-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
DOI 10.1038/35888
-
Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., Mello, C.C. (1998) Potent and specifi c genetic interference by doublestranded RNA in Caenorhabditis elegans . Nature 391: 806-811. (Pubitemid 28099681)
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
58449134534
-
Small silencing RNAs: An expanding universe
-
Ghildiyal, M., Zamore, P.D. (2009) Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 10: 94-108.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 94-108
-
-
Ghildiyal, M.1
Zamore, P.D.2
-
3
-
-
62749171803
-
The fascinating world of RNA interference
-
Naqvi, A.R., Islam, M.N., Choudhury, N.R., Haq, Q.M. (2009) The fascinating world of RNA interference. Int. J. Biol. Sci . 5: 97-117.
-
(2009)
Int. J. Biol. Sci .
, vol.5
, pp. 97-117
-
-
Naqvi, A.R.1
Islam, M.N.2
Choudhury, N.R.3
Haq, Q.M.4
-
4
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
DOI 10.1038/35078107
-
Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498. (Pubitemid 32494397)
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
5
-
-
0242317385
-
Small RNA: Can RNA interference be exploited for therapy?
-
DOI 10.1016/S0140-6736(03)14637-5
-
Wall, N.R., Shi, Y. (2003) Small RNA: can RNA interference be exploited for therapy? Lancet 362: 1401-1403. (Pubitemid 37338343)
-
(2003)
Lancet
, vol.362
, Issue.9393
, pp. 1401-1403
-
-
Wall, N.R.1
Shi, Y.2
-
6
-
-
59349116903
-
Knocking down barriers: Advances in siRNA delivery
-
Whitehead, K.A., Langer, R., Anderson, D.G. (2009) Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov . 8: 129-138.
-
(2009)
Nat. Rev. Drug Discov .
, vol.8
, pp. 129-138
-
-
Whitehead, K.A.1
Langer, R.2
Anderson, D.G.3
-
7
-
-
0042941765
-
Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro
-
Chen, Y., Stamatoyannopoulos, G., Song, C.Z. (2003) Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res. 63: 4801-4804. (Pubitemid 37022609)
-
(2003)
Cancer Research
, vol.63
, Issue.16
, pp. 4801-4804
-
-
Chen, Y.1
Stamatoyannopoulos, G.2
Song, C.-Z.3
-
8
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
-
Cunha, D.A., Hekerman, P., Ladriere, L., Bazarra-Castro, A., Ortis, F., Wakeham, M.C. Moore, F., Rasschaert, J., Cardozo, A.K., Bellomo, E., Overbergh, L., Mathieu, C., Lupi, R., Hai, T., Herchuelz, A., Marchetti, P., Rutter, G.A., Eizirik, D.L., Cnop, M. (2008) Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J. Cell Sci. 121: 2308-2318.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham Moore, C.M.F.6
Rasschaert, J.7
Cardozo, A.K.8
Bellomo, E.9
Overbergh, L.10
Mathieu, C.11
Lupi, R.12
Hai, T.13
Herchuelz, A.14
Marchetti, P.15
Rutter, G.A.16
Eizirik, D.L.17
Cnop, M.18
-
9
-
-
0036787671
-
SiRNA-mediated gene silencing in vitro and in vivo
-
Xia, H., Mao, Q., Paulson, H.L., Davidson, B.L. (2002) siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 20: 1006-1010.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.L.3
Davidson, B.L.4
-
10
-
-
45249091262
-
Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes
-
DOI 10.1042/BST0360321
-
Eizirik, D.L., Moore, F., Flamez, D., Ortis, F. (2008) Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem. Soc. Trans. 36: 321-327. (Pubitemid 351839324)
