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Volumn 4, Issue 7, 2013, Pages

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1b-induced apoptosis via Bim/A1 imbalance

Author keywords

A1; Apoptosis; Bim; Endoplasmic reticulum stress; Pancreatic beta cells; Type 1 diabetes

Indexed keywords

BCL2 RELATED PROTEIN A1; BIM PROTEIN; CYCLOPIAZONIC ACID; INTERLEUKIN 1BETA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; X BOX BINDING PROTEIN 1;

EID: 84881048861     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.236     Document Type: Article
Times cited : (40)

References (51)
  • 1
    • 67649364114 scopus 로고    scopus 로고
    • The role of inflammation in insulitis and b-cell loss in type 1 diabetes
    • Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and b-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009; 5: 219-226.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 219-226
    • Eizirik, D.L.1    Colli, M.L.2    Ortis, F.3
  • 2
    • 77951891703 scopus 로고    scopus 로고
    • Prediction and pathogenesis in type 1 diabetes
    • Ziegler AG, Nepom GT. Prediction and pathogenesis in type 1 diabetes. Immunity 2010; 32: 468-478.
    • (2010) Immunity , vol.32 , pp. 468-478
    • Ziegler, A.G.1    Nepom, G.T.2
  • 3
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373: 2027-2033.
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyurus, E.3    Green, A.4    Soltesz, G.5
  • 4
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: Etiology, immunology, and therapeutic strategies
    • Van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91: 79-118.
    • (2011) Physiol Rev , vol.91 , pp. 79-118
    • Van Belle, T.L.1    Coppieters, K.T.2    Von Herrath, M.G.3
  • 6
    • 84860783172 scopus 로고    scopus 로고
    • Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden
    • Carlsson A, Kockum I, Lindblad B, Engleson L, Nilsson A, Forsander G et al. Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden. Int J Obes (Lond) 2011; 36: 718-724.
    • (2011) Int J Obes (Lond) , vol.36 , pp. 718-724
    • Carlsson, A.1    Kockum, I.2    Lindblad, B.3    Engleson, L.4    Nilsson, A.5    Forsander, G.6
  • 7
    • 84855605795 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, obesity and diabetes
    • Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2012; 18: 59-68.
    • (2012) Trends Mol Med , vol.18 , pp. 59-68
    • Cnop, M.1    Foufelle, F.2    Velloso, L.A.3
  • 8
    • 84878777666 scopus 로고    scopus 로고
    • Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    • Eizirik DL, Miani M, Cardozo AK. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013; 56: 234-241.
    • (2013) Diabetologia , vol.56 , pp. 234-241
    • Eizirik, D.L.1    Miani, M.2    Cardozo, A.K.3
  • 9
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008; 29: 42-61.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 10
    • 77952574173 scopus 로고    scopus 로고
    • ER stress in pancreatic b-cells: The thin red line between adaptation and failure
    • Eizirik DL, Cnop M. ER stress in pancreatic b-cells: the thin red line between adaptation and failure. Sci Signal 2010; 3: pe7.
    • (2010) Sci Signal , vol.3
    • Eizirik, D.L.1    Cnop, M.2
  • 11
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011; 334: 1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 12
    • 79959618962 scopus 로고    scopus 로고
    • Bcl-2 proteins in diabetes: Mitochondrial pathways of b-cell death and dysfunction
    • Gurzov EN, Eizirik DL. Bcl-2 proteins in diabetes: mitochondrial pathways of b-cell death and dysfunction. Trends Cell Biol 2011; 21: 424-431.
    • (2011) Trends Cell Biol , vol.21 , pp. 424-431
    • Gurzov, E.N.1    Eizirik, D.L.2
  • 13
    • 79959897450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and pancreatic b-cell death
    • Fonseca SG, Gromada J, Urano F. Endoplasmic reticulum stress and pancreatic b-cell death. Trends Endocrinol Metab 2011; 22: 266-274.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 266-274
    • Fonseca, S.G.1    Gromada, J.2    Urano, F.3
  • 14
    • 19944432792 scopus 로고    scopus 로고
    • Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2\+ ATPase 2b and deplete endoplasmic reticulum Ca2\+, leading to induction of endoplasmic reticulum stress in pancreatic b-cells
    • Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2\+ ATPase 2b and deplete endoplasmic reticulum Ca2\+, leading to induction of endoplasmic reticulum stress in pancreatic b-cells. Diabetes 2005; 54: 452-461.
