메뉴 건너뛰기




Volumn 5, Issue 7, 2013, Pages 490-494

M(o)TOR of aging: MTOR as a universal molecular hypothalamus

Author keywords

Diseases; Geroconversion; Molecular hypothalamus; Rapamycin; Senescence

Indexed keywords


EID: 84881094811     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100580     Document Type: Article
Times cited : (28)

References (90)
  • 1
    • 84877785566 scopus 로고    scopus 로고
    • Physiology: Inflammation links ageing to the brain
    • Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature. 2013; 497: 197-198.
    • (2013) Nature , vol.497 , pp. 197-198
    • Gabuzda, D.1    Yankner, B.A.2
  • 2
    • 84877734347 scopus 로고    scopus 로고
    • Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH
    • Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D. Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature. 2013; 497: 211-216.
    • (2013) Nature , vol.497 , pp. 211-216
    • Zhang, G.1    Li, J.2    Purkayastha, S.3    Tang, Y.4    Zhang, H.5    Yin, Y.6    Li, B.7    Liu, G.8    Cai, D.9
  • 3
    • 84863431784 scopus 로고    scopus 로고
    • Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB
    • Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging (Albany NY). 2012; 4: 98-115.
    • (2012) Aging (Albany NY) , vol.4 , pp. 98-115
    • Cai, D.1    Liu, T.2
  • 4
    • 79960117277 scopus 로고    scopus 로고
    • Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB
    • Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nat Med. 2011; 17: 883-887.
    • (2011) Nat Med. , vol.17 , pp. 883-887
    • Purkayastha, S.1    Zhang, G.2    Cai, D.3
  • 5
    • 80051662211 scopus 로고    scopus 로고
    • Does hypothalamic SIRT1 regulate aging?
    • Ramadori G, Coppari R. Does hypothalamic SIRT1 regulate aging? Aging (Albany NY). 2011; 3: 325-328.
    • (2011) Aging (Albany NY). , vol.3 , pp. 325-328
    • Ramadori, G.1    Coppari, R.2
  • 6
    • 84886949439 scopus 로고
    • [Age-connected hypercholesterinemia as an index of increased activity of the hypothalamic centers]
    • Dil'Man VM. [Age-connected hypercholesterinemia as an index of increased activity of the hypothalamic centers]. Ter Arkh. 1960; 32: 72-77.
    • (1960) Ter Arkh , vol.32 , pp. 72-77
    • Dil'Man, V.M.1
  • 7
    • 0014419104 scopus 로고
    • Hypothalamopituitary hyperactivity and endometrial carcinoma Qualitative and quantitative disturbances in hormone production.
    • Dilman VM, Berstein LM, Bobrov YF, Bohman YV, Kovaleva IG, Krylova NV. Hypothalamopituitary hyperactivity and endometrial carcinoma. Qualitative and quantitative disturbances in hormone production. Am J Obstet Gynecol. 1968; 102: 880-889.
    • (1968) Am J Obstet Gynecol , vol.102 , pp. 880-889
    • Dilman, V.M.1    Berstein, L.M.2    Bobrov, Y.F.3    Bohman, Y.V.4    Kovaleva, I.G.5    Krylova, N.V.6
  • 8
    • 0015220921 scopus 로고
    • Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease
    • Dilman VM. Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease. Lancet. 1971; 1: 1211-1219.
    • (1971) Lancet , vol.1 , pp. 1211-1219
    • Dilman, V.M.1
  • 9
    • 0016210446 scopus 로고
    • Increase with age in the hypothalamo-hypophyseal threshold to the inhibitory action of estrogens and the effect of pineal extract on this process
    • Anisimov VN, Ostroumova MN, Dil'man VM. Increase with age in the hypothalamo-hypophyseal threshold to the inhibitory action of estrogens and the effect of pineal extract on this process. Bull Exp Biol Med. 1974; 77: 440-442.
    • (1974) Bull Exp Biol Med , vol.77 , pp. 440-442
    • Anisimov, V.N.1    Ostroumova, M.N.2    Dil'man, V.M.3
  • 10
    • 0016576652 scopus 로고
    • [An increase in hypothalamic sensitivity to the inhibiting effects of estrogens caused by use of L-DOPA, diphenine, epithalamin and phenformin in old rats]
    • Dil'man VM, Anisimov VN. [An increase in hypothalamic sensitivity to the inhibiting effects of estrogens caused by use of L-DOPA, diphenine, epithalamin and phenformin in old rats]. Biull Eksp Biol Med. 1975; 80: 96-98.
    • (1975) Biull Eksp Biol Med , vol.80 , pp. 96-98
    • Dil'man, V.M.1    Anisimov, V.N.2
  • 12
    • 0018402590 scopus 로고
    • Hypothalmic mechanisms of ageing and of specific age pathology--I.Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system
    • Dilman VM, Anisimov VN. Hypothalmic mechanisms of ageing and of specific age pathology--I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system. Exp Gerontol. 1979; 14: 161-174.
    • (1979) Exp Gerontol , vol.14 , pp. 161-174
    • Dilman, V.M.1    Anisimov, V.N.2
  • 13
    • 0018895934 scopus 로고
    • Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice
    • Dilman VM, Anisimov VN. Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology. 1980; 26: 241-246.
    • (1980) Gerontology , vol.26 , pp. 241-246
    • Dilman, V.M.1    Anisimov, V.N.2
  • 17
    • 84864541430 scopus 로고    scopus 로고
    • Metformin in obesity, cancer and aging: addressing controversies
    • Berstein LM. Metformin in obesity, cancer and aging: addressing controversies. Aging (Albany NY). 2012; 4: 320-329.
    • (2012) Aging (Albany NY) , vol.4 , pp. 320-329
    • Berstein, L.M.1
  • 19
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A
    • Serrano M, Lim AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A. Cell. 1997; 88: 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lim, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 20
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998; 12: 3008-3019.
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 21
    • 0038441503 scopus 로고    scopus 로고
    • Cell senescence and hypermitogenic arrest
    • Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep. 2003; 4: 358-362.
    • (2003) EMBO Rep , vol.4 , pp. 358-362
    • Blagosklonny, M.V.1
  • 22
    • 84862891914 scopus 로고    scopus 로고
    • Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
    • Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY). 2012; 4: 159-165.
    • (2012) Aging (Albany NY) , vol.4 , pp. 159-165
    • Blagosklonny, M.V.1
  • 24
    • 84874793452 scopus 로고    scopus 로고
    • IL1- and TGFbeta-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'Bystander senescence'
    • Hubackova S, Krejcikova K, Bartek J, Hodny Z. IL1- and TGFbeta-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'Bystander senescence'. Aging (Albany NY). 2012; 4: 932-951.
    • (2012) Aging (Albany NY) , vol.4 , pp. 932-951
    • Hubackova, S.1    Krejcikova, K.2    Bartek, J.3    Hodny, Z.4
  • 27
    • 33747172229 scopus 로고    scopus 로고
    • Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
    • Salvioli S, Capri M, Valensin S, Tieri P, Monti D, Ottaviani E, Franceschi C. Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology. Curr Pharm Des. 2006; 12:161-3171.
    • (2006) Curr Pharm Des. , vol.12 , pp. 161-3171
    • Salvioli, S.1    Capri, M.2    Valensin, S.3    Tieri, P.4    Monti, D.5    Ottaviani, E.6    Franceschi, C.7
  • 30
    • 84863329778 scopus 로고    scopus 로고
    • Inflammaging: disturbed interplay between autophagy and inflammasomes
    • Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY). 2012; 4: 166-175.
    • (2012) Aging (Albany NY) , vol.4 , pp. 166-175
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 31
    • 79961099905 scopus 로고    scopus 로고
    • From growing to secreting: new roles for mTOR in aging cells
    • Pani G. From growing to secreting: new roles for mTOR in aging cells. Cell Cycle. 2011; 10: 2450-2453.
    • (2011) Cell Cycle , vol.10 , pp. 2450-2453
    • Pani, G.1
  • 33
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7: 3355-3361.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 37
    • 84871503188 scopus 로고    scopus 로고
    • Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
    • Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle. 2012; 11: 4642 - 4649.
    • (2012) Cell Cycle , vol.11 , pp. 4642-4649
    • Leontieva, O.V.1    Lenzo, F.2    Demidenko, Z.N.3    Blagosklonny, M.V.4
  • 39
    • 84861917512 scopus 로고    scopus 로고
    • Autophagy and cardiovascular aging: lesson learned from rapamycin
    • Nair S, Ren J. Autophagy and cardiovascular aging: lesson learned from rapamycin. Cell Cycle. 2012; 11: 2092-2099.
    • (2012) Cell Cycle , vol.11 , pp. 2092-2099
    • Nair, S.1    Ren, J.2
  • 40
    • 84862881405 scopus 로고    scopus 로고
    • Dissecting the role of mTOR complexes in cellular senescence
    • Serrano M. Dissecting the role of mTOR complexes in cellular senescence. Cell Cycle. 2012; 11: 2231-2232.
    • (2012) Cell Cycle , vol.11 , pp. 2231-2232
    • Serrano, M.1
  • 41
    • 79958248002 scopus 로고    scopus 로고
    • Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
    • Dulic V. Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence? Aging (Albany NY). 2011; 3: 3-4.
    • (2011) Aging (Albany NY) , vol.3 , pp. 3-4
    • Dulic, V.1
  • 42
    • 80655140600 scopus 로고    scopus 로고
    • mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging
    • Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez- Martin A. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle. 2011; 10: 3658-3677.
    • (2011) Cell Cycle , vol.10 , pp. 3658-3677
    • Menendez, J.A.1    Vellon, L.2    Oliveras-Ferraros, C.3    Cufi, S.4    Vazquez-Martin, A.5
  • 44
    • 84870692721 scopus 로고    scopus 로고
    • Exploiting the mTOR paradox for disease prevention
