Iyengar, S.2    Roberts, R.L.3
  • 156
    • 34248580190 scopus 로고    scopus 로고
    • Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines?
    • Laidler P, Dulinska J, Mrozicki S. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? Arch Biochem Biophys 2007; 462: 1-12.
    • (2007) Arch Biochem Biophys , vol.462 , pp. 1-12
    • Laidler, P.1    Dulinska, J.2    Mrozicki, S.3
  • 157
    • 79958811217 scopus 로고    scopus 로고
    • Troglitazone suppresses c-Myc levels in human prostate cancer cells via a PPARgamma-independent mechanism
    • Akinyeke TO, Stewart LV. Troglitazone suppresses c-Myc levels in human prostate cancer cells via a PPARgamma-independent mechanism. Cancer Biol Ther 2011; 11: 1046-58.
    • (2011) Cancer Biol Ther , vol.11 , pp. 1046-1058
    • Akinyeke, T.O.1    Stewart, L.V.2
  • 158
    • 58549099485 scopus 로고    scopus 로고
    • Thiazolidinediones regulate expression of cell cycle proteins in human prostate cancer cells via PPARgamma-dependent and PPARgamma-independent pathways
    • Lyles BE, Akinyeke TO, Moss PE, Stewart LV. Thiazolidinediones regulate expression of cell cycle proteins in human prostate cancer cells via PPARgamma-dependent and PPARgamma-independent pathways. Cell Cycle 2009; 8: 268-77.
    • (2009) Cell Cycle , vol.8 , pp. 268-277
    • Lyles, B.E.1    Akinyeke, T.O.2    Moss, P.E.3    Stewart, L.V.4
  • 159
    • 84860401241 scopus 로고    scopus 로고
    • Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFkappaB via suppression of GSK-3beta expression
    • Ban JO, Oh JH, Son SM, et al. Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFkappaB via suppression of GSK-3beta expression. Cancer Biol Ther 2011; 12: 288-96.
    • (2011) Cancer Biol Ther , vol.12 , pp. 288-296
    • Ban, J.O.1    Oh, J.H.2    Son, S.M.3
  • 160
    • 34548306411 scopus 로고    scopus 로고
    • Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma
    • Wei S, Lin LF, Yang CC, et al. Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma. Mol Pharmacol 2007; 72: 725-33.
    • (2007) Mol Pharmacol , vol.72 , pp. 725-733
    • Wei, S.1    Lin, L.F.2    Yang, C.C.3
  • 161
    • 78650732476 scopus 로고    scopus 로고
    • Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells
    • Zhu H, Pan X, Qi H, et al. Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells. Oncol Rep 2011; 25: 81-90.
    • (2011) Oncol Rep , vol.25 , pp. 81-90
    • Zhu, H.1    Pan, X.2    Qi, H.3
  • 162
    • 33749626553 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer
    • Annicotte JS, Iankova I, Miard S, et al. Peroxisome proliferatoractivated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol 2006; 26: 7561-74.
    • (2006) Mol Cell Biol , vol.26 , pp. 7561-7574
    • Annicotte, J.S.1    Iankova, I.2    Miard, S.3
  • 163
    • 0034306976 scopus 로고    scopus 로고
    • Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer
    • Hisatake JI, Ikezoe T, Carey M, et al. Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer. Cancer Res 2000; 60: 5494-8.
    • (2000) Cancer Res , vol.60 , pp. 5494-5498
    • Hisatake, J.I.1    Ikezoe, T.2    Carey, M.3
  • 164
    • 33645803202 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells
    • Yang CC, Ku CY, Wei S, et al. Peroxisome proliferator-activated receptor gamma-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells. Mol Pharmacol 2006; 69: 1564-70.
    • (2006) Mol Pharmacol , vol.69 , pp. 1564-1570
    • Yang, C.C.1    Ku, C.Y.2    Wei, S.3
  • 165
    • 13944280963 scopus 로고    scopus 로고
    • Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of BclxL/Bcl-2 functions independently of PPARgamma
    • Shiau CW, Yang CC, Kulp SK, et al. Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of BclxL/Bcl-2 functions independently of PPARgamma. Cancer Res 2005; 65: 1561-9.
    • (2005) Cancer Res , vol.65 , pp. 1561-1569
    • Shiau, C.W.1    Yang, C.C.2    Kulp, S.K.3
  • 166
    • 33745404148 scopus 로고    scopus 로고
    • PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells
    • Nunez NP, Liu H, Meadows GG. PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. Cancer Lett 2006; 236: 133-41.
