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Volumn 28, Issue SUPPL. 5, 2011, Pages 1-18

Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study

Author keywords

Cancer; Detemir; Diabetes; Glargine; Insulin; Insulin receptor; Insulin like growth factor; Mitogenicity

Indexed keywords

INSULIN; INSULIN DERIVATIVE; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN X10; ISOPHANE INSULIN; METFORMIN; SHORT ACTING DRUG; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SULFONYLUREA; UNCLASSIFIED DRUG;

EID: 84860388926     PISSN: 0741238X     EISSN: 18658652     Source Type: Journal    
DOI: 10.1007/s12325-011-0047-8     Document Type: Conference Paper
Times cited : (15)

References (79)
  • 1
    • 68449104156 scopus 로고    scopus 로고
    • Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: A cohort study
    • Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia. 2009;52:1732-1744.
    • (2009) Diabetologia , vol.52 , pp. 1732-1744
    • Hemkens, L.G.1    Grouven, U.2    Bender, R.3
  • 2
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 2009;52:1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 3
    • 68449104625 scopus 로고    scopus 로고
    • Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in sweden
    • Jonasson JM, Ljung R, Talbäck M, Haglund B, Gudbjörnsdó ttir S, Steineck G. Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in Sweden. Diabetologia. 2009;52:1745-1754.
    • (2009) Diabetologia , vol.52 , pp. 1745-1754
    • Jonasson, J.M.1    Ljung, R.2    Talbäck, M.3    Haglund, B.4    Gudbjörnsdó ttir, S.5    Steineck, G.6
  • 4
    • 68449094354 scopus 로고    scopus 로고
    • Use of insulin glargine and cancer incidence in Scotland: A study from the scottish diabetes research network epidemiology group
    • SDRN Epidemiology Group
    • Colhoun HM; SDRN Epidemiology Group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia. 2009;52:1755-1765.
    • (2009) Diabetologia , vol.52 , pp. 1755-1765
    • Colhoun, H.M.1
  • 5
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    • DOI 10.1093/aje/kwh161
    • Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol. 2004;159:1160-1167. (Pubitemid 38747263)
    • (2004) American Journal of Epidemiology , vol.159 , Issue.12 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3    Petrelli, J.4    Thun, M.J.5
  • 6
    • 70349658548 scopus 로고    scopus 로고
    • A cohort study of the risk of cancer associated with type 2 diabetes
    • Ogunleye AA, Ogston SA, Morris AD, Evans JM. A cohort study of the risk of cancer associated with type 2 diabetes. Br J Cancer. 2009;101:1199-1201.
    • (2009) Br J Cancer , vol.101 , pp. 1199-1201
    • Ogunleye, A.A.1    Ogston, S.A.2    Morris, A.D.3    Evans, J.M.4
  • 7
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • DOI 10.1016/S0140-6736(08)60269-X, PII S014067360860269X
    • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569-578. (Pubitemid 351232031)
    • (2008) The Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 9
    • 84869237080 scopus 로고    scopus 로고
    • Metformin and cancer: New applications for an old drug
    • In press
    • Kourelis TV, Siegel RD. Metformin and cancer: new applications for an old drug. Med Oncol. 2011. In press.
    • (2011) Med Oncol.
    • Kourelis, T.V.1    Siegel, R.D.2
  • 10
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care. 2006;29:254-258. (Pubitemid 44106500)
    • (2006) Diabetes Care , vol.29 , Issue.2 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 11
    • 77951006620 scopus 로고    scopus 로고
    • Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
    • Hassan MM, Curley SA, Li D, et al. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer. 2010;116:1938-1946.
    • (2010) Cancer , vol.116 , pp. 1938-1946
    • Hassan, M.M.1    Curley, S.A.2    Li, D.3
  • 12
    • 68349148204 scopus 로고    scopus 로고
    • Insulin glargine and malignancy: An unwarranted alarm
    • Pocock SJ, Smeeth L. Insulin glargine and malignancy: an unwarranted alarm. Lancet. 2009;374:511-513.
    • (2009) Lancet , vol.374 , pp. 511-513
    • Pocock, S.J.1    Smeeth, L.2
  • 14
    • 77954832956 scopus 로고    scopus 로고
    • Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients
    • Mannucci E, Monami M, Balzi D, et al. Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care. 2010;33:1997-2003.
