Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

Journal of Leukocyte Biology

Volumn 91, Issue 6, 2012, Pages 967-976

  Honda, Hiroe ^a,b   Nagai, Yoshinori ^b   Matsunaga, Takayuki ^a   Saitoh, Shin Ichiro ^c   Akashi Takamura, Sachiko ^c   Hayashi, Hiroaki ^d   Fujii, Isao ^d   Miyake, Kensuke ^c   Muraguchi, Atsushi ^b   Takatsu, Kiyoshi ^a,b  

^a Toyama Prefectural Institute for Pharmaceutical Research   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Glycyrrhiza uralensis; IL 6; Innate immunity; MAPK; NF B

Indexed keywords

CD14 ANTIGEN; CHALCONE; FLAVANONE; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOLIQUIRITIGENIN; LIPID A; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; PROTEIN MD 2; SAPONIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; GLYCYRRHIZA URALENSIS; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD14; CELL LINE; CHALCONES; ENZYME INHIBITORS; GLYCYRRHIZA URALENSIS; GLYCYRRHIZIC ACID; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; PROTEIN MULTIMERIZATION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

GLYCYRRHIZA URALENSIS; MUS;

EID: 84861933674     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0112038     Document Type: Article

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