Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1093-1097

  Chen, Bai Li ^a   Yu, Jun ^b   Zeng, Zhi Rong ^a   Chu, Wai Kit ^b   Wong, Christine Y P ^b   Cheng, Yuen Yee ^b   Sung, Joseph J Y ^b   Hu, Pin Jin ^a   Leung, Wai K ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Peroxisome proliferator activated receptors; Rosiglitazone

Indexed keywords

HYPERTENSION RELATED CALCIUM RELATED PROTEIN; METHYLNITRONITROSOGUANIDINE; ROSIGLITAZONE; TUMOR PROTEIN; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; HCARG PROTEIN, RAT; NUCLEAR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMOPROPHYLAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; UPREGULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; METHYLNITRONITROSOGUANIDINE; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; THIAZOLIDINEDIONES; UP-REGULATION;

EID: 58149329042     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000114     Document Type: Article

References (28)

1. Debril MB, Renaud JP, Fajas L, et al: The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med 79: 30-47, 2001.
2. Michalik L, Desvergne B and Wahli W: Peroxisome proliferatoractivated receptors and cancers: complex stories. Cancer 4: 61-70, 2004.
3. Kang DW, Choi CH, Park JY, et al: Ciglitazone induces caspaseindependent apoptosis through down-regulation of XIAP and survivin in human glioma cells. Neurochem Res 33: 551-561, 2008.
4. Kim KY, Ahn JH and Cheon HG: Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non-small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Mol Pharmacol 72: 674-685, 2007.
5. Yu J, Qiao L, Lars Z, et al: Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo. Hepatology 43: 134-143, 2006.
6. Lin MS, Chen WC, Bai X, et al: Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. J Dig Dis 8: 82-88, 2007.
7. Kamagata C, Tsuji N, Moriai M, et al: 15-Deoxy-Delta(12,14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. Breast Cancer Res Treat 102: 263-273, 2007.
8. Leung WK, Bai AHC, Chan VYW, et al: Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. Gut 53: 331-338, 2004.
9. Sawai H, Liu J, Reber HA, et al: Activation of peroxisome proliferator activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res 4: 159-167, 2006.
10. Panigrahy D, Huang S, Kieran MW, et al: PPAR gamma as a therapeutic target for tumor angiogenesis and metastasis. Cancer Biol Ther 4: 687-693, 2005.
11. Giaginis C, Margeli A and Theocharis S: Peroxisome proliferatoractivated receptor-gamma ligands as investigational modulators of angiogenesis. Expert Opin Investig Drugs 16: 1561-1572, 2007.
12. Chou FS, Wang PS, Kulp S, et al: Effects of thiazolidinediones on differentiation, proliferation, and apoptosis. Mol Cancer Res 5: 523-530, 2007.
13. Bonofiglio D, Aquila S, Catalano S, et al: Peroxisome proliferatoractivated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappa B sequence in human MCF7 breast cancer cells. Mol Endocrinol 20: 3083-3092, 2006.
14. Liao SY, Zeng ZR, Leung WK, et al: Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese. Aliment Pharmacol Ther 23: 289-294, 2006.
15. Leung WK, Liao S, Zeng Z, et al: Effects of peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, on chemoprevention of gastric cancer in rat. Gastroenterology 130: A9, 2006.
16. Solban N, Jia HP, Richard S, et al: HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. J Biol Chem 275: 32234-32243, 2000.
17. Hu PJ, Yu J, Zeng ZR, et al: Chemoprevention of gastric cancer by celecoxib in rats. Gut 53: 195-200, 2004.
18. Parkin DM, Whelan SL, Ferlay J, et al: Cancer incidence in five continents, vols I to VIII. IARC Cancer Base No. 7. International Association for Research on Cancer, Lyon, 2005.
19. Leung WK and Sung JJY: Chemoprevention of gastric cancer. Eur J Gastroenterol Hepatol 18: 867-871, 2006.
20. Cilloni D, Martinelli G, Messa F, et al: Nuclear factor B as a target for new drug development in myeloid malignancies. Haematologica 92: 1124-1229, 2007.
21. Eli P and Yinon BN: NF-κB inhibition: A double-edged sword in cancer? Eur J Cancer 42: 779-784, 2006
22. 2M arrest. Am J Physiol Renal Physiol 284: F753-F762, 2003.
23. Han S, Zheng Y and Roman J: Rosiglitazone, an agonist of PPARγ, inhibits non-small cell carcinoma cell proliferation in part through activation of tumor sclerosis complex-2. PPAR Res 2007: 29632, 2007.
24. Koufany M, Moulin D, Bianchi A, et al: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. Arthritis Res Ther 16: R6, 2008
25. Perez-Ortiz JM, Tranque P, Vaquero CF, et al: Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J Biol Chem 279: 8976-8985, 2004.
26. Clay CE, Monjazeb A, Thorburn J, et al: 15-Deoxy-delta12,14- prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res 43: 1818-1828, 2002.
27. Kim EJ, Park KS, Chung SY, et al: Peroxisome proliferatoractivated receptor-gamma activator 15-deoxy-Delta12,14- prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signalregulated kinase signal pathway. J Pharmacol Exp Ther 307: 505-517, 2003.
28. Bruemmer D, Yin F, Liu J, et al: Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. Circ Res 93: e38-e47, 2003.