    • (2010) Diabetes Care , vol.33 , pp. 1997-2003
    • Mannucci, E.1    Monami, M.2    Balzi, D.3
  • 16
    • 77954559516 scopus 로고    scopus 로고
    • Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma
    • Donadon V, Balbi M, Valent F, Avogaro A. Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma. World J Gastroenterol. 2010;16:3025-3032.
    • (2010) World J Gastroenterol , vol.16 , pp. 3025-3032
    • Donadon, V.1    Balbi, M.2    Valent, F.3    Avogaro, A.4
  • 17
    • 77955560604 scopus 로고    scopus 로고
    • Diabetes, prediabetes and cancer mortality
    • DECODE Study Group
    • Zhou XH, Qiao Q, Zethelius B, et al; DECODE Study Group. Diabetes, prediabetes and cancer mortality. Diabetologia. 2010;53:1867-1876.
    • (2010) Diabetologia , vol.53 , pp. 1867-1876
    • Zhou, X.H.1    Qiao, Q.2    Zethelius, B.3
  • 18
    • 78650857644 scopus 로고    scopus 로고
    • The effects of type 2 diabetes and hypertension on changes in serum prostate specific antigen levels: Results from the Olmsted County study
    • Wallner LP, Morgenstern H, McGree ME, et al. The effects of type 2 diabetes and hypertension on changes in serum prostate specific antigen levels: results from the Olmsted County study. Urology. 2011;77:137-141.
    • (2011) Urology , vol.77 , pp. 137-141
    • Wallner, L.P.1    Morgenstern, H.2    McGree, M.E.3
  • 19
    • 78649601393 scopus 로고    scopus 로고
    • Association of diabetes mellitus with prostate cancer: Nested case-control study (prostate testing for cancer and treatment study)
    • Turner EL, Lane JA, Donovan JL, et al. Association of diabetes mellitus with prostate cancer: nested case-control study (prostate testing for cancer and treatment study). Int J Cancer. 2011;128:440-446.
    • (2011) Int J Cancer , vol.128 , pp. 440-446
    • Turner, E.L.1    Lane, J.A.2    Donovan, J.L.3
  • 20
    • 23844551318 scopus 로고    scopus 로고
    • Role of the growth hormone/insulin-like growth factor system in mammalian aging
    • DOI 10.1210/en.2005-0411
    • Bartke A. Minireview: role of the growth hormone/ insulin-like growth factor system in mammalian aging. Endocrinology. 2005;146:3718-3723. (Pubitemid 41175738)
    • (2005) Endocrinology , vol.146 , Issue.9 , pp. 3718-3723
    • Bartke, A.1
  • 22
    • 0036606952 scopus 로고    scopus 로고
    • A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    • DOI 10.1016/S0168-9525(02)02696-3, PII S0168952502026963
    • Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 2002;18:295-301. (Pubitemid 34607119)
    • (2002) Trends in Genetics , vol.18 , Issue.6 , pp. 295-301
    • Carter, C.S.1    Ramsey, M.M.2    Sonntag, W.E.3
  • 23
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: Insights from long-lived mutants
    • DOI 10.1016/j.cell.2005.02.002
    • Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell. 2005;120:449-460. (Pubitemid 40269760)
    • (2005) Cell , vol.120 , Issue.4 , pp. 449-460
    • Kenyon, C.1
  • 25
    • 33745115859 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: Eight years on
    • DOI 10.1677/erc.1.01219
    • Renehan AG, Harvie M, Howell A. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on. Endocr Relat Cancer. 2006;13:273-278. (Pubitemid 43886658)
    • (2006) Endocrine-Related Cancer , vol.13 , Issue.2 , pp. 273-278
    • Renehan, A.G.1    Harvie, M.2    Howell, A.3
  • 29
    • 68549126809 scopus 로고    scopus 로고
    • Unraveling insulin-like growth factor binding protein-3 actions in human disease
    • Jogie-Brahim S, Feldman D, Oh Y. Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev. 2009;30:417-437.
