Aluminum as an adjuvant in Crohn's disease induction

Lupus

Volumn 21, Issue 2, 2012, Pages 231-238

  Lerner, A ^a,b  

^a CARMEL MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

adjuvant; aluminum; Crohn's disease; environmental factor; intestine; pathogenesis

Indexed keywords

ALUMINUM; CHEMOKINE; CYTOKINE; INFLAMMASOME; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ADSORPTION; ARTICLE; AUTOIMMUNE DISEASE; CHRONIC DISEASE; CROHN DISEASE; DIET; ENVIRONMENTAL FACTOR; EXPOSURE; GENETIC SUSCEPTIBILITY; GRANULOMA; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; INFLAMMATORY DISEASE; INNATE IMMUNITY; INTESTINE FLORA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELAPSE; STRESS; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM; ANIMALS; CROHN DISEASE; ENVIRONMENT; HUMANS; INFLAMMATION; INTESTINAL MUCOSA;

EID: 84855820668     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203311430090     Document Type: Article

References (59)

1. Sartor RB. Key questions to guide a better understanding of host-commensal microbiota interactions in intestinal inflammation. Mucosal Immunol. 2011 ; 4: 127-132
2. Bamias G, Nyce MR, De La Rue SA, Cominelli F. New concepts in the pathophysiology of inflammatory bowel disease. Ann Inter Med. 2005 ; 143: 895-904 (Pubitemid 46202223)
3. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004 ; 126: 1620-1633 (Pubitemid 38649878)
4. Lerner A, Shoenfeld Y. Serological markers in inflammatory bowel disease: the pros and cons. Eur J Gastroenterol Hepatol. 2002 ; 14: 103-105 (Pubitemid 34163987)
5. Mahmud N, Weir DG. The urban diet and Crohn's disease: is there a relationship?. Eur J Gastroenterol Hepatol. 2001 ; 13: 93-95 (Pubitemid 32158199)
6. Xia TL, Li N, Nel AE. Potential health impact of nanoparticles. Ann Rev Pub Health. 2009 ; 30: 137-150
7. Powell JJ, Faria N, Thomas-McKay E, Pele LC. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun. 2010 ; 34: j226 - j233
8. Ganrot PO Inflammatory bowel disease. Jarnerot G, ed. New York: Raven Press ; 1987: 119-128.
9. Perl DP, Fogarty U, Harpaz N, et al. Bacterial-metal interactions: the potential role of aluminum and other trace elements in the etiology of Crohn's disease. Inflamm Bowel Dis. 2004 ; 10: 881-883 (Pubitemid 39545232)
10. Lerner A. Extended hypothesis: Aluminum is a potential environmental factor for Crohn's disease induction. Ann N Y Acad Sci. 2007 ; 1107: 329-345 (Pubitemid 47528810)
11. Lomer MC, Thompson RP, Powell JJ. Fine and ultrafine particles of the diet: influence on the mucosal immune response and association with Crohn's disease. Proc Nutr Soc. 2002 ; 61: 123-130 (Pubitemid 34173020)
12. Shepherd NA, Crocker PR, Smith AP. Exogenous pigment in Peyer's patches. Hum Pathol. 1987 ; 18: 50-54 (Pubitemid 17026158)
13. Urbanski SJ, Arsenault AL, Green FH. Pigment resembling atmospheric dust in Peyer's patches. Mod Pathol. 1989 ; 2: 222-226
14. Powell JJ, Ainley C, Harvey RS. Characterization of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. Gut. 2007 ; 38: 390-395
15. Powell JJ, Thoree V, Pele LC. Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract. Br J Nutr. 2007 ; 98: s59 - s63
16. Chess S, Chess D, Olander G, et al. Production of chronic enteritis and other systemic lesions by ingestion of finely divided foreign materials. Surgery. 1950 ; 27: 220-234
17. Fogarty U, Perl D, Good P. A cluster of equine granulomatous enteritis cases: the link with aluminium. Vet Hum Toxicol. 1998 ; 40: 297-305 (Pubitemid 28442975)
18. Lerner A, Eluri S, Perl D, et al. Bacterial-aluminum interactions. The role of aluminum in bacterial-induced colitis in IL-10 deficient mice. Gastroenterology. 2006 ; 130: 362-363
19. Di Sabatino A, Ciccocioppo R, Luinetti O, et al. Increased enterocyte apoptosis in inflamed areas of Crohn's disease. Dis Colon Rectum. 2003 ; 46: 1498-1507 (Pubitemid 37429731)
20. Lerner A. New therapeutic strategies for celiac disease. Autoimmun Rev. 2010 ; 9: 144-147
21. Salim SY, Soderholm JD. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis. 2011 ; 17: 362-381
22. Zaki MH, Lamkanfi M, Kanneganti TD. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol. 2011 ; 32: 171-179
23. Aimanianda V, Haensler J, Lacroix-desmazes S, Kaveri SV, Bayry J. Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol Sci. 2009 ; 30: 287-295
24. Mankertz J, Schulzke JD. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol. 2007 ; 23: 379-383 (Pubitemid 46878948)
25. Gullberg E, Soderholm JD. Peyer's patches and M cells as a potential sites of the inflammatory onset in Crohn's disease. Ann N Y Acad Sci. 2006 ; 1072: 218-232 (Pubitemid 44448455)
26. Ashwood P, Thompson RP, Powell JJ. Fine particles that adsorb lipopolysacchride via bridging calcium cations may mimic bacterial pathogenicity towards cells. Exp Biol Med. 2007 ; 232: 107-117 (Pubitemid 46089945)
27. Powell JJ, Harvey RS, Ashwood P, Wolstencroft R, Gershwin ME, Thompson RP. Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease. J Autoimmun. 2000 ; 14: 99-105 (Pubitemid 30080542)