    • (2005) Diabetes , vol.54 , pp. 452-461
    • Cardozo, A.K.1    Ortis, F.2    Storling, J.3    Feng, Y.M.4    Rasschaert, J.5    Tonnesen, M.6
  • 15
    • 58149337392 scopus 로고    scopus 로고
    • Cytokineinduced b-cell death is independent of endoplasmic reticulum stress signaling
    • Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM et al. Cytokineinduced b-cell death is independent of endoplasmic reticulum stress signaling. Diabetes 2008; 57: 3034-3044.
    • (2008) Diabetes , vol.57 , pp. 3034-3044
    • Akerfeldt, M.C.1    Howes, J.2    Chan, J.Y.3    Stevens, V.A.4    Boubenna, N.5    McGuire, H.M.6
  • 16
    • 84870988528 scopus 로고    scopus 로고
    • C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in b-cells
    • Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L et al. C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in b-cells. Cell Death Differ 2012; 19: 1836-1846.
    • (2012) Cell Death Differ , vol.19 , pp. 1836-1846
    • Allagnat, F.1    Fukaya, M.2    Nogueira, T.C.3    Delaroche, D.4    Welsh, N.5    Marselli, L.6
  • 17
    • 84859553400 scopus 로고    scopus 로고
    • Islet b-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
    • Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC et al. Islet b-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 2012; 61: 818-827.
    • (2012) Diabetes , vol.61 , pp. 818-827
    • Tersey, S.A.1    Nishiki, Y.2    Templin, A.T.3    Cabrera, S.M.4    Stull, N.D.5    Colvin, S.C.6
  • 18
    • 84866130866 scopus 로고    scopus 로고
    • Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes
    • Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 2012; 55: 2417-2420.
    • (2012) Diabetologia , vol.55 , pp. 2417-2420
    • Marhfour, I.1    Lopez, X.M.2    Lefkaditis, D.3    Salmon, I.4    Allagnat, F.5    Richardson, S.J.6
  • 19
    • 84862742723 scopus 로고    scopus 로고
    • Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1b in pancreatic rat b-cells via the IRE1a/XBP1s pathway
    • Miani M, Colli ML, Ladriere L, Cnop M, Eizirik DL. Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1b in pancreatic rat b-cells via the IRE1a/XBP1s pathway. Endocrinology 2012; 153: 3017-3028.
    • (2012) Endocrinology , vol.153 , pp. 3017-3028
    • Miani, M.1    Colli, M.L.2    Ladriere, L.3    Cnop, M.4    Eizirik, D.L.5
  • 20
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 21
    • 80655144735 scopus 로고    scopus 로고
    • Cytokines TNF-a and IFN-g induce pancreatic b-cell apoptosis through STAT1-mediated Bim protein activation
    • Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P et al. Cytokines TNF-a and IFN-g induce pancreatic b-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem 2011; 286: 39632-39643.
    • (2011) J Biol Chem , vol.286 , pp. 39632-39643
    • Barthson, J.1    Germano, C.M.2    Moore, F.3    Maida, A.4    Drucker, D.J.5    Marchetti, P.6
  • 22
    • 70350028224 scopus 로고    scopus 로고
    • Signaling by IL-1b\+IFN-g and ER stress converge on DP5/Hrk activation: A novel mechanism for pancreatic b-cell apoptosis
    • Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK et al. Signaling by IL-1b\+IFN-g and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic b-cell apoptosis. Cell Death Differ 2009; 16: 1539-1550.
    • (2009) Cell Death Differ , vol.16 , pp. 1539-1550
    • Gurzov, E.N.1    Ortis, F.2    Cunha, D.A.3    Gosset, G.4    Li, M.5    Cardozo, A.K.6
  • 23
    • 77953755226 scopus 로고    scopus 로고
    • P53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic b-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress
    • Gurzov EN, Germano CM, Cunha DA, Ortis F, Vanderwinden JM, Marchetti P et al. p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic b-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem 2010; 285: 19910-19920.