    • (2006) Cancer Lett , vol.236 , pp. 133-141
    • Nunez, N.P.1    Liu, H.2    Meadows, G.G.3
  • 167
    • 48149088476 scopus 로고    scopus 로고
    • Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells
    • Papageorgiou E, Pitulis N, Manoussakis M, et al. Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. Mol Med 2008; 14: 403-11.
    • (2008) Mol Med , vol.14 , pp. 403-411
    • Papageorgiou, E.1    Pitulis, N.2    Manoussakis, M.3
  • 168
    • 80051975232 scopus 로고    scopus 로고
    • Targeting Sp1 transcription factors in prostate cancer therapy
    • Sankpal UT, Goodison S, Abdelrahim M, Basha R. Targeting Sp1 transcription factors in prostate cancer therapy. Med Chem 2011; 7: 518-25.
    • (2011) Med Chem , vol.7 , pp. 518-525
    • Sankpal, U.T.1    Goodison, S.2    Abdelrahim, M.3    Basha, R.4
  • 169
    • 33847106393 scopus 로고    scopus 로고
    • PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma
    • Chaffer CL, Thomas DM, Thompson EW, Williams ED. PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. BMC Cancer 2006; 6: 53.
    • (2006) BMC Cancer , vol.6 , pp. 53
    • Chaffer, C.L.1    Thomas, D.M.2    Thompson, E.W.3    Williams, E.D.4
  • 170
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, et al. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 1998; 58: 3344-52.
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3
  • 171
    • 0343855442 scopus 로고    scopus 로고
    • Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer
    • Mueller E, Smith M, Sarraf P, et al. Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc Natl Acad Sci USA 2000; 97: 10990-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10990-10995
    • Mueller, E.1    Smith, M.2    Sarraf, P.3
  • 172
    • 4844219655 scopus 로고    scopus 로고
    • Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy
    • Smith MR, Manola J, Kaufman DS, et al. Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy. Cancer 2004; 101: 1569-74.
    • (2004) Cancer , vol.101 , pp. 1569-1574
    • Smith, M.R.1    Manola, J.2    Kaufman, D.S.3
  • 173
    • 78651098932 scopus 로고    scopus 로고
    • Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids
    • Gottfried E, Rogenhofer S, Waibel H, et al. Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids. Cancer Chemother Pharmacol 2011; 67: 117-26.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 117-126
    • Gottfried, E.1    Rogenhofer, S.2    Waibel, H.3
  • 174
    • 25444511570 scopus 로고    scopus 로고
    • The PPAR-gamma agonist pioglitazone post-transcriptionally induces p21 in PC3 prostate cancer but not in other cell lines
    • Radhakrishnan SK, Gartel AL. The PPAR-gamma agonist pioglitazone post-transcriptionally induces p21 in PC3 prostate cancer but not in other cell lines. Cell Cycle 2005; 4: 582-4.
    • (2005) Cell Cycle , vol.4 , pp. 582-584
    • Radhakrishnan, S.K.1    Gartel, A.L.2
  • 175
    • 33748323449 scopus 로고    scopus 로고
    • 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis
    • Nakata S, Yoshida T, Shiraishi T, et al. 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. Mol Cancer Ther 2006; 5: 1827-35.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1827-1835
    • Nakata, S.1    Yoshida, T.2    Shiraishi, T.3
  • 176
    • 78049478724 scopus 로고    scopus 로고
    • Modular therapy approach in metastatic castration-refractory prostate cancer
    • Walter B, Rogenhofer S, Vogelhuber M, et al. Modular therapy approach in metastatic castration-refractory prostate cancer. World J Urol 2010; 28: 745-50.
    • (2010) World J Urol , vol.28 , pp. 745-750
    • Walter, B.1    Rogenhofer, S.2    Vogelhuber, M.3
  • 177
    • 9644270534 scopus 로고    scopus 로고
    • Marked hyperglycemia after androgen-deprivation therapy for prostate cancer and usefulness of pioglitazone for its treatment
    • Inaba M, Otani Y, Nishimura K, et al. Marked hyperglycemia after androgen-deprivation therapy for prostate cancer and usefulness of pioglitazone for its treatment. Metabolism 2005; 54: 55-9.