28. Evans SM, Ashwood P, Warley A, Berisha F, Thompson RPH, Powell JJ. The role of dietary microparticles and calcium in apoptosis and interleukin-1ß release of intestinal macrophages. Gastroenterology. 2002 ; 123: 1543-1553 (Pubitemid 35231654)
29. Thoree V, Skepper J, Deere H, Pele LC, Thompson RP, Powell JJ. Phenotype of exogenous microparticle-containing pigment cells of the human Peyer's patch in inflamed and normal ileum. Inflamm Res. 2008 ; 57: 374-378
30. Pele LC, Powell JJ IBD: translation from basic research to clinical practice. Colombel JF Gasche C Scholmerich J Vucelic B, ed. Dordrecht: Kluwer Academic Publishers ; 2005: 123-137.
31. Powell JJ, Harvey RS, Thompson RP. Microparticles in Crohn's disease-has the dust settled?. Gut. 1996 ; 39: 340-341 (Pubitemid 26276019)
32. Lomer MC, Hutchinson C, Volkert S. Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease. Br J Nutr. 2004 ; 92: 947-955 (Pubitemid 40028856)
33. Butler M, Boyle JJ, Powell JJ, Playford RJ, Ghosh S. Dietary microparticles implicated in Crohn's disease can impair macrophage phagocytic activity and act as adjuvants in the presence of bacterial stimuli. Inflamm Res. 2007 ; 56: 353-361 (Pubitemid 47443565)
34. Mannhalter JW, Neychev HO, Zlabinger GJ, et al. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation. Clin Exp Immunol. 1985 ; 61: 143-151 (Pubitemid 15029859)
35. Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008 ; 456: 264-268
36. Lomer MC, Harvey RS, Evans S-M. Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn's disease. Eur J Gastroenterol Hepatol. 2001 ; 13: 101-106 (Pubitemid 32158201)
37. Lomer MC, Grainger SL. Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn's disease. Eur J Gastroenterol Hepatol. 2005 ; 17: 377-384 (Pubitemid 40411227)
38. Mitsuhashi M, Targan SR. Ex vivo stimulation of IgG Fc and T-cell receptor function: an application to inflammatory bowel disease. Inflamm Bowel Dis. 2006 ; 14: 1061-1067
39. Vuckovic S, Florin TH, Khalil D, et al. CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel disease. Am J Gastroenterology. 2001 ; 96: 2946-2956 (Pubitemid 32959538)
40. Philpott JR, Miner PB. Antisense inhibition of ICAM-1 expression as therapy provides insight into basic inflammatory pathways through early experiences in IBD. Expert Opin Biol Ther. 2008 ; 8: 1627-1632
41. Papadakis KA. Chemokines in inflammatory bowel disease. Curr Allergy Asthma Rep. 2004 ; 4: 83-89 (Pubitemid 38899122)
42. Stallmach A, Giese T, Schmidt C, et al. Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease. Int J Colorectal Dis. 2004 ; 19: 308-315 (Pubitemid 38868295)
43. Kaser A, Blumberg RS. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology. 2011 ; 140: 1738-1747
44. Marrack P, McKee A, Munks MW. Towards an understanding of the adjuvant action of aluminum. Nature Rev Immunol. 2009 ; 9: 287-293
45. Dotan I, Fishman S, Dgani Y, et al. Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease. Gastroenterology. 2006 ; 131: 366-378 (Pubitemid 44142445)
46. Lindblad EB. Aluminum compounds for use in vaccines. Immun Cell Biol. 2004 ; 82: 497-505
47. Wasan SK, Baker SE, Skolnik PR, Farraye FA. A practical guide to vaccinating the inflammatory bowel disease. Patient Amer J Gastroenterol. 2010 ; 105: 1231-1238
48. Bamonti F, Fulgenzi A, Novembrino C, Ferrero ME. Metal chelation therapy in rheumatoid arthritis: a case report. Biometals 2011; 24: 1093-1098.
49. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Macrophage myofasciitis a vaccine (alum) autoimmune-related disease. Clin Rev Allergy Immun 2011; 41: 163-168.
50. Flaten TP. Aluminum as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Res Bull. 2001 ; 15: 187-196 (Pubitemid 32722158)
51. Exley C, Mamutse G, Korchazhkina O, et al. Elevated urinary excretion of aluminum and iron in multiple sclerosis. Mult Scler. 2006 ; 12: 533-540 (Pubitemid 46940625)
52. Cai HR, Cao M, Meng FQ, Wei JY. Pulmonary sarcoid-like granulomatosis induced by aluminum dust: report of a case and literature review. Chin Med J. 2007 ; 120: 1556-1560 (Pubitemid 47496596)
53. de Carvalho JF, Pereira RM, Shoenfeld Y. The mosaic of autoimmunity: the role of environmental factors. Front Biosci (Elite edn). 2009 ; 1: 501-509
54. Molina V, Shoenfeld Y. Infection, vaccines and other environmental triggers of autoimmunity. Autoimmunity. 2005 ; 38: 235-245 (Pubitemid 40959897)
55. Shoenfeld Y. Infections, vaccines and autoimmunity. Lupus. 2009 ; 18: 1127-1128
56. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus. 2009 ; 18: 1217-1225
57. Fournie GJ, Mas M, Cautain B, et al. Induction of autoimmunity through bystander effects. Lessons from immunological disorders induced by heavy metals. J Autoimmun. 2001 ; 16: 319-326
58. Meroni PL. Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA): old truth and a new syndrome?. J Autoimmun. 2011 ; 36: 1-3
59. Shoenfeld Y, Agmon-levin N. 'ASIA'-autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011 ; 36: 4-8