메뉴 건너뛰기




Volumn 175, Issue 3, 2009, Pages 1270-1280

Combined low doses of PPARγ and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CASPASE 9; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; P21 ACTIVATED KINASE; PROTEIN P53; ROSIGLITAZONE;

EID: 70349257304     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.081078     Document Type: Article
Times cited : (79)

References (53)
  • 5
    • 24044526526 scopus 로고    scopus 로고
    • Retinoic acid and retinoid receptors: Potential chemopreventive and therapeutic role in cervical cancer
    • DOI 10.1016/S1470-2045(05)70319-3, PII S1470204505703193
    • Abu J, Batuwangala M, Herbert K, Symonds P: Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 2005, 6:712-720 (Pubitemid 41222762)
    • (2005) Lancet Oncology , vol.6 , Issue.9 , pp. 712-720
    • Abu, J.1    Batuwangala, M.2    Herbert, K.3    Symonds, P.4
  • 8
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E, Müller C, Koshizuka K, Williamson EA, Park D, Asou H, Shintaku P, Said JW, Heber D, Koeffler HP: Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998, 95:8806-8811
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Müller, C.2    Koshizuka, K.3    Williamson, E.A.4    Park, D.5    Asou, H.6    Shintaku, P.7    Said, J.W.8    Heber, D.9    Koeffler, H.P.10
  • 9
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM: Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994, 79:1147-1156
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 11
    • 0033571433 scopus 로고    scopus 로고
    • A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). GW7845, inhibits rat mammary carcinogenesis
    • Suh N, Wang Y, Williams CR, Risingsong R, Gilmer T, Willson TM, Sporn MB: A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). GW7845, inhibits rat mammary carcinogenesis. Cancer Res 1999, 59:5671-5673
    • (1999) Cancer Res , vol.59 , pp. 5671-5673
    • Suh, N.1    Wang, Y.2    Williams, C.R.3    Risingsong, R.4    Gilmer, T.5    Willson, T.M.6    Sporn, M.B.7
  • 12
    • 33751517072 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells
    • DOI 10.1210/me.2006-0192
    • Bonofiglio D, Aquila S, Catalano S, Gabriele S, Belmonte M, Middea E, Qi H, Morelli C, Gentile M, Maggiolini M, Andò S: Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells. Mol Endocrinol 2006, 20:3083-3092 (Pubitemid 44833557)
    • (2006) Molecular Endocrinology , vol.20 , Issue.12 , pp. 3083-3092
    • Bonofiglio, D.1    Aquila, S.2    Catalano, S.3    Gabriele, S.4    Belmonte, M.5    Middea, E.6    Qi, H.7    Morelli, C.8    Gentile, M.9    Maggiolini, M.10    Ando, S.11
  • 13
    • 24344455975 scopus 로고    scopus 로고
    • Estrogen receptor alpha binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor gamma signaling in breast cancer cells
    • DOI 10.1158/1078-0432.CCR-04-2453
    • Bonofiglio D, Gabriele S, Aquila S, Catalano S, Gentile M, Middea E, Giordano F, Andò S: Estrogen receptor alpha binds to peroxisome proliferator-activated receptor (PPAR) response element and negatively interferes with PPAR gamma signalling in breast cancer cells. Clin Cancer Res 2005, 11:6139-6147 (Pubitemid 41262940)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6139-6147
    • Bonofiglio, D.1    Gabriele, S.2    Aquila, S.3    Catalano, S.4    Gentile, M.5    Middea, E.6    Giordano, F.7    Ando, S.8
  • 14
    • 58549093767 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells
    • Bonofiglio D, Gabriele S, Aquila S, Qi H, Belmonte M, Catalano S, Andò S: Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells. Breast Cancer Res Treat 2009, 113:423-434
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 423-434
    • Bonofiglio, D.1    Gabriele, S.2    Aquila, S.3    Qi, H.4    Belmonte, M.5    Catalano, S.6    Andò, S.7
  • 15
  • 17
    • 2542491213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma in diabetes and metabolism
    • DOI 10.1016/j.tips.2004.03.012, PII S0165614704001154
    • Rangwala SM and Lazar MA: Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 2004, 25:331-336 (Pubitemid 38692426)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.6 , pp. 331-336
    • Rangwala, S.M.1    Lazar, M.A.2
  • 18
    • 25144441178 scopus 로고    scopus 로고