    • (2005) Metabolism , vol.54 , pp. 55-59
    • Inaba, M.1    Otani, Y.2    Nishimura, K.3
  • 178
    • 0029876241 scopus 로고    scopus 로고
    • Epidemiology and risk factors in pancreatic cancer
    • Ahlgren JD. Epidemiology and risk factors in pancreatic cancer. Semin Oncol 1996; 23: 241-50.
    • (1996) Semin Oncol , vol.23 , pp. 241-250
    • Ahlgren, J.D.1
  • 179
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 1997; 94: 4312-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 180
    • 0034306992 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human. Pancreatic carcinoma cells
    • Motomura W, Okumura T, Takahashi N, et al. Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human. Pancreatic carcinoma cells. Cancer Res 2000; 60: 5558-64.
    • (2000) Cancer Res , vol.60 , pp. 5558-5564
    • Motomura, W.1    Okumura, T.2    Takahashi, N.3
  • 181
    • 0043163884 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway
    • Tsujie M, Nakamori S, Okami J, et al. Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. Exp Cell Res 2003; 289: 143-51.
    • (2003) Exp Cell Res , vol.289 , pp. 143-151
    • Tsujie, M.1    Nakamori, S.2    Okami, J.3
  • 182
    • 0035744786 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer
    • Sasaki T, Fujimoto Y, Tsuchida A, et al. Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer. Pathobiology 2001; 69: 258-65.
    • (2001) Pathobiology , vol.69 , pp. 258-265
    • Sasaki, T.1    Fujimoto, Y.2    Tsuchida, A.3
  • 183
    • 7244234089 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms
    • Galli A, Ceni E, Crabb DW, et al. Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms. Gut 2004; 53: 1688-97.
    • (2004) Gut , vol.53 , pp. 1688-1697
    • Galli, A.1    Ceni, E.2    Crabb, D.W.3
  • 184
    • 84895069235 scopus 로고    scopus 로고
    • The PPAR-gamma agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-beta treated pancreatic cancer cells
    • Vitale G, Zappavigna S, Marra M, et al. The PPAR-gamma agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-beta treated pancreatic cancer cells. Biotechnol Adv 2011.
    • (2011) Biotechnol Adv
    • Vitale, G.1    Zappavigna, S.2    Marra, M.3
  • 185
    • 19344376702 scopus 로고    scopus 로고
    • Involvement of MEKERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells
    • Motomura W, Tanno S, Takahashi N, et al. Involvement of MEKERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells. Biochem Biophys Res Commun 2005; 332: 89-94.
    • (2005) Biochem Biophys Res Commun , vol.332 , pp. 89-94
    • Motomura, W.1    Tanno, S.2    Takahashi, N.3
  • 186
    • 1542497567 scopus 로고    scopus 로고
    • Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway
    • Tsujie M, Nakamori S, Okami J, et al. Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. Int J Oncol 2003; 23: 325-31.
    • (2003) Int J Oncol , vol.23 , pp. 325-331
    • Tsujie, M.1    Nakamori, S.2    Okami, J.3
  • 187
    • 0037083972 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1
    • Toyota M, Miyazaki Y, Kitamura S, et al. Peroxisome proliferatoractivated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1. Life Sci 2002; 70: 1565-75.
    • (2002) Life Sci , vol.70 , pp. 1565-1575
    • Toyota, M.1    Miyazaki, Y.2    Kitamura, S.3
  • 188
    • 0036135985 scopus 로고    scopus 로고
    • Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone
    • Kawa S, Nikaido T, Unno H, et al. Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone. Pancreas 2002; 24: 1-7.
    • (2002) Pancreas , vol.24 , pp. 1-7
    • Kawa, S.1    Nikaido, T.2    Unno, H.3
  • 189
    • 9444255249 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins
    • Hong J, Samudio I, Liu S, et al. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology 2004; 145: 5774-85.
    • (2004) Endocrinology , vol.145 , pp. 5774-5785
    • Hong, J.1    Samudio, I.2    Liu, S.3
  • 190
    • 60649089738 scopus 로고    scopus 로고
    • Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells
    • Kumei S, Motomura W, Yoshizaki T, et al. Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun 2009; 380: 614-9.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 614-619
    • Kumei, S.1    Motomura, W.2    Yoshizaki, T.3
  • 191
    • 0042829213 scopus 로고    scopus 로고
    • Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator
    • Farrow B, O'Connor KL, Hashimoto K, et al. Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. Surgery 2003; 134: 206-12.