    • (2009) Endocr Rev , vol.30 , pp. 417-437
    • Jogie-Brahim, S.1    Feldman, D.2    Oh, Y.3
  • 31
    • 0037110602 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
    • DOI 10.1002/cncr.10945
    • Weber MM, Fottner C, Liu SB, Jung MC, Engelhardt D, Baretton GB. Overexpression of the insulinlike growth factor I receptor in human colon carcinomas. Cancer. 2002;95:2086-2095. (Pubitemid 35253369)
    • (2002) Cancer , vol.95 , Issue.10 , pp. 2086-2095
    • Weber, M.M.1    Fottner, C.2    Liu, S.B.3    Jung, M.C.4    Engelhardt, D.5    Baretton, G.B.6
  • 33
    • 0025189619 scopus 로고
    • Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation
    • Kaleko M, Rutter WJ, Miller AD. Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol. 1990;10:464-473.
    • (1990) Mol Cell Biol , vol.10 , pp. 464-473
    • Kaleko, M.1    Rutter, W.J.2    Miller, A.D.3
  • 34
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulinlike growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulinlike growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene. 2009;28:3009-3021.
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 35
    • 57749089652 scopus 로고    scopus 로고
    • Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival
    • Law JH, Habibi G, Hu K, et al. Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 2008;68:10238-10246.
    • (2008) Cancer Res , vol.68 , pp. 10238-10246
    • Law, J.H.1    Habibi, G.2    Hu, K.3
  • 36
    • 50449153417 scopus 로고
    • A study of the hormonal relations of epidermal mitotic activity in vitro. II. Insulin and pituitary growth hormone
    • Bullough WS. A study of the hormonal relations of epidermal mitotic activity in vitro. II. Insulin and pituitary growth hormone. Exp Cell Res. 1954;7:186-196.
    • (1954) Exp Cell Res , vol.7 , pp. 186-196
    • Bullough, W.S.1
  • 37
    • 84860423493 scopus 로고
    • Studies on the mitosis of mouse ear epidermis in vitro. I. Effect of insulin pretreatment on epidermal mitotic activity in vitro
    • Katayama H. Studies on the mitosis of mouse ear epidermis in vitro. I. effect of insulin pretreatment on epidermal mitotic activity in vitro. Annot Zool Jpn. 1957;30:71-76.
    • (1957) Annot Zool Jpn , vol.30 , pp. 71-76
    • Katayama, H.1
  • 38
    • 77949307940 scopus 로고    scopus 로고
    • Mitogenic action of insulin: Friend, foe or 'frenemy'?
    • Draznin B. Mitogenic action of insulin: friend, foe or 'frenemy'? Diabetologia. 2010;53:229-233.
    • (2010) Diabetologia , vol.53 , pp. 229-233
    • Draznin, B.1
  • 42
    • 27544434895 scopus 로고    scopus 로고
    • The insulin/IGF-1 signaling in mammals and its relevance to human longevity
    • DOI 10.1016/j.exger.2005.06.014, PII S0531556505001609, Metabolism, Aging and Longevity
    • Rincon M, Rudin E, Barzilai N. The insulin/IGF-1 signaling in mammals and its relevance to human longevity. Exp Gerontol. 2005;40:873-877. (Pubitemid 41540436)
    • (2005) Experimental Gerontology , vol.40 , Issue.11 , pp. 873-877
    • Rincon, M.1    Rudin, E.2    Barzilai, N.3
  • 43
    • 77949654035 scopus 로고    scopus 로고
    • IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer
    • Ibanez de Caceres I, Cortes-Sempere M, Moratilla C, et al. IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. Oncogene. 2010;29:1681-1690.
    • (2010) Oncogene , vol.29 , pp. 1681-1690
    • Ibanez De Caceres, I.1    Cortes-Sempere, M.2    Moratilla, C.3
  • 44
    • 77952309862 scopus 로고    scopus 로고
    • Insulin- like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: A comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression
    • Dziadziuszko R, Merrick DT, Witta SE, et al. Insulin- like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression. J Clin Oncol. 2010;28:2174-2180.