    • Fluid retention mediated by renal PPARgamma
    • Staels B: Fluid retention mediated by renal PPARgamma. Cell Metab 2005, 2:77-78
    • (2005) Cell Metab , vol.2 , pp. 77-78
    • Staels, B.1
  • 19
    • 37649030471 scopus 로고    scopus 로고
    • Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome
    • Pinaire JA, Reifel-Miller A: Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome. PPAR Res 2007, 2007:94156
    • (2007) PPAR Res , vol.2007 , pp. 94156
    • Pinaire, J.A.1    Reifel-Miller, A.2
  • 20
    • 0036020402 scopus 로고    scopus 로고
    • Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor κB/CCAAT-binding transcription factor-1 complex
    • DOI 10.1210/me.2002-0006
    • Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S: Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor κB/CCAAT-binding transcription factor-1 complex. Mol Endocrinol 2002, 16:1793-1809 (Pubitemid 34830403)
    • (2002) Molecular Endocrinology , vol.16 , Issue.8 , pp. 1793-1809
    • Qin, C.1    Nguyen, T.2    Stewart, J.3    Samudio, I.4    Burghardt, R.5    Safe, S.6
  • 21
    • 0030266977 scopus 로고    scopus 로고
    • Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifen
    • Herman ME, Katzenellenbogen BS: Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifen. J Steroid Biochem Mol Biol 1996, 59:121-134
    • (1996) J Steroid Biochem Mol Biol , vol.59 , pp. 121-134
    • Herman, M.E.1    Katzenellenbogen, B.S.2
  • 22
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 23
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews NC, Faller DV: A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 1991, 19:2499
    • (1991) Nucleic Acids Res , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 24
    • 0027374638 scopus 로고
    • A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro- 1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
    • DOI 10.1006/bbrc.1993.2438
    • Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C: A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′- tetrachloro-1,1′,3,3′ tetraethylbenzimidazolylcarbo-cyanine iodide (JC-1). Biochem Biophys Res Commun 1993, 197:40-45 (Pubitemid 23358874)
    • (1993) Biochemical and Biophysical Research Communications , vol.197 , Issue.1 , pp. 40-45
    • Cossarizza, A.1    Baccarani-Contri, M.2    Kalashnikova, G.3    Franceschi, C.4
  • 25
    • 0034161814 scopus 로고    scopus 로고
    • A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions
    • Mehta RG, Williamson E, Patel MK, Koeffler HP: A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions. J Natl Cancer Inst 2000, 92:418-423 (Pubitemid 30154824)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.5 , pp. 418-423
    • Mehta, R.G.1    Williamson, E.2    Patel, M.K.3    Koeffler, H.P.4
  • 26
    • 4644363465 scopus 로고    scopus 로고
    • A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands
    • Crowe DL, Chandraratna RA: A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. Breast Cancer Res 2004, 6:R546-R555
    • (2004) Breast Cancer Res , vol.6
    • Crowe, D.L.1    Chandraratna, R.A.2
  • 28
    • 0026592518 scopus 로고
    • Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone, and vitamin D3 signaling
    • Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM: Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone, and vitamin D3 signaling. Nature 1992, 355:446-449
    • (1992) Nature , vol.355 , pp. 446-449
    • Kliewer, S.A.1    Umesono, K.2    Mangelsdorf, D.J.3    Evans, R.M.4
  • 29
    • 0026536522 scopus 로고
    • Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
    • Zhang XK, Hoffmann B, Tran PBV, Graupner G, Pfahl M: Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 1992, 355:441-445
    • (1992) Nature , vol.355 , pp. 441-445
    • Zhang, X.K.1    Hoffmann, B.2    Tran, P.B.V.3    Graupner, G.4    Pfahl, M.5
  • 31
    • 0033006938 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ induces growth arrest and differentiation markers of human colon cancer cells
    • Kitamura S, Miyazaki Y, Shinomura Y, Kondo S, Kanayama S, Matsuzawa Y: Peroxisome proliferator activated receptor γ induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res 1999, 90:75-80 (Pubitemid 29084314)
