Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated bim protein activation

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39632-39643

  Barthson, Jenny ^a   Germano, Carla M ^a   Moore, Fabrice ^a   Maida, Adriano ^b   Drucker, Daniel J ^b   Marchetti, Piero ^c   Gysemans, Conny ^d   Mathieu, Chantal ^d   Nuñez, Gabriel ^e   Jurisicova, Andrea ^b   Eizirik, Decio L ^a   Gurzov, Esteban N ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATOR PROTEINS; CASPASES; CELL APOPTOSIS; CELL LOSS; CONTEXT DEPENDENT; CYTOKINES; DATA SUPPORT; HUMAN ISLETS; KNOCK OUTS; MITOCHONDRIAL PATHWAYS; MOLECULAR MECHANISM; P53 UP-REGULATED MODULATOR OF APOPTOSIS; PANCREATIC ISLET; PROTEIN ACTIVATION; RNA INTERFERENCE; TUMOR NECROSIS FACTORS; TYPE 1 DIABETES;

ANTIBIOTICS; CHEMICAL ACTIVATION; GLYCOPROTEINS; MACROPHAGES; MAMMALS; MITOCHONDRIA; RNA; TUMORS;

CELL DEATH;

BH3 PROTEIN; BIM PROTEIN; CYTOCHROME C; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN C JUN; PROTEIN DP5; PUMA PROTEIN; SMALL INTERFERING RNA; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INSULITIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION INITIATION; UPREGULATION;

ADULT; AGED; ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MIDDLE AGED; NEUROPEPTIDES; PROTO-ONCOGENE PROTEINS; STAT1 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

MUS; RODENTIA;

EID: 80655144735     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.253591     Document Type: Article

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