Peroxisome proliferator-activated receptor γ agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest

Journal of Biological Chemistry

Volumn 280, Issue 8, 2005, Pages 6742-6751

  Lu, Meiling ^a,b   Kwan, Toni ^a,b   Yu, Chunjiang ^a   Chen, Feng ^a,b   Freedman, Bethany ^a   Schafer, Jennifer M ^b   Lee, Eun Jig ^a   Jameson, J Larry ^a   Jordan, V Craig ^b   Cryns, Vincent L ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CELLS; DRUG THERAPY; MUTAGENESIS; PROTEINS; RNA; SIGNALING;

CANCER CELLS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Γ (PPARΓ); THIAZOLIDINEDIONE (TZD); TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL);

TUMORS;

2,4 THIAZOLIDINEDIONE DERIVATIVE; CASPASE; CYCLIN D3; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEASOME; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER THERAPY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DRUG SENSITIZATION; ENZYME ACTIVATION; FEMALE; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CYCLINS; DOWN-REGULATION; DRUG SYNERGISM; FEMALE; G1 PHASE; HUMANS; MEMBRANE GLYCOPROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; NEOPLASM PROTEINS; PPAR GAMMA; THIAZOLIDINEDIONES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20044372348     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411519200     Document Type: Article

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