Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides

Biophysical Journal

Volumn 100, Issue 11, 2011, Pages 2652-2661

  Kaconis, Yani ^a   Kowalski, Ina ^a   Howe, Jörg ^a   Brauser, Annemarie ^a   Richter, Walter ^b   Razquin Olazarán, Iosu ^c   Inĩgo Pestaña, Melania ^c   Garidel, Patrick ^d,e   Rössle, Manfred ^f   De Tejada, Guillermo Martinez ^c   Gutsmann, Thomas ^b   Brandenburg, Klaus ^b  

^a RESEARCH CENTER BORSTEL   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF NAVARRA   (Spain)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^e Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^f EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); MAMMALIA; SALPIDA;

EID: 79960327681     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.04.041     Document Type: Article

References (40)

1. Rietschel, E. Th., T. Kirikae, ..., Di Padova. 1994. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8:217-225. (Pubitemid 24067145)
2. Rietschel, E. T., H. Brade, ..., R. R. Schumann. 1996. Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification. Curr. Top. Microbiol. Immunol. 216:39-81. (Pubitemid 28012915)
3. Springer, J., M. Safley, ..., R. R. McGoey. 2010. Histopathological findings in fatal novel H1N1: an autopsy case series from September-November 2009 in New Orleans, LA. J. LA. State Med. Soc. 162:88-91.
4. Brandenburg, K., G. Jürgens, ..., M. H. Koch. 2001. Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin. Biol. Chem. 382:1215-1225. (Pubitemid 32894028)
5. Andrä, J., M. H. J. Koch, ..., K. Brandenburg. 2004. Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin. Antimicrob. Agents Chemother. 48:1593-1599. (Pubitemid 38544364)
6. Andrä, J., P. Garidel, ..., K. Brandenburg. 2004. Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide. Eur. J. Biochem. 271: 2037-2046. (Pubitemid 38657356)
7. Dankesreiter, S., A. Hoess, ..., T. Miethke. 2000. Synthetic endotoxinbinding peptides block endotoxin-triggered TNF-a production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J. Immunol. 164:4804-4811. (Pubitemid 30238083)
8. Garidel, P., and K. Brandenburg. 2009. Current understanding of polymyxin B application in bacteraemia/sepsis therapy prevention: clinical, pharmaceutical, structural and mechanistic aspects. Anti-Infect. Agents Med. Chem. 8:367-385.
9. Brandenburg, K., A. B. Schromm, and T. Gutsmann. 2010. Endotoxins: relationship between structure, function, and activity. Subcell. Biochem. 53:53-67.
10. Gutsmann, T., I. Razquin-Olazarán, ..., K. Brandenburg. 2010. New antiseptic peptides to protect against endotoxin-mediated shock. Antimicrob. Agents Chemother. 54:3817-3824.
11. Galanos, C., O. Lüderitz, and O.Westphal. 1969. A new method for the extraction of R lipopolysaccharides. Eur. J. Biochem. 9:245-249.
12. Hirschfeld, M., Y. Ma, ..., J. J.Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165:618-622. (Pubitemid 30484724)
13. Garidel, P., M. Rappolt, ..., K. Brandenburg. 2005. Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity. Biochim. Biophys. Acta. 1715:122-131. (Pubitemid 41219700)
14. Schromm, A. B., K. Brandenburg, ..., U. Seydel. 1996. Lipopolysaccharide- binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes. FEBS Lett. 399:267-271. (Pubitemid 26426864)
15. Brandenburg, K., I. Moriyon, ..., U. Seydel. 2002. Biophysical investigations into the interaction of lipopolysaccharide with polymyxins. Thermochim. Acta. 382:189-198.
16. Brandenburg, K., S. Kusumoto, and U. Seydel. 1997. Conformational studies of synthetic lipid A analogues and partial structures by infrared spectroscopy. Biochim. Biophys. Acta. 1329:183-201. (Pubitemid 27464813)
17. Howe, J., J. Andrä, ..., K. Brandenburg. 2007. Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B. Biophys. J. 92:2796-2805. (Pubitemid 46557854)
