Terminal Differentiation of Human Breast Cancer through PPARγ

Molecular Cell

Volumn 1, Issue 3, 1998, Pages 465-470

  Mueller, Elisabetta ^a   Sarraf, Pasha ^a   Tontonoz, Peter ^b,c   Evans, Ronald M ^c   Martin, Katherine J ^a   Zhang, Ming ^a   Fletcher, Christopher ^d   Singer, Samuel ^a   Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UCSD MEDICAL CENTER   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CELL RECEPTOR; ENZYME INHIBITOR; FLAVONOID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR;

ARTICLE; BREAST TUMOR; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIPID METABOLISM; METABOLISM; PHYSIOLOGY;

BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; CELL DIVISION; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID METABOLISM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN KINASE INHIBITORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0031993322     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80047-7     Document Type: Article

References (33)

1. Adams, M., Reginato, M.J., Shao, D., Lazar, M.A., and Chatterjee, V.K. (1997). Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J. Biol. Chem. 272, 5128-5132.
2. Altiok, S., Xu, M., and Spiegelman, B.M. (1997). PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA binding activity via downregulation of PP2A. Genes Dev. 11, 1987-1998.
3. Band, V., Zajchowski, D., Stenman, G., Morton, C.C., Kulesa, V., Connolly, J., and Sager, R. (1989). A newly established metastatic breast tumor cell line with integrated amplified copies of ERBB2 and double minute chromosomes. Genes Chromosom. Cancer 1, 48-58.
4. Band, V., Zajchowsky, D., Swisshelm, K., Trask, D., Kulesa, V., Cohen, C., Connolly, J., and Sager, R. (1990). Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res. 50, 7351-7357.
5. Camp, H.S., and Tafuri, S.R. (1997). Regulation of PPARγ activity by mitogen-activated protein kinase. J. Biol. Chem. 272, 10811-10816.
6. Chawla, A., Schwarz, E.J., Dimaculangan, D.D., and Lazar, M.A. (1994). Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135, 798-800.
7. de The, H., Lavau, C., Marchio, A., Chomienne, C., Degos, L., and Dejean, A. (1991). The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66, 675-684.
8. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992). Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879-887.
9. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812.
10. Ghazzi, M.N., Perez, J.E., Antonucci, T.K., Driscoll, J.H., Huang, S.M., Faja, B.M., and Whitcomb, R.W. (1997). Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group. Diabetes 46, 433-439.
11. Gottardis, M.M., Bischoff, E.D., Shirley, M.A., Wagoner, M.A., Lamph, W.W.L., and Heyman, R.A. (1996). Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand. Cancer Res. 56, 5566-5570.
12. Greene, H., and Kehinde, O. (1974). Sublines of mouse 3T3 cells that accumulate lipid. Cell 1, 113-116.
13. Harris, J.R., Lippman, M.E., Veronesi, U., and Willett, W. (1992). Medical progress: breast cancer (part II). N. Engl. J. Med. 327, 390-398.
14. Hu, E., Kim, J.B., Sarraf, P., and Spiegelman, B.M. (1996). Inhibition of adipogenesis through MAP Kinase-mediated phosphorylation of PPARγ. Science 274, 2100-2103.
15. Kakizuka, A., Miller, W.H.J., Umesono, K., Warrel, R.P.J., Frankel, S.R., Murty, V.V., Dmitrovsky, E., and Evans, R.M. (1991). Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66, 663-674.
16. Kawai, K., Kawasaki-tokui, Y., Odaka, T., Tsuruta, F., Kazui, M., Iwabuchi, H., Nakamura, T., Kinoshita, T., Ikeda, T., Yoshioka, T., et al. (1997). Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs. Arzneimittelforschung 47, 356-368.
17. Kliewer, S.A., Forman, B.M., Blumberg, B., Ong, E.S., Borgmeyer, U., Mangelsdorf, D.J., Umesono, K., and Evans, R.M. (1994). Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359.
18. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83, 813-819.
19. Kliewer, S.A., Sundseth, S.S., Jones, S.A., Brown, P.J., Wisely, G.B., Koble, C.S., Devchand, P., Wahli, W., Willson, T.M., Lenhard, J.M., and Lehmann, J.M. (1997). Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptor α and γ. Proc. Natl. Acad. Sci. USA 94, 4318-4323.
20. Kufe, D., Inghirami, G., Abe, M., Hayes, D., Justi-Wheeler, H., and Schlom, J. (1984). Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 3, 223-232.
21. Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Willson, T.M., and Kliewer, S.A. (1995). An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 270, 12953-12956.
22. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1989). Molecular Cloning: A Laboratory Manual, Second Edition (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
23. Menck, H.R., Jessup, J.M., Eyre, H.J., Cunningham, M.P., Fremgen, A., Murphy, G.P., and Winchester, D.P. (1997). Clinical highlights from the National Cancer Data Base: 1997. CA Cancer J. Clin. 47, 161-170.
24. Mukherjee, R., Davies, P.J., Crombie, D.L., Bishoff, E.D., Cesario, R.M., Jow, L., Hamann, L.G., Boehm, M.F., Mondon, C.E., Nadzan, A.M., et al. (1997). Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386, 407-410.
25. Nolan, J.J., Ludvik, B., Beerdsen, P., Joyce, M., and Olefsky, J. (1994). Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331, 1188-1193.
26. Pierce, G.B. (1961). Teratocarcinomas. Can. Cancer Conf. 4, 119-137.
27. Sivamaran, V.S., Wang, H., Nuovo, G.J., and Malbon, C.C. (1997). Hyperexpression of mitogen-activated protein kinase in human breast cancer. J. Clin. Invest. 99, 1478-1483.
28. Spicer, A.P., Rowse, G.J., Lidner, T.K., and Gendler, S.J. (1995). Delayed mammary tumor progression in muc-1 null mice. J. Biol. Chem. 270, 30093-30101.
29. Spiegelman, B.M., and Flier, J.S. (1996). Adipogenesis and obesity: rounding out the big picture. Cell 87, 377-389.
30. Tontonoz, P., Hu, E., Graves, R.A., Budavari, A.I., and Spiegelman, B.M. (1994a). mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234.
31. Tontonoz, P., Hu, E., and Spiegelman, B.M. (1994b). Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156.
32. Zhu, Y., Alvares, K., Huang, Q., Rao, M.S., and Reddy, J.K. (1993). Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268, 26817-26820.
33. Zou, Z., Anisowic, A., Hendrix, M.J.C., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., and Sager, R. (1994). Identification of a novel serpin with tumor suppressor activity in human mammary epithelial cells. Science 256, 526-529.