Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Kissner, Teri L ^a   Ruthel, Gordon ^a   Alam, Shahabuddin ^a   Mann, Enrique ^b   Ajami, Dariush ^b   Rebek, Mitra ^b   Larkin, Eileen ^a   Fernandez, Stefan ^a   Ulrich, Robert G ^a   Ping, Sun ^c   Waugh, David S ^c   Rebek, Julius ^c   Saikh, Kamal U ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EM 163; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN INHIBITOR; STAPHYLOCOCCUS ENTEROTOXIN B; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEATH; DRUG SYNTHESIS; EXPOSURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTOXICATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTECTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TOXIC SHOCK SYNDROME; WESTERN BLOTTING;

ANIMALS; BIOMIMETIC MATERIALS; CYTOKINES; ENTEROTOXINS; HUMANS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

MUS;

EID: 84864408767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040773     Document Type: Article

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