18. Seydel, U., M. H. J. Koch, and K. Brandenburg. 1993. Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota. J. Struct. Biol. 110:232-243.
19. Roessle, M., R. Klaering, ..., D. Svergun. 2007. Upgrade of the smallangle X-ray scattering beamline at the European Molecular Biology Laboratory, Hamburg. J. Appl. Cryst. 40:190-194.
20. Andrä, J., J. Howe, ..., K. Brandenburg. 2007. Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. Biochem. J. 406:297-307. (Pubitemid 47310960)
21. Andrä, J., M. Lamata, ..., K. Brandenburg. 2004. Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide. Biochem. Pharmacol. 68:1297-1307. (Pubitemid 39185859)
22. Galanos, C., M. A. Freudenberg, and W. Reutter. 1979. Galactosamineinduced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA. 76:5939-5943. (Pubitemid 10216692)
23. Brandenburg, K., and A. Wiese. 2004. Endotoxins: relationships between structure, function, and activity. Curr. Top. Med. Chem. 4: 1127-1146. (Pubitemid 38930792)
24. Gutsmann, T., J. Howe, ..., K. Brandenburg. 2010. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. Innate Immun. 16:39-47.
25. Vaara, M., and T. Vaara. 1983. Polycations sensitize enteric bacteria to antibiotics. Antimicrob. Agents Chemother. 24:107-113. (Pubitemid 13076187)
26. Andrä, J., T. Gutsmann, ..., K. Brandenburg. 2006. Mechanisms of endotoxin neutralization by synthetic cationic compounds. J. Endotoxin Res. 12:261-277. (Pubitemid 47471338)
27. Rosenfeld, Y., H. G. Sahl, and Y. Shai. 2008. Parameters involved in antimicrobial and endotoxin detoxification activities of antimicrobial peptides. Biochemistry. 47:6468-6478. (Pubitemid 351874238)
28. Rosenfeld, Y., N. Papo, and Y. Shai. 2006. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. J. Biol. Chem. 281:1636-1643.
29. Tobias, P. S., K. Soldau, ..., J.Weiss. 1997. Lipopolysaccharide (LPS)- binding proteins BPI and LBP form different types of complexes with LPS. J. Biol. Chem. 272:18682-18685. (Pubitemid 27318211)
30. Brandenburg, K., M. H. J. Koch, and U. Seydel. 1992. Phase diagram of deep rough mutant lipopolysaccharide from Salmonella minnesota R595. J. Struct. Biol. 108:93-106.
31. Brandenburg, K., M. H. J. Koch, and U. Seydel. 1990. Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide. J. Struct. Biol. 105:11-21.
32. Richter, W., V. Vogel, ..., K. Brandenburg. 2010. Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin. Innate. Immun., Aug 3 [Epub ahead of print].
33. Tobias, P. S., J. Gegner, ..., R. J. Ulevitch. 1994. LPS binding protein and CD14 in the LPS dependent activation of cells. Prog. Clin. Biol. Res. 388:31-39.
34. Tobias, P. S., K. Soldau, ..., R. J. Ulevitch. 1995. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270:10482-10488.
35. Kirkland, T. N., F. Finley, ..., P. S. Tobias. 1993. Analysis of lipopolysaccharide binding by CD14. J. Biol. Chem. 268:24818-24823. (Pubitemid 23335496)
36. Seydel, U., M. Oikawa, ..., K. Brandenburg. 2000. Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity. Eur. J. Biochem. 267:3032-3039. (Pubitemid 30321351)
37. Calhoun, W. I., and G. G. Shipley. 1979. Sphingomyelin-lecithin bilayers and their interaction with cholesterol. Biochemistry. 18:1717- 1722. (Pubitemid 9190401)
38. Untrach, S. H., and G. G. Shipley. 1977. Molecular interactions between lecithin and sphingomyelin. Temperature- and compositiondependent phase separation. J. Biol. Chem. 252:4449-4457. (Pubitemid 8155960)
39. Gandhavadi, M., D. Allende, ..., T. J. McIntosh. 2002. Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. Biophys. J. 82:1469-1482. (Pubitemid 34204767)
40. Opal, S. M., P. J. Scannon, ..., J. H. Lemke. 1999. Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J. Infect. Dis. 180:1584-1589. (Pubitemid 29506461)