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Volumn 110, Issue 7, 2002, Pages 923-932

PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIRINIXIC ACID; PROSTATE SPECIFIC ANTIGEN; ROSIGLITAZONE; TROGLITAZONE; VASCULOTROPIN; 2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2,4-THIAZOLIDINEDIONE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CELL RECEPTOR; FIBROBLAST GROWTH FACTOR 2; LIGAND; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

EID: 0036771776     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215634     Document Type: Article
Times cited : (362)

References (48)
  • 1
    • 0035851187 scopus 로고    scopus 로고
    • PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth
    • Rosen, E.D., and Spiegelman, B.M. 2001. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276:37731-37734.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37731-37734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 2
    • 0033213637 scopus 로고    scopus 로고
    • PPAR-γ is required for placental, cardiac, and adipose tissue development
    • Barak, Y., et al. 1999. PPAR-γ is required for placental, cardiac, and adipose tissue development. Mol. Cell. 4:585-595.
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1
  • 3
    • 0028641559 scopus 로고
    • Stimulation ofadipogenesis in fibroblasts by PPARγ 2, a lipid activated transcription factor
    • Tontonoz, P., Hu, E., and Spiegelman, B.M. 1994. Stimulation ofadipogenesis in fibroblasts by PPARγ 2, a lipid activated transcription factor. Cell. 79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 4
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A., and Evans, R.M. 1998. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93:241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 5
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPARγ
    • Mueller, E., et al. 1998. Terminal differentiation of human breast cancer through PPARγ. Mol. Cell. 1:465-470.
    • (1998) Mol. Cell , vol.1 , pp. 465-470
    • Mueller, E.1
  • 6
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARγ
    • Sarraf, P., et al. 1998. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med. 4:1046-1052.
    • (1998) Nat. Med. , vol.4 , pp. 1046-1052
    • Sarraf, P.1
  • 7
    • 12644265334 scopus 로고
    • Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
    • Tontonoz, P., et al. 1991. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc. Natl. Acad. Sci. USA. 94:237-241.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 237-241
    • Tontonoz, P.1
  • 8
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor γ and retinoic acid and receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner, E., et al. 1998. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid and receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. USA. 95:8806-8811.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8806-8811
    • Elstner, E.1
  • 9
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome-activated receptor γ (Troglitazone) has potent antitumor effect against human prostate cancer both in vivo and in vitro
    • Kubota, T., et al. 1998 Ligand for peroxisome-activated receptor γ (Troglitazone) has potent antitumor effect against human prostate cancer both in vivo and in vitro. Cancer Res. 58:3344-3352.
    • (1998) Cancer Res. , vol.58 , pp. 3344-3352
    • Kubota, T.1
  • 10
    • 0034880165 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor γ and its ligands in non-neoplastic and neoplastic human urothelial cells
    • Nakashiro, K., et al. 2001. Role of peroxisome proliferator-activated receptor γ and its ligands in non-neoplastic and neoplastic human urothelial cells. Am. J. Pathol. 159:591-597.
    • (2001) Am. J. Pathol. , vol.159 , pp. 591-597
    • Nakashiro, K.1
  • 11
    • 0035019640 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor γ inhibit growth and induce apoprosis of human papillary thyroid carcinoma cells
    • Ohta, K., Endo, T., Haraguchi, K., Hershman, J.M., and Onaya, T. 2001. Ligands for peroxisome proliferator-activated receptor γ inhibit growth and induce apoprosis of human papillary thyroid carcinoma cells. J. Clin. Endocrinol Metab. 86:2170-2177.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 2170-2177
    • Ohta, K.1    Endo, T.2    Haraguchi, K.3    Hershman, J.M.4    Onaya, T.5
  • 12
    • 0035881317 scopus 로고    scopus 로고
    • Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation
    • Palakurthi, S.S., Aktas, H., Grubissich, L.M., Mortensen, R.M., and Halperin, J.A. 2001. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation. Cancer Res. 61:6213-6218.
    • (2001) Cancer Res. , vol.61 , pp. 6213-6218
    • Palakurthi, S.S.1    Aktas, H.2    Grubissich, L.M.3    Mortensen, R.M.4    Halperin, J.A.5
  • 13
    • 0001123485 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • J.F. Holland et al., editors. B.C. Decker Inc. Hamilton, Ontario, Canada
    • Folkman, J. 2000. Tumor angiogenesis. In Cancer medicine. 5th edition. J.F. Holland et al., editors. B.C. Decker Inc. Hamilton, Ontario, Canada. 132-152.
    • (2000) Cancer medicine. 5th edition , pp. 132-152
    • Folkman, J.1
  • 14
    • 0032587328 scopus 로고    scopus 로고
    • PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARγ as a potential mediator in vascular disease
    • Marx, N., Bourcier, T., Sukhova, G.K., Libby, P., and Plutzky, J. 1999. PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARγ as a potential mediator in vascular disease. Arterioscler Thromb. Vasc. Biol. 19:546-551.