    • (1999) Japanese Journal of Cancer Research , vol.90 , Issue.1 , pp. 75-80
    • Kitamura, S.1    Miyazaki, Y.2    Shinomura, Y.3    Kondo, S.4    Kanayama, S.5    Matsuzawa, Y.6
  • 32
    • 0033849091 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptors in tumorigenesis: Targets of tumor promotion and treatment
    • Roberts-Thomson SJ: Peroxisome proliferator activated receptors in tumorigenesis: targets of tumor promotion and treatment. Immunol Cell Biol 2000, 78:436-441
    • (2000) Immunol Cell Biol , vol.78 , pp. 436-441
    • Roberts-Thomson, S.J.1
  • 35
    • 0029115655 scopus 로고
    • 9-cis retinoic acid signaling: Changing partners causes some excitement
    • Leblanc BP, Stunnenberg HG: 9-cis retinoic acid signaling: changing partners causes some excitement. Genes Dev 1995, 9:1811-1816
    • (1995) Genes Dev , vol.9 , pp. 1811-1816
    • Leblanc, B.P.1    Stunnenberg, H.G.2
  • 36
    • 28544444282 scopus 로고    scopus 로고
    • Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid
    • DOI 10.1038/sj.onc.1208939
    • Gee MF, Tsuchida R, Eichler-Jonsson C, Das B, Baruchel S, Malkin D: Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-transretinoic acid. Oncogene 2005, 24:8025-8037 (Pubitemid 41746746)
    • (2005) Oncogene , vol.24 , Issue.54 , pp. 8025-8037
    • Gee, M.F.W.1    Tsuchida, R.2    Eichler-Jonsson, C.3    Das, B.4    Baruchel, S.5    Malkin, D.6
  • 37
    • 33748358908 scopus 로고    scopus 로고
    • Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60
    • DOI 10.1248/bpb.29.1803
    • Mizuguchi Y, Wada A, Nakagawa K, Ito M, Okano T: Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60. Biol Pharm Bull 2006, 29:1803-1809 (Pubitemid 44338398)
    • (2006) Biological and Pharmaceutical Bulletin , vol.29 , Issue.9 , pp. 1803-1809
    • Mizuguchi, Y.1    Wada, A.2    Nakagawa, K.3    Ito, M.4    Okano, T.5
  • 38
    • 0035863299 scopus 로고    scopus 로고
    • Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma
    • Wan H, Hong WK, Lotan R: Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma. Cancer Res 2001, 61:556-564
    • (2001) Cancer Res , vol.61 , pp. 556-564
    • Wan, H.1    Hong, W.K.2    Lotan, R.3
  • 39
    • 33645220720 scopus 로고    scopus 로고
    • Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade
    • Wu K, DuPré E, Kim H, Tin-U CK, Bissonnette RP, Lamph WW, Brown PH: Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade. Breast Cancer Res Treat 2006, 96:147-157
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 147-157
    • Wu, K.1    DuPré, E.2    Kim, H.3    Tin-U, C.K.4    Bissonnette, R.P.5    Lamph, W.W.6    Brown, P.H.7
  • 40
    • 3042842755 scopus 로고    scopus 로고
    • How retinoids regulate breast cancer cell proliferation and apoptosis
    • Simeone AM, Tari AM: How retinoids regulate breast cancer cell proliferation and apoptosis. Cell Mol Life Sci 2004, 61:1475-1484 (Pubitemid 38858353)
    • (2004) Cellular and Molecular Life Sciences , vol.61 , Issue.12 , pp. 1475-1484
    • Simeone, A.-M.1    Tari, A.M.2
  • 41
    • 0032006028 scopus 로고    scopus 로고
    • Beyond tamoxifen: The retinoid X receptor selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma
    • Bischoff ED, Gottardis MM, Moon TE, Heyman RA, Lamph WW: Beyond tamoxifen: the retinoid X receptor selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma. Cancer Res 1998, 58:479-484
    • (1998) Cancer Res , vol.58 , pp. 479-484
    • Bischoff, E.D.1    Gottardis, M.M.2    Moon, T.E.3    Heyman, R.A.4    Lamph, W.W.5
  • 42
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists
    • DOI 10.1016/S1470-2045(04)01509-8, PII S1470204504015098
    • Grommes C, Landreth GE, Heneka MT: Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. Lancet Oncol 2004, 5:419-429 (Pubitemid 38878045)
    • (2004) Lancet Oncology , vol.5 , Issue.7 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 44
    • 0034847431 scopus 로고    scopus 로고
    • Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs)
    • DOI 10.1016/S1471-4914(01)02100-1, PII S1471491401021001
    • Sporn MB, Suh N, Mangelsdorf DJ: Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol Med 2001, 7:395-400 (Pubitemid 32823988)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.9 , pp. 395-400