    • (2010) J Clin Oncol , vol.28 , pp. 2174-2180
    • Dziadziuszko, R.1    Merrick, D.T.2    Witta, S.E.3
  • 45
    • 74549203484 scopus 로고    scopus 로고
    • IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
    • Rajski M, Zanetti-Dällenbach R, Vogel B, Herrmann R, Rochlitz C, Buess M. IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients. BMC Med. 2010;8:1.
    • (2010) BMC Med. , vol.8 , pp. 1
    • Rajski, M.1    Zanetti-Dällenbach, R.2    Vogel, B.3    Herrmann, R.4    Rochlitz, C.5    Buess, M.6
  • 47
    • 0037470152 scopus 로고    scopus 로고
    • Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor
    • DOI 10.1074/jbc.M209809200
    • Yu D, Watanabe H, Shibuya H, Miura M. Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor. J Biol Chem. 2003;278:6702-6709. (Pubitemid 36800657)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.9 , pp. 6702-6709
    • Yu, D.1    Watanabe, H.2    Shibuya, H.3    Miura, M.4
  • 48
    • 0030738695 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
    • Dunn SE, Hardman RA, Kari FW, Barrett JC. Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res. 1997;57:2687-2693. (Pubitemid 27283781)
    • (1997) Cancer Research , vol.57 , Issue.13 , pp. 2687-2693
    • Dunn, S.E.1    Hardman, R.A.2    Kari, F.W.3    Barrett, J.C.4
  • 49
    • 54249117292 scopus 로고    scopus 로고
    • Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors
    • Buck E, Eyzaguirre A, Rosenfeld-Franklin M, et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res. 2008;68:8322-8332.
    • (2008) Cancer Res , vol.68 , pp. 8322-8332
    • Buck, E.1    Eyzaguirre, A.2    Rosenfeld-Franklin, M.3
  • 51
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • DOI 10.1038/nrc1456
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 2004;4:806-813. (Pubitemid 39331152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 52
    • 34249899156 scopus 로고    scopus 로고
    • Glargine blood biotransformation: in vitro appraisal with human insulin immunoassay
    • DOI 10.1016/j.diabet.2006.12.002, PII S1262363607000523
    • Agin A, Jeandidier N, Gasser F, Grucker D, Sapin R. Glargine blood biotransformation: in vitro appraisal with human insulin immunoassay. Diabetes Metab. 2007;33:205-212. (Pubitemid 46863409)
    • (2007) Diabetes and Metabolism , vol.33 , Issue.3 , pp. 205-212
    • Agin, A.1    Jeandidier, N.2    Gasser, F.3    Grucker, D.4    Sapin, R.5
  • 53
    • 77951703382 scopus 로고    scopus 로고
    • Treatment with insulin glargine (Lantus) increases the proliferative potency of the serum of patients with type-1diabetes: A pilot study on MCF-7 breast cancer cells
    • Mayer D, Chantelau E. Treatment with insulin glargine (Lantus) increases the proliferative potency of the serum of patients with type-1diabetes: a pilot study on MCF-7 breast cancer cells. Arch Physiol Biochem. 2010;116:73-78.
    • (2010) Arch Physiol Biochem. , vol.116 , pp. 73-78
    • Mayer, D.1    Chantelau, E.2
  • 56
    • 0028953352 scopus 로고
    • Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen
    • Nielsen FS, Jørgensen LN, Ipsen M, Voldsgaard AI, Parving HH. Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen. Diabetologia. 1995;38:592-598.
    • (1995) Diabetologia , vol.38 , pp. 592-598
    • Nielsen, F.S.1    Jørgensen, L.N.2    Ipsen, M.3    Voldsgaard, A.I.4    Parving, H.H.5
  • 57
    • 0027097641 scopus 로고
    • The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake
    • Drejer K. The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab Rev. 1992;8:259-285.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 259-285
    • Drejer, K.1
  • 59
    • 0342657181 scopus 로고    scopus 로고
    • Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
    • Kurtzhals P, Schäffer L, Sørensen A, et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes. 2000;49:999-1005. (Pubitemid 30349423)
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 999-1005
    • Kurtzhals, P.1    Schaffer, L.2    Sorensen, A.3    Kristensen, C.4    Jonassen, I.5    Schmid, C.6    Trub, T.7
  • 60
    • 0025894102 scopus 로고
    • Binding and biological effects of insulin, insulin analogues and insulinlike rowth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities
    • Bornfeldt KE, Gidlöf RA, Wasteson A, Lake M, kottner A, Arnqvist HJ. Binding and biological effects of insulin, insulin analogues and insulinlike rowth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities. Diabetologia. 1991;34:307-313.