    • Iglesias-Bartolome R, Gutkind SJ. Exploiting the mTOR paradox for disease prevention. Oncotarget. 2012; 3: 1061-1063.
    • (2012) Oncotarget , vol.3 , pp. 1061-1063
    • Iglesias-Bartolome, R.1    Gutkind, S.J.2
  • 45
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY). 2009; 1: 1008-1016.
    • (2009) Aging (Albany NY) , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 46
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: a common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging (Albany NY). 2009; 1: 357-362.
    • (2009) Aging (Albany NY) , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 47
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 48
    • 74849115774 scopus 로고    scopus 로고
    • mTOR-driven aging: speeding car without brakes
    • Blagosklonny MV. mTOR-driven aging: speeding car without brakes. Cell Cycle. 2009; 8: 4055-4059.
    • (2009) Cell Cycle , vol.8 , pp. 4055-4059
    • Blagosklonny, M.V.1
  • 49
    • 84866494334 scopus 로고    scopus 로고
    • Prospective treatment of age-related diseases by slowing down aging
    • Blagosklonny MV. Prospective treatment of age-related diseases by slowing down aging. Am J Pathol. 2012; 181: 1142-1146.
    • (2012) Am J Pathol , vol.181 , pp. 1142-1146
    • Blagosklonny, M.V.1
  • 50
    • 84874801912 scopus 로고    scopus 로고
    • Answering the ultimate question "What is the Proximal Cause of Aging?"
    • Blagosklonny M. Answering the ultimate question "What is the Proximal Cause of Aging?" Aging (Albany NY). 2012; 4: 861-877.
    • (2012) Aging (Albany NY) , vol.4 , pp. 861-877
    • Blagosklonny, M.1
  • 51
    • 38149107357 scopus 로고    scopus 로고
    • Paradoxes of aging
    • Blagosklonny MV. Paradoxes of aging. Cell Cycle. 2007; 6: 2997-3003.
    • (2007) Cell Cycle , vol.6 , pp. 2997-3003
    • Blagosklonny, M.V.1
  • 52
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans)
    • Blagosklonny MV. Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans). Cell Cycle. 2010; 9: 683-688.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 53
    • 77955739991 scopus 로고    scopus 로고
    • Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
    • Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging(Albany NY). 2010; 2: 265-273.
    • (2010) Aging(Albany NY) , vol.2 , pp. 265-273
    • Blagosklonny, M.V.1
  • 54
    • 83755206847 scopus 로고    scopus 로고
    • Hormesis does not make sense except in the light of TOR-driven aging
    • Blagosklonny MV. Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY). 2011; 3: 1051-1062.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1051-1062
    • Blagosklonny, M.V.1
  • 55
    • 84874807522 scopus 로고    scopus 로고
    • Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
    • Leontieva OV, Geraldine M. Paszkiewicz GM, Blagosklonny MV. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY). 2012; 4: 899-916
    • (2012) Aging (Albany NY) , vol.4 , pp. 899-916
    • Leontieva, O.V.1    Geraldine, M.2    Paszkiewicz, G.M.3    Blagosklonny, M.V.4
  • 56
    • 33847226657 scopus 로고    scopus 로고
    • An anti-aging drug today: from senescence-promoting genes to anti-aging pill
    • Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today. 2007; 12: 218-224.
    • (2007) Drug Disc Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1
  • 57
    • 84864008371 scopus 로고    scopus 로고
    • Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress
    • Wang M, Miller RA. Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress. Aging Cell. 2012; 11:668-674.
    • (2012) Aging Cell , vol.11 , pp. 668-674
    • Wang, M.1    Miller, R.A.2
  • 58
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging: Four years later
    • Blagosklonny MV. Rapamycin and quasi-programmed aging: Four years later. Cell Cycle. 2010; 9: 1859-1862.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 65
    • 84857926653 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice
    • Spong A, Bartke A. Rapamycin slows aging in mice. Cell Cycle. 2012; 11:845.
    • (2012) Cell Cycle , vol.11 , pp. 845
    • Spong, A.1    Bartke, A.2
  • 66
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers RWr, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006; 20: 174-184.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 68
    • 83755186554 scopus 로고    scopus 로고
    • Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression
    • Leontieva OV, Blagosklonny MV. Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY). 2011; 3: 1078-1091.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1078-1091
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 69
    • 84859485410 scopus 로고    scopus 로고