    • Sporn, M.B.1    Suh, N.2    Mangelsdorf, D.J.3
  • 45
    • 4143115845 scopus 로고    scopus 로고
    • The increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usage
    • DOI 10.1158/0008-5472.CAN-04-0043
    • Wang X, Southard RC, Kilgore MW: The increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usage. Cancer Res 2004, 64:5592-5596 (Pubitemid 39095554)
    • (2004) Cancer Research , vol.64 , Issue.16 , pp. 5592-5596
    • Wang, X.1    Southard, R.C.2    Kilgore, M.W.3
  • 46
    • 0034693323 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor κB
    • Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS: Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor κB. J Biol Chem 2000, 275:32681-32687 (Pubitemid 30797038)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.42 , pp. 32681-32687
    • Su Wol, C.1    Bok Yun, K.2    Seung Hyun, K.3    Youngmi Kim, P.4    Cho, D.5    Trinchieri, G.6    Tae Sung, K.7
  • 47
    • 0033551608 scopus 로고    scopus 로고
    • 2 gene in vascular smooth muscle cells by a nuclear factor κB and peroxisome proliferator-activated receptor-mediated process
    • Couturier C, Brouillet A, Couriaud C, Koumanov K, Bereziat G, Andreani M: Interleukin 1beta induces type II-secreted phospholipase A2 gene in vascular smooth muscle cells by a nuclear factor κB and peroxisome proliferator-activated receptor-mediated process. J Biol Chem 1999, 274:23085-23093 (Pubitemid 129529137)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.33 , pp. 23085-23093
    • Couturier, C.1    Brouillet, A.2    Couriaud, C.3    Koumanov, K.4    Bereziat, G.5    Andreani, M.6
  • 48
    • 0037082305 scopus 로고    scopus 로고
    • Alpha1-antichymotrypsin/Alzheimer's peptide Abeta (1-42) complex perturbs lipid metabolism and activates transcription factors PPARγ and NFκB in human neuroblastoma (Kelly) cells
    • Sun YX, Wright HT, Janciasukiene S: Alpha1-antichymotrypsin/Alzheimer's peptide Abeta (1-42) complex perturbs lipid metabolism and activates transcription factors PPARγ and NFκB in human neuroblastoma (Kelly) cells. J Neurosci Res 2002, 67:511-522
    • (2002) J Neurosci Res , vol.67 , pp. 511-522
    • Sun, Y.X.1    Wright, H.T.2    Janciasukiene, S.3
  • 49
    • 0035399154 scopus 로고    scopus 로고
    • Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells
    • DOI 10.1006/excr.2001.5233
    • Ikawa H, Kameda H, Kamitani H, Baek SJ, Nixon JB, His LC, Eling TE: Effect of PPAR activators on cytokine stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. Exp Cell Res 2001, 267:73-80 (Pubitemid 32579142)
    • (2001) Experimental Cell Research , vol.267 , Issue.1 , pp. 73-80
    • Ikawa, H.1    Kameda, H.2    Kamitani, H.3    Baek, S.J.4    Nixon, J.B.5    Hsi, L.C.6    Eling, T.E.7
  • 50
    • 0037114137 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ-mediated NF-kB activation and apoptosis in pre-B cells
    • Schlezinger JJ, Jensen BA, Mann KK, Ryu HY, Sherr DH: Peroxisome proliferator-activated receptor γ-mediated NFkB activation and apoptosis in pre-B cells. J Immunol 2002, 169:6831-6841 (Pubitemid 36899268)
    • (2002) Journal of Immunology , vol.169 , Issue.12 , pp. 6831-6841
    • Schlezinger, J.J.1    Jensen, B.A.2    Mann, K.K.3    Ryu, H.-Y.4    Sherr, D.H.5
  • 51
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • DOI 10.1210/en.2002-220620
    • Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JMW, Harper ME, Barrow D, Wakeling AE, Nicholson RI: Elevated levels of EGFR/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 2003, 144:1032-1044 (Pubitemid 36262870)
    • (2003) Endocrinology , vol.144 , Issue.3 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.W.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 53
    • 33745402375 scopus 로고    scopus 로고
    • Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells
    • DOI 10.1007/s10549-005-9120-9
    • Hiscox S, Morgan L, Green TP, Barrow D, Gee J, Nicholson RI: Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res Treat 2005, 7:1-12 (Pubitemid 43945756)
    • (2006) Breast Cancer Research and Treatment , vol.97 , Issue.3 , pp. 263-274
    • Hiscox, S.1    Morgan, L.2    Green, T.P.3    Barrow, D.4    Gee, J.5    Nicholson, R.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.