Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis

Shock

Volumn 37, Issue 5, 2012, Pages 548-555

  Xie, Keliang ^a   Yu, Yonghao ^a   Huang, Yi ^b   Zheng, Lina ^c   Li, Jipeng ^b   Chen, Hongguang ^a   Han, Huanzhi ^a   Hou, Lichao ^b   Gong, Gu ^d   Wang, Guolin ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^d CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Acute lung injury; Apoptosis; Chemokines; Hydrogen gas; Inflammation

Indexed keywords

CASPASE 3; HIGH MOBILITY GROUP B1 PROTEIN; HYDROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HISTOPATHOLOGY; LUNG ALVEOLUS CELL; LUNG LAVAGE; LUNG WEIGHT; MALE; MOUSE; NEUTROPHIL; NICK END LABELING; NONHUMAN; OXYGEN TENSION; OXYGENATION; PNEUMONIA; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; CYTOKINES; HYDROGEN; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; NF-KAPPA B;

EID: 84859903016     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31824ddc81     Document Type: Article

References (35)

1. Rubenfeld GD, Herridge MS: Epidemiology and outcomes of acute lung injury. Chest 131:554-562, 2007. (Pubitemid 46280419)
2. Avecillas JF, Freire AX, Arroliga AC: Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes. Clin Chest Med 27:549-557, 2006. (Pubitemid 44666245)
3. Wheeler AP, Bernard GR: Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 369:1553-1564, 2007. (Pubitemid 46670280)
4. Imanifooladi AA, Yazdani S, Nourani MR: The role of nuclear factor-kappaB in inflammatory lung disease. Inflamm Allergy Drug Targets 9:197-205, 2010.
5. Huang Y, Xie K, Li J, Xu N, Gong G, Wang G, Yu Y, Dong H, Xiong L: Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Res 1378:125-136, 2011.
6. Zheng J, Liu K, Kang Z, Cai J, Liu W, Xu W, Li R, Tao H, Zhang JH, Sun X: Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med 37:185-192, 2010.
7. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13: 688-694, 2007. (Pubitemid 46889750)
8. Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 361:670-674, 2007. (Pubitemid 47238041)
9. Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant 8:2015-2024, 2008.
10. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et al.: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 373:30-35, 2008.
11. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G: Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock 34:90-97, 2010.
12. Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, Hou L, Wang G: Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model. Shock 34:495-501, 2010.
13. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, et al.: Supplementation of hydrogenrich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 28:137-143, 2008. (Pubitemid 351452069)
14. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S: Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 377:1195-1198, 2008.
15. Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, et al.: Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett 453:81-85, 2009.
16. Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X: Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res 1256:129-137, 2009.
17. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int 77:101-109, 2010.
18. Ji X, Liu W, Xie K, Qu Y, Chao X, Chen T, Zhou J, Fei Z: Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Res 1354:196-205, 2010.
19. Huang CS, Kawamura T, Toyoda Y, Nakao A: Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res 44:971-982, 2010.
20. Sun H, Chen L, ZhouW, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, et al.: The protective role of hydrogen-rich saline in experimental liver injury in mice. J Hepatol 54:471-480, 2011.
21. Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, Nakao A, Toyoda Y: Hydrogen inhalation reduced epithelial apoptosis in ventilatorinduced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun 408:253-258, 2011.
22. Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A: Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care 14:R234, 2010.
23. Sun Q, Cai J, Liu S, Liu Y, Xu W, Tao H, Sun X: Hydrogen-rich saline provides protection against hyperoxic lung injury. J Surg Res 165:e43-e49, 2011.
24. Matute-Bello G, Frevert CW, Martin TR: Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295:L379-L399, 2008.
25. Bhandary YP, Velusamy T, Shetty P, Shetty RS, Idell S, Cines DB, Jain D, Bdeir K, Abraham E, Tsuruta Y, et al.: Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharideinduced acute lung injury. Am J Respir Crit Care Med 179:288-298, 2009.
26. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, et al.: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 12:1286-1293, 2006. (Pubitemid 44706931)
27. D'Agostini F, Izzotti A, Bennicelli C, Camoirano A, Tampa E, De Flora S: Induction of apoptosis in the lung but not in the liver of rats receiving intratracheal instillations of chromium(VI). Carcinogenesis 23:587-593, 2002. (Pubitemid 34498495)
28. Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M: Nuclear factorkappaB activation in neonatal mouse lung protects against lipopolysaccharideinduced inflammation. Am J Respir Crit Care Med 175:805-815, 2007. (Pubitemid 46631792)
29. Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y: Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation 90:1344-1351, 2010.
30. Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, et al.: Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol 301:L415-L426, 2011
31. Fang Y, Fu XJ, Gu C, Xu P, Wang Y, Yu WR, Sun Q, Sun XJ, Yao M: Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res 32:e82-e91, 2011.
32. Liu S, Liu K, Sun Q, Liu W, Xu W, Denoble P, Tao H, Sun X: Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol 2011:305086, 2011.
33. Galani V, Tatsaki E, Bai M, Kitsoulis P, Lekka M, Nakos G, Kanavaros P: The role of apoptosis in the pathophysiology of acute respiratory distress syndrome (ARDS): an up-to-date cell-specific review. Pathol Res Pract 206:145-150, 2010.
34. Kaufmann SH, Lee SH, Meng XW, Loegering DA, Kottke TJ, Henzing AJ, Ruchaud S, Samejima K, Earnshaw WC: Apoptosis-associated caspase activation assays. Methods 44:262-272, 2008. (Pubitemid 351296442)
35. Song G, Tian H, Liu J, Zhang H, Sun X, Qin S: H2 inhibits TNF-!Yinduced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor .B activation in endothelial cells. Biotechnol Lett 33:1715-1722, 2011.