Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes

APMIS

Volumn 121, Issue 6, 2013, Pages 531-538

  Ladefoged, Mette ^a   Buschard, Karsten ^b   Hansen, Ann Maria Kruse ^a  

^a NOVO NORDISK A S   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

Cytokines; Db db mouse; Interleukin 6; Islets of Langerhans; Toll like receptor 4; Type 2 diabetes

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTERLEUKIN-6; ISLETS OF LANGERHANS; MALE; MICE; MICE, OBESE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878263657     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12018     Document Type: Article

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