    • (1991) Diabetologia , vol.34 , pp. 307-313
    • Bornfeldt, K.E.1    Gidlöf, R.A.2    Wasteson, A.3    Lake, M.4    Kottner, A.5    Arnqvist, H.J.6
  • 61
    • 0030614323 scopus 로고    scopus 로고
    • 10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: Evidence for enhanced interactions with the insulin-like growth factor-I receptor
    • DOI 10.1002/(SICI)1098-2744(199701)18:1<19::AID-MC3>3.0.CO;2-M
    • Milazzo G, Sciacca L, Papa V, Goldfine ID, Vigneri R. ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor. Mol Carcinog. 1997;18:19-25. (Pubitemid 27107371)
    • (1997) Molecular Carcinogenesis , vol.18 , Issue.1 , pp. 19-25
    • Milazzo, G.1    Sciacca, L.2    Papa, V.3    Goldfine, I.D.4    Vigneri, R.5
  • 62
    • 0025990972 scopus 로고
    • Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells
    • Drejer K, Kruse V, Larsen UD, Hougaard P, Bjørn S, Gammeltoft S. Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells. Diabetes. 1991;40:1488-1495.
    • (1991) Diabetes , vol.40 , pp. 1488-1495
    • Drejer, K.1    Kruse, V.2    Larsen, U.D.3    Hougaard, P.4    Bjørn, S.5    Gammeltoft, S.6
  • 63
    • 0032895627 scopus 로고    scopus 로고
    • Differences in the cellular processing of Asp(B10) human insulin compared with human insulin and Lys(B28)Pro(B29) human insulin
    • DOI 10.1016/S0026-0495(99)90059-8
    • Hamel FG, Siford GL, Fawcett J, Chance RE, Frank BH, Duckworth WC. Differences in the cellularprocessing of AspB10 human insulin compared with human insulin and LysB28ProB29 human insulin. Metabolism. 1999;48:611-617. (Pubitemid 29230522)
    • (1999) Metabolism: Clinical and Experimental , vol.48 , Issue.5 , pp. 611-617
    • Hamel, F.G.1    Siford, G.L.2    Fawcett, J.3    Chance, R.E.4    Frank, B.H.5    Duckworth, W.C.6
  • 65
    • 35848933452 scopus 로고    scopus 로고
    • IGF-1 receptor signalling determines the mitogenic potency of insulin analogues in human smooth muscle cells and fibroblasts
    • DOI 10.1007/s00125-007-0815-9
    • Eckardt K, May C, Koenen M, Eckel J. IGF-1 receptor signalling determines the mitogenic potency of insulin analogues in human smooth muscle cells and fibroblasts. Diabetologia. 2007;50:2534-2543. (Pubitemid 350060636)
    • (2007) Diabetologia , vol.50 , Issue.12 , pp. 2534-2543
    • Eckardt, K.1    May, C.2    Koenen, M.3    Eckel, J.4
  • 66
    • 70450239958 scopus 로고    scopus 로고
    • Combined randomised controlled trial experience of malignancies in studies using insulin glargine
    • Home PD, Lagarenne P. Combined randomised controlled trial experience of malignancies in studies using insulin glargine. Diabetologia. 2009;52:2499-2506.
    • (2009) Diabetologia , vol.52 , pp. 2499-2506
    • Home, P.D.1    Lagarenne, P.2
  • 67
    • 70949084349 scopus 로고    scopus 로고
    • No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: A meta-analysis
    • Dejgaard A, Lynggaard H, Råstam J, Krogsgaard Thomsen M. No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: a meta-analysis. Diabetologia. 2009;52:2507-2512.
    • (2009) Diabetologia , vol.52 , pp. 2507-2512
    • Dejgaard, A.1    Lynggaard, H.2    Råstam, J.3    Krogsgaard Thomsen, M.4
  • 68
    • 36749121985 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: The ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)
    • Origin Trial Investigators
    • Origin Trial Investigators, Gerstein H, Yusuf S, Riddle MC, Ryden L, Bosch J. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention). Am Heart J. 2008;155:26-32.
