Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K/Akt activation and PKC inhibition

Biochemical Pharmacology

Volumn 82, Issue 2, 2011, Pages 148-155

  Lan, Tao Hua ^a,b   Xu, Zhi Wei ^a   Wang, Zhi ^b   Wu, Yi Ling ^c   Wu, Wei Kang ^a,b   Tan, Hong Mei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c Hebei Yiling Academy of Medicine   (China)

Author keywords

Ginsenoside Rb1; Homocysteine; NO; PI3K Akt; PKC

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GINSENOSIDE RB 1; HOMOCYSTEINE; NITRATE REDUCTASE; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE C; SERINE; THREONINE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GINSENOSIDES; HOMOCYSTEINE; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION; VON WILLEBRAND FACTOR;

EID: 79958103461     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.04.001     Document Type: Article

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