-
(2008)
Biochemical Society Transactions
, vol.36
, Issue.3
, pp. 321-327
-
-
Eizirik, D.L.1
Moore, F.2
Flamez, D.3
Ortis, F.4
-
11
-
-
0021854805
-
A new in vitro model for the study of pancreatic A and B cells
-
Pipeleers, D.G., in't Veld, P.A., Van de Winkel, M., Maes, E., Schuit, F.C., Gepts, W. (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806-816. (Pubitemid 15019997)
-
(1985)
Endocrinology
, vol.117
, Issue.3
, pp. 806-816
-
-
Pipeleers, D.G.1
In't Veld, P.A.2
Van De Winkel, M.3
-
12
-
-
26644460214
-
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-γ-induced apoptosis in primary pancreatic β-cells
-
DOI 10.1074/jbc.M502213200
-
Rasschaert, J., Ladriere, L., Urbain, M., Dogusan, Z., Katabua, B., Sato, S., Akira, S, Gysemans, C., Mathieu, C., Eizirik, D.L. (2005) Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA + interferongamma- induced apoptosis in primary pancreatic beta-cells. J. Biol. Chem. 280: 33984-33991. (Pubitemid 41443119)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.40
, pp. 33984-33991
-
-
Rasschaert, J.1
Ladriere, L.2
Urbain, M.3
Dogusan, Z.4
Katabua, B.5
Sato, S.6
Akira, S.7
Gysemans, C.8
Mathieu, C.9
Eizirik, D.L.10
-
13
-
-
0028084965
-
Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
-
Ling, Z., Hannaert, J.C., Pipeleers, D. (1994) Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 37: 15-21. (Pubitemid 24044702)
-
(1994)
Diabetologia
, vol.37
, Issue.1
, pp. 15-21
-
-
Ling, Z.1
Hannaert, J.C.2
Pipeleers, D.3
-
14
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi, R., Dotta, F., Marselli, L., Del Guerra, S., Masini, M., Santangelo, C. Patané, G., Boggi, U., Piro, S., Anello, M., Bergamini, E., Mosca, F., Di Mario, U., Del Prato, S., Marchetti, P. (2002) Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442. (Pubitemid 34826609)
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
Di Mario, U.13
Del Prato, S.14
Marchetti, P.15
-
15
-
-
0030923812
-
Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
-
DOI 10.1210/en.138.6.2610
-
Delaney, C.A., Pavlovic, D., Hoorens, A., Pipeleers, D.G., Eizirik, D.L. (1997) Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138: 2610-2614. (Pubitemid 27215269)
-
(1997)
Endocrinology
, vol.138
, Issue.6
, pp. 2610-2614
-
-
Delaney, C.A.1
Pavlovic, D.2
Hoorens, A.3
Pipeleers, D.G.4
Eizirik, D.L.5
-
16
-
-
33747761923
-
On the art of identifying effective and specific siRNAs
-
DOI 10.1038/nmeth911, PII NMETH911
-
Pei, Y., Tuschl, T. (2006) On the art of identifying effective and specifi c siRNAs. Nat. Methods 3: 670-676. (Pubitemid 44275732)
-
(2006)
Nature Methods
, vol.3
, Issue.9
, pp. 670-676
-
-
Pei, Y.1
Tuschl, T.2
-
17
-
-
38449100230
-
A protocol for designing siRNAs with high functionality and specificity
-
DOI 10.1038/nprot.2007.278, PII NPROT.2007.278
-
Birmingham, A., Anderson, E., Sullivan, K., Reynolds, A., Boese, Q., Leake, D., Karpilow, J., Khvorova, A. (2007) A protocol for designing siRNAs with high functionality and specifi city. Nat. Protoc . 2: 2068-2078. (Pubitemid 351565844)
-
(2007)
Nature Protocols
, vol.2
, Issue.9
, pp. 2068-2078
-
-
Birmingham, A.1
Anderson, E.2
Sullivan, K.3
