Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles

Toxicological Sciences

Volumn 77, Issue 2, 2004, Pages 347-357

  Bermudez, Edilberto ^a   Mangum, James B ^a   Wong, Brian A ^a   Asgharian, Bahman ^a   Hext, Paul M ^b   Warheit, David B ^c   Everitt, Jeffrey I ^d  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^c DUPONT COMPANY   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Hamsters; Inhalation; Lung response; Mice; Rats; Ultrafine titanium dioxide

Indexed keywords

LACTATE DEHYDROGENASE; TITANIUM DIOXIDE;

AEROSOL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; DOSIMETRY; DRY WEIGHT; EXPOSURE; FEMALE; HAMSTER; HISTOPATHOLOGY; LEUKOCYTE COUNT; LEUKOCYTE FUNCTION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG CLEARANCE; LUNG FIBROSIS; LUNG INJURY; LUNG INTERSTITIUM; LUNG LAVAGE; LUNG TOXICITY; LYMPH NODE; METAPLASIA; MOUSE; NEUTROPHIL; NONHUMAN; PARTICLE SIZE; PNEUMONIA; RAT; SPECIES DIFFERENCE;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE; CELL DIVISION; COLORING AGENTS; CRICETINAE; FEMALE; INFLAMMATION; LUNG; LYMPH NODES; MICE; MICE, INBRED STRAINS; PARTICLE SIZE; RATS; RATS, INBRED STRAINS; RESPIRATORY MECHANICS; SPECIES SPECIFICITY; TIME FACTORS; TITANIUM; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; CRICETINAE; RODENTIA;

EID: 1342267646     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh019     Document Type: Article

References (29)

1. Baggs, R. B., Ferin, J., and Oberdorster, G. (1997). Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet. Pathol. 34, 592-597.
2. Bajpai, R., Waseem, M., Gupta, G. S., and Kaw, J. L. (1992). Ranking toxicity of industrial dusts by bronchoalveolar lavage fluid analysis. Toxicology 73, 161-167.
3. Bermudez, E., Mangum, J. B., Asgharian, B., Wong, B. A., Reverdy, E. E., Janszen, D. B., Hext, P. M., Warheit, D. B., and Everitt, J. I. (2002). Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol. Sci. 70, 86-97.
4. Bingham, E., Corhssen, B., and Powell, C. H., Eds. (2002). Patty's Toxicology, Vol. 2. Wiley, New York.
5. Creutzenberg, O., Bellmann, B., Heinrich, U., Fuhst, R., Koch, W., and Muhle, H. (1990). Clearance and retention of inhaled diesel exhaust particles, carbon black, and titanium dioxide in rats at lung overload conditions. J. Aerosol Sci. 21, S455-S458.
6. 2, and crystalline silica, utilizing a tracer technique during chronic inhalation exposure in Syrian golden hamsters. Inhal. Toxicol. 10, 731-751.
7. Cullen, R. T., Tran, C. L., Buchanan, D., Davis, J. M., Searl, A., Jones, A. D., and Donaldson, K. (2000). Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Inhal. Toxicol. 12, 1089-1111.
8. Donaldson, K., Li, X. Y., and MacNee, W. (1998). Ultrafine (nanometre) particle mediated lung injury. J. Aerosol Sci. 29, 553-560.
9. Donaldson, K. (2000). Nonneoplastic lung responses induced in experimental animals by exposure to poorly soluble nonfibrous particles. Inhal. Toxicol. 12, 121-139.
10. Donaldson, K., and Tran, C. L. (2002). Inflammation caused by particles and fibers. Inhal. Toxicol. 14, 5-27.
11. Donaldson, K., Brown, D., Clouter, A., Duffin, R., MacNee, W., Renwick, L., Tran, L., and Stone, V. (2002). The pulmonary toxicology of ultrafine particles. J. Aerosol Med. 15, 213-220.
12. Driscoll, K. E., Lindenschmidt, R. C., Maurer, J. K., Higgins, J. M., and Ridder, G. (1990). Pulmonary response to silica or titanium dioxide: Inflammatory cells, alveolar macrophage-derived cytokines, and histopathology. Am. J. Respir. Cell Mol. Biol. 2, 381-390.
13. Ferin, J., Oberdorster, G., and Penney, D. P. (1992). Pulmonary retention of ultrafine and fine particles in rats. Am. J. Respir. Cell Mol. Biol. 6, 535-542.
14. Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., Fuhst, R., Mohr, U., Pott, F., and Stober, W. (1986). Chronic effects on the respiratory tract of hamsters, mice, and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J. Appl. Toxicol. 6, 383-395.
15. Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., and Levsen, K. (1995). Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 7, 533-556.
16. Hext, P. M. (1994). Current perspectives on particulate induced pulmonary tumours. Hum. Exp. Toxicol. 13, 700-715.
17. Janssen, Y. M., Marsh, J. P., Driscoll, K. E., Borm, P. J., Oberdorster, G., and Mossman, B. T. (1994). Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. Free Radic. Biol. Med. 16, 315-322.
18. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79, 179-192.
19. Levine, K. E., Fernando, R. A., Lang, M., Essader, A., and Wong, B. A. (2003). Development and validation of a high-throughput method for the determination of titanium dioxide in rodent lung and lung-associated lymph node tissues. Anal. Lett. 36, 563-576.
20. Li, X. Y., Brown, D., Smith, S., MacNee, W., and Donaldson, K. (1999). Short-term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal. Toxicol. 11, 709-731.
21. Mauderly, J. L., Jones, R. K., Griffith, W. C., Henderson, R. F., and McClellan, R. O. (1987). Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. Appl. Toxicol. 9, 208-221.
22. Mauderly, J. L., Snipes, M. B., Barr, E. B., Belinsky, S. A., Bond, J. A., Brooks, A. L., Chang, I. Y., Cheng, Y. S., Gillett, N. A., Griffith, W. C., et al. (1994). Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I. Neoplastic and nonneoplastic lung lesions. Res. Rep. Health Eff. Inst. 68, 1-75; discussion 77-97.
23. Morrow, P. E. (1992). Dust overloading of the lungs: Update and appraisal. Toxicol. Appl. Pharmacol. 113, 1-12.
24. 2, and crystalline silica upon chronic inhalation exposure in Syrian golden hamsters. Inhal. Toxicol. 10, 699-729.
25. Muhle, H., Creutzenberg, O., Bellmann, B., Heinrich, U., and Mermelstein, R. (1990). Dust overloading of lungs: Investigations of various materials, species differences, and irreversibility of effects. J. Aerosol Med. 3, S111-S128.
26. Oberdorster, G., Ferin, J., Gelein, R., Soderholm, S. C., and Finkelstein, J. (1992). Role of the alveolar macrophage in lung injury: Studies with ultrafine particles. Environ. Health Perspect. 97, 193-199.
27. Oberdorster, G. (1996). Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal. Toxicol. 8, 73-89.
28. Rutten, A. A., Bermudez, E., Mangum, J. B., Wong, B. A., Moss, O. R., and Everitt, J. I. (1994). Mesothelial cell proliferation induced by intrapleural instillation of man-made fibers in rats and hamsters. Fundam. Appl. Toxicol. 23, 107-116.
29. Warheit, D. B., Hansen, J. F., Yuen, I. S., Kelly, D. P., Snajdr, S. I., and Hartsky, M. A. (1997). Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation. Toxicol. Appl. Pharmacol. 145, 10-22.