    • (2010) J Biol Chem , vol.285 , pp. 19910-19920
    • Gurzov, E.N.1    Germano, C.M.2    Cunha, D.A.3    Ortis, F.4    Vanderwinden, J.M.5    Marchetti, P.6
  • 24
    • 82255185820 scopus 로고    scopus 로고
    • PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic b-cell apoptosis via regulation of the BH3-only protein Bim
    • Santin I, Moore F, Colli ML, Gurzov EN, Marselli L, Marchetti P et al. PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic b-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes 2011; 60: 3279-3288.
    • (2011) Diabetes , vol.60 , pp. 3279-3288
    • Santin, I.1    Moore, F.2    Colli, M.L.3    Gurzov, E.N.4    Marselli, L.5    Marchetti, P.6
  • 25
    • 80053435959 scopus 로고    scopus 로고
    • Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic b-cell apoptosis via a Bim/Mcl-1 imbalance
    • Colli ML, Nogueira TC, Allagnat F, Cunha DA, Gurzov EN, Cardozo AK et al. Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic b-cell apoptosis via a Bim/Mcl-1 imbalance. PLoS Pathog 2011; 7: e1002267.
    • (2011) PLoS Pathog , vol.7
    • Colli, M.L.1    Nogueira, T.C.2    Allagnat, F.3    Cunha, D.A.4    Gurzov, E.N.5    Cardozo, A.K.6
  • 26
    • 84856739052 scopus 로고    scopus 로고
    • The transcription factor C/EBPd has anti-apoptotic and anti-inflammatory roles in pancreatic b-cells
    • Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P et al. The transcription factor C/EBPd has anti-apoptotic and anti-inflammatory roles in pancreatic b-cells. PLoS One 2012; 7: e31062.
    • (2012) PLoS One , vol.7
    • Moore, F.1    Santin, I.2    Nogueira, T.C.3    Gurzov, E.N.4    Marselli, L.5    Marchetti, P.6
  • 27
    • 78651303018 scopus 로고    scopus 로고
    • Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to b-cell apoptosis
    • Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to b-cell apoptosis. Cell Death Differ 2011; 18: 328-337.
    • (2011) Cell Death Differ , vol.18 , pp. 328-337
    • Allagnat, F.1    Cunha, D.2    Moore, F.3    Vanderwinden, J.M.4    Eizirik, D.L.5    Cardozo, A.K.6
  • 28
    • 84859254586 scopus 로고    scopus 로고
    • The human pancreatic islet transcriptome: Expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
    • Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M et al. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet 2012; 8: e1002552.
    • (2012) PLoS Genet , vol.8
    • Eizirik, D.L.1    Sammeth, M.2    Bouckenooghe, T.3    Bottu, G.4    Sisino, G.5    Igoillo-Esteve, M.6
  • 29
    • 33646533330 scopus 로고    scopus 로고
    • IFN-gpotentiates endoplasmic reticulum stress-induced death by reducing pancreatic b-cell defence mechanisms
    • Pirot P, Eizirik DL, Cardozo AK. IFN-gpotentiates endoplasmic reticulum stress-induced death by reducing pancreatic b-cell defence mechanisms. Diabetologia 2006; 49: 1229-1236.
    • (2006) Diabetologia , vol.49 , pp. 1229-1236
    • Pirot, P.1    Eizirik, D.L.2    Cardozo, A.K.3
  • 30
    • 34147106529 scopus 로고    scopus 로고
    • Global profiling of genes modified by endoplasmic reticulum stress in pancreatic b-cells reveals the early degradation of insulin mRNAs
    • Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, Cardozo AK et al. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic b-cells reveals the early degradation of insulin mRNAs. Diabetologia 2007; 50: 1006-1014.