Reynolds, A.4
Boese, Q.5
Leake, D.6
Karpilow, J.7
Khvorova, A.8
-
18
-
-
15044358407
-
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites
-
DOI 10.1093/nar/gki312
-
Du, Q., Thonberg, H., Wang, J., Wahlestedt, C., Liang, Z. (2005) A systematic analysis of the silencing effects of an active siRNA at all singlenucleotide mismatched target sites. Nucleic Acids Res. 33: 1671-1677. (Pubitemid 41418395)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.5
, pp. 1671-1677
-
-
Du, Q.1
Thonberg, H.2
Wang, J.3
Wahlestedt, C.4
Liang, Z.5
-
19
-
-
33646891110
-
Induction of the interferon response by siRNA is cell type- and duplex length-dependent
-
DOI 10.1261/rna.2340906
-
Reynolds, A., Anderson, E.M., Vermeulen, A., Fedorov, Y., Robinson, K., Leake, D., Karpilow, J., Marshall, W.S., Khvorova, A. (2006) Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA 12: 988-993. (Pubitemid 43788117)
-
(2006)
RNA
, vol.12
, Issue.6
, pp. 988-993
-
-
Reynolds, A.1
Anderson, E.M.2
Vermeulen, A.3
Fedorov, Y.4
Robinson, K.5
Leake, D.6
Karpilow, J.7
Marshall, W.S.8
Khvorova, A.9
-
20
-
-
33644860608
-
Improving RNA interference in mammalian cells by 4′-thio-modified small interfering RNA (siRNA): Effect on siRNA activity and nuclease stability when used in combination with 2′-O-alkyl modifications
-
DOI 10.1021/jm050822c
-
Dande, P., Prakash, T.P., Sioufi N., Gaus, H., Jarres, R., Berdeja, A., Swayze, E.E., Griffey, R.H., Bhat, B. (2006) Improving RNA interference in mammalian cells by 4-thio-modifi ed small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2-O-alkyl modifi cations. J. Med. Chem. 49: 1624-1634. (Pubitemid 43376507)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.5
, pp. 1624-1634
-
-
Dande, P.1
Prakash, T.P.2
Sioufi, N.3
Gaus, H.4
Jarres, R.5
Berdeja, A.6
Swayze, E.E.7
Griffey, R.H.8
Bhat, B.9
-
21
-
-
11344257391
-
RNA interference using boranophosphate siRNAs: Structure-activity relationships
-
DOI 10.1093/nar/gkh936
-
Hall, A.H., Wan, J., Shaughnessy, E.E., Ramsay, S.B., Alexander, K.A. (2004) RNA interference using boranophosphate siRNAs: structureactivity relationships. Nucleic Acids Res. 32: 5991-6000. (Pubitemid 40073994)
-
(2004)
Nucleic Acids Research
, vol.32
, Issue.20
, pp. 5991-6000
-
-
Hall, A.H.S.1
Wan, J.2
Shaughnessy, E.E.3
Shaw, B.R.4
Alexander, K.A.5
-
22
-
-
62549121199
-
RNA interference in mammalian cells by siRNAs modifi ed with morpholino nucleoside analogues
-
Zhang, N., Tan, C., Cai, P., Zhang, P., Zhao, Y., Jiang, Y. (2009) RNA interference in mammalian cells by siRNAs modifi ed with morpholino nucleoside analogues. Bioorg. Med. Chem . 17: 2441-2446.
-
(2009)
Bioorg. Med. Chem .
, vol.17
, pp. 2441-2446
-
-
Zhang, N.1
Tan, C.2
Cai, P.3
Zhang, P.4
Zhao, Y.5
Jiang, Y.6
-
23
-
-
0037804642
-
Whither RNAi?
-
Editorial Comment
-
Editorial Comment (2003) Whither RNAi? Nat. Cell Biol . 5: 489-490.
-
(2003)
Nat. Cell Biol .
, vol.5
, pp. 489-490
-
-
-
24
-
-
66649132790
-
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
-
Moore, F., Colli, M.L., Cnop, M., Esteve, M.I., Cardozo, A.K., Cunha, D.A., Buglian, M., Marchetti, P., Eizirik, D.L. (2009) PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes 58: 1283-1291.