    • (1999) Arterioscler Thromb. Vasc. Biol. , vol.19 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Sukhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 15
    • 0033605677 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
    • Xin, X., Yang, S., Kowalskij, and Gerritsen, M.E. 1999. Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem. 274:9116-9121.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9116-9121
    • Xin, X.1    Yang, S.2    Kowalski, J.3    Gerritsen, M.E.4
  • 17
    • 0031750208 scopus 로고    scopus 로고
    • Effects of troglirazone and pioglitazone on cytokine-mediated endothelial cell proliferation in vitro
    • Gralinski, M.R., Rowse, P.E., and Breider, M.A. 1998. Effects of troglirazone and pioglitazone on cytokine-mediated endothelial cell proliferation in vitro. J. Cardiovasc. Pharmacol. 31:909-913.
    • (1998) J. Cardiovasc. Pharmacol. , vol.31 , pp. 909-913
    • Gralinski, M.R.1    Rowse, P.E.2    Breider, M.A.3
  • 18
    • 2142701648 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ ligands inhibit choroidal neovascularization
    • Murata, T., et al. 2000. Peroxisome proliferator-activated receptor-γ ligands inhibit choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 41:2309-2317.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 2309-2317
    • Murata, T.1
  • 19
    • 0035156236 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer
    • Inoue, K., et al. 2001. Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Res. 21:2471-2476.
    • (2001) Anticancer Res. , vol.21 , pp. 2471-2476
    • Inoue, K.1
  • 20
    • 0032719528 scopus 로고    scopus 로고
    • Interferon-α-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule
    • Slaron, J.W., Perrotte, P., Inoue, K., Dinney, C., and Fidler, I.J. 1999. Interferon-α-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin. Cancer Res. 5:2726-2734.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2726-2734
    • Slaron, J.W.1    Perrotte, P.2    Inoue, K.3    Dinney, C.4    Fidler, I.J.5
  • 22
    • 0034161878 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activities of cyclooxgenase-2 inhibitors
    • Masferrer, J.L., et al. 2000 Antiangiogenic and antitumor activities of cyclooxgenase-2 inhibitors. Cancer Res. 60:1306-1311.
    • (2000) Cancer Res. , vol.60 , pp. 1306-1311
    • Masferrer, J.L.1
  • 23
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
    • O'Reilly, M.S., et al 1994. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma. Cell. 79:315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1
  • 24
    • 0026652533 scopus 로고
    • Metastatic model for human prostate cancer using orthoropic implantation in nude mice
    • Stephenson, R.A., et al. 1992. Metastatic model for human prostate cancer using orthoropic implantation in nude mice. J. Natl. Cancer Inst. 84:951-957.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 951-957
    • Stephenson, R.A.1
  • 25
    • 0028306887 scopus 로고
    • Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP)
    • Braunhut, S., and Moses, M. 1994. Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). J. Biol. Chem. 269:13472-13479.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13472-13479
    • Braunhut, S.1    Moses, M.2
  • 26
    • 0025351278 scopus 로고
    • Identification of an inhibitor of neovascularization from cartilage
    • Moses, M.A., Sudhalter, J., and Langer, R. 1990. Identification of an inhibitor of neovascularization from cartilage. Science. 248:1408-1410.
    • (1990) Science , vol.248 , pp. 1408-1410
    • Moses, M.A.1    Sudhalter, J.2    Langer, R.3
  • 27
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand dependent activation
    • Hauser, S., et al. 2000. Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand dependent activation. J. Biol. Chem. 275:18527-18533.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18527-18533
    • Hauser, S.1
  • 28
    • 13044311402 scopus 로고    scopus 로고
    • Troponin I is present in human cartilage and inhibits angiogenesis
    • Moses, M.A., et al. 1999. Troponin I is present in human cartilage and inhibits angiogenesis. Proc. Natl. Acad. Sci. USA. 96:2645-2650.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2645-2650
    • Moses, M.A.1
  • 29
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder, T., et al. 2000. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60:1878-1886.
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1
  • 30
    • 0036183630 scopus 로고    scopus 로고
    • Mechanism of action of PPARs
    • Berger, J., and Moller, D.E. 2002. Mechanism of action of PPARs. Annu. Rev. Med. 53:409-435.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 31
    • 0034232194 scopus 로고    scopus 로고
    • The chick embryo chorioallantoic membrane as a model for in vivo research on antiangiogenesis
    • Ribatti, D., Vacca, A., Roncali, L., and Dammacco, F. 2000 The chick embryo chorioallantoic membrane as a model for in vivo research on antiangiogenesis. Curr. Pharm. Biotechnol. 1:73-82.