    • (2003) Surgery , vol.134 , pp. 206-212
    • Farrow, B.1    O'Connor, K.L.2    Hashimoto, K.3
  • 192
    • 84895072331 scopus 로고    scopus 로고
    • PPARgamma potentiates anticancer effects of gemcitabine on human pancreatic cancer cells
    • Koga H, Selvendiran K, Sivakumar R, et al. PPARgamma potentiates anticancer effects of gemcitabine on human pancreatic cancer cells. Int J Oncol 2011.
    • (2011) Int J Oncol
    • Koga, H.1    Selvendiran, K.2    Sivakumar, R.3
  • 193
    • 34548063105 scopus 로고    scopus 로고
    • Suppression of Nnitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferatoractivated receptor gamma
    • Takeuchi Y, Takahashi M, Sakano K, et al. Suppression of Nnitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferatoractivated receptor gamma. Carcinogenesis 2007; 28: 1692-6.
    • (2007) Carcinogenesis , vol.28 , pp. 1692-1696
    • Takeuchi, Y.1    Takahashi, M.2    Sakano, K.3
  • 194
    • 0035501635 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo
    • Itami A, Watanabe G, Shimada Y, et al. Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo. Int J Cancer 2001; 94: 370-6.
    • (2001) Int J Cancer , vol.94 , pp. 370-376
    • Itami, A.1    Watanabe, G.2    Shimada, Y.3
  • 195
    • 45249084803 scopus 로고    scopus 로고
    • The Role of PPARgamma in Hepatocellular Carcinoma
    • Borbath I, Horsmans Y. The Role of PPARgamma in Hepatocellular Carcinoma. PPAR Res 2008; 2008: 209520.
    • (2008) PPAR Res , vol.2008 , pp. 209520
    • Borbath, I.1    Horsmans, Y.2
  • 196
    • 17844395188 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma
    • Rumi MA, Sato H, Ishihara S, et al. Peroxisome proliferatoractivated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma. Br J Cancer 2001; 84: 1640-7.
    • (2001) Br J Cancer , vol.84 , pp. 1640-1647
    • Rumi, M.A.1    Sato, H.2    Ishihara, S.3
  • 197
    • 0035035402 scopus 로고    scopus 로고
    • Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazoneinduced cell-cycle arrest in human hepatoma cell lines
    • Koga H, Sakisaka S, Harada M, et al. Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazoneinduced cell-cycle arrest in human hepatoma cell lines. Hepatology 2001; 33: 1087-97.
    • (2001) Hepatology , vol.33 , pp. 1087-1097
    • Koga, H.1    Sakisaka, S.2    Harada, M.3
  • 198
    • 6044267548 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells
    • Cheng J, Nakamura H, Imanishi H, et al. Peroxisome proliferatoractivated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. Biochem Biophys Res Commun 2004; 322: 458-64.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 458-464
    • Cheng, J.1    Nakamura, H.2    Imanishi, H.3
  • 199
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • Galli A, Crabb DW, Ceni E, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 2002; 122: 1924-40.
    • (2002) Gastroenterology , vol.122 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Ceni, E.3
  • 200
    • 1642524221 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    • Hazra S, Xiong S, Wang J, et al. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 2004; 279: 11392-401.
    • (2004) J Biol Chem , vol.279 , pp. 11392-11401
    • Hazra, S.1    Xiong, S.2    Wang, J.3
  • 201
    • 0036278855 scopus 로고    scopus 로고
    • A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells
    • Toyoda M, Takagi H, Horiguchi N, et al. A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells. Gut 2002; 50: 563-7.
    • (2002) Gut , vol.50 , pp. 563-567
    • Toyoda, M.1    Takagi, H.2    Horiguchi, N.3
  • 202
    • 33644792520 scopus 로고    scopus 로고
    • Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo
    • Yu J, Qiao L, Zimmermann L, et al. Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo. Hepatology 2006; 43: 134-43.
    • (2006) Hepatology , vol.43 , pp. 134-143
    • Yu, J.1    Qiao, L.2    Zimmermann, L.3
  • 203
    • 74549184686 scopus 로고    scopus 로고
    • The peroxisome proliferatoractivated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells
    • Shim J, Kim BH, Kim YI, et al. The peroxisome proliferatoractivated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. Int J Oncol 2010; 36: 223-31.
    • (2010) Int J Oncol , vol.36 , pp. 223-231
    • Shim, J.1    Kim, B.H.2    Kim, Y.I.3
  • 204
    • 34447251654 scopus 로고    scopus 로고
    • The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver
    • Borbath I, Leclercq I, Moulin P, et al. The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver. Eur J Cancer 2007; 43: 1755-63.
