A ligand for peroxisome proliferator-activated receptor γ inhibits human cholangiocarcinoma cell growth: Potential molecular targeting strategy for cholangioma

Digestive Diseases and Sciences

Volumn 51, Issue 9, 2006, Pages 1650-1657

  Kobuke, T ^a   Tazuma, S ^a   Hyogo, H ^a   Chayama, K ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell cycle; Peroxisome proliferator activated receptor

Indexed keywords

CASPASE 3; CASPASE 9; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TROGLITAZONE;

APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CASPASE 3; CASPASE 9; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; CHROMANS; HUMANS; LIGANDS; MOLECULAR BIOLOGY; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; THIAZOLIDINEDIONES;

EID: 33748628875     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9064-2     Document Type: Article

References (23)

1. Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis by PPARγ2, a lipid-activated transcription factor. Cell 79:1147-1156
2. Kliwer SA, Lenhard JM, Wilson TM, Patel I, Morris DC, Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferators-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819
3. Forman BM, Tontonoz P, Chen J (1995) 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 813:803-812
4. Mansen A, Guardiola-Diaz H, Rafter J, et al. (1996) Expression of the peroxisome proliferators-activated receptor (PPAR) in the mouse colonic mucosa. Biochem Biophys Res Commun 222:844-851
5. Fajas L, Auboef D, Raspe E, et al. (1997) The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 272:18779-18789
6. Dubuquoy L, Dharancy S, Nutten S, et al. (2002) Role of peroxisome proliferators-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological disease. Lancet 360:1410-1418
7. Kubota T, Koshizuka K, Williamson EA, et al. (1998) Ligand for peroxisome proliferators-activated receptor γ (troglitazone) has potent antitumor effect against human prostatic cancer both in vitro and in vivo. Cancer Res 58:3344-3352
8. Yoshizawa K, Cioca DP, Kawa S, Tanaka E, Kiyosawa K (2002) Peroxisome proliferators-activated receptor γ induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. Cancer 95:2243-2251
9. Sarraf P, Mueller E, Jones D, et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat Med 4:1046-1052
10. Toyota M, Miyazaki Y, Kitamura S, et al. (2002) Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1. Life Sci 70:1565-1575
11. Eibl G, Wente MN, Reber HA, et al. (2001) Peroxisome proliferators- activated receptor γ induces pancreatic cancer cell apoptosis. Biochem Biophys Res Commun 287:522-529
12. Debrock G, Vanhentenrijk V, Sciot R, Debiec-Rychter M, Oyen R, Van Oosterom A (2003) A phase II trial with rosiglitazone in liposarcoma patients. Br J Cancer 89:1409-1412
13. Kitamura S, Miyazaki Y, Shimomura Y, et al. (1999) Peroxisome proliferators-activated receptor γ induces growth arrest and differentiation of human colon cancer cells. Jpn J Cancer Res 90:75-80
14. Rumi MA, Ishihara S, Kadowaki Y, et al. (2004) Peroxisome proliferators-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumor cells. Genes Cells 11:1113-1123
15. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
16. Musgrove EA, Lee CS, Buckley MF, Suthurland RL (1994) Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci USA 91:8022-8026
17. Morrison RF, Farmer SR (1999) Role of PPARg in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18 (INC4c) and p21 (Waf1/Cip1), during adipogenesis. J Biol Chem 274:17088-17097
18. INC4c in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. Hepatology 38:1087-1096
19. WAF/Cip1 pathway. Hepatology 38:167-177
20. Yoshizawa K, Cioca DP, Kawa S, et al. (2002) Peroxisome proliferator-activated receptor γ ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. Cancer 95:2243-2251
21. Elsmer E, Muller C, Koshizuka K, et al. (1998) Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 95:8806-8811
22. Takahashi N, Okumura T, Motomura W, et al. (1999) Activation of PPAR gamma inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett 16:135-139
23. Takahashi T, Fujiwara Y, Higuchi K, et al. (2001) PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. Int J Oncol 19:465-471