    • (2000) Curr. Pharm. Biotechnol. , vol.1 , pp. 73-82
    • Ribatti, D.1    Vacca, A.2    Roncali, L.3    Dammacco, F.4
  • 32
    • 0035211504 scopus 로고    scopus 로고
    • Angiogenesis-dependent diseases
    • Folkman, J. 2001. Angiogenesis-dependent diseases. Semin. Oncol. 28:536-542.
    • (2001) Semin. Oncol. , vol.28 , pp. 536-542
    • Folkman, J.1
  • 33
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: Microvessel density, what it does and does not tell us
    • Hlatky, L., Hahnfeldt, P., and Folkman, J. 2002. Clinical application of antiangiogenic therapy: microvessel density, what it does and does not tell us. J. Natl. Cancer Inst. 94:883-893.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 34
    • 0032170033 scopus 로고    scopus 로고
    • Centrosome defects and genetic instability in malignant minors
    • Pihan, G.A., et al. 1998. Centrosome defects and genetic instability in malignant minors. Cancer Res. 58:3974-3985.
    • (1998) Cancer Res. , vol.58 , pp. 3974-3985
    • Pihan, G.A.1
  • 35
    • 0030590074 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterizasion of human peroxisome proliferator activated receptors γ1 and γ2
    • Elbrecht, A., et al. 1996. Molecular cloning, expression and characterizasion of human peroxisome proliferator activated receptors γ1 and γ2. Biochem. Biophys. Res. Commun. 224:431-437.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 431-437
    • Elbrecht, A.1
  • 37
    • 0032508682 scopus 로고    scopus 로고
    • Biological action of leptin as an angiogenic factor
    • Sietta-Honigmann, M.R., et al. 1998. Biological action of leptin as an angiogenic factor. Science. 281:1683-1686.
    • (1998) Science , vol.281 , pp. 1683-1686
    • Sietta-Honigmann, M.R.1
  • 38
    • 0033974302 scopus 로고    scopus 로고
    • Maspin is an angiogenesis inhibitor
    • Zhang, M., Volpert, O., Shi, Y.H., and Bouck, N. 2000. Maspin is an angiogenesis inhibitor. Nat. Med. 6:196-199.
    • (2000) Nat. Med. , vol.6 , pp. 196-199
    • Zhang, M.1    Volpert, O.2    Shi, Y.H.3    Bouck, N.4
  • 39
    • 0342445431 scopus 로고    scopus 로고
    • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    • Jimenez, B., et al. 2000. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat. Med. 6:41-48.
    • (2000) Nat. Med. , vol.6 , pp. 41-48
    • Jimenez, B.1
  • 40
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa, S., et al. 2002. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J. Pathol. 160:985-1000.
    • (2002) Am. J. Pathol. , vol.160 , pp. 985-1000
    • Morikawa, S.1
  • 42
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., and Glass, C.K. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature 391:79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 43
    • 0034711678 scopus 로고    scopus 로고
    • Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-γ activators
    • Pasceri, V., Wu, H.D., Willerson, J.T., and Yeh, E.T.H. 2000. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-γ activators. Circulation. 101:235-238.
    • (2000) Circulation , vol.101 , pp. 235-238
    • Pasceri, V.1    Wu, H.D.2    Willerson, J.T.3    Yeh, E.T.H.4
  • 44
    • 0343293956 scopus 로고    scopus 로고
    • Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepasectomy
    • Drixler, T.A., et al. 2000. Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepasectomy. Cancer Res. 60:1761-1765
    • (2000) Cancer Res. , vol.60 , pp. 1761-1765
    • Drixler, T.A.1
  • 45
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained rumor regression without overt toxicity
    • Klement, G., et al. 2000. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained rumor regression without overt toxicity. J. Clin. Invest. 105:15-24.
    • (2000) J. Clin. Invest. , vol.105 , pp. 15-24
    • Klement, G.1
  • 46
    • 0034889267 scopus 로고    scopus 로고
    • Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells
    • Clay, C.E., et al. 2001. Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. J Investig. Med. 49:413-420.
    • (2001) J. Investig. Med. , vol.49 , pp. 413-420
    • Clay, C.E.1
  • 47
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta, L.A., Steeg, P.S., and Stetler-Stevenson, W.G. 1991. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 64:327-336.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 48
    • 0036006943 scopus 로고    scopus 로고
    • PPARγ ligands as modulators of inflammatory and catabolic responses in arthritis. An overview
    • Fahmi, H., Pelletier, J.P., and Martel-Pelletier, J. 2002. PPARγ ligands as modulators of inflammatory and catabolic responses in arthritis. An overview. J. Rheumatol. 29:3-14.
    • (2002) J. Rheumatol. , vol.29 , pp. 3-14
    • Fahmi, H.1    Pelletier, J.P.2    Martel-Pelletier, J.3


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