    • Conserved role of medium acidification in chronological senescence of yeast and mammalian cells
    • Fabrizio P, Wei M. Conserved role of medium acidification in chronological senescence of yeast and mammalian cells. Aging (Albany NY). 2011; 3: 1127-1129.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1127-1129
    • Fabrizio, P.1    Wei, M.2
  • 71
    • 84867240472 scopus 로고    scopus 로고
    • Chronological and replicative lifespan in yeast: do they meet in the middle?
    • Polymenis M, Kennedy BK. Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle. 2012; 11: 3531-3532.
    • (2012) Cell Cycle , vol.11 , pp. 3531-3532
    • Polymenis, M.1    Kennedy, B.K.2
  • 72
    • 84862881961 scopus 로고    scopus 로고
    • Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
    • Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012; 11: 2391-2401.
    • (2012) Cell Cycle , vol.11 , pp. 2391-2401
    • Kolesnichenko, M.1    Hong, L.2    Liao, R.3    Vogt, P.K.4    Sun, P.5
  • 74
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991; 253: 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 75
    • 84869381457 scopus 로고    scopus 로고
    • Glutaminolysis feeds mTORC1
    • Duran RV, Hall MN. Glutaminolysis feeds mTORC1. Cell Cycle. 2012; 11: 4107-4108.
    • (2012) Cell Cycle , vol.11 , pp. 4107-4108
    • Duran, R.V.1    Hall, M.N.2
  • 76
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 79
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010; 40: 310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 80
    • 34447131534 scopus 로고    scopus 로고
    • Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha
    • Dan HC, Adli M, Baldwin AS. Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer Res. 2007; 67: 6263-6269.
    • (2007) Cancer Res , vol.67 , pp. 6263-6269
    • Dan, H.C.1    Adli, M.2    Baldwin, A.S.3
  • 81
    • 38149108890 scopus 로고    scopus 로고
    • All roads lead to mTOR: integrating inflammation and tumor angiogenesis
    • Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle. 2007; 6: 3011-3014.
    • (2007) Cell Cycle , vol.6 , pp. 3011-3014
    • Lee, D.F.1    Hung, M.C.2
  • 82
    • 47249125723 scopus 로고    scopus 로고
    • Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt
    • Dan HC, Baldwin AS. Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt. J Immunol. 2008; 180: 7582-7589.
    • (2008) J Immunol , vol.180 , pp. 7582-7589
    • Dan, H.C.1    Baldwin, A.S.2
  • 83
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008; 22: 1490-1500.
    • (2008) Genes Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 84
    • 84864927001 scopus 로고    scopus 로고
    • Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
    • Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 75: 425-436.
    • Neuron , vol.75 , pp. 425-436
    • Yang, S.B.1    Tien, A.C.2    Boddupalli, G.3    Xu, A.W.4    Jan, Y.N.5    Jan, L.Y.6
  • 85
    • 0033576579 scopus 로고    scopus 로고
    • Regulation of lifespan by sensory perception in Caenorhabditis elegans
    • Apfeld J, Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature. 1999; 402: 804-809.
    • (1999) Nature , vol.402 , pp. 804-809
    • Apfeld, J.1    Kenyon, C.2
  • 86
    • 0347854376 scopus 로고    scopus 로고
    • Regulation of C. elegans longevity by specific gustatory and olfactory neurons.
    • Alcedo J, Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron. 2004; 41: 45-55.
    • (2004) Neuron , vol.41 , pp. 45-55
    • Alcedo, J.1    Kenyon, C.2
  • 87
    • 33847421281 scopus 로고    scopus 로고
    • Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
    • Lans H, Jansen G. Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 2007; 303: 474-482.
    • (2007) Dev Biol , vol.303 , pp. 474-482
    • Lans, H.1    Jansen, G.2
  • 88
    • 65549165654 scopus 로고    scopus 로고
    • Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans
    • Lee SJ, Kenyon C. Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol. 2009; 19: 715-722.
    • (2009) Curr Biol , vol.19 , pp. 715-722
    • Lee, S.J.1    Kenyon, C.2
  • 89
    • 34548645020 scopus 로고    scopus 로고
    • Caenorhabditis elegans integrates food and reproductive signals in lifespan determination
    • Crawford D, Libina N, Kenyon C. Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell. 2007; 6: 715-721.
    • (2007) Aging Cell , vol.6 , pp. 715-721
    • Crawford, D.1    Libina, N.2    Kenyon, C.3
  • 90
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C elegans.
    • Hsin H, Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature. 1999; 399: 362-366.
    • (1999) Nature , vol.399 , pp. 362-366
    • Hsin, H.1    Kenyon, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.