-
(2009)
Diabetes
, vol.58
, pp. 1283-1291
-
-
Moore, F.1
Colli, M.L.2
Cnop, M.3
Esteve, M.I.4
Cardozo, A.K.5
Cunha, D.A.6
Buglian, M.7
Marchetti, P.8
Eizirik, D.L.9
-
25
-
-
0029797603
-
Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program
-
Hoorens, A., Van de Casteele, M., Kloppel, G., Pipeleers, D. (1996) Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J. Clin. Invest. 98: 1568-1574. (Pubitemid 26327866)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.7
, pp. 1568-1574
-
-
Hoorens, A.1
Van De Casteele, M.2
Kloppel, G.3
Pipeleers, D.4
-
26
-
-
0035668779
-
A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis
-
DOI 10.1007/s001250100021
-
Eizirik, D.L., Mandrup-Poulsen, T. (2001) A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44: 2115-2133. (Pubitemid 34015464)
-
(2001)
Diabetologia
, vol.44
, Issue.12
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
27
-
-
78651389664
-
STAT1 is a master regulator of pancreatic beta cell apoptosis and islet infl ammation
-
Moore, F., Naamane, N., Colli, M.L., Bouckenooghe, T., Ortis, F., Gurzov, E.N., Igoillo-Esteve, M., Mathieu, C., Bontempi, G., Thykjaer, T., ørntoft, T.F., Eizirik, D.L. (2011) STAT1 is a master regulator of pancreatic beta cell apoptosis and islet infl ammation. J. Biol. Chem. 286: 929-941.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 929-941
-
-
Moore, F.1
Naamane, N.2
Colli, M.L.3
Bouckenooghe, T.4
Ortis, F.5
Gurzov, E.N.6
Igoillo-Esteve, M.7
Mathieu, C.8
Bontempi, G.9
Thykjaer, T.10
Ørntoft, T.F.11
Eizirik, D.L.12
-
28
-
-
34547561721
-
Deletion of STAT-1 pancreatic islets protects against streptozotocin- induced diabetes and early graft failure but not against late rejection
-
DOI 10.2337/db07-0052
-
Callewaert, H.I., Gysemans, C.A., Ladriere, L., D'Hertog, W., Hagenbrock, J., Overbergh, L. Eizirik, D.L., Mathieu C. (2007) Deletion of STAT-1 pancreatic islets protects against streptozotocin- induced diabetes and early graft failure but not against late rejection. Diabetes 56: 2169-2173. (Pubitemid 47195839)
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 2169-2173
-
-
Callewaert, H.I.1
Gysemans, C.A.2
Ladriere, L.3
D'Hertog, W.4
Hagenbrock, J.5
Overbergh, L.6
Eizirik, D.L.7
Mathieu, C.8
-
29
-
-
23644437526
-
Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β-cells
-
DOI 10.2337/diabetes.54.8.2396
-
Gysemans, C.A., Ladriere, L., Callewaert, H., Rasschaert, J., Flamez, D., Levy, D.E., Matthys, P., Eizirik, D.L., Mathieu, C. (2005) Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 54: 2396-2403. (Pubitemid 41134268)
-
(2005)
Diabetes
, vol.54
, Issue.8
, pp. 2396-2403
-
-
Gysemans, C.A.1
Ladriere, L.2
Callewaert, H.3
Rasschaert, J.4
Flamez, D.5
Levy, D.E.6
Matthys, P.7
Eizirik, D.L.8
Mathieu, C.9
-
30
-
-
33646187810
-
Highthroughput RNAi screening in cultured cells: A user's guide
-
Echeverri, C.J., Perrimon, N. (2006) Highthroughput RNAi screening in cultured cells: a user's guide. Nat. Rev. Genet. 7: 373-384.
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 373-384
-
-
Echeverri, C.J.1
Perrimon, N.2
-
31
-
-
23844483215
-
Identification of JAK/STAT signalling components by genome-wide RNA interference
-
DOI 10.1038/nature03869
-
Muller, P., Kuttenkeuler, D., Gesellchen, V., Zeidler, M.P., Boutros, M. (2005) Identifi cation of JAK/STAT signalling components by genome-wide RNA interference. Nature 436: 871-875. (Pubitemid 41160648)
-
(2005)
Nature
, vol.436
, Issue.7052
, pp. 871-875
-
-
Muller, P.1
Kuttenkeuler, D.2
Gesellchen, V.3
Zeidler, M.P.4
Boutros, M.5
-
32
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
DOI 10.1038/nature02371
-
Berns, K., Hijmans, E.M., Mullenders, J., Brummelkamp, T.R., Velds, A., Heimerikx, M. Kerkhoven, R.M., Madiredjo, M., Nijkamp, W., Weigelt, B., Agami, R., Ge, W., Cavet, G., Linsley, P.S., Beijersbergen, R.L., Bernards, R. (2004) A large-scale RNAi screen in human cells identifi es new components of the p53 pathway. Nature 428: 431-437. (Pubitemid 38419689)
-
(2004)
Nature
, vol.428
, Issue.6981
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madlredjo, M.8
Nijkamp, W.9
Weigelt, B.10
Agami, R.11
Ge, W.12
Cavet, G.13
Linsley, P.S.14
Beijersbergen, R.L.15
Bernards, R.16
|