Urothelial Carcinogenesis in the Urinary Bladder of Male Rats Treated with Muraglitazar, a PPARα/γ Agonist: Evidence for Urolithiasis as the Inciting Event in the Mode of Action

Toxicologic Pathology

Volumn 34, Issue 7, 2006, Pages 903-920

  Dominick, Mark A ^a   White, Melvin R ^a   Sanderson, Thomas P ^a   Van Vleet, Terry ^a   Cohen, Samuel M ^b   Arnold, Lora E ^b   Cano, Marty ^b   Tannehill Gregg, Sarah ^a   Moehlenkamp, Jeffrey D ^a   Waites, Crystal R ^a   Schilling, Beth E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

carcinogenesis; Dual PPAR agonist; hypocalciuria; urinary bladder; urolithiasis; urothelial

Indexed keywords

AMMONIUM CHLORIDE; AMMONIUM MAGNESIUM PHOSPHATE; CALCIUM; CALCIUM OXALATE; CALCIUM PHOSPHATE; CITRIC ACID; MAGNESIUM; MURAGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLADDER CARCINOGENESIS; BLADDER TUMOR; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL; DIET; DOSE TIME EFFECT RELATION; FEEDING; KIDNEY CARCINOMA; MALE; MICROMORPHOLOGY; MITOGENESIS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SOLID; URINALYSIS; UROLITHIASIS;

ANIMALS; ANTIMETABOLITES; APOPTOSIS; AREA UNDER CURVE; BROMODEOXYURIDINE; CALCIUM; CARCINOGENS; CELL PROLIFERATION; CITRATES; ELECTROLYTES; GLYCINE; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, SCANNING; ORGAN SIZE; OXALATES; OXAZOLES; PHOSPHATES; PPAR ALPHA; PPAR GAMMA; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, X-RAY EMISSION; URINARY BLADDER NEOPLASMS; UROLITHIASIS; UROTHELIUM;

EID: 33845789088     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230601072327     Document Type: Article

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