    • (2007) Diabetologia , vol.50 , pp. 1006-1014
    • Pirot, P.1    Naamane, N.2    Libert, F.3    Magnusson, N.E.4    Orntoft, T.F.5    Cardozo, A.K.6
  • 31
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal-transduction of immunemediated b-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T. A choice of death: the signal-transduction of immunemediated b-cell apoptosis. Diabetologia 2001; 44: 2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 33
    • 84871682971 scopus 로고    scopus 로고
    • Susceptibility to fatty acid-induced b-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: A potential link between b-cell lipotoxicity and islet inflammation
    • Tang C, Naassan AE, Chamson-Reig A, Koulajian K, Goh TT, Yoon F et al. Susceptibility to fatty acid-induced b-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between b-cell lipotoxicity and islet inflammation. Endocrinology 2013; 154: 89-101.
    • (2013) Endocrinology , vol.154 , pp. 89-101
    • Tang, C.1    Naassan, A.E.2    Chamson-Reig, A.3    Koulajian, K.4    Goh, T.T.5    Yoon, F.6
  • 34
    • 84864693470 scopus 로고    scopus 로고
    • Thioredoxininteracting protein mediates ER stress-induced b cell death through initiation of the inflammasome
    • Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M et al. Thioredoxininteracting protein mediates ER stress-induced b cell death through initiation of the inflammasome. Cell Metab 2012; 16: 265-273.
    • (2012) Cell Metab , vol.16 , pp. 265-273
    • Oslowski, C.M.1    Hara, T.2    O'Sullivan-Murphy, B.3    Kanekura, K.4    Lu, S.5    Hara, M.6
  • 35
    • 84864682160 scopus 로고    scopus 로고
    • IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
    • Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A et al. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab 2012; 16: 250-264.
    • (2012) Cell Metab , vol.16 , pp. 250-264
    • Lerner, A.G.1    Upton, J.P.2    Praveen, P.V.3    Ghosh, R.4    Nakagawa, Y.5    Igbaria, A.6
  • 36
    • 79953276389 scopus 로고    scopus 로고
    • Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
    • Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C et al. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 2011; 145: 104-116.
    • (2011) Cell , vol.145 , pp. 104-116
    • Edlich, F.1    Banerjee, S.2    Suzuki, M.3    Cleland, M.M.4    Arnoult, D.5    Wang, C.6
  • 38
    • 79951818357 scopus 로고    scopus 로고
    • Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
    • Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM et al. Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS. Cell Death Dis 2010; 1: e69.
    • (2010) Cell Death Dis , vol.1
    • Jiang, C.C.1    Lai, F.2    Tay, K.H.3    Croft, A.4    Rizos, H.5    Becker, T.M.6
  • 39
    • 84856698334 scopus 로고    scopus 로고
    • BCL2A1: The underdog in the BCL2 family
    • Vogler M. BCL2A1: the underdog in the BCL2 family. Cell Death Differ 2012; 19: 67-74.
    • (2012) Cell Death Differ , vol.19 , pp. 67-74
    • Vogler, M.1
  • 40
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992; 130: 167-178.
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 42
    • 26644460214 scopus 로고    scopus 로고
    • Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA\+IFN-g-induced apoptosis in primary pancreatic b-cells
    • Rasschaert J, Ladriere L, Urbain M, Dogusan Z, Katabua B, Sato S et al. Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA\+IFN-g-induced apoptosis in primary pancreatic b-cells. J Biol Chem 2005; 280: 33984-33991.
    • (2005) J Biol Chem , vol.280 , pp. 33984-33991
    • Rasschaert, J.1    Ladriere, L.2    Urbain, M.3    Dogusan, Z.4    Katabua, B.5    Sato, S.6
  • 43
    • 0242363618 scopus 로고    scopus 로고
    • Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
    • Kutlu B, Cardozo AK, Darville MI, Kruhoffer M, Magnusson N, Orntoft T et al. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 2003; 52: 2701-2719.
    • (2003) Diabetes , vol.52 , pp. 2701-2719
    • Kutlu, B.1    Cardozo, A.K.2    Darville, M.I.3    Kruhoffer, M.4    Magnusson, N.5    Orntoft, T.6
  • 44
    • 0033119065 scopus 로고    scopus 로고
    • Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR
    • Overbergh L, Valckx D, Waer M, Mathieu C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 1999; 11: 305-312.