    • (2007) Eur J Cancer , vol.43 , pp. 1755-1763
    • Borbath, I.1    Leclercq, I.2    Moulin, P.3
  • 205
    • 9244257823 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats
    • Guo YT, Leng XS, Li T, et al. Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats. World J Gastroenterol 2004; 10: 3419-23.
    • (2004) World J Gastroenterol , vol.10 , pp. 3419-3423
    • Guo, Y.T.1    Leng, X.S.2    Li, T.3
  • 206
    • 84895069851 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in nonalcoholic steatohepatitis: Growing evidence of an epidemic?
    • Hashimoto E, Tokushige K. Hepatocellular carcinoma in nonalcoholic steatohepatitis: Growing evidence of an epidemic? Hepatol Res 2011.
    • (2011) Hepatol Res
    • Hashimoto, E.1    Tokushige, K.2
  • 208
    • 68849117389 scopus 로고    scopus 로고
    • Liver safety in patients with type 2 diabetes treated with pioglitazone: Results from a 3-year, randomized, comparator-controlled study in the US
    • Tolman KG, Freston JW, Kupfer S, Perez A. Liver safety in patients with type 2 diabetes treated with pioglitazone: results from a 3-year, randomized, comparator-controlled study in the US. Drug Saf 2009; 32: 787-800.
    • (2009) Drug Saf , vol.32 , pp. 787-800
    • Tolman, K.G.1    Freston, J.W.2    Kupfer, S.3    Perez, A.4
  • 209
    • 77954881040 scopus 로고    scopus 로고
    • Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
    • Liu SH, Shen CC, Yi YC, et al. Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Br J Pharmacol 2010; 160: 1963-72.
    • (2010) Br J Pharmacol , vol.160 , pp. 1963-1972
    • Liu, S.H.1    Shen, C.C.2    Yi, Y.C.3
  • 210
    • 0033741281 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists
    • Sato H, Ishihara S, Kawashima K, et al. Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists. Br J Cancer 2000; 83: 1394-400.
    • (2000) Br J Cancer , vol.83 , pp. 1394-1400
    • Sato, H.1    Ishihara, S.2    Kawashima, K.3
  • 211
    • 77956598987 scopus 로고    scopus 로고
    • Association between peroxisome proliferator-activated receptorgamma gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis
    • Bazargani A, Khoramrooz SS, Kamali-Sarvestani E, et al. Association between peroxisome proliferator-activated receptorgamma gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis. Scand J Gastroenterol 2010; 45: 1162-7.
    • (2010) Scand J Gastroenterol , vol.45 , pp. 1162-1167
    • Bazargani, A.1    Khoramrooz, S.S.2    Kamali-Sarvestani, E.3
  • 212
    • 46249125608 scopus 로고    scopus 로고
    • Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease
    • Prasad KN, Saxena A, Ghoshal UC, et al. Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. Ann Oncol 2008; 19: 1299-303.
    • (2008) Ann Oncol , vol.19 , pp. 1299-1303
    • Prasad, K.N.1    Saxena, A.2    Ghoshal, U.C.3
  • 213
    • 77956365662 scopus 로고    scopus 로고
    • Reversal of P-glycoproteinmediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone
    • Chen Q, Zhou J, Jiang C, Chen J. Reversal of P-glycoproteinmediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone. J Huazhong Univ Sci Technolog Med Sci 2010; 30: 326-31.
    • (2010) J Huazhong Univ Sci Technolog Med Sci , vol.30 , pp. 326-331
    • Chen, Q.1    Zhou, J.2    Jiang, C.3    Chen, J.4
  • 214
    • 78651388245 scopus 로고    scopus 로고
    • Troglitazone induces apoptosis in gastric cancer cells through the NAG-1 pathway
    • Wang C, Wang J, Bai P. Troglitazone induces apoptosis in gastric cancer cells through the NAG-1 pathway. Mol Med Report 2011; 4: 93-7.
    • (2011) Mol Med Report , vol.4 , pp. 93-97
    • Wang, C.1    Wang, J.2    Bai, P.3
  • 215
    • 0037513312 scopus 로고    scopus 로고
    • PPAR gamma ligandinduced apoptosis through a p53-dependent mechanism in human gastric cancer cells
    • Nagamine M, Okumura T, Tanno S, et al. PPAR gamma ligandinduced apoptosis through a p53-dependent mechanism in human gastric cancer cells. Cancer Sci 2003; 94: 338-43.