    • (2008) Am Heart J. , vol.155 , pp. 26-32
    • Gerstein, H.1    Yusuf, S.2    Riddle, M.C.3    Ryden, L.4    Bosch, J.5
  • 69
    • 77949411117 scopus 로고    scopus 로고
    • Insulin analogues and cancer risk: Cause for concern or cause célébre?
    • Pollak M, Russell-Jones D. Insulin analogues and cancer risk: cause for concern or cause célébre? Int J Clin Pract. 2010;64:628-636.
    • (2010) Int J Clin Pract , vol.64 , pp. 628-636
    • Pollak, M.1    Russell-Jones, D.2
  • 70
    • 67650504265 scopus 로고    scopus 로고
    • Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines
    • Shukla A, Grisouard J, Ehemann V, Hermani A, Enzmann H, Mayer D. Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines. Endocr Relat Cancer. 2009;16:429-441.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 429-441
    • Shukla, A.1    Grisouard, J.2    Ehemann, V.3    Hermani, A.4    Enzmann, H.5    Mayer, D.6
  • 71
    • 77955515434 scopus 로고    scopus 로고
    • Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    • Sciacca L, Cassarino MF, Genua M, et al. Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling. Diabetologia. 2010;53:1743-1753.
    • (2010) Diabetologia , vol.53 , pp. 1743-1753
    • Sciacca, L.1    Cassarino, M.F.2    Genua, M.3
  • 72
    • 65549138380 scopus 로고    scopus 로고
    • Insulin analogues display IGF-1-like mitogenic and anti-apoptotic activities in cultured cancer cells
    • Weinstein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-1-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev. 2009;25:41-49.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 41-49
    • Weinstein, D.1    Simon, M.2    Yehezkel, E.3    Laron, Z.4    Werner, H.5
  • 73
    • 78649320787 scopus 로고    scopus 로고
    • Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor
    • Yehezkel E, Weinstein D, Simon M, Sarfstein R, Laron Z, Werner H. Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor. Diabetologia. 2010;53:2667-2675.
    • (2010) Diabetologia , vol.53 , pp. 2667-2675
    • Yehezkel, E.1    Weinstein, D.2    Simon, M.3    Sarfstein, R.4    Laron, Z.5    Werner, H.6
  • 74
    • 24944566769 scopus 로고    scopus 로고
    • Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells
    • DOI 10.1007/s00125-005-1874-4
    • Staiger K, Staiger H, Schweitzer MA, et al. Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells. Diabetologia. 2005;48:1898-1905. (Pubitemid 41317846)
    • (2005) Diabetologia , vol.48 , Issue.9 , pp. 1898-1905
    • Staiger, K.1    Staiger, H.2    Schweitzer, M.A.3    Metzinger, E.4    Balletshofer, B.5    Haring, H.-U.6    Kellerer, M.7
  • 75
    • 47049123594 scopus 로고    scopus 로고
    • Mitogenic effect of the insulin analogue glargine in malignant cells in comparison with insulin and IGF-I
    • DOI 10.1055/s-2008-1062739
    • Liefvendahl E, Arnqvist HJ. Mitogenic effect of the insulin analogue glargine in malignant cells in comparison with insulin and IGF-1. Horm Metab Res. 2008;40:369-374. (Pubitemid 351967126)
    • (2008) Hormone and Metabolic Research , vol.40 , Issue.6 , pp. 369-374
    • Liefvendahl, E.1    Arnqvist, H.J.2
  • 76
    • 77949760139 scopus 로고    scopus 로고
    • In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites
    • Sommerfeld MR, Müller G, Tschank G, et al. In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites. PLoS One. 2010;5:e9540.
    • (2010) PLoS One , vol.5
    • Sommerfeld, M.R.1    Müller, G.2    Tschank, G.3
  • 79
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulinlike growth factor receptor hybrids in physiology and disease
    • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulinlike growth factor receptor hybrids in physiology and disease. Endocr Rev. 2009;30:586-623.
    • (2009) Endocr Rev. , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.