Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 20868-20882

  Kang, Min Suk ^a   Baek, Seung Hoon ^b   Chun, Yoon Sun ^c   Moore, A Zenobia ^a   Landman, Natalie ^a   Berman, Diego ^a   Yang, Hyun Ok ^d   Morishima Kawashima, Maho ^e   Osawa, Satoko ^f   Funamoto, Satoru ^g   Ihara, Yasuo ^g   Di Paolo, Gilbert ^a   Park, Jeong Hill ^h   Chung, Sungkwon ^c   Kim, Tae Wan ^a  

^a Department of Medicine   (United States)

^b Ajou University   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e HOKKAIDO UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g DOSHISHA UNIVERSITY   (Japan)

^h Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ALZHEIMER DISEASE; AMYLOID-BETA PEPTIDES; INVARIANT FEATURES; LIPID RAFT ASSOCIATION; MOLECULAR MECHANISM; NATURAL COMPOUNDS; PHOSPHOINOSITIDES; SYNTHETIC PATHWAYS;

PHOSPHOLIPIDS;

AMYLOID BETA PROTEIN; GAMMA SECRETASE; GINSENOSIDE RG 3; NEUROTROPHIN RECEPTOR P75; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 4 KINASE IIALPHA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PRESENILIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; LIPID RAFT; MOUSE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84880548804     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.445734     Document Type: Article

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