Exposure to the viral by-product dsrna or coxsackievirus b5 triggers pancreatic beta cell apoptosis via a bim/ mcl-1 imbalance

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Colli, Maikel L ^a   Nogueira, Tatiane C ^a   Allagnat, Florent ^a   Cunha, Daniel A ^a   Gurzov, Esteban N ^a   Cardozo, Alessandra K ^a   Roivainen, Merja ^b   de beeck, Anne Op ^a   Eizirik, Decio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BH3 PROTEIN; BIM PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; DOUBLE STRANDED RNA; INITIATION FACTOR 2ALPHA; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN BCL 2; PROTEIN KINASE R; PROTEIN MCL 1; SMALL INTERFERING RNA; THAPSIGARGIN; TUBULIN; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; INITIATION FACTOR 2; MEMBRANE PROTEIN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; ONCOPROTEIN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; COXSACKIE VIRUS B; COXSACKIE VIRUS B5; COXSACKIE VIRUS INFECTION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; GENETIC TRANSFECTION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VIRUS CAPSID; ANIMAL; CELL LINE; ENTEROVIRUS; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; PHOSPHORYLATION; VIROLOGY; WISTAR RAT;

COXSACKIEVIRUS; ENTEROVIRUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CELL SURVIVAL; COXSACKIEVIRUS INFECTIONS; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS B, HUMAN; EUKARYOTIC INITIATION FACTOR-2; HUMANS; INSULIN-SECRETING CELLS; MALE; MEMBRANE PROTEINS; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RNA, DOUBLE-STRANDED; RNA, VIRAL;

EID: 80053435959     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002267     Document Type: Article

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