    • (1999) Cytokine , vol.11 , pp. 305-312
    • Overbergh, L.1    Valckx, D.2    Waer, M.3    Mathieu, C.4
  • 45
    • 0035029867 scopus 로고    scopus 로고
    • Identification of novel cytokineinduced genes in pancreatic b-cells by high-density oligonucleotide arrays
    • Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL. Identification of novel cytokineinduced genes in pancreatic b-cells by high-density oligonucleotide arrays. Diabetes 2001; 50: 909-920.
    • (2001) Diabetes , vol.50 , pp. 909-920
    • Cardozo, A.K.1    Kruhoffer, M.2    Leeman, R.3    Orntoft, T.4    Eizirik, D.L.5
  • 46
    • 0035013235 scopus 로고    scopus 로고
    • Double-stranded ribonucleic acid (RNA) induces b-cell Fas messenger RNA expression and increases cytokine-induced b-cell apoptosis
    • Liu D, Darville M, Eizirik DL. Double-stranded ribonucleic acid (RNA) induces b-cell Fas messenger RNA expression and increases cytokine-induced b-cell apoptosis. Endocrinology 2001; 142: 2593-2599.
    • (2001) Endocrinology , vol.142 , pp. 2593-2599
    • Liu, D.1    Darville, M.2    Eizirik, D.L.3
  • 47
    • 66649132790 scopus 로고    scopus 로고
    • PTPN2, a candidate gene for type 1 diabetes, modulates IFN-g-induced pancreatic b-cell apoptosis
    • Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA et al. PTPN2, a candidate gene for type 1 diabetes, modulates IFN-g-induced pancreatic b-cell apoptosis. Diabetes 2009; 58: 1283-1291.
    • (2009) Diabetes , vol.58 , pp. 1283-1291
    • Moore, F.1    Colli, M.L.2    Cnop, M.3    Esteve, M.I.4    Cardozo, A.K.5    Cunha, D.A.6
  • 48
    • 77952093535 scopus 로고    scopus 로고
    • Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic b-cell dysfunction and apoptosis
    • Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S et al. Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic b-cell dysfunction and apoptosis. Diabetologia 2010; 53: 1120-1130.
    • (2010) Diabetologia , vol.53 , pp. 1120-1130
    • Allagnat, F.1    Christulia, F.2    Ortis, F.3    Pirot, P.4    Lortz, S.5    Lenzen, S.6
  • 49
    • 84555187770 scopus 로고    scopus 로고
    • Use of RNA interference to investigate cytokine signal transduction in pancreatic b-cells
    • Moore F, Cunha DA, Mulder H, Eizirik DL. Use of RNA interference to investigate cytokine signal transduction in pancreatic b-cells. Methods Mol Biol 2012; 820: 179-194.
    • (2012) Methods Mol Biol , vol.820 , pp. 179-194
    • Moore, F.1    Cunha, D.A.2    Mulder, H.3    Eizirik, D.L.4
  • 50
    • 78651389664 scopus 로고    scopus 로고
    • STAT1 is a master regulator of pancreatic b-cell apoptosis and islet inflammation
    • Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN et al. STAT1 is a master regulator of pancreatic b-cell apoptosis and islet inflammation. J Biol Chem 2011; 286: 929-941.
    • (2011) J Biol Chem , vol.286 , pp. 929-941
    • Moore, F.1    Naamane, N.2    Colli, M.L.3    Bouckenooghe, T.4    Ortis, F.5    Gurzov, E.N.6
  • 51
    • 33746594835 scopus 로고    scopus 로고
    • Cytokineinduced pro-apoptotic gene expression in insulin-producing cells is related to rapid, sustained and non-oscillatory NF-kB activation
    • Ortis F, Cardozo AK, Crispim D, Storling J, Mandrup-Poulsen T, Eizirik DL. Cytokineinduced pro-apoptotic gene expression in insulin-producing cells is related to rapid, sustained and non-oscillatory NF-kB activation. Mol Endocrinol 2006; 20: 1867-1879.
    • (2006) Mol Endocrinol , vol.20 , pp. 1867-1879
    • Ortis, F.1    Cardozo, A.K.2    Crispim, D.3    Storling, J.4    Mandrup-Poulsen, T.5    Eizirik, D.L.6


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