    • (2003) Cancer Sci , vol.94 , pp. 338-343
    • Nagamine, M.1    Okumura, T.2    Tanno, S.3
  • 216
    • 0036053466 scopus 로고    scopus 로고
    • Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells
    • Takeuchi S, Okumura T, Motomura W, et al. Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells. Jpn J Cancer Res 2002; 93: 774-82.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 774-782
    • Takeuchi, S.1    Okumura, T.2    Motomura, W.3
  • 217
    • 10744231241 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells
    • Leung WK, Bai AH, Chan VY, et al. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. Gut 2004; 53: 331-8.
    • (2004) Gut , vol.53 , pp. 331-338
    • Leung, W.K.1    Bai, A.H.2    Chan, V.Y.3
  • 218
    • 0033584727 scopus 로고    scopus 로고
    • PPARgamma inhibits the expression of c-MET in human gastric cancer cells through the suppression of Ets
    • Kitamura S, Miyazaki Y, Hiraoka S, et al. PPARgamma inhibits the expression of c-MET in human gastric cancer cells through the suppression of Ets. Biochem Biophys Res Commun 1999; 265: 453-6.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 453-456
    • Kitamura, S.1    Miyazaki, Y.2    Hiraoka, S.3
  • 219
    • 58149329042 scopus 로고    scopus 로고
    • Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression
    • Chen BL, Yu J, Zeng ZR, et al. Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncol Rep 2008; 20: 1093-7.
    • (2008) Oncol Rep , vol.20 , pp. 1093-1097
    • Chen, B.L.1    Yu, J.2    Zeng, Z.R.3
  • 220
    • 53149151440 scopus 로고    scopus 로고
    • Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In vitro via PPARgamma Dependent and Independent Mechanisms
    • He Q, Pang R, Song X, et al. Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In vitro via PPARgamma Dependent and Independent Mechanisms. PPAR Res 2008; 2008: 649808.
    • (2008) PPAR Res , vol.2008 , pp. 649808
    • He, Q.1    Pang, R.2    Song, X.3
  • 221
    • 21144439861 scopus 로고    scopus 로고
    • Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice
    • Lu J, Imamura K, Nomura S, et al. Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice. Cancer Res 2005; 65: 4769-74.
    • (2005) Cancer Res , vol.65 , pp. 4769-4774
    • Lu, J.1    Imamura, K.2    Nomura, S.3
  • 222
    • 0032586875 scopus 로고    scopus 로고
    • Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells
    • Takahashi N, Okumura T, Motomura W, et al. Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett 1999; 455: 135-9.
    • (1999) FEBS Lett , vol.455 , pp. 135-139
    • Takahashi, N.1    Okumura, T.2    Motomura, W.3
  • 223
    • 79952034503 scopus 로고    scopus 로고
    • PPARgamma is functionally expressed in clear cell renal cell carcinoma
    • Collet N, Theoleyre S, Rageul J, et al. PPARgamma is functionally expressed in clear cell renal cell carcinoma. Int J Oncol 2011; 38: 851-7.
    • (2011) Int J Oncol , vol.38 , pp. 851-857
    • Collet, N.1    Theoleyre, S.2    Rageul, J.3
  • 224
    • 20444410811 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines
    • Yang FG, Zhang ZW, Xin DQ, et al. Peroxisome proliferatoractivated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines. Acta Pharmacol Sin 2005; 26: 753-61.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 753-761
    • Yang, F.G.1    Zhang, Z.W.2    Xin, D.Q.3
  • 225
    • 0035964872 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists
    • Inoue K, Kawahito Y, Tsubouchi Y, et al. Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res Commun 2001; 287: 727-32.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 727-732
    • Inoue, K.1    Kawahito, Y.2    Tsubouchi, Y.3
  • 226
    • 0036633930 scopus 로고    scopus 로고
    • Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferatoractivated receptor-gamma ligands
    • Rumi MA, Sato H, Ishihara S, et al. Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferatoractivated receptor-gamma ligands. J Lab Clin Med 2002; 140: 17-26.
    • (2002) J Lab Clin Med , vol.140 , pp. 17-26
    • Rumi, M.A.1    Sato, H.2    Ishihara, S.3
  • 227
    • 70349652053 scopus 로고    scopus 로고
    • Differential effects of PPARgamma activation by the oral antidiabetic agent pioglitazone in Barrett's carcinoma in vitro and in vivo
    • Al-Taie OH, Graf T, Illert B, et al. Differential effects of PPARgamma activation by the oral antidiabetic agent pioglitazone in Barrett's carcinoma in vitro and in vivo. J Gastroenterol 2009; 44: 919-29.
    • (2009) J Gastroenterol , vol.44 , pp. 919-929
    • Al-Taie, O.H.1    Graf, T.2    Illert, B.3
  • 228
    • 3242679874 scopus 로고    scopus 로고
    • The ligands of peroxisome proliferator-activated receptor (PPAR) gamma inhibit growth of human esophageal carcinoma cells through induction of apoptosis and cell cycle arrest
    • Fujii D, Yoshida K, Tanabe K, et al. The ligands of peroxisome proliferator-activated receptor (PPAR) gamma inhibit growth of human esophageal carcinoma cells through induction of apoptosis and cell cycle arrest. Anticancer Res 2004; 24: 1409-16.
    • (2004) Anticancer Res , vol.24 , pp. 1409-1416
    • Fujii, D.1    Yoshida, K.2    Tanabe, K.3
  • 229
    • 33748628875 scopus 로고    scopus 로고
    • A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: Potential molecular targeting strategy for cholangioma
    • Kobuke T, Tazuma S, Hyogo H, Chayama K. A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma. Dig Dis Sci 2006; 51: 1650-7.
    • (2006) Dig Dis Sci , vol.51 , pp. 1650-1657
    • Kobuke, T.1    Tazuma, S.2    Hyogo, H.3    Chayama, K.4
  • 230
    • 0038121972 scopus 로고    scopus 로고
    • PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway
    • Han C, Demetris AJ, Michalopoulos GK, et al. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Hepatology 2003; 38: 167-77.
    • (2003) Hepatology , vol.38 , pp. 167-177
    • Han, C.1    Demetris, A.J.2    Michalopoulos, G.K.3
  • 231
    • 35748973296 scopus 로고    scopus 로고
    • Beneficial effects of pioglitazone on cholangiohepatitis induced by bile duct carcinoma
    • Suzuki S, Mori J, Yamazaki M, et al. Beneficial effects of pioglitazone on cholangiohepatitis induced by bile duct carcinoma. Intern Med 2007; 46: 1723-7.
    • (2007) Intern Med , vol.46 , pp. 1723-1727
    • Suzuki, S.1    Mori, J.2    Yamazaki, M.3
  • 232
    • 21244506742 scopus 로고    scopus 로고
    • Action of thiazolidinediones on differentiation, proliferation and apoptosis of normal and transformed thyrocytes in culture
    • Frohlich E, Machicao F, Wahl R. Action of thiazolidinediones on differentiation, proliferation and apoptosis of normal and transformed thyrocytes in culture. Endocr Relat Cancer 2005; 12: 291-303.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 291-303
    • Frohlich, E.1    Machicao, F.2    Wahl, R.3
  • 233
    • 66149137603 scopus 로고    scopus 로고
    • Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    • Antonelli A, Ferrari SM, Fallahi P, et al. Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells. Clin Endocrinol (Oxf) 2009; 70: 946-53.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 946-953
    • Antonelli, A.1    Ferrari, S.M.2    Fallahi, P.3
  • 234
    • 80054899975 scopus 로고    scopus 로고
    • Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma
    • Dobson ME, Diallo-Krou E, Grachtchouk V, et al. Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. Endocrinology 2011; 152: 4455-65.
    • (2011) Endocrinology , vol.152 , pp. 4455-4465
    • Dobson, M.E.1    Diallo-Krou, E.2    Grachtchouk, V.3
  • 235
    • 77954758190 scopus 로고    scopus 로고
    • Activation of vitamin D receptor (VDR)-and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines
    • Sertznig P, Seifert M, Tilgen W, Reichrath J. Activation of vitamin D receptor (VDR)-and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines. Dermatoendocrinol 2009; 1: 232-8.
    • (2009) Dermatoendocrinol , vol.1 , pp. 232-238
    • Sertznig, P.1    Seifert, M.2    Tilgen, W.3    Reichrath, J.4
  • 236
    • 65049088109 scopus 로고    scopus 로고
    • In vitro and in vivo antimelanoma effects of ciglitazone
    • Botton T, Puissant A, Bahadoran P, et al. In vitro and in vivo antimelanoma effects of ciglitazone. J Invest Dermatol 2009; 129: 1208-18.
    • (2009) J Invest Dermatol , vol.129 , pp. 1208-1218
    • Botton, T.1    Puissant, A.2    Bahadoran, P.3
  • 237
    • 0036381783 scopus 로고    scopus 로고
    • Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma
    • Mossner R, Schulz U, Kruger U, et al. Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma. J Invest Dermatol 2002; 119: 576-82.
    • (2002) J Invest Dermatol , vol.119 , pp. 576-582
    • Mossner, R.1    Schulz, U.2    Kruger, U.3
  • 238
    • 33645025989 scopus 로고    scopus 로고
    • Survival of infants with neural tube defects in the presence of folic acid fortification
    • Bol KA, Collins JS, Kirby RS. Survival of infants with neural tube defects in the presence of folic acid fortification. Pediatrics 2006; 117: 803-13.
    • (2006) Pediatrics , vol.117 , pp. 803-813
    • Bol, K.A.1    Collins, J.S.2    Kirby, R.S.3
  • 239
    • 67449095059 scopus 로고    scopus 로고
    • Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells
    • Papi A, Rocchi P, Ferreri AM, et al. Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells. Oncol Rep 2009; 21: 1083-9.
    • (2009) Oncol Rep , vol.21 , pp. 1083-1089
    • Papi, A.1    Rocchi, P.2    Ferreri, A.M.3
  • 240
    • 33749374780 scopus 로고    scopus 로고
    • Growth inhibition and differentiation induced by peroxisome proliferator activated receptor gamma ligand rosiglitazone in human melanoma cell line A375
    • Liu Y, Meng Y, Li H, et al. Growth inhibition and differentiation induced by peroxisome proliferator activated receptor gamma ligand rosiglitazone in human melanoma cell line A375. Med Oncol 2006; 23: 393-402.
    • (2006) Med Oncol , vol.23 , pp. 393-402
    • Liu, Y.1    Meng, Y.2    Li, H.3
  • 241
    • 33847624711 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib augments anti-proliferative effects of mistletoe lectin-I and the PPAR-gamma agonist rosiglitazone in human melanoma cells
    • Freudlsperger C, Thies A, Pfuller U, Schumacher U. The proteasome inhibitor bortezomib augments anti-proliferative effects of mistletoe lectin-I and the PPAR-gamma agonist rosiglitazone in human melanoma cells. Anticancer Res 2007; 27: 207-13.
    • (2007) Anticancer Res , vol.27 , pp. 207-213
    • Freudlsperger, C.1    Thies, A.2    Pfuller, U.3    Schumacher, U.4
  • 242
    • 0142025382 scopus 로고    scopus 로고
    • The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells
    • Placha W, Gil D, Dembinska-Kiec A, Laidler P. The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. Melanoma Res 2003; 13: 447-56.
    • (2003) Melanoma Res , vol.13 , pp. 447-456
    • Placha, W.1    Gil, D.2    Dembinska-Kiec, A.3    Laidler, P.4
  • 243
    • 77957284996 scopus 로고    scopus 로고
    • Mistletoe lectin-I augments antiproliferative effects of the PPARgamma agonist rosiglitazone on human malignant melanoma cells
    • Freudlsperger C, Dahl A, Hoffmann J, et al. Mistletoe lectin-I augments antiproliferative effects of the PPARgamma agonist rosiglitazone on human malignant melanoma cells. Phytother Res 2010; 24: 1354-8.
    • (2010) Phytother Res , vol.24 , pp. 1354-1358
    • Freudlsperger, C.1    Dahl, A.2    Hoffmann, J.3
  • 244
    • 7644238341 scopus 로고    scopus 로고
    • Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma
    • Reichle A, Bross K, Vogt T, et al. Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma. Cancer 2004; 101: 2247-56.
    • (2004) Cancer , vol.101 , pp. 2247-2256
    • Reichle, A.1    Bross, K.2    Vogt, T.3
  • 245
    • 36048987307 scopus 로고    scopus 로고
    • Targeted combined antiinflammatory and angiostatic therapy in advanced melanoma: A randomized phase II trial
    • Reichle A, Vogt T, Coras B, et al. Targeted combined antiinflammatory and angiostatic therapy in advanced melanoma: a randomized phase II trial. Melanoma Res 2007; 17: 360-4.
    • (2007) Melanoma Res , vol.17 , pp. 360-364
    • Reichle, A.1    Vogt, T.